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α5β1 integrin receptor antagonist. Reduces liver metastasis and improves survival in combination with 5-FU (Cat. No. 3257) in a mouse model of colon cancer. Reduces MLL tumor growth in rats and decreases tumor volume of human MDA-MB-231 cell xenografts in mice.
(Modifications: Pro-1 = N-terminal Ac, Asn-5 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 2 mg/ml in water|
References are publications that support the biological activity of the product.
Livant et al (2000) Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma. Cancer Res. 60 309 PMID: 10667582
Khalili et al (2006) A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol.Cancer Ther. 5 2271 PMID: 16985061
Stoeltzing et al (2003) Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int.J.Cancer. 104 496 PMID: 12584749
If you know of a relevant reference for ATN 161, please let us know.
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Keywords: ATN 161, ATN 161 supplier, ATN161, α5β1, integrin, receptors, alpha5beta1, a5b1, antagonists, antagonism, Integrins, 6058, Tocris Bioscience
1 Citation for ATN 161
Citations are publications that use Tocris products. Selected citations for ATN 161 include:
Albarrán-Juárez et al (2018) Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med 215 2655 PMID: 30194266
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Literature in this Area
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