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Description: Integrin ligand for degrader development and targeted delivery, with alkyne click handle for conjugation
Purity: ≥95% (HPLC)
Literature (2)

Biological Activity for Alkyne-cRGD

Alkyne-cRGD is an integrin ligand for degrader development and targeted delivery. It contains an alkyne handle that enables the attachment of additional groups via copper-catalyzed azide-alkyne cycloaddition click reactions.

Technical Data for Alkyne-cRGD

M. Wt 713.78
Formula C33H47N9O9
Sequence RGDYK

(Modifications: Tyr-4 = D-Tyr, Lys-5 = N6-(1-oxo-5-hexyn-1-yl)-Lys, Lactam bridge: Arg-1 to Lys-5)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2665674-77-9
Smiles NC(NCCC[C@H](NC([C@@H](NC([C@@H](CC1=CC=C(O)C=C1)N2)=O)CCCCNC(CCCC#C)=O)=O)C(NCC(N[C@@H](CC(O)=O)C2=O)=O)=O)=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Alkyne-cRGD

Solubility Soluble to 2 mg/ml in water

References for Alkyne-cRGD

References are publications that support the biological activity of the product.

Zheng et al (2022) Bifunctional compounds as molecular degraders for integrin-facilitated targeted protein degradation. J.Am.Chem.Soc. 144 21831 PMID: 36417563

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Keywords: Alkyne-cRGD, Alkyne-cRGD supplier, click-activated, ligands, targeted, degraders, protein, degradation, development, copper-catalyzed, azide-alkyne, cycloaddition, Integrins, Biochemicals, and, Molecular, Biology, LYTAC, Building, Blocks, 8042, Tocris Bioscience

Citations for Alkyne-cRGD

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.