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K34c is a potent and selective α5β1 integrin inhibitor (IC50 = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide (Cat. No. 2706) or Ellipticine (Cat. No. 3357) and promotes apoptosis in U87MG cells. K34c also prevents TGFβ-induced infiltration in vivo and reduces cell adhesion on fibronectin.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 447.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.23 mL||11.17 mL||22.34 mL|
|5 mM||0.45 mL||2.23 mL||4.47 mL|
|10 mM||0.22 mL||1.12 mL||2.23 mL|
|50 mM||0.04 mL||0.22 mL||0.45 mL|
References are publications that support the biological activity of the product.
Heckmann et al (2007) Probing integrin selectivity: rational design of highly active and selective ligands for the α5β1 and αvβ3 integrin receptor. Angew.Chem.Int.Ed.Engl 46 3571 PMID: 17394271
Martinkova et al (2010) α5β1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int.J.Cancer 127 1240 PMID: 20099278
Renner et al (2016) Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells. Oncotarget 7 62194 PMID: 27613837
Kuonen et al (2018) TGF-β, fibronectin and integrin α5β1 promote invasion in basal cell carcinoma. J.Invest.Dermatol. 138 2432 PMID: 29758283
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Keywords: K34c, K34c supplier, alpha5beta1, integrins, inhibitors, potent, selective, cell, adhesion, a5b1, alfa5beta1, Integrins, 5114, Tocris Bioscience
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