Actin

Actin is a ubiquitous globular protein that is one of the most highly-conserved proteins known. It is found in two main states: G-actin is the globular monomeric form, whereas F-actin forms helical polymers. Both G- and F-actin are intrinsically flexible structures.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5804 Chaetoglobosin A
Inhibitor of actin polymerization; apoptosis inducer
3950 CK 666
Arp2/3 inhibitor; inhibits actin polymerization
4984 CK 869
Arp2/3 inhibitor; inhibits actin polymerization
5474 Cytochalasin B
Inhibitor of actin polymerization
3973 Latrunculin A
Inhibitor of actin assembly and polymerization
3974 Latrunculin B
Inhibitor of actin polymerization
2067 187-1, N-WASP inhibitor
N-WASP inhibitor; inhibits actin assembly
4434 Wiskostatin
N-WASP inhibitor; inhibits Arp2/3 activation

Other

Cat No Product Name / Activity
1233 Cytochalasin D
Disrupts actin filament function
2792 Jasplakinolide
Stabilizes F-actin; promotes actin polymerization
3715 Narciclasine
Antiproliferative agent; induces actin polymerization
4535 Phalloidin
Promotes actin polymerization
4401 SMIFH2
FH2 domain inhibitor; prevents actin nucleation
3390 Thymosin β4
Potent actin polymerization regulator

Actin is a ubiquitous globular protein that is one of the most highly-conserved proteins known. It is found in two main states: G-actin is the globular monomeric form, whereas F-actin forms helical polymers. Both G- and F-actin are intrinsically flexible structures - a feature vital in actin's role as a dynamic filament network.

Actin has four major functions. Firstly, F-actin polymers form microfilaments - polar intracellular 'tracks' for kinesin motor proteins, allowing the transport of vesicles, organelles and other cargo. Actin is a component of the cytoskeleton and links to α-actinin, E-cadherin and β-catenin at adherens junctions. This gives mechanical support to cells and attaches them to each other and the extracellular matrix. In muscle cells, actin-rich thin filaments associate with myosin-rich thick filaments to form actomyosin myofibrils. Using energy from the hydrolysis of ATP, myofibrils undergo cyclic shortening through actin-myosin head interactions, which represents the mechanics of muscle contraction. Finally, actin has a role in cell motility through polymerization and depolymerization of fibrils.

Literature for Actin

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Actin Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
α1 actin Human ACTA1 NM_001100 P68133
Mouse Acta1 NM_009606 P68134
Rat Acta1 NM_019212 NP_062085
α2 actin Human ACTA2 NM_001613 P62736
Mouse Acta2 NM_007392 P62737
Rat Acta2 NM_031004 P62738
β actin Human ACTB NM_001101 Q96HG5
Mouse Actb NM_007393 P60710
Rat Actb NM_031144 P60711
γ1 actin Human ACTG1 NM_001614 P63261
Mouse Actg1 NM_009609 P63260
Rat Actg1 NM_001127449 P63259
γ2 actin Human ACTG2 NM_001615 P63267
Mouse Actg2 NM_009610 P63268
Rat Actg2 NM_012893 P63269