New Products

View all New Products by pharmacological action

Search for new products by date added, alphabetically, or by pharmacological action.

New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

Voltage-gated Sodium (NaV) Channels

Cat. No. Product Name / Activity Date Added
7029 GX 201 Aug 2020
Potent and selective Nav1.7 blocker; analgesic

Unnatural Amino Acids / Non Canonical Amino Acids

Cat. No. Product Name / Activity Date Added
7370 3-Aminotyrosine Dec 2020
Unnatural amino acid for inducing red shift in fluorescent proteins and fluorescent protein-based biosensors

σ1 Receptors

Cat. No. Product Name / Activity Date Added
7156 WQ 1 Dec 2020
Potent and selective σ1 receptor antagonist; active in vivo

CB1 Receptors

Cat. No. Product Name / Activity Date Added
7131 TM 38837 Dec 2020
Highly potent CB1 inverse agonist; peripherally restricted

MTH1

Cat. No. Product Name / Activity Date Added
6562 BAY 707 Dec 2020
Potent and selective MTH1 inhibitor

Adenosine A1 Receptors

Cat. No. Product Name / Activity Date Added
6261 VCP 171 Jan 2021
Postitive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist

Histamine H2 Receptors

Cat. No. Product Name / Activity Date Added
7290 Famotidine Aug 2020
Potent and high affinity H2 biased inverse agonist

ACE2

Cat. No. Product Name / Activity Date Added
7322 SP 10 Dec 2020
Highly potent inhibitor of SARS-CoV Spike (S) protein and ACE2 interaction

3C and 3CL Proteases

Cat. No. Product Name / Activity Date Added
7228 MPro 13b Dec 2020
Coronavirus Mpro inhibitor

Ubiquitin E3 Ligases

Cat. No. Product Name / Activity Date Added
7192 SMIP 004 Jan 2021
SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase

Functionalized E3 Ligase Ligands

Cat. No. Product Name / Activity Date Added
7178 LCL 161, phenol Sep 2020
Functionalized IAP ligand for PROTACs

Histone Acetyltransferases

Cat. No. Product Name / Activity Date Added
7270 iP300w Jul 2020
Potent p300/CBP inhibitor

Acid-Sensing Ion Channels

Cat. No. Product Name / Activity Date Added
5927 NS 383 Nov 2020
ASIC blocker; active in vivo

Active Degraders

Cat. No. Product Name / Activity Date Added
7298 xStAx-VHLL Sep 2020
Selective peptide-based β-catenin degrader
7255 ARCC 4 negative control Nov 2020
Negative control for ARCC 4 (Cat. No. 7254)
7260 TBK1 control PROTAC® 4 Nov 2020
Negative control for TBK1 PROTAC® 3i (Cat. No. 7259)
7219 CRBN PROTAC® 14a Oct 2020
Cereblon Degrader
7287 FAM-DEALA-Hyp-YIPD Sep 2020
Fluorescent HIF-1α peptide; can be used to evaluate the effect of VHL binding on degradation activity
7254 ARCC 4 Nov 2020
Potent and selective androgen receptor degrader
7268 SJFα Jan 2021
Potent and selective p38α degrader
7266 SJF 8240 Dec 2020
c-MET Degrader; also degrades exon-14-deleted c-MET
7261 SJF 1521 Sep 2020
Selective EGFR Degrader
7258 Gefitinib-based PROTAC® 3 Nov 2020
Potent EGFR Degrader
7267 SJFδ Dec 2020
Potent and selective p38δ degrader
7262 SJF 1528 Sep 2020
Potent EGFR Degrader; also degrades HER2
7259 TBK1 PROTAC® 3i Nov 2020
Potent TANK-binding kinase 1 (TBK1) Degrader

Amine-Reactive Janelia Fluor® Dyes

Cat. No. Product Name / Activity Date Added
7312 HM Janelia Fluor® 526, SE Dec 2020
Spontaneously blinking green-emitting dye for SMLSM; λabsλem 526/550 nm

Aptamer-based RNA Imaging

Cat. No. Product Name / Activity Date Added
7277 HBC 530 Sep 2020
GFP fluorophore mimic for imaging RNA in live cells; activated by binding to Pepper aptamers; suitable for confocal and two-photon microscopy

Protein Arginine Methyltransferases

Cat. No. Product Name / Activity Date Added
7184 SGC 6870N Dec 2020
Negative control for SGC 6870 (Cat. No. 7182)
7182 SGC 6870 Dec 2020
Potent and selective PRMT6 inhibitor

Biochemicals and Molecular Biology

Cat. No. Product Name / Activity Date Added
7175 DOPE Jan 2021
Liposome/lipoplex transfection reagent
7302 Sulfo-NHS-LC-Biotin Nov 2020
Amine reactive biotinylation reagent, cell impermeable

Caspases

Cat. No. Product Name / Activity Date Added
7143 VX 765 Oct 2020
High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable

Fluorescent Lipid Probes and Cell Membrane Stains

Cat. No. Product Name / Activity Date Added
7273 C-Laurdan Jan 2021
Two-photon polarity-sensitive lipid membrane probe

Cereblon Targeting Ligands Plus Linkers

Cat. No. Product Name / Activity Date Added
7331 Thalidomide 4'-ether-alkylC4-acid Oct 2020
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
7329 Thalidomide 4'-ether-alkylC2-acid Oct 2020
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
6913 Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine Sep 2020
Cereblon ligand with alkyl-PEG-alkyl linker and terminal amine for onward chemistry
7335 Thalidomide 4'-ether-alkylC8-acid Oct 2020
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
7334 Thalidomide 4'-ether-alkylC7-acid Sep 2020
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
7333 Thalidomide 4'-ether-alkylC6-acid Sep 2020
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
7332 Thalidomide 4'-ether-alkylC5-acid Sep 2020
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
7330 Thalidomide 4'-ether-alkylC3-acid Sep 2020
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
7213 Pomalidomide 4'-PEG4-acid Nov 2020
Cereblon ligand with PEG linker and terminal acid for onward chemistry
7212 Pomalidomide 4'-PEG2-acid Jul 2020
Cereblon ligand with PEG linker and terminal acid for onward chemistry
7209 Pomalidomide 4'-alkylC4-acid Aug 2020
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
7095 Pomalidomide 4'-PEG5-acid Sep 2020
Cereblon ligand with PEG linker and terminal acid for onward chemistry
7093 Lenalidomide 4'-PEG2-amine Aug 2020
Cereblon ligand with PEG linker and terminal amine for onward chemistry
7076 Lenalidomide 4'-PEG3-amine Sep 2020
Cereblon ligand with PEG linker and terminal amine for onward chemistry
7075 Lenalidomide 4'-PEG1-amine Sep 2020
Cereblon ligand with PEG linker and terminal amine for onward chemistry

Class I HDACs

Cat. No. Product Name / Activity Date Added
7191 Santacruzamate A Sep 2020
Highly potent and selective HDAC2 inhibitor

Click-Reactive Janelia Fluor® Dyes

Cat. No. Product Name / Activity Date Added
7279 Janelia Fluor® 646, Tetrazine Sep 2020
Red dye (Reactive group: tetrazine). Applications: super-resolution microscopy e.g. dSTORM & STED, confocal and live cell imaging

Tocriscreen Compound Libraries

Cat. No. Product Name / Activity Date Added
7350 Tocriscreen Antiviral Library Oct 2020
Antiviral compound library for high throughput screening, chemical biology applications and drug repurposing; contains 240 bioactive compounds (100 μL 10 mM DMSO solutions)

Cyclin-Dependent Protein Kinases

Cat. No. Product Name / Activity Date Added
7159 FMF-04-159-R Sep 2020
Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14
7158 FMF-04-159-2 Sep 2020
Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members
6789 K 03861 Jul 2020
Potent Cdk2 inhibitor

TAG Degradation Platform

Cat. No. Product Name / Activity Date Added
6916 dTAG-13-NEG Aug 2020
Negative control for dTAG-13 (Cat. No. 6605)
6915 dTAGV-1-NEG Aug 2020
Negative control for dTAGV-1 (Cat. No. 6914)
6914 dTAGV-1 Aug 2020
Potent and selective degrader of mutant FKBP12F36V fusion proteins
7374 dTAGV-1 hydrochloride Jan 2021
Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use

Other Dehydrogenases

Cat. No. Product Name / Activity Date Added
6322 LW 6 Nov 2020
Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α

STING-Dependent Signaling

Cat. No. Product Name / Activity Date Added
7353 MSA 2 Dec 2020
Non-nucleotide STING agonist; orally bioavailable

Protein Dimerizers

Cat. No. Product Name / Activity Date Added
6297 AP 20187 Aug 2020
Chemical inducer of protein dimerization; active in vivo

DNA, RNA and Protein Synthesis

Cat. No. Product Name / Activity Date Added
7338 K 22 Dec 2020
Inhibits coronavirus RNA replication; impairs double membrane vesicle (DMV) formation

DREADD Ligands

Cat. No. Product Name / Activity Date Added
7193 Deschloroclozapine Oct 2020
High affinity and highly potent activator of hM3Dq and hM4Di DREADDs; rapidly blood brain barrier penetrant
7198 JHU 37160 Nov 2020
High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
7197 JHU 37152 Nov 2020
High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

Enzyme Probes and Enzyme Substrates

Cat. No. Product Name / Activity Date Added
7288 Thalidomide-Cyanine 5 Sep 2020
Fluorescent cereblon probe

Fluorescent Integrin Probes

Cat. No. Product Name / Activity Date Added
6997 BOP-JF646 Aug 2020
Red fluorescent dual α9β1/α4β1 integrin inhibitor comprising BOP conjugated to Janelia Fluor® 646; fluorogenic; photostable
6996 BOP-JF549 Sep 2020
Yellow fluorescent dual α9β1/α4β1 integrin inhibitor comprising BOP conjugated to Janelia Fluor® 549; fluorogenic; photostable

Heterotrimeric G-protein GTPases

Cat. No. Product Name / Activity Date Added
7352 YM 254890 Jan 2021
Gα-protein inhibitor; potent inhibitor of Gq/11 signaling

Rho GTPases

Cat. No. Product Name / Activity Date Added
7091 Miro1 Reducer Aug 2020
Promotes mitochondrial Rho GTPase 1 (Miro1) degradation

Other Hydrolases

Cat. No. Product Name / Activity Date Added
7187 Zanamivir Aug 2020
Potent influenza virus neuraminidase inhibitor

Integrins

Cat. No. Product Name / Activity Date Added
7059 GLPG 0187 Oct 2020
Potent αv integrin inhibitor

Other Kinases

Cat. No. Product Name / Activity Date Added
7285 DCLK1-IN-1 Oct 2020
Potent and selective doublecortin like kinase 1/2 (DCLK1/2) inhibitor; orally bioavailable
7283 Apilimod dimesylate Aug 2020
Potent and selective PIKfyve inhibitor

Src Kinases

Cat. No. Product Name / Activity Date Added
7189 Saracatinib Aug 2020
Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable

VHL Targeting Ligands Plus Linkers

Cat. No. Product Name / Activity Date Added
7293 VH 101 phenol-alkylC4-amine Oct 2020
VHL ligand with alkyl linker and terminal amine for onward chemistry
7106 VH 032 amide-alkylC2-acid Oct 2020
VHL ligand with alkyl linker and terminal acid for onward chemistry
7104 VH 032 amide-PEG1-acid Sep 2020
VHL ligand with PEG linker and terminal acid for onward chemistry
7294 VH 101 phenol-alkylC6-amine Oct 2020
VHL ligand with alkyl linker and terminal amine for onward chemistry
7216 VH 032 amide-alkylC3-acid Dec 2020
VHL ligand with alkyl linker and terminal acid for onward chemistry
7073 VH 032 amide-alkylC3-amine Dec 2020
VHL ligand with alkyl linker and terminal amine for onward chemistry
7105 VH 032 amide-PEG5-acid Nov 2020
VHL ligand with PEG linker and terminal acid for onward chemistry

Papain-like Proteases

Cat. No. Product Name / Activity Date Added
7357 PLpro inhibitor 6 Oct 2020
SARS-CoV and SARS-CoV-2 PLpro inhibitor
7280 GRL 0617 Aug 2020
Coronavirus PLpro inhibitor

Microtubule Probes

Cat. No. Product Name / Activity Date Added
6267 Taxol Janelia Fluor ® 549 Aug 2020
Yellow fluorescent taxol derivative; probe for microtubule staining

NPY Receptors

Cat. No. Product Name / Activity Date Added
7377 BIIE 0246 hydrochloride Dec 2020
Potent, selective and competitive non-peptide NPY Y2 receptor antagonist; active in vivo

Other Peptide Receptors

Cat. No. Product Name / Activity Date Added
6238 PKRA 7 Sep 2020
Potent prokineticin (PK) 1 and 2 receptor antagonist; antitumor; BBB penetrant

Other Oxygenases/Oxidases

Cat. No. Product Name / Activity Date Added
5950 Ethyl LipotF Oct 2020
Selective FTO inhibitor

Protein Ser/Thr Phosphatases

Cat. No. Product Name / Activity Date Added
7303 iHAP1 Nov 2020
Allosteric activator of protein phosphatase 2A (PP2A)

RNA Polymerase

Cat. No. Product Name / Activity Date Added
7231 EIDD 1931 Aug 2020
Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide

Proteasome

Cat. No. Product Name / Activity Date Added
7188 Carfilzomib Oct 2020
Potent irreversible proteasome inhibitor; active in vivo
7282 Bortezomib Jan 2021
High affinity proteasome inhibitor

TRPC

Cat. No. Product Name / Activity Date Added
7170 D-GsMTx4 Aug 2020
TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion

TRPV

Cat. No. Product Name / Activity Date Added
7199 (±)-Eriodictyol Oct 2020
Potent TRPV1 antagonist; also antioxidant; activates Nrf2/ARE signaling
6990 SET 2 Dec 2020
Selective TRPV2 antagonist