New ProductsView all New Products by pharmacological action
Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
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Calcium-Activated Potassium (KCa) Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
|---|---|---|
| 5814 | GoSlo SR 5-69 | Apr 2020 |
| BK channel activator | ||
| 6398 | SKA 121 | Jan 2020 |
| Positive allosteric modulator of KCa3.1 channels | ||
Glutamate (Metabotropic) Group II Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6928 | VU 6001966 | Feb 2020 |
| Potent and selective negative allosteric modulator of mGlu2 receptors | ||
Akt (Protein Kinase B) | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7001 | AT 7867 | Jun 2020 |
| Potent pan-Akt and PKA inhibitor | ||
CB1 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 5746 | NESS 0327 | Feb 2020 |
| Ultra-high affinity and selective CB1 antagonist | ||
Trace Amine 1 Receptor | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6833 | RO 5263397 hydrochloride | Feb 2020 |
| Potent TA1 receptor agonist | ||
5-HT2C Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 5755 | PF 04479745 | Apr 2020 |
| Potent and selective 5-HT2C agonist | ||
K+/Cl- Cotransporter 2 | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6758 | CLP 290 | Mar 2020 |
| K+/Cl- cotransporter 2 (KCC2) activator; orally bioavailable prodrug of CLP 257 (Cat. No.5242) | ||
OX2 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6739 | YNT 185 | Mar 2020 |
| Potent and selective OX2 agonist | ||
CB2 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6220 | PM 226 | Jan 2020 |
| Potent and selective CB2 receptor agonist; BBB permeable; neuroprotective | ||
M2 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6964 | LY 2119620 | Jan 2020 |
| Positive allosteric modulator of M2 and M4 receptors | ||
ACE2 | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7232 | SBP1-FITC | Jun 2020 |
| Fluorescent ACE2-derived peptide; binds receptor binding domain of SARS-CoV-2 spike protein | ||
| 7233 | SBP1 | May 2020 |
| ACE2 derived peptide; binds SARS-CoV-2 spike protein receptor binding domain | ||
5-HT3 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7038 | Palonosetron hydrochloride | Feb 2020 |
| Highly potent and high affinity 5-HT3 antagonist | ||
D3 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7039 | SK 609 | Feb 2020 |
| Dopamine D3 receptor biased agonist | ||
Functionalized E3 Ligase Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6952 | VH 101, phenol | Jan 2020 |
| Hydroxyl functionalized VHL ligand | ||
| 6911 | VH 032, phenol | Mar 2020 |
| Hydroxyl functionalized VHL ligand | ||
Free Acid Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6993 | Janelia Fluor® 646, free acid | Feb 2020 |
| Red dye (Reactive group: free acid). Applications: super resolution microscopy e.g. dSTORM & STED, confocal, flow and live cell imaging | ||
Free Fatty Acid Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6826 | AZ 1729 | Mar 2020 |
| FFA2 allosteric agonist; displays bias for the Gi signaling pathway | ||
Retinoic Acid Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6873 | DC 271 | Jul 2020 |
| Fluorescent retinoic acid analog; solvochromatic probe | ||
Free Fatty Acid Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7082 | DL 175 | Apr 2020 |
| Potent and selective GPR84 agonist | ||
Active Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6945 | dBET6 | Jun 2020 |
| Potent and selective (+)-JQ1 based PROTAC targeting BET bromodomains, active in vivo | ||
| 6943 | dBRD9-A | Jul 2020 |
| Potent BRD9 Degrader | ||
| 7177 | NR 7h | May 2020 |
| Potent and selective p38α and p38β degrader; active in vivo | ||
| 6939 | cis-VZ 185 | Mar 2020 |
| Negative control for VZ 185 (Cat. No. 6936) | ||
Amyloid β Peptides | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6779 | Davunetide | Apr 2020 |
| Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo | ||
Antivirals | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7235 | Arbidol | Jul 2020 |
| Broad spectrum antiviral | ||
Protein Arginine Methyltransferases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6838 | SGC 3027N | May 2020 |
| Negative control for SGC 3027 (Cat. No. 6825) | ||
| 6825 | SGC 3027 | May 2020 |
| Potent and selective PRMT7 inhibitor | ||
Fluorescent Probes for Imaging Bacteria | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6650 | YADA | May 2020 |
| Green-yellow lucifer yellow-based fluorescent D-amino acid for labeling peptidoglycans in live bacteria | ||
| 6649 | RADA | Apr 2020 |
| Orange-red TAMRA-based fluorescent D-amino acid for labeling peptidoglycans in live bacteria | ||
Biochemicals and Molecular Biology | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6458 | Cyanine 5 Tyramide | Jan 2020 |
| Red fluorescent reagent widely used for signal amplification in IHC and ISH | ||
| 6457 | Cyanine 3 Tyramide | Jan 2020 |
| Orange fluorescent reagent widely used for signal amplification in IHC and ISH | ||
| 6456 | Fluorescein Tyramide | Jan 2020 |
| Green fluorescent reagent widely used for signal amplification in IHC and ISH | ||
| 7015 | IA-Alkyne | Jan 2020 |
| Broad spectrum cysteine reactive probe | ||
Bromodomains | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6670 | TP 238 | Mar 2020 |
| CECR2 and BPTF/FALZ inhibitor | ||
cGMP Stem Cell Compounds | ||
| Cat. No. | Product Name / Activity | Date Added |
| TB3748-GMP | XAV 939 | Jan 2020 |
| XAV 939 synthesized to cGMP guidelines | ||
Caged Dopamine Compounds | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6354 | CNV Dopamine | May 2020 |
| Caged dopamine; photolysed by UV light | ||
Other Cannabinoids | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6372 | PSB CB5 | Mar 2020 |
| Selective GPR18 antagonist | ||
Cereblon Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7210 | Pomalidomide 4'-alkylC6-acid | Jul 2020 |
| Cereblon ligand with alkyl linker and terminal acid for onward chemistry | ||
| 7205 | Pomalidomide 4'-alkylC3-amine | Jun 2020 |
| Cereblon ligand with alkyl linker and terminal amine for onward chemistry | ||
| 7096 | Pomalidomide 4'-alkylC3-acid | Jul 2020 |
| Cereblon ligand with alkyl linker and terminal acid for onward chemistry | ||
| 6944 | Pomalidomide 4'-alkylC8-amine | Apr 2020 |
| Cereblon ligand with alkyl linker and terminal amine for onward chemistry | ||
| 7208 | Pomalidomide 4'-alkylC7-amine | Jul 2020 |
| Cereblon ligand with alkyl linker and terminal amine for onward chemistry | ||
| 7204 | Pomalidomide 4'-PEG3-amine | Jul 2020 |
| Cereblon ligand with PEG linker and terminal amine for onward chemistry | ||
| 7203 | Pomalidomide 4'-PEG1-amine | Jul 2020 |
| Cereblon ligand with PEG linker and terminal amine for onward chemistry | ||
Other Chemokine Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7116 | Chemerin-9, Human | Apr 2020 |
| Potent CMKLR1 agonist; c-terminal peptide of full length human chemerin | ||
| 7117 | Chemerin-9, Mouse | Apr 2020 |
| Potent CMKLR1 agonist; c-terminal peptide of full length mouse chemerin | ||
Class II HDACs | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7051 | Tasquinimod | Jan 2020 |
| High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic | ||
Click-Reactive Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7088 | Janelia Fluor® 646, Azide | Feb 2020 |
| Red dye (Reactive group: azide). Applications: super resolution microscopy e.g. dSTORM & STED, confocal, and live cell imaging | ||
Tocriscreen Compound Libraries | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7152 | Tocriscreen 2.0 Micro | Jan 2020 |
| A library of 1280 biologically active compounds (15 μL 10 mM DMSO solutions) | ||
| 7151 | Tocriscreen 2.0 Mini | Jan 2020 |
| A library of 1280 biologically active compounds (50 μL 10 mM DMSO solutions) | ||
| 7150 | Tocriscreen 2.0 Max | Jan 2020 |
| A library of 1280 biologically active compounds (250 μL 10 mM DMSO solutions) | ||
| 7200 | Tocriscreen FDA-Approved Drugs Library | Apr 2020 |
| Drug repurposing library; a library of 190 compounds equivalent to active components of drug formulations approved by the FDA | ||
STING-Dependent Signaling | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7040 | C 176 | Feb 2020 |
| mSTING antagonist | ||
Protein Dimerizers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6130 | AP 1903 | Jul 2020 |
| Protein dimerizer; active in vivo | ||
Fluorescent DNA Stains | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7246 | Nucleic Acid Dye Green I | Jun 2020 |
| High affinity double-stranded DNA (dsDNA) probe; used in RT-LAMP and qPCR | ||
DNA Polymerase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7090 | Digoxigenin-11-dUTP | Mar 2020 |
| Hapten modified dUTP for ISH | ||
Fluorescent DNA Stains | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7121 | 7-Aminoactinomycin D | Feb 2020 |
| Fluorescent DNA stain | ||
DNA, RNA and Protein Synthesis | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7004 | NAI | May 2020 |
| Reagent for RNA SHAPE-MaP experiments in vivo; cell permeable | ||
EGFR | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6962 | JBJ-03-142-02 | May 2020 |
| Highly potent EGFR and ErbB2 inhibitor; inhibts wild type and mutated receptors | ||
Glucagon Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6807 | NNC 0640 | May 2020 |
| Negative allosteric modulator of glucagon and GLP-1 receptors | ||
Glycosylases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7056 | Conduritol B epoxide | Jun 2020 |
| Irreversible glucocerebrosidase (β-glucosidase) inhibitor; used to generate Gaucher disease models | ||
Hedgehog Signaling | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6896 | Dynapyrazole A | May 2020 |
| Hedgehog signaling inhibitor; dynein inhibitor | ||
Other Hydrolases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6391 | CD38 inhibitor 78c | Jun 2020 |
| Potent CD38 inhibitor; active in vivo | ||
| 7224 | Oseltamivir phosphate | Jul 2020 |
| Influenza virus neuraminidase inhibitor; antiviral prodrug | ||
IAP Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7220 | A 410099.1 amide-PEG4-amine | Jun 2020 |
| A 410099.1 amide-PEG4-amine | ||
| 7221 | A 410099.1 amide-PEG5-amine | Jun 2020 |
| A 410099.1 amide-PEG5-amine | ||
Inflammasomes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6925 | NBC 6 | Jan 2020 |
| NLRP3 inflammasome inhibitor | ||
| 6722 | NBC 19 | Apr 2020 |
| Potent NLRP3 inflammasome inhibitor | ||
Receptor Interacting Protein Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6892 | RIPGBM | Apr 2020 |
| RIPK2 modulator; pro-drug of cRIPGM; orally bioavailable and brain penetrant | ||
JAK Kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7222 | Baricitinib | Jun 2020 |
| Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2 | ||
| 7064 | Ruxolitinib | Feb 2020 |
| Potent and selective JAK1/JAK2 inhibitor; orally bioavailable | ||
| 7048 | Ruxolitinib phosphate | Feb 2020 |
| Phosphate salt of Ruxolitinib (Cat. No. 7064); potent and selective JAK1/JAK2 inhibitor | ||
Other Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6430 | Takinib | Jun 2020 |
| Potent and selective TAK1/MAP3K7 kinase inhibitor | ||
Raf Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7223 | Dabrafenib mesylate | Jun 2020 |
| Potent and selective B-Raf, CDK16 and NEK9 inhibitor; anticancer; also targets human proteins in the SARS-CoV-2 interactome | ||
Rho-Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7163 | Chroman 1 | Mar 2020 |
| Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogeneisis | ||
VHL Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7074 | VH 032 amide-alkylC7-amine | Mar 2020 |
| VHL ligand with alkyl linker and terminal amine for onward chemistry | ||
| 6985 | VH 032 amide-alkylC5-amine | Jan 2020 |
| VHL ligand with alkyl linker and terminal amine for onward chemistry | ||
Toll-like Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6858 | MMG 11 | Jan 2020 |
| TLR2 antagonist | ||
Other Notch Signaling | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6599 | Yhhu 3792 | Jun 2020 |
| Notch signaling pathway activator; enhances the self-renewal capability of NSCs; active in vivo | ||
Other Oxygenases/Oxidases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7234 | Nitazoxanide | Jul 2020 |
| Pyruvate flavodoxin/ferredoxin oxidoreductase inhibitor; also inhibits Wnt signaling; broad spectrum anti-infective | ||
Other Synthases/Synthetases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6791 | BC-LI-0186 | Feb 2020 |
| Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor | ||
Other Reductases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7162 | iFSP1 | Feb 2020 |
| Ferroptosis suppressor protein 1 (FSP1) inhibitor; ferroptosis inducer | ||
Other Transferases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6998 | SHIN 1 | May 2020 |
| Potent SHMT inhibitor | ||
Other Proteases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7081 | LY 2886721 Hydrochloride | Jun 2020 |
| Potent and selective β-secretase (BACE) inhibitor | ||
| 7052 | Lopinavir | Jun 2020 |
| Highly potent and selective HIV-1 protease inhibitor | ||
PDGFR | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6976 | JNJ 10198409 | Mar 2020 |
| Potent PDGFRα and PDGFRβ inhbitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases | ||
RNA Polymerase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7227 | GS 441524 | Jun 2020 |
| Viral RNA-dependent RNA polymerase inhibitor; broad spectrum antiviral nucelotide | ||
| 7226 | Remdesivir | Jun 2020 |
| Viral RNA-dependent RNA polymerase inhibitor; broad spectrum antiviral nucelotide prodrug | ||
| 7225 | Favipiravir | Jun 2020 |
| Viral RNA polymerase inhibitor | ||
STATs | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6110 | HJC 0416 hydrochloride | Feb 2020 |
| STAT3 inhibitor | ||
TRPV | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6831 | TRPV3 74a | May 2020 |
| Selective TRPV3 antagonist; brain penetrant | ||