New ProductsView all New Products by pharmacological action
Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
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Calcium-Activated Potassium (KCa) Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
|---|---|---|
| 6398 | SKA 121 | Jan 2020 |
| Positive allosteric modulator of KCa3.1 channels | ||
| 6481 | AP 14145 hydrochloride | Nov 2019 |
| KCa2 channel negative allosteric modulator | ||
Glutamate (Metabotropic) Group II Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6928 | VU 6001966 | Feb 2020 |
| Potent and selective negative allosteric modulator of mGlu2 receptors | ||
Glutamate (Metabotropic) Group I Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6895 | VU 0424465 | Oct 2019 |
| Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity | ||
Adenosine A1 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6863 | N6-Cyclohexyladenosine | Nov 2019 |
| High affinity A1 receptor agonist | ||
Trace Amine 1 Receptor | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6833 | RO 5263397 hydrochloride | Feb 2020 |
| Potent TA1 receptor agonist | ||
CB1 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 5746 | NESS 0327 | Feb 2020 |
| Ultra-high affinity and selective CB1 antagonist | ||
OX2 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6739 | YNT 185 | Mar 2020 |
| Potent and selective OX2 agonist | ||
K+/Cl- Cotransporter 2 | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6758 | CLP 290 | Mar 2020 |
| K+/Cl- cotransporter 2 (KCC2) activator; orally bioavailable prodrug of CLP 257 (Cat. No.5242) | ||
CB2 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6220 | PM 226 | Jan 2020 |
| Potent and selective CB2 receptor agonist; BBB permeable; neuroprotective | ||
M2 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6964 | LY 2119620 | Jan 2020 |
| Positive allosteric modulator of M2 and M4 receptors | ||
Functionalized E3 Ligase Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6911 | VH 032, phenol | Mar 2020 |
| Hydroxyl functionalized VHL ligand | ||
5-HT3 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7038 | Palonosetron hydrochloride | Feb 2020 |
| Highly potent and high affinity 5-HT3 antagonist | ||
Functionalized E3 Ligase Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6952 | VH 101, phenol | Jan 2020 |
| Hydroxyl functionalized VHL ligand | ||
Adrenergic β3 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7070 | Mirabegron | Nov 2019 |
| Potent and selective β3 agonist | ||
D3 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7039 | SK 609 | Feb 2020 |
| Dopamine D3 receptor biased agonist | ||
Functionalized E3 Ligase Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6471 | A 410099.1, amine | Nov 2019 |
| Functionalized IAP ligand for PROTACs | ||
M4 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6932 | VU 0467485 | Oct 2019 |
| Potent and selective positive allosteric modulator of M4 receptors; orally bioavailable and brain penetrant | ||
Orphan 7-TM Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6931 | AF 64394 | Dec 2019 |
| Potent and selective GPR3 inverse agonist | ||
Free Fatty Acid Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6826 | AZ 1729 | Mar 2020 |
| FFA2 allosteric agonist; displays bias for the Gi signaling pathway | ||
Free Acid Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6993 | Janelia Fluor® 646, free acid | Feb 2020 |
| Red dye (Reactive group: free acid). Applications: super resolution microscopy e.g. dSTORM & STED, confocal, flow and live cell imaging | ||
Active Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6939 | cis-VZ 185 | Mar 2020 |
| Negative control for VZ 185 (Cat. No. 6936) | ||
| 6936 | VZ 185 | Oct 2019 |
| Potent and selective BRD7/9 Degrader | ||
Poly(ADP-ribose) Polymerase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7026 | Veliparib dihydrochloride | Dec 2019 |
| High affinity PARP-1 and -2 inhibitor; orally bioavailable | ||
AMPA Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6847 | TAT-GluA2 3Y | Oct 2019 |
| Inhibitor of AMPA receptor endocytosis | ||
Amyloid β Peptides | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7031 | Amyloid β-Peptide (1-37) (human) | Nov 2019 |
| Amyloid β-protein fragment | ||
Apelin Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7053 | MM 07 | Dec 2019 |
| Apelin receptor biased agonist; exhibits bias for the G protein pathway | ||
Biochemicals and Molecular Biology | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7044 | (±)-α-Lipoic acid | Nov 2019 |
| Liquid-liquid phase separated condensate modifier; reduces stress granule formation | ||
| 7015 | IA-Alkyne | Jan 2020 |
| Broad spectrum cysteine reactive probe | ||
| 7045 | (±)-α-Lipoamide | Oct 2019 |
| Phase-separated condensate modifier; orally bioavailable | ||
| 6456 | Fluorescein Tyramide | Jan 2020 |
| Green fluorescent reagent widely used for signal amplification in IHC and ISH | ||
| 6574 | Fluorescein-NAD+ | Oct 2019 |
| Fluorescent NAD+; substrate for ADP-ribosylation for use in PARP assays | ||
| 6458 | Cyanine 5 Tyramide | Jan 2020 |
| Red fluorescent reagent widely used for signal amplification in IHC and ISH | ||
| 6457 | Cyanine 3 Tyramide | Jan 2020 |
| Orange fluorescent reagent widely used for signal amplification in IHC and ISH | ||
Bromodomains | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6670 | TP 238 | Mar 2020 |
| CECR2 and BPTF/FALZ inhibitor | ||
cGMP Stem Cell Compounds | ||
| Cat. No. | Product Name / Activity | Date Added |
| TB3748-GMP | XAV 939 | Jan 2020 |
| XAV 939 synthesized to cGMP guidelines | ||
Other Cannabinoids | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6372 | PSB CB5 | Mar 2020 |
| Selective GPR18 antagonist | ||
β-catenin | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7002 | KYA 1797K | Dec 2019 |
| Wnt/β-catenin signaling inhibitor | ||
| 6961 | FzM1.8 | Dec 2019 |
| Frizzled 4 allosteric agonist; exhibits biased siginaling; preserves stemness | ||
Chemokine CC Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7071 | GSK 2239633A | Dec 2019 |
| Potent CCR4 antagonist | ||
Stem Cell Proliferation | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6991 | Poly Vinyl Alcohol | Dec 2019 |
| Carrier molecule for stem cell culture; replaces serum albumin for ex vivo stem cell expansion | ||
Cereblon Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6946 | Thalidomide 4'-oxyacetamide-alkylC8-amine | Nov 2019 |
| Cereblon ligand with alkyl linker and terminal amine for onward chemistry | ||
Class II HDACs | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7051 | Tasquinimod | Jan 2020 |
| High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic | ||
| 6725 | CHDI 00390576 | Dec 2019 |
| Potent and selective class IIa HDAC inhibitor; brain penetrant | ||
Click-Reactive Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7088 | Janelia Fluor® 646, Azide | Feb 2020 |
| Red dye (Reactive group: azide). Applications: super resolution microscopy e.g. dSTORM & STED, confocal, and live cell imaging | ||
Complement | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6860 | SB 290157 trifluoroacetate | Dec 2019 |
| Potent C3a receptor antagonist | ||
Tocriscreen Compound Libraries | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7152 | Tocriscreen 2.0 Micro | Jan 2020 |
| A library of 1280 biologically active compounds (15 μL 10 mM DMSO solutions) | ||
| 7151 | Tocriscreen 2.0 Mini | Jan 2020 |
| A library of 1280 biologically active compounds (50 μL 10 mM DMSO solutions) | ||
| 7150 | Tocriscreen 2.0 Max | Jan 2020 |
| A library of 1280 biologically active compounds (250 μL 10 mM DMSO solutions) | ||
Cyclin-Dependent Protein Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7050 | Ribociclib | Dec 2019 |
| Dual cdk4/cdk6 inhibitor; orally bioavailable | ||
Cytokines | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7066 | RCGD 423 | Nov 2019 |
| gp130 modulator; activates JAK/STAT signaling | ||
TAG Degradation Platform | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6971 | aTAG 4531 | Nov 2019 |
| Degrader of MTH1 fusion proteins for use within the aTAG system | ||
| 6912 | dTAG-7 | Dec 2019 |
| First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation | ||
STING-Dependent Signaling | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7040 | C 176 | Feb 2020 |
| mSTING antagonist | ||
RNA/DNA Polymerase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6974 | BMS 986094 | Oct 2019 |
| Prodrug of HCV RNA polymerase inhibitor 2'-C-methyl guanosine triphosphate; potent HCV replication inhibitor | ||
| 7090 | Digoxigenin-11-dUTP | Mar 2020 |
| Hapten modified dUTP for ISH | ||
DNA, RNA and Protein Synthesis | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6586 | Targapremir 210 | Dec 2019 |
| Inhibits formation of miR-210 | ||
Fluorescent DNA Stains | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7121 | 7-Aminoactinomycin D | Feb 2020 |
| Fluorescent DNA stain | ||
DREADD Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7119 | Sorbic acid | Nov 2019 |
| Activator of hFFA2-DREADDs | ||
Dynamin | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6799 | MB 0223 | Dec 2019 |
| Dynamin-related GTPase DRP1 partial inhibitor | ||
| 6897 | P110 | Oct 2019 |
| Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable | ||
Viral Transduction Enhancers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6982 | Cyclosporin H | Oct 2019 |
| Enhances lentiviral transduction | ||
Other Transcription Factors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 4265 | AS 1842856 | Nov 2019 |
| Potent and selective Foxo1 inhibitor; orally bioavailable | ||
Other Hydrolases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7007 | PDD 00017238 | Dec 2019 |
| High affinity and potent PARG inhibitor | ||
| 6691 | LP 922056 | Oct 2019 |
| Notum inhibitor; activates Wnt signaling | ||
| 7009 | PDD 00031705 | Dec 2019 |
| Negative control for PDD 00017238 (Cat. No. 7007). | ||
IAP Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6474 | A 410099.1 amide-alkylC4-amine | Nov 2019 |
| A 410099.1 amide-alkylC4-amine | ||
| 6472 | A 410099.1 amide-PEG3-amine | Nov 2019 |
| A 410099.1 amide-PEG3-amine | ||
| 6473 | A 410099.1 amide-PEG2-amine | Nov 2019 |
| A 410099.1 amide-PEG2-amine | ||
Inflammasomes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6925 | NBC 6 | Jan 2020 |
| NLRP3 inflammasome inhibitor | ||
JAK Kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7064 | Ruxolitinib | Feb 2020 |
| Potent and selective JAK1/JAK2 inhibitor; orally bioavailable | ||
| 7048 | Ruxolitinib phosphate | Feb 2020 |
| Phosphate salt of Ruxolitinib (Cat. No. 7064); potent and selective JAK1/JAK2 inhibitor | ||
Kainate Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7065 | Kainic acid (synthetic) | Oct 2019 |
| Kainate agonist; excitant and neurotoxin | ||
Rho-Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7163 | Chroman 1 | Mar 2020 |
| Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogeneisis | ||
Src Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6981 | TL 0259 | Dec 2019 |
| Selective and highly potent Fgr and Lyn kinase inhibitor; orally bioavailable | ||
VHL Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7074 | VH 032 amide-alkylC7-amine | Mar 2020 |
| VHL ligand with alkyl linker and terminal amine for onward chemistry | ||
| 6985 | VH 032 amide-alkylC5-amine | Jan 2020 |
| VHL ligand with alkyl linker and terminal amine for onward chemistry | ||
Photoswitchable Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7013 | OptoBI-1 | Nov 2019 |
| Photoswitchable TRPC3/6/7 agonist | ||
Toll-like Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6858 | MMG 11 | Jan 2020 |
| TLR2 antagonist | ||
δ Opioid Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6729 | TAN 452 | Dec 2019 |
| Potent and selective peripherally acting δ opioid antagonist; antianalgesic. | ||
Other Reductases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7162 | iFSP1 | Feb 2020 |
| Ferroptosis suppressor protein 1 (FSP1) inhibitor; ferroptosis inducer | ||
Other Transferases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6775 | ST 045849 | Dec 2019 |
| O-GlcNAc transferase (OGT) inhibitor | ||
| 6900 | NNMTi | Dec 2019 |
| Nicotinamide N-methyltransferase (NNMT) inhibitor; promotes myoblast differentiation | ||
Other Synthases/Synthetases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6791 | BC-LI-0186 | Feb 2020 |
| Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor | ||
Other RTKs | ||
| Cat. No. | Product Name / Activity | Date Added |
| 5860 | 7rh | Dec 2019 |
| Potent and selective DDR1 inhibitor; orally bioavailable | ||
PDGFR | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6976 | JNJ 10198409 | Mar 2020 |
| Potent PDGFRα and PDGFRβ inhbitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases | ||
TGF-β Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6870 | AZ 12799734 | Nov 2019 |
| Potent TGF-βRI inhibitor | ||
STATs | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6110 | HJC 0416 hydrochloride | Feb 2020 |
| STAT3 inhibitor | ||
TRPC | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6940 | BTD | Oct 2019 |
| Selective TRPC5 activator | ||
| 6875 | TRPC6-PAM-C20 | Dec 2019 |
| Selective TRPC6 positive allosteric modulator | ||
VEGFR | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7049 | Nintedanib | Dec 2019 |
| Potent VEGFR, PDGFR and FGFR inhibitor | ||