LDV

Pricing Availability   Qty
Cat.No. 7020 - LDV | N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-Leu-Asp-Val-Pro-Ala-Ala-Lys | CAS No. 1155866-55-9
Description: α4β1 (VLA-4) ligand
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC (Cat. No. 4577).

Technical Data

M. Wt 979.13
Formula C48H70N10O12
Sequence LDVPAAK (Modifications: Leu-1 = N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-Leu)
Storage Store at -20°C
CAS Number 1155866-55-9
InChI Key FQYZPSNPTJYQKB-CGTMUHGOSA-N
Smiles CC(C)C[C@@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)C)=O)C)=O)=O)C(C)C)=O)CC(O)=O)=O)NC(CC(C=C2)=CC=C2NC(NC3=C(C)C=CC=C3)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in 0.01M PBS (pH 7.4)

References

References are publications that support the biological activity of the product.

Chigaev et al (2009) Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation. J.Biol.Chem. 284 14337 PMID: 19251697


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Keywords: LDV, LDV supplier, VLA4, very, late, antigen, 4, ligand, integrin, a4b1, alpha4beta1, Integrins, 7020, Tocris Bioscience

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.