ATN 161

Pricing Availability   Qty
Cat.No. 6058 - ATN 161 | Ac-Pro-His-Ser-Cys-Asn-NH2 | CAS No. 262438-43-7
Description: α5β1 integrin receptor antagonist
Datasheet
Citations
Reviews
Literature

Biological Activity

α5β1 integrin receptor antagonist. Reduces liver metastasis and improves survival in combination with 5-FU (Cat. No. 3257) in a mouse model of colon cancer. Reduces MLL tumor growth in rats and decreases tumor volume of human MDA-MB-231 cell xenografts in mice.

Technical Data

M. Wt 597.65
Formula C23H35N9O8S
Sequence PHSCN

(Modifications: Pro-1 = N-terminal Ac, Asn-5 = C-terminal amide)

Storage Store at -20°C
CAS Number 262438-43-7
PubChem ID 9960285
InChI Key MMHDBUJXLOFTLC-WOYTXXSLSA-N
Smiles CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Livant et al (2000) Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma. Cancer Res. 60 309 PMID: 10667582

Khalili et al (2006) A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol.Cancer Ther. 5 2271 PMID: 16985061

Stoeltzing et al (2003) Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int.J.Cancer. 104 496 PMID: 12584749


If you know of a relevant reference for ATN 161, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Integrin Inhibitors

Keywords: ATN 161, ATN 161 supplier, ATN161, α5β1, integrin, receptors, alpha5beta1, a5b1, antagonists, antagonism, Integrins, 6058, Tocris Bioscience

Citations for ATN 161

Citations are publications that use Tocris products.

Currently there are no citations for ATN 161. Do you know of a great paper that uses ATN 161 from Tocris? Please let us know.

Reviews for ATN 161

There are currently no reviews for this product. Be the first to review ATN 161 and earn rewards!

Have you used ATN 161?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation