ATN 161

Pricing Availability   Qty
Description: α5β1 integrin receptor antagonist
Purity: ≥95% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (2)

Biological Activity for ATN 161

ATN 161 is a α5β1 integrin receptor antagonist. Reduces liver metastasis and improves survival in combination with 5-FU (Cat. No. 3257) in a mouse model of colon cancer. Reduces MLL tumor growth in rats and decreases tumor volume of human MDA-MB-231 cell xenografts in mice.

Technical Data for ATN 161

M. Wt 597.65
Formula C23H35N9O8S
Sequence PHSCN

(Modifications: Pro-1 = N-terminal Ac, Asn-5 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 262438-43-7
PubChem ID 9960285
InChI Key MMHDBUJXLOFTLC-WOYTXXSLSA-N
Smiles CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ATN 161

Solubility Soluble to 2 mg/ml in water

Product Datasheets for ATN 161

Certificate of Analysis / Product Datasheet
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References for ATN 161

References are publications that support the biological activity of the product.

Livant et al (2000) Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma. Cancer Res. 60 309 PMID: 10667582

Khalili et al (2006) A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol.Cancer Ther. 5 2271 PMID: 16985061

Stoeltzing et al (2003) Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int.J.Cancer. 104 496 PMID: 12584749


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Keywords: ATN 161, ATN 161 supplier, ATN161, α5β1, integrin, receptors, alpha5beta1, a5b1, antagonists, antagonism, Integrins, 6058, Tocris Bioscience

4 Citations for ATN 161

Citations are publications that use Tocris products. Selected citations for ATN 161 include:

Aejaz et al (2019) Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth. iScience 14 199-209 PMID: 30981115

Albarrán-Juárez et al (2018) Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med 215 2655 PMID: 30194266

Giovanni et al (2023) The interaction of β-arrestin1 with talin1 driven by endothelin A receptor as a feature of α5β1 integrin activation in high-grade serous ovarian cancer. Cell Death Dis 14 73 PMID: 36717550

Viola et al (2020) Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis. Elife 9 PMID: 33026975


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Reviews for ATN 161

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.