New Products

View all New Products by pharmacological action

Search for new products by date added, alphabetically, or by pharmacological action.

New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

Cyanine Dyes (Cy Dyes)

Cat. No. Product Name / Activity Date Added
7510 Indocyanine green Jun 2022
Near-infrared fluorescent dye

Class III HDACs (Sirtuins)

Cat. No. Product Name / Activity Date Added
7558 SRT 1720 Jul 2022
Selective SIRT1 activator; induces autophagy and mitochondrial biogenesis

Tyramide Signal Amplification (TSA)

Cat. No. Product Name / Activity Date Added
7236 Digoxigenin Tyramide Jul 2022
Reagent used for Tyramide Signal Amplification in IHC, ICC and ISH

Sphingosine-1-Phosphate Receptors

Cat. No. Product Name / Activity Date Added
7663 Ozanimod May 2022
Potent and selective S1P1 and S1P5 agonist

σ1 Receptors

Cat. No. Product Name / Activity Date Added
7630 Pridopidine Mar 2022
Highly selective σ1 agonist

Bcl-2 Family

Cat. No. Product Name / Activity Date Added
7680 ABT 263 May 2022
High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor

5-HT2A Receptors

Cat. No. Product Name / Activity Date Added
7667 Pimavanserin Mar 2022
Selective 5-HT2A inverse agonist

Ubiquitin E3 Ligases

Cat. No. Product Name / Activity Date Added
7089 CSN5i-3 Apr 2022
Potent and selective CSN5 (COP9 signalosome) inhibitor
7542 SJ 1008066 Mar 2022
MAGE-A11 inhibitor disrupts MAGE-A11:PCF11 interaction
7483 BDY FL VH032 Mar 2022
High-affinity VHL fluorescent probe for TR-FRET and FP assays

Functionalized E3 Ligase Ligands

Cat. No. Product Name / Activity Date Added
7716 N-methylated pomalidomide Jul 2022
Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control
7678 5-Amino-Thalidomide Jul 2022
Cereblon ligand with amine on C5 for onward chemistry
7670 Phenyl-glutarimide 4'-oxyacetic acid Jun 2022
Functionalized cereblon ligand for PROTAC development

3C and 3CL Proteases

Cat. No. Product Name / Activity Date Added
7695 Mpro 61 Jul 2022
Potent non-covalent inhibitor of SARS-CoV-2 main protease

Ubiquitin E3 Ligases

Cat. No. Product Name / Activity Date Added
7532 CSN5i-3-NEG Apr 2022
Negative control for CSN5i-3 (Cat. No. 7089)
7498 SPOP-i-6lc Mar 2022
SPOP E3 ubiquitin ligase inhibitor

Glycogen Synthase Kinase 3

Cat. No. Product Name / Activity Date Added
7650 AZD 2858 May 2022
Highly potent GSK-3 inhibitor; inhibits tau phosphorylation

PI 3-kinase

Cat. No. Product Name / Activity Date Added
7631 Idelalisib Feb 2022
Potent PI 3-Kinase δ isoform inhibitor

5-HT Transporters

Cat. No. Product Name / Activity Date Added
2395 Sertraline hydrochloride Mar 2022
5-HT reuptake inhibitor

Histone Acetyltransferases

Cat. No. Product Name / Activity Date Added
7584 iP300v Feb 2022
Negative control for iP300w (Cat. No. 7270)

Fluorescent Actin Probes

Cat. No. Product Name / Activity Date Added
7201 Phalloidin-Janelia Fluor® 646 Mar 2022
Red fluorescent F-actin probe

Active Degraders

Cat. No. Product Name / Activity Date Added
7528 BSJ-4-116 Jul 2022
Selective CDK12 PROTAC® Degrader
7583 SK 575 May 2022
Potent PARP1 Degrader (PROTAC®)
7278 α1A-AR Degrader 9c May 2022
Selective α1A adrenergic receptor Degrader (PROTAC®)
7675 SJ 1008030 Jun 2022
Selective JAK2 Degrader (PROTAC®)
7682 JQAD1 Feb 2022
Potent and selective EP300 Degrader
7588 SK 575-NEG May 2022
Negative control for SK 575 (Cat. No. 7583)
7529 BSJ-4-116-NC Jul 2022
Negative control for BSJ-4-116 (Cat. No. 7528).

Protease-Activated Receptors

Cat. No. Product Name / Activity Date Added
7742 TFRGAP-NH2 Aug 2022
PAR3 peptide agonist

Cell Adhesion Molecules

Cat. No. Product Name / Activity Date Added
7723 RGD peptide May 2022
Minimal recognition sequence for integrin binding; potent integrin inhibitor
7692 C26-A6 Jul 2022
Disrupts MTDH and SND1 interaction, enhances immune surveillance

Poly(ADP-ribose) Polymerase

Cat. No. Product Name / Activity Date Added
6795 GeA-69 Jul 2022
Selective allosteric PARP14 inhibitor

AMPK

Cat. No. Product Name / Activity Date Added
7685 IND 1316 Jul 2022
AMPK activator

Fluorescent Amyloid β Probes

Cat. No. Product Name / Activity Date Added
7122 Thioflavin T Apr 2022
Fluorescent amyloid stain, binds to the stacked β sheets of amyloid fibrils

Amyloid β Peptides

Cat. No. Product Name / Activity Date Added
7712 Semax Jun 2022
Reduces Aβ aggregation and fibrillogenesis; neuroprotective and neurotrophic peptide

Ancillary Material Grade Small Molecules

Cat. No. Product Name / Activity Date Added
TB1285-RMU Staurosporine Mar 2022
Staurosporine synthesized to Ancillary Material Grade
TB2939-RMU A 83-01 May 2022
A 83-01 synthesized to Ancillary Material Grade
TB6666-RMU T3 May 2022
T3 synthesized to Ancillary Material Grade
TB4439-RMU ISX 9 Mar 2022
ISX 9 synthesized to Ancillary Material Grade

Coronavirus Antivirals

Cat. No. Product Name / Activity Date Added
7554 SSYA10-001 Jul 2022
Potent coronavirus helicase inhibitor; also inhibits human papillomavirus E6

Aptamer-based RNA Imaging

Cat. No. Product Name / Activity Date Added
7660 TBI Aug 2022
Fluorogenic ligand for Broccoli RNA aptamer

Fluorescent Probes for Imaging Bacteria

Cat. No. Product Name / Activity Date Added
7714 EDA-DA May 2022
Unnatural dipeptide building block with alkyne group for functionalizing peptidoglycan

Biochemicals and Molecular Biology

Cat. No. Product Name / Activity Date Added
7301 NHS-LC-Biotin Jul 2022
Amine reactive biotinylation reagent, cell permeable
7726 DMSO, Cell Cryopreserve Grade Apr 2022
Intracellular cryoprotective agent
7553 Ac4ManNDAz Apr 2022
Photo-crosslinking probe for studying glycoproteins and glycolipids
7506 Click N-Acetylmuramic acid - azide Jul 2022
Bacterial peptidoglycan derivative; suitable for 'click'-conjugation to fluorescent dyes.
7479 Ac4ManNAz Jul 2022
Azide-containing monosaccharide building block; used as glycoprotein, glycolipid and glycoRNA probe

LYTAC Building Blocks

Cat. No. Product Name / Activity Date Added
7635 tri-GalNAc biotin May 2022
Biotinylated ASGPR ligand for LYTAC research and development

β-catenin

Cat. No. Product Name / Activity Date Added
7580 WIC1 Jul 2022
Inhibitor of Wnt/β-catenin signaling

Fluorescent Lipid Probes and Cell Membrane Stains

Cat. No. Product Name / Activity Date Added
7538 NBD-PE Jul 2022
Single tail (16:0) phospholipid derivative with a fluorophore (NBD) on the head

Fluorescent Cell Indicators and Sensors

Cat. No. Product Name / Activity Date Added
7641 Mito-HE May 2022
Fluorescent mitochondrial superoxide indicator in live cells

Cereblon Targeting Ligands Plus Linkers

Cat. No. Product Name / Activity Date Added
7737 Thalidomide 5'-amine-PEG3-amine Jul 2022
Cereblon ligand with PEG linker and terminal amine for onward chemistry
7736 Thalidomide 5'-amine-PEG2-amine Jul 2022
Cereblon ligand with PEG linker and terminal amine for onward chemistry
7735 Thalidomide 5'-amine-PEG1-amine Jul 2022
Cereblon ligand with PEG linker and terminal amine for onward chemistry
7733 Thalidomide 5'-amine-alkylC10-amine Jun 2022
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
7732 Pomalidomide 4'-alkylC10-amine Jul 2022
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
7557 Thalidomide 5'-amine-alkylC8-amine May 2022
Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Checkpoint Control Kinases

Cat. No. Product Name / Activity Date Added
7589 Adavosertib Feb 2022
Potent and selective Wee1 inhibitor

Tissue Clearing

Cat. No. Product Name / Activity Date Added
7565 Tissue Clearing Pro-Organoid Reagent Jul 2022
3D cell culture clearing reagent
7564 Tissue Clearing Pro Reagent 2 Jul 2022
Tissue clearing reagent
7563 Tissue Clearing Pro Reagent 1 Jul 2022
Tissue clearing reagent

Cytokine Receptors

Cat. No. Product Name / Activity Date Added
7010 EM 163 Mar 2022
TIR-TIR interaction inhibitor

TAG Degradation Platform

Cat. No. Product Name / Activity Date Added
7531 dTAG-47-NEG May 2022
Negative control for dTAG-47 (Cat. No. 7530)
7687 BromoTag® cis-AGB1 Apr 2022
Negative control for BromoTag® AGB1 (Cat.No. 7686)
7686 BromoTag® AGB1 Apr 2022
Potent and selective Degrader of Brd4BD2 L387A fusion proteins (BromoTag®)
7530 dTAG-47 May 2022
Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation
7392 5-Ph-IAA May 2022
Selective and potent TAG Degrader for auxin-inducible degron 2 system

Dihydrofolate Reductase

Cat. No. Product Name / Activity Date Added
7362 Phototrexate Mar 2022
Photoswitchable inhibitor of human dihydrofolate reductase

Protein Dimerizers

Cat. No. Product Name / Activity Date Added
7681 Mandi Jul 2022
Highly efficient chemical inducer of proximity (CIP)

Fluorescent DNA Stains

Cat. No. Product Name / Activity Date Added
7665 5-TAMRA NHS Aug 2022
Fluorescent amine-reactive DNA and RNA probe; also stains telomeres

DNA Polymerase

Cat. No. Product Name / Activity Date Added
7684 Rilpivirine May 2022
Non-nucleoside reverse transcriptase inhibitor

DNA, RNA and Protein Synthesis

Cat. No. Product Name / Activity Date Added
7679 RECTAS May 2022
IKBKAP pre-mRNA splicing modulator
7376 2A3 Mar 2022
Reagent for RNA SHAPE-MaP experiments in vivo; cell permeable
7485 Covidcil-19 Apr 2022
Binds to SARS-CoV-2 frameshifting element and reduces frameshifting efficiency
7586 Molnupiravir Mar 2022
Prodrug of antiviral nucleoside analog; inhibits SARS-CoV, SARS-CoV-2 and MERS-CoV infection

EGFR

Cat. No. Product Name / Activity Date Added
7640 Tucatinib May 2022
Potent and selective ErbB2 inhibitor
6290 WZ 4002 Aug 2022
Potent mutant-selective EGFR inhibitor

Viral Transduction Enhancers

Cat. No. Product Name / Activity Date Added
7711 Polybrene Jul 2022
Viral transduction enhancer

Other Fluorescent Probes

Cat. No. Product Name / Activity Date Added
7446 SCOTfluor 510, fluoro May 2022
Amine-reactive fluorescent probe precursor

Functionalized Warhead Ligands

Cat. No. Product Name / Activity Date Added
7689 (+)-JQ1 bump, acid functionalized May 2022
Functionalized BET bromodomain ligand; precursor for Tag Degraders

Molecular Glues

Cat. No. Product Name / Activity Date Added
7720 SJ 6986 Jul 2022
Molecular glue; induces degradation of GSPT1/2

GMP Small Molecules

Cat. No. Product Name / Activity Date Added
TB6053-GMP LDN 193189 Apr 2022
LDN 193189 synthesized to cGMP guidelines

Ras GTPases

Cat. No. Product Name / Activity Date Added
7488 MRTX 849 Feb 2022
Mutation-selective inhibitor of KRASG12C

Non-selective HDACs

Cat. No. Product Name / Activity Date Added
7629 Panobinostat Jun 2022
Pan-histone deacetylase inhibitor

Hedgehog Signaling

Cat. No. Product Name / Activity Date Added
7710 Vismodegib Aug 2022
Potent hedgehog pathway inhibitor

HIV Protease

Cat. No. Product Name / Activity Date Added
7196 Indinavir sulfate Jun 2022
Potent and selective HIV-1 and HIV-2 protease inhibitor

Other Hydrolases

Cat. No. Product Name / Activity Date Added
6923 AMZ 30 Jun 2022
Potent, selective and irreversible protein phosphatase methylesterase-1 (PME-1) inhibitor
7137 Cambinol May 2022
nSMase2 inhibitor

Insulin and Insulin-like Receptors

Cat. No. Product Name / Activity Date Added
7652 Linsitinib Apr 2022
Potent and selective dual inhibitor of the IGF-1 receptor and insulin receptor

Receptor Interacting Protein Kinases

Cat. No. Product Name / Activity Date Added
7339 RIPA 56 May 2022
Potent and metabolically stable RIP1 kinase inhibitor

Other Ion Pumps/Transporters

Cat. No. Product Name / Activity Date Added
6878 BMS 466442 May 2022
Potent and selective inhibitor of asc-1

Other Kinases

Cat. No. Product Name / Activity Date Added
6604 VER 246608 May 2022
Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 /4 inhibitor
6529 SGC AAK1 1N May 2022
Negative control for SGC AAK1 1 (Cat.No. 6528)
7018 CBR-470-1 Feb 2022
PGK1 inhibitior; activates Nrf2

VHL Targeting Ligands Plus Linkers

Cat. No. Product Name / Activity Date Added
7215 VH 032 amide-PEG4-acid May 2022
VHL ligand with PEG linker and terminal acid for onward chemistry

Other Lipid Metabolism

Cat. No. Product Name / Activity Date Added
7492 Lomitapide mesylate May 2022
Potent microsomal triglyceride transfer protein (MTP) inhibitor

MEK

Cat. No. Product Name / Activity Date Added
7709 Trametinib Jul 2022
Potent and selective MEK inhibitor; orally bioavailable

Melatonin Receptors

Cat. No. Product Name / Activity Date Added
7493 Tasimelteon Aug 2022
Selective dual melatonin receptor (MT1/MT2) agonist

Monocarboxylate Transporters

Cat. No. Product Name / Activity Date Added
7512 3-Bromopyruvate Apr 2022
MCT1 inhibitor; also inhibits hexokinase II

Other Nuclear Receptors

Cat. No. Product Name / Activity Date Added
7494 CIA 1 Apr 2022
COUP-TFII inhibitor

Other Proteases

Cat. No. Product Name / Activity Date Added
7659 Verubecestat Apr 2022
BACE1 and BACE2 inhibitor

Other RTKs

Cat. No. Product Name / Activity Date Added
7696 Selpercatinib May 2022
Potent and selective RET inhibitor
7590 Pexidartinib Apr 2022
Potent CSF-1R inhibitor

Proteasome

Cat. No. Product Name / Activity Date Added
6781 Capzimin dimer Jul 2022
Selective proteasome inhibitor

RAGE

Cat. No. Product Name / Activity Date Added
7701 RAGE 229 Jun 2022
ctRAGE-DIAPH1 interaction antagonist; reduces inflammatory signaling in diabetic mice