K34c

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Cat.No. 5114 - K34c | C26H29N3O4 | CAS No. 939769-93-4
Description: Potent and selective α5β1 integrin inhibitor
Chemical Name: N-(2,6-Dimethylbenzoyl)-O-[3-(2-pyridinylamino)propyl]-L-tyrosine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for K34c

K34c is a potent and selective α5β1 integrin inhibitor (IC50 = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide (Cat. No. 2706) or Ellipticine (Cat. No. 3357) and promotes apoptosis in U87MG cells. K34c also prevents TGFβ-induced infiltration in vivo and reduces cell adhesion on fibronectin.

Technical Data for K34c

M. Wt 447.53
Formula C26H29N3O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 939769-93-4
PubChem ID 16663328
InChI Key VLNHAQFIBARCQP-UHFFFAOYSA-N
Smiles O=C(C3=C(C)C=CC=C3C)N[C@H](C(O)=O)CC(C=C2)=CC=C2OCCCNC1=CC=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for K34c

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.75 100
ethanol 44.75 100

Preparing Stock Solutions for K34c

The following data is based on the product molecular weight 447.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.17 mL 22.34 mL
5 mM 0.45 mL 2.23 mL 4.47 mL
10 mM 0.22 mL 1.12 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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References for K34c

References are publications that support the biological activity of the product.

Heckmann et al (2007) Probing integrin selectivity: rational design of highly active and selective ligands for the α5β1 and αvβ3 integrin receptor. Angew.Chem.Int.Ed.Engl 46 3571 PMID: 17394271

Martinkova et al (2010) α5β1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int.J.Cancer 127 1240 PMID: 20099278

Renner et al (2016) Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells. Oncotarget 7 62194 PMID: 27613837

Kuonen et al (2018) TGF-β, fibronectin and integrin α5β1 promote invasion in basal cell carcinoma. J.Invest.Dermatol. 138 2432 PMID: 29758283


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Keywords: K34c, K34c supplier, alpha5beta1, integrins, inhibitors, potent, selective, cell, adhesion, a5b1, alfa5beta1, Integrins, 5114, Tocris Bioscience

Citations for K34c

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.