ATN 161

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Cat.No. 6058 - ATN 161 | Ac-Pro-His-Ser-Cys-Asn-NH2 | CAS No. 262438-43-7
Description: α5β1 integrin receptor antagonist
Datasheet
Citations
Literature

Biological Activity

α5β1 integrin receptor antagonist. Reduces liver metastasis and improves survival in combination with 5-FU (Cat. No. 3257) in a mouse model of colon cancer. Reduces MLL tumor growth in rats and decreases tumor volume of human MDA-MB-231 cell xenografts in mice.

Technical Data

M. Wt 597.65
Formula C23H35N9O8S
Sequence PHSCN

(Modifications: Pro-1 = N-terminal Ac, Asn-5 = C-terminal amide)

Storage Store at -20°C
CAS Number 262438-43-7
PubChem ID 9960285
InChI Key MMHDBUJXLOFTLC-WOYTXXSLSA-N
Smiles CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 597.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.67 mL 8.37 mL 16.73 mL
5 mM 0.33 mL 1.67 mL 3.35 mL
10 mM 0.17 mL 0.84 mL 1.67 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Livant et al (2000) Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma. Cancer Res. 60 309 PMID: 10667582

Khalili et al (2006) A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol.Cancer Ther. 5 2271 PMID: 6985061

Stoeltzing et al (2003) Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int.J.Cancer. 104 496 PMID: 12584749


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Keywords: ATN 161, supplier, ATN161, α5β1, integrin, receptors, alpha5beta1, a5b1, antagonists, antagonism, Integrins, Tocris Bioscience

Citations for ATN 161

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Literature in this Area

Immunology

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