New Products

View all New Products by pharmacological action

Search for new products by date added, alphabetically, or by pharmacological action.

New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

5-HT2A Receptors

Cat No Product Name / Activity Date Added
6336 Trazodone hydrochloride Sep 2017
5-HT2A and α1 adrenoceptor antagonist; also enhances neural differentiation; antidepressant and neuroprotectant

ADAMs

Cat No Product Name / Activity Date Added
5523 TAPI 0 Sep 2017
ADAM-17 (TACE) and MMP inhibitor
6013 TAPI 2 Sep 2017
ADAM-17 (TACE) and MMP inhibitor
6162 TAPI 1 Sep 2017
ADAM-17 (TACE) and MMP inhibitor

Adenylyl Cyclases

Cat No Product Name / Activity Date Added
6271 ST 034307 May 2017
Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

AMPA Receptors

Cat No Product Name / Activity Date Added
6278 JNJ 55511118 Aug 2017
Selective, high affinity negative modulator of AMPA receptors containing TARP-γ8

Antibiotics

Cat No Product Name / Activity Date Added
6337 Sulopenem Nov 2017
Penem antibiotic

Antivirals

Cat No Product Name / Activity Date Added
6045 NITD 008 Jul 2017
Antiviral; selective flavivirus inhibitor
6339 Netilmicin sulfate Oct 2017
Inhibits HIV-1 replication; also semisynthetic aminoglycoside antibiotic

Apelin Receptors

Cat No Product Name / Activity Date Added
6293 ELA-14 (human) Jun 2017
Potent apelin (APJ) receptor agonist
6294 ELA-14 negative control Jun 2017
Negative control for ELA-14 (Cat.No.6293).
6291 ELA-32 (human) Jul 2017
Potent, high affinity apelin receptor agonist; stimulates angiogenesis
6292 ELARR>GG Jul 2017
Negative control for ELA-32 (Cat.No.6291).

Aptamers

Cat No Product Name / Activity Date Added
6103 CD133-A15, 5'-DY647 Oct 2017
High affinity fluorescently tagged aptamer for CD133 (AC133 epitope)
6104 CD133-B19, 5'-DY647 Oct 2017
High affinity fluorescently tagged aptamer for CD133 (extracellular domain epitope)
6102 Ep23, 5'-DY647 Oct 2017
High affinity fluorescently tagged aptamer for EpCam

Bcl-2 Family

Cat No Product Name / Activity Date Added
5733 ML 311 Nov 2017
Inhibits Mcl-1-BIM interaction

Bromodomains

Cat No Product Name / Activity Date Added
6181 OTX 015 May 2017
BET bromodomain inhibitor; orally bioavailable

Buffers, Solvents and Solutions

Cat No Product Name / Activity Date Added
5889 PIPES, free acid Oct 2017
Commonly used buffer
5886 HEPPSO Nov 2017
Buffering agent
5883 CHES Nov 2017
Buffering agent
5877 MOPS, sodium salt Oct 2017
Used as a buffering agent
5885 HEPPS Oct 2017
Used as a buffering agent
5875 MES sodium salt Nov 2017
Buffering agent
5891 TES, free acid Nov 2017
Buffering agent
5887 MES, free acid Oct 2017
Commonly used buffer
5884 DIPSO Nov 2017
Buffering agents

Calcium-Sensing Receptor

Cat No Product Name / Activity Date Added
6165 AC 265347 Jul 2017
CaSR biased allosteric modulator

Casein Kinase 1

Cat No Product Name / Activity Date Added
6346 PF 5006739 Sep 2017
Potent CK1δ/ε inhibitor

Caspases

Cat No Product Name / Activity Date Added
6172 INF 4E Oct 2017
Caspase-1 and NLRP3 inflammasome inhibitor

CB1 Receptors

Cat No Product Name / Activity Date Added
6193 AM 4113 Aug 2017
Selective, high affinity CB1 antagonist

Cyclin-Dependent Protein Kinases

Cat No Product Name / Activity Date Added
6174 CVT 313 Jun 2017
cdk2 inhibitor

Death-Associated Protein Kinase

Cat No Product Name / Activity Date Added
5768 HS 38 Jul 2017
ATP-competitive inhibitor of DAPK and ZIPK

Diacylglycerol O-Acyltransferase

Cat No Product Name / Activity Date Added
5863 PF 04620110 Sep 2017
Potent and selective DGAT-1 inhibitor; orally bioavailable
6348 PF 06424439 Oct 2017
Potent and selective DGAT2 inhibitor

Dihydrofolate Reductase

Cat No Product Name / Activity Date Added
6185 Pemetrexed Jun 2017
High affinity dihydrofolate reductase inhibitor; also inhibits thymidylate synthase, GARFT and AICART

DREADD Ligands

Cat No Product Name / Activity Date Added
6329 Clozapine N-oxide dihydrochloride Sep 2017
Activator of muscarinic DREADDs

EGFR

Cat No Product Name / Activity Date Added
6231 Dacomitinib Jul 2017
Potent irreversible pan ErbB inhibitor

Estrogen (GPER) Receptors

Cat No Product Name / Activity Date Added
6116 BHPI Aug 2017
ERα antagonist; also activates unfolded protein response; active in vivo

Estrogen and Related Receptors

Cat No Product Name / Activity Date Added
6342 Tamoxifen Sep 2017
Estrogen receptor partial agonist/antagonist

Fatty Acid Amide Hydrolase

Cat No Product Name / Activity Date Added
6374 PF 04457845 Nov 2017
Potent and selective irreversible FAAH inhibitor

Free Fatty Acid Receptors

Cat No Product Name / Activity Date Added
6163 AR 420626 Oct 2017
FFA3 agonist

GABAA Receptors

Cat No Product Name / Activity Date Added
6192 PZ-II-029 Sep 2017
α6β3γ2-selective GABAA channel modulator

Ghrelin Receptors

Cat No Product Name / Activity Date Added
6347 PF 04628935 Sep 2017
Potent ghrelin receptor inverse agonist

Glucocorticoid Receptors

Cat No Product Name / Activity Date Added
6357 Ciclesonide Nov 2017
Glucocorticoid antiasthmatic prodrug

Glucose Transporters

Cat No Product Name / Activity Date Added
6143 WZB 117 Aug 2017
GLUT inhibitor

GPR171

Cat No Product Name / Activity Date Added
6304 BigLEN (mouse) Jul 2017
GPR171 agonist
6306 BigLEN (rat) Jul 2017
Potent GPR171 agonist
6299 MS 15203 Aug 2017
Potent and selective GPR171 partial agonist
6298 MS 21570 Nov 2017
GPR171 antagonist

Heme Oxygenase

Cat No Product Name / Activity Date Added
6119 OB 24 hydrochloride Aug 2017
Potent and selective heme oxygenase 1 (HO-1) inhibitor

Hexokinases

Cat No Product Name / Activity Date Added
6049 PF 04937319 Aug 2017
Glucokinase partial activator
6345 PF 04991532 Sep 2017
Potent hepatoselective glucokinase activator

Histone Acetyltransferases

Cat No Product Name / Activity Date Added
5103 Lys-CoA Jun 2017
Selective p300 inhibitor

Histone Deacetylases

Cat No Product Name / Activity Date Added
6208 MS 275 Jun 2017
HDAC (Class I) inhibitor
6284 BRD 73954 Jun 2017
Dual histone deacetylase (HDAC) 6/8 inhibitor
6270 Tubastatin A hydrochloride Jun 2017
Potent HDAC6 inhibitor

HMG-CoA Reductase

Cat No Product Name / Activity Date Added
6343 Rosuvastatin calcium Nov 2017
Potent HMG-CoA reductase inhibitor

Integrins

Cat No Product Name / Activity Date Added
6048 R-BC154 Aug 2017
High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs

IRAK

Cat No Product Name / Activity Date Added
6373 PF 06650833 Nov 2017
Potent and selective IRAK4 inhibitor

ITK

Cat No Product Name / Activity Date Added
5401 GSK 2250665A Aug 2017
Itk inhibitor

JAK Kinase

Cat No Product Name / Activity Date Added
5818 NVP BSK 805 Aug 2017
Potent JAK2 inhibitor; orally bioavailable

JNK/c-Jun

Cat No Product Name / Activity Date Added
6258 CC 401 dihydrochloride May 2017
High affinity JNK inhibitor; also inhibits HCMV replication

Labels & Stains

Cat No Product Name / Activity Date Added
6182 Pimonidazole Nov 2017
Hypoxia detection reagent

LRRK2

Cat No Product Name / Activity Date Added
6289 JH-II-127 Aug 2017
Potent and selective LRRK2 inhibitor

Lysine Methyltransferases

Cat No Product Name / Activity Date Added
4930 UNC 2399 Jun 2017
Biotinylated UNC 1999 (Cat.No. 4904)
6128 GSK 343 Jun 2017
Potent and selective SAM-competitive EZH2 inhibitor
6282 BRD 4770 Jun 2017
G9a inhibitor and S-adenosyl methionine mimetic; cell permeable
6167 A 196 Jul 2017
Potent and selective SUV420H1/H2 inhibitor

Monoacylglycerol Lipase

Cat No Product Name / Activity Date Added
5956 NF 1819 Aug 2017
Potent and selective irreversible MAGL inhibitor; membrane permeable and brain penetrant

Monocarboxylate Transporters

Cat No Product Name / Activity Date Added
5658 AR-C 141990 hydrochloride Jul 2017
MCT1 inhibitor

Nek2 Kinase

Cat No Product Name / Activity Date Added
4322 JH 295 May 2017
Irreversible Nek2 inhibitor

Neural Stem Cells

Cat No Product Name / Activity Date Added
6385 Phenanthroline Nov 2017
Enhances hPSC differentiation into cranial placode cells

NMDA Receptors

Cat No Product Name / Activity Date Added
6226 IC 87201 Oct 2017
nNOS-PSD95 protein-protein interaction inhibitor; also antinociceptive and antidepressant

NPY Receptors

Cat No Product Name / Activity Date Added
6288 Peptide YY (3-36) human Jun 2017
NPY Y2 receptor agonist

NTPDase

Cat No Product Name / Activity Date Added
6083 PSB 12379 Aug 2017
Ecto-5'-nucleotidase (CD73) inhibitor

Orphan 7-TM Receptors

Cat No Product Name / Activity Date Added
6307 PEN (human) Sep 2017
GPR83 agonist
6309 PEN (rat) Sep 2017
GPR83 agonist
6277 7α,25-Dihydroxycholesterol Jun 2017
Highly potent GPR183 (EBI2) agonist
6308 PEN (mouse) Sep 2017
GPR83 agonist

Other Dehydrogenases

Cat No Product Name / Activity Date Added
6084 ASP 9521 Sep 2017
Potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor;orally bioavailable
6196 Brequinar sodium Aug 2017
Potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor

Other Hydrolases

Cat No Product Name / Activity Date Added
6098 Lalistat 1 Aug 2017
Potent and selective lysosomal acid lipase (LAL) inhibitor
6099 Lalistat 2 Sep 2017
Selective lysosomal acid lipase inhibitor
6370 Nor NOHA monoacetate Sep 2017
Arginase inhibitor

Other Proteases

Cat No Product Name / Activity Date Added
6194 TM 5441 Jun 2017
Plasminogen activator inhibitor-1 (PAI-1) inhibitor
6414 Rupintrivir Nov 2017
Potent and selective irreversible human rhinovirus 3C protease inhibitor
6333 Phosphoramidon disodium salt Nov 2017
Neutral endopeptidase and endothelin converting enzyme inhibitor

Oxytocin Receptors

Cat No Product Name / Activity Date Added
6332 Atosiban Nov 2017
Potent oxytocin receptor antagonist

P21-activated Kinases

Cat No Product Name / Activity Date Added
6051 G 5555 Sep 2017
High affinity group 1 PAK inhibitor
6132 NVS PAK1 1 Oct 2017
Potent and selective PAK1 inhibitor

Parathyroid Hormone Receptors

Cat No Product Name / Activity Date Added
6301 Parathyroid hormone (1-34) (rat) Jun 2017
Parathyroid hormone (PTH) receptor agonist
6303 Parathyroid hormone (1-34) (bovine) Jun 2017
Parathyroid hormone (PTH) receptor agonist.

Phosphodiesterases

Cat No Product Name / Activity Date Added
6035 (S)-C33 Oct 2017
Potent PDE9 inhibitor
6024 PF 04671536 hydrochloride Nov 2017
Potent and selective PDE8B/8A inhibitor
6311 Tadalafil May 2017
Potent and highly selective PDE5 inhibitor; orally bioavailable

Pim Kinase

Cat No Product Name / Activity Date Added
6310 AZD 1208 Oct 2017
Potent pan Pim kinase inhibitor

Poly(ADP-ribose) Polymerase

Cat No Product Name / Activity Date Added
6230 Rucaparib camsylate Aug 2017
PARP inhibitor

Prostanoid Receptors

Cat No Product Name / Activity Date Added
5924 ER 819762 Sep 2017
Potent EP4 receptor antagonist; orally bioavailable
6240 DG 041 Aug 2017
Potent and selective EP3 antagonist; antiplatelet and antithrombotic

Protein Kinase A

Cat No Product Name / Activity Date Added
6286 st-Ht31 Jul 2017
Inhibits PKA/AKAP interactions; cell permeable
6287 st-Ht31 P Jul 2017
Negative control for st-Ht31 (Cat. No. 6286)

Protein Kinase C

Cat No Product Name / Activity Date Added
5343 TPPB May 2017
High affinity PKC activator; also APP modulator

Protein Prenyltransferases

Cat No Product Name / Activity Date Added
6265 Lonafarnib Jul 2017
Potent farnesyl transferase inhibitor

Purinergic (P2Y) Receptors

Cat No Product Name / Activity Date Added
6078 BPTU Jul 2017
P2Y1 allosteric antagonist
6317 Prasugrel Jul 2017
Irreversible P2Y12 antagonist; antiplatelet and orally active

RAGE

Cat No Product Name / Activity Date Added
6237 FPS ZM1 Aug 2017
High affinity antagonist of RAGE

Rev-Erb Receptors

Cat No Product Name / Activity Date Added
6038 SR 10067 Aug 2017
Selective Rev-Erbα/β agonist; anxiolytic

Src Kinases

Cat No Product Name / Activity Date Added
6073 P21d hydrochloride Jun 2017
Potent and selective Brk inhibitor

Syk Kinase

Cat No Product Name / Activity Date Added
6012 OXSI 2 May 2017
Potent Syk kinase inhibitor; also inhibits assembly of NLRP3 inflammasomes

TGF-β Receptors

Cat No Product Name / Activity Date Added
6016 IN 1130 Jul 2017
Potent and selective inhibitor of TGF-βRI

Thioredoxin Reductases

Cat No Product Name / Activity Date Added
6189 Myricetin Jun 2017
Irreversible TrxR inhibitor

Toll-like Receptors

Cat No Product Name / Activity Date Added
5705 M62812 Aug 2017
TLR-4 inhibitor
6142 CL 075 Sep 2017
TLR8 agonist
6191 TH 1020 Jul 2017
Toll-like receptor (TLR) 5/Flagellin complex antagonist

TRPA1

Cat No Product Name / Activity Date Added
5914 AM 0902 Oct 2017
Potent and selective TRPA1 antagonist

TRPC

Cat No Product Name / Activity Date Added
5831 SAR 7334 Sep 2017
Potent TRPC6 inhibitor

Ubiquitin E3 Ligases

Cat No Product Name / Activity Date Added
6075 Nutlin 3a Sep 2017
MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
6327 dBET1 Aug 2017
(+)-JQ1 based PROTAC that selectively degrades BET bromodomains in cells
6305 Lenalidomide Jun 2017
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
6302 Pomalidomide Jun 2017
Cereblon ubiquitination inhibitor; also TNF-α inhibitor and antiangiogenic

Vasopressin Receptors

Cat No Product Name / Activity Date Added
6195 SSR 149415 Nov 2017
Potent and selective vasopressin V1B antagonist