Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.
Purinergic (P2Y) Receptors | ||
| Cat No | Product Name / Activity | Date Added |
|---|---|---|
| 6864 | Ticagrelor | Apr 2019 |
| High affinity and reversible P2Y12 antagonist; displays inverse agonism in vitro; also inhibits ENT1 | ||
Akt (Protein Kinase B) | ||
| Cat No | Product Name / Activity | Date Added |
| 6762 | Urolithin A | Apr 2019 |
| PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro | ||
CaV3.x Channels (T-type) | ||
| Cat No | Product Name / Activity | Date Added |
| 6770 | ABT 639 | Mar 2019 |
| CaV3.2 and CaV3.1 channel blocker; orally bioavailable | ||
Nicotinic (α4β2) Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6706 | DPNB-ABT 594 | Mar 2019 |
| Caged ABT 594; suitable for one- or two-photon photolysis | ||
Casein Kinase 1 | ||
| Cat No | Product Name / Activity | Date Added |
| 6340 | Epiblastin A | Jan 2019 |
| CK1 inhibitor; converts epiblast stem cells to ESCs and promotes ESC self-renewal | ||
Glucagon-Like Peptide 1 Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6355 | VU 0650991 | Apr 2019 |
| Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant | ||
CRF1 Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6530 | R 121919 hydrochloride | Dec 2018 |
| High affinity CRF1 antagonist; orally bioavailable | ||
Sphingosine-1-Phosphate Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6690 | Ceralifimod | May 2019 |
| Highly potent and selective S1P1 and S1P5 agonist | ||
| 6709 | GSK 2018682 | Jan 2019 |
| S1P1 and S1P5 agonist | ||
Casein Kinase 1 | ||
| Cat No | Product Name / Activity | Date Added |
| 6676 | IC 261 | Dec 2018 |
| CK1 inhibitor; displays selectivity for CK1δ and CK1ε | ||
CRF1 Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6451 | Pexacerfont | Apr 2019 |
| Potent and selective CRF1 antagonist; anxiolytic | ||
CB1 Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6763 | AVE 1625 | Apr 2019 |
| Potent and selective CB1 receptor antagonist | ||
Nrf2 | ||
| Cat No | Product Name / Activity | Date Added |
| 6243 | ML 385 | Jan 2019 |
| Nrf2 inhibitor; phenotypically lethal | ||
σ2 Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6740 | Siramesine hydrochloride | Apr 2019 |
| High affinity σ agonist (σ2 > σ1) | ||
Cdc2-like Kinases | ||
| Cat No | Product Name / Activity | Date Added |
| 6644 | KuWal151 | Jan 2019 |
| Potent and selective CLK inhibitor | ||
Adenosine A2B Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6787 | KI-7 | Mar 2019 |
| A2B receptor positive allosteric modulator | ||
CB2 Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6832 | Ec2la | May 2019 |
| CB2 receptor positive allosteric modulator; active in vivo | ||
EZH2 | ||
| Cat No | Product Name / Activity | Date Added |
| 6708 | SAH-EZH2 | May 2019 |
| EZH2/EDD interaction inhibitor; suppresses PCR2 complex function | ||
P21-activated Kinases | ||
| Cat No | Product Name / Activity | Date Added |
| 6177 | AZ 13705339 | Dec 2018 |
| Highly potent PAK1 and PAK2 inhibitor | ||
| 6490 | GNE 2861 | Mar 2019 |
| Group II PAK inhibitor; potently inhibits PAK4 and PAK 6 | ||
Glycogen Synthase Kinase 3 | ||
| Cat No | Product Name / Activity | Date Added |
| 6695 | CHIR 98014 | Feb 2019 |
| Highly potent and selective GSK-3 inhibitor | ||
Functionalized E3 Ligase Ligands | ||
| Cat No | Product Name / Activity | Date Added |
| 6685 | Thalidomide, propargyl | Jan 2019 |
| Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs | ||
| 6683 | VH 032, propargyl | Jan 2019 |
| Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs | ||
PI 3-kinase | ||
| Cat No | Product Name / Activity | Date Added |
| 6792 | Omipalisib | May 2019 |
| Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK | ||
FLT3 | ||
| Cat No | Product Name / Activity | Date Added |
| 6788 | Quizartinib | Jan 2019 |
| Highly potent FLT3 inhibitor | ||
Histamine H4 Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6279 | JNJ 39758979 dihydrochloride | Dec 2018 |
| High affinity and selective histamine H4 receptor antagonist; orally bioavailable | ||
5-HT6 Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6748 | PRX 07034 | Apr 2019 |
| Potent and selective 5-HT6 antagonist | ||
GPR55 | ||
| Cat No | Product Name / Activity | Date Added |
| 6668 | ML 184 | Jan 2019 |
| Selective GPR55 agonist; also promotes NSC proliferation and differentiation | ||
Orphan 7-TM Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6784 | FTBMT | Mar 2019 |
| Potent and selective GPR52 agonist; orally bioavailable and BBB permeable | ||
A-Kinase-Anchoring Proteins | ||
| Cat No | Product Name / Activity | Date Added |
| 6567 | RI-STAD 2 | Feb 2019 |
| AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable | ||
| 6566 | STAD 2 | Feb 2019 |
| AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable | ||
Histone Acetyltransferases | ||
| Cat No | Product Name / Activity | Date Added |
| 6692 | WM 1119 | Mar 2019 |
| High affinity KAT6A (MOZ) competitive inhibitor | ||
Retinoic Acid Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 5984 | LY 2955303 | Jan 2019 |
| High affinity and selective RARγ antagonist | ||
Acid-Sensing Ion Channels | ||
| Cat No | Product Name / Activity | Date Added |
| 6705 | Diminazene aceturate | Feb 2019 |
| ASIC blocker; antihyperalgesic | ||
Fatty Acid Synthase | ||
| Cat No | Product Name / Activity | Date Added |
| 6702 | Cerulenin | Feb 2019 |
| Irreversible fatty acid synthase inhibitor | ||
Active Degraders | ||
| Cat No | Product Name / Activity | Date Added |
| 6746 | TL 13-110 | Apr 2019 |
| Negative control for TL 13-112 | ||
| 6607 | dTRIM 24 | Jan 2019 |
| TRIM24 degrading PROTAC | ||
| 6605 | dTAG-13 | Mar 2019 |
| Degrades mutant FKBPF36V fusion proteins; useful alternative to genetic methods for target validation | ||
Protease-Activated Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6806 | AZ 3451 | Apr 2019 |
| Potent negative allosteric modulator of PAR2 | ||
Active Degraders | ||
| Cat No | Product Name / Activity | Date Added |
| 6606 | dBRD9 | Jan 2019 |
| Potent and selective BRD9 degrading PROTAC | ||
| 6745 | TL 13-112 | Apr 2019 |
| Selective ALK Degrader | ||
| 6747 | TL 13-22 | Apr 2019 |
| Negative control for TL 13-12 | ||
| 6744 | TL 13-12 | Apr 2019 |
| Selective ALK degrader | ||
BMP and Other Activin Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6881 | SB 4 | May 2019 |
| Potent BMP4 agonist | ||
Cell Adhesion Molecules | ||
| Cat No | Product Name / Activity | Date Added |
| 6634 | Surfen | Apr 2019 |
| Heparin sulfate antagonist | ||
Carbonic Anhydrases | ||
| Cat No | Product Name / Activity | Date Added |
| 6742 | Acetazolamide | Dec 2018 |
| Carbonic anhydrase inhibitor | ||
Antimalarials | ||
| Cat No | Product Name / Activity | Date Added |
| 6818 | Artemether | Mar 2019 |
| Antimalarial; also inhibits neuroinflammation | ||
Apelin Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6698 | ELA-11 (human) | Jan 2019 |
| High affinity apelin agonist | ||
| 6697 | ELA-21 (human) | Jan 2019 |
| High affinity apelin agonist | ||
Inhibitor of Apoptosis | ||
| Cat No | Product Name / Activity | Date Added |
| 6470 | A 410099.1 | Feb 2019 |
| High affinity XIAP antagonist; active in vivo | ||
Biochemicals and Molecular Biology | ||
| Cat No | Product Name / Activity | Date Added |
| 6798 | Click N-Acetylmuramic acid - alkyne | Feb 2019 |
| Bacterial peptidoglycan derivative; suitable for 'click'-conjugation to fluorescent dyes | ||
| 6786 | BzF | Feb 2019 |
| Photoreactive unnatural amino acid | ||
Bromodomains | ||
| Cat No | Product Name / Activity | Date Added |
| 5496 | LP 99 | Dec 2018 |
| Selective BRD7 and BRD9 inhibitor | ||
| 5497 | ent-LP 99 | Dec 2018 |
| Negative Control for LP 99 | ||
Bruton's Tyrosine Kinase | ||
| Cat No | Product Name / Activity | Date Added |
| 6813 | Ibrutinib | Apr 2019 |
| Potent and selective BTK inhibitor | ||
cGMP Stem Cell Compounds | ||
| Cat No | Product Name / Activity | Date Added |
| TB4423-GMP | CHIR 99021 | Dec 2018 |
| CHIR 99021 synthesized to cGMP guidelines | ||
Caged Glutamate Compounds | ||
| Cat No | Product Name / Activity | Date Added |
| 6553 | JF-NP-26 | Jan 2019 |
| Caged Raseglurant (Cat. No. 4416) | ||
Cancer Stem Cells | ||
| Cat No | Product Name / Activity | Date Added |
| 6856 | α-Mangostin | Apr 2019 |
| Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines | ||
| 6840 | AD 01 | May 2019 |
| FKBPL (FK506-binding protein like)-based peptide; inhibits breast cancer stem cell self-renewal; also antiangiogenic | ||
Chemokine CC Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6541 | AZD 2098 | Jan 2019 |
| Potent and selective CCR4 antagonist | ||
Organelle and Cell Structure Stains | ||
| Cat No | Product Name / Activity | Date Added |
| 5783 | Phalloidin-TRITC | Dec 2018 |
| Red-orange fluorescent cytoskeleton stain | ||
| 6266 | Taxol Janelia Fluor® 646 | Feb 2019 |
| Red fluorescent taxol derivative | ||
| 5782 | Phalloidin-FITC | Dec 2018 |
| Green fluorescent cytoskeleton stain | ||
| 6622 | Phalloidin-TFAX 488 | Dec 2018 |
| Green fluorescent cytoskeletal stain; binds F-actin | ||
Stem Cell Proliferation | ||
| Cat No | Product Name / Activity | Date Added |
| 6719 | YH 239-EE | Feb 2019 |
| Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity | ||
Cereblon Targeting Ligands Plus Linkers | ||
| Cat No | Product Name / Activity | Date Added |
| 6682 | Pomalidomide - linker 3 | Jan 2019 |
| Pomalidomide-alkylC5-carboxylic acid | ||
| 6686 | Thalidomide - linker 5 | Jan 2019 |
| Thalidomide-PEG2-alkyne | ||
| 6681 | Pomalidomide - linker 2 | Jan 2019 |
| Pomalidomide-PEG3-carboxylic acid | ||
| 6949 | Thalidomide - linker 10 | May 2019 |
| Thalidomide-alkylC2-amine | ||
| 6851 | Pomalidomide - linker 7 | Mar 2019 |
| Pomalidomide-alkylC2-amine | ||
| 6850 | Thalidomide - linker 6 | Mar 2019 |
| Thalidomide-AlkylC2-Amine | ||
| 6951 | Thalidomide - linker 12 | May 2019 |
| Thalidomide-PEG5-ethylamine | ||
Gap Channels | ||
| Cat No | Product Name / Activity | Date Added |
| 6819 | Mefloquine hydrochloride | Mar 2019 |
| Cx36 and Cx50 gap channel blocker; also antimalarial and antischistosomal | ||
Two-P Potassium Channels | ||
| Cat No | Product Name / Activity | Date Added |
| 6689 | GI 530159 | Jan 2019 |
| TREK1 and TREK2 channel activator | ||
Other Chemokine Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6378 | JMS 17-2 hydrochloride | Apr 2019 |
| CX3CR1 antagonist | ||
Class I HDACs | ||
| Cat No | Product Name / Activity | Date Added |
| 6728 | RGFP 966 | Mar 2019 |
| Potent and selective HDAC3 inhibitor | ||
Mas-Related G Protein-Coupled Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6352 | (S)-ZINC 3573 | Jan 2019 |
| Negative control for (R)-ZINC 3573 | ||
| 6351 | (R)-ZINC 3573 | Jan 2019 |
| MRGPRX2 agonist | ||
Cyclin-Dependent Protein Kinases | ||
| Cat No | Product Name / Activity | Date Added |
| 6535 | NVP 2 | Feb 2019 |
| Potent and selective ATP-competitive CDK9 inhibitor | ||
| 6752 | LDC 000067 | Mar 2019 |
| Potent and selective CDK9 inhibitor | ||
Deaminases | ||
| Cat No | Product Name / Activity | Date Added |
| 6868 | 8-Azaadenosine | May 2019 |
| ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal | ||
Histone Demethylases | ||
| Cat No | Product Name / Activity | Date Added |
| 6935 | GSK J5 HCl | May 2019 |
| Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable | ||
Other Differentiation Products | ||
| Cat No | Product Name / Activity | Date Added |
| 6582 | D-3 | Dec 2018 |
| Selective PSC eliminating agent | ||
Protein Dimerizers | ||
| Cat No | Product Name / Activity | Date Added |
| 6834 | Auxin | Mar 2019 |
| Chemical dimerizer used in auxin-inducible degron (AID) system; phytohormone | ||
Dipeptidyl Peptidase IV | ||
| Cat No | Product Name / Activity | Date Added |
| 3719 | Talabostat mesylate | Feb 2019 |
| Potent DPP IV inhibitor; activates NLRP1b inflammasome | ||
| 6816 | Sitagliptin phosphate | Feb 2019 |
| Potent and selective DPP IV inhibitor | ||
Other Fluorescent Dyes | ||
| Cat No | Product Name / Activity | Date Added |
| 6488 | 5(6)-SFX (Fluorescein), SE | Dec 2018 |
| Green fluorescent dye for the labeling of primary amines | ||
TFAX Dyes | ||
| Cat No | Product Name / Activity | Date Added |
| 6624 | TFAX 568, SE | Dec 2018 |
| Orange fluorescent dye; amine reactive | ||
| 6621 | TFAX 488, TFP | Jan 2019 |
| Green fluorescent dye; amine reactive | ||
Janelia Fluor® Dyes | ||
| Cat No | Product Name / Activity | Date Added |
| 6502 | Janelia Fluor® 549, Tetrazine | Apr 2019 |
| Cell permeable yellow fluorescent dye; supplied as a tetrazine for 'click' chemistry | ||
TFAX Dyes | ||
| Cat No | Product Name / Activity | Date Added |
| 6625 | TFAX 594, SE | Dec 2018 |
| Red fluorescent dye; amine reactive | ||
Janelia Fluor® Dyes | ||
| Cat No | Product Name / Activity | Date Added |
| 6590 | Janelia Fluor® 646, Maleimide | Dec 2018 |
| Red fluorescent dye, supplied with a maleimide reactive group | ||
EGFR | ||
| Cat No | Product Name / Activity | Date Added |
| 6812 | Afatinib dimaleate | Mar 2019 |
| Potent dual specificity EGFR/HER2 inhibitor; active in vivo | ||
| 6811 | Lapatinib | Apr 2019 |
| Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor | ||
Other ER Stress/UPR | ||
| Cat No | Product Name / Activity | Date Added |
| 6759 | AA 147 | Feb 2019 |
| ER proteostasis regulator | ||
Hypoxia Inducible Factors | ||
| Cat No | Product Name / Activity | Date Added |
| 6653 | FM19G11 | Feb 2019 |
| HIF α-subunit inhibitor | ||
Other Transcription Factors | ||
| Cat No | Product Name / Activity | Date Added |
| 6845 | RCM 1 | May 2019 |
| FOXM1 inhibitor | ||
Other Fluorescent Probes | ||
| Cat No | Product Name / Activity | Date Added |
| 6434 | DFHO | Apr 2019 |
| Mimic of RFP fluorophore for imaging RNA in living cells | ||
Fluorescent Substrates | ||
| Cat No | Product Name / Activity | Date Added |
| 6717 | FFN 270 | May 2019 |
| Fluorescent substrate for NET and VMAT2 | ||
| 6882 | DiFMUP | May 2019 |
| Fluorescent phophatase substrate | ||
Other Fluorescent Probes | ||
| Cat No | Product Name / Activity | Date Added |
| 6802 | 6 TMR Tre | Feb 2019 |
| Fluorescent trehalose; selectively labels mycobacterial cell envelope | ||
| 6659 | sBADA | Feb 2019 |
| Green fluorescent D-amino acid for labeling peptidoglycans in bacteria | ||
GABAA Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6334 | THDOC | Jan 2019 |
| Positive modulator of GABAA receptors; endogenous neurosteroid | ||
GIP Receptor | ||
| Cat No | Product Name / Activity | Date Added |
| 6699 | [D-Ala2]-GIP (human) | Jan 2019 |
| Highly potent GIP agonist | ||
Glutaminase | ||
| Cat No | Product Name / Activity | Date Added |
| 6809 | L-DON | Feb 2019 |
| Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters | ||
Glycosylases | ||
| Cat No | Product Name / Activity | Date Added |
| 6749 | TH 5487 | Apr 2019 |
| Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor | ||
Ras GTPases | ||
| Cat No | Product Name / Activity | Date Added |
| 6429 | ML 210 | Mar 2019 |
| Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis | ||
Other Small Monomeric GTPases | ||
| Cat No | Product Name / Activity | Date Added |
| 6575 | StRIP16 | Apr 2019 |
| Rab8a GTPase-binding stapled peptide | ||
Other Hydrolases | ||
| Cat No | Product Name / Activity | Date Added |
| 6510 | LNT 1 | Apr 2019 |
| Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response | ||
| 5862 | ARN 14686 | Apr 2019 |
| Potent N-acylethanolamine acid amidase inhibitor; NAAA activity-based protein profiling (ABPP) probe | ||
Ion Indicators | ||
| Cat No | Product Name / Activity | Date Added |
| 6704 | Indo 1AM | Nov 2018 |
| Fluorescent Ca2+ indicator | ||
Inflammasomes | ||
| Cat No | Product Name / Activity | Date Added |
| 6827 | Artesunate | Mar 2019 |
| Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial | ||
| 6774 | 16673-34-0 NLRP3i | Jan 2019 |
| NLRP3 inflammasome inhibitor | ||
Integrins | ||
| Cat No | Product Name / Activity | Date Added |
| 6785 | E 7820 | Apr 2019 |
| α2 integrin inhibitor; anti-angiogenic | ||
Receptor Interacting Protein Kinases | ||
| Cat No | Product Name / Activity | Date Added |
| 6598 | OD 36 hydrochloride | Jan 2019 |
| Potent RIP2 kinase inhibitor | ||
Other Ion Pumps/Transporters | ||
| Cat No | Product Name / Activity | Date Added |
| 5026 | KYT 0353 | May 2019 |
| Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo | ||
| 6518 | BI 01383298 | Feb 2019 |
| Potent and selective SLC13A5 (Na+/citrate cotransporter) inhibitor | ||
JAK Kinase | ||
| Cat No | Product Name / Activity | Date Added |
| 6577 | Pyridone 6 | Feb 2019 |
| Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable | ||
Other Kinases | ||
| Cat No | Product Name / Activity | Date Added |
| 6246 | BF 738735 | Apr 2019 |
| Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor | ||
Syk Kinase | ||
| Cat No | Product Name / Activity | Date Added |
| 6362 | GSK 143 | May 2019 |
| Syk inhibitor | ||
Src Kinases | ||
| Cat No | Product Name / Activity | Date Added |
| 6793 | Dasatinib | Feb 2019 |
| Highly potent pan-Src/Bcr-Abl inhibitor | ||
Raf Kinases | ||
| Cat No | Product Name / Activity | Date Added |
| 6814 | Sorafenib | Apr 2019 |
| Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT | ||
Kinesin | ||
| Cat No | Product Name / Activity | Date Added |
| 6664 | Kinesore | Mar 2019 |
| Kinesin-1 modulator; cell permeable | ||
VHL Targeting Ligands Plus Linkers | ||
| Cat No | Product Name / Activity | Date Added |
| 6890 | VH 032 - linker 11 | Apr 2019 |
| VH 032-AlkylC8-Amine | ||
| 6880 | VH 032 - linker 10 | Apr 2019 |
| VH 032-alkylC10-amine | ||
| 6853 | VH 032 - linker 8 | Apr 2019 |
| VH 032-AlkylC6-Amine | ||
| 6684 | VH 032 - linker 6 | Jan 2019 |
| VH 032-PEG2-alkyne | ||
| 6680 | VH 032 - linker 5 | Jan 2019 |
| VH 032-alkylC4-terminal carboxylic acid | ||
| 6679 | VH 032 - linker 4 | Apr 2019 |
| VH 032-PEG3-CH2CH2COOH | ||
| 6907 | VH 032 - linker 12 | Apr 2019 |
| VH 032-PEG2-amine | ||
| 6879 | VH 032 - linker 9 | Apr 2019 |
| VH 032-PEG1-amine | ||
| 6852 | VH 032 - linker 7 | Apr 2019 |
| VH 032-AlkylC2-Amine | ||
Toll-like Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6587 | TAK 242 | Dec 2018 |
| TLR4 signaling inhibitor | ||
Lipoxygenases | ||
| Cat No | Product Name / Activity | Date Added |
| 1304 | BW-B 70C | Mar 2019 |
| 5-Lipoxygenase inhibitor | ||
Matrix Metalloproteases | ||
| Cat No | Product Name / Activity | Date Added |
| 6439 | JNJ 0966 | Mar 2019 |
| Pro-MMP9 activation inhibitor | ||
MEK | ||
| Cat No | Product Name / Activity | Date Added |
| 6815 | Selumetinib | May 2019 |
| Potent and selective MEK inhibitor; orally bioavailable | ||
Melatonin Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6777 | TAK 375 | Jan 2019 |
| Very high affinity and selective melatonin receptor agonist | ||
Microtubules | ||
| Cat No | Product Name / Activity | Date Added |
| 6726 | T-peptide | Jan 2019 |
| Cytotoxic Tau peptide; cell permeable | ||
NADPH Oxidase | ||
| Cat No | Product Name / Activity | Date Added |
| 6654 | VAS 2870 | Dec 2018 |
| NADPH oxidase (Nox) inhibitor | ||
NAMPT | ||
| Cat No | Product Name / Activity | Date Added |
| 6753 | CHS 828 | Mar 2019 |
| NAMPT inhibitor; active in vivo and cytotoxic | ||
Natriuretic Peptide Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6715 | A 71915 | Jan 2019 |
| Highly potent and competitive NPRA antagonist | ||
NMDA Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6369 | GNE 9278 | Jan 2019 |
| Positive allosteric modulator of NMDA receptors; acts in transmembrane domain | ||
Other Proteases | ||
| Cat No | Product Name / Activity | Date Added |
| 6272 | KYP 2047 | Mar 2019 |
| High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant | ||
| 6710 | Darunavir | Dec 2018 |
| Highly potent HIV protease inhibitor | ||
Other Transferases | ||
| Cat No | Product Name / Activity | Date Added |
| 6618 | MB 05032 | Dec 2018 |
| Potent FBPase inhibitor; promotes HSC expansion | ||
Other Reductases | ||
| Cat No | Product Name / Activity | Date Added |
| 6597 | SPRi 3 | Feb 2019 |
| Potent sepiapterin reductase (SPR) inhibitor; attenuates proliferation of CD4+ T cells | ||
Other RTKs | ||
| Cat No | Product Name / Activity | Date Added |
| 6579 | BAY 826 | Dec 2018 |
| Potent Tie2 inhibitor | ||
Other Oxygenases/Oxidases | ||
| Cat No | Product Name / Activity | Date Added |
| 6867 | Rhein | Apr 2019 |
| FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3 | ||
Other Transferases | ||
| Cat No | Product Name / Activity | Date Added |
| 6652 | NGI 1 | Dec 2018 |
| Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral | ||
Protein Ser/Thr Phosphatases | ||
| Cat No | Product Name / Activity | Date Added |
| 6760 | Raphin 1 | Mar 2019 |
| Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant | ||
Protein Tyrosine Phosphatases | ||
| Cat No | Product Name / Activity | Date Added |
| 6771 | PHPS1 sodium salt | May 2019 |
| Shp2 (PTPN11) inhibitor | ||
| 6829 | (R)-Shikonin | May 2019 |
| PTEN inhibitor; induces necroptosis; anti-inflammatory | ||
Phospholipases | ||
| Cat No | Product Name / Activity | Date Added |
| 6755 | Darapladib | Mar 2019 |
| Potent lp-PLA2 inhibitor | ||
PSEMs | ||
| Cat No | Product Name / Activity | Date Added |
| 6865 | uPSEM 792 hydrochloride | Apr 2019 |
| Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant | ||
| 6866 | uPSEM 817 tartrate | Mar 2019 |
| Highly potent and selective uPSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant | ||
TGF-β Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6245 | SM 16 | Jan 2019 |
| Potent TGF-βRI inhibitor; orally bioavailable | ||
Vasopressin Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6830 | Conivaptan hydrochloride | Mar 2019 |
| Very high affinity vasopressin V1A and V2 antagonist; orally bioavailable | ||
TGF-β Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6712 | A 77-01 | Dec 2018 |
| Potent inhibitor of TGF-βRI | ||
RSK | ||
| Cat No | Product Name / Activity | Date Added |
| 6754 | LJI308 | Mar 2019 |
| Potent pan-RSK inhibitor | ||
TRPC | ||
| Cat No | Product Name / Activity | Date Added |
| 6766 | AC 1903 | Mar 2019 |
| Selective TRPC5 blocker | ||
TRPM | ||
| Cat No | Product Name / Activity | Date Added |
| 6724 | CBA | Feb 2019 |
| Selective TRPM4 blocker | ||