New Products

View all New Products by pharmacological action

Search for new products by date added, alphabetically, or by pharmacological action.

New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

Purinergic (P2Y) Receptors

Cat No Product Name / Activity Date Added
6864 Ticagrelor Apr 2019
High affinity and reversible P2Y12 antagonist; displays inverse agonism in vitro; also inhibits ENT1

Akt (Protein Kinase B)

Cat No Product Name / Activity Date Added
6762 Urolithin A Apr 2019
PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro

CaV3.x Channels (T-type)

Cat No Product Name / Activity Date Added
6770 ABT 639 Mar 2019
CaV3.2 and CaV3.1 channel blocker; orally bioavailable

Nicotinic (α4β2) Receptors

Cat No Product Name / Activity Date Added
6706 DPNB-ABT 594 Mar 2019
Caged ABT 594; suitable for one- or two-photon photolysis

Casein Kinase 1

Cat No Product Name / Activity Date Added
6340 Epiblastin A Jan 2019
CK1 inhibitor; converts epiblast stem cells to ESCs and promotes ESC self-renewal

Glucagon-Like Peptide 1 Receptors

Cat No Product Name / Activity Date Added
6355 VU 0650991 Apr 2019
Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant

CRF1 Receptors

Cat No Product Name / Activity Date Added
6530 R 121919 hydrochloride Dec 2018
High affinity CRF1 antagonist; orally bioavailable

Sphingosine-1-Phosphate Receptors

Cat No Product Name / Activity Date Added
6690 Ceralifimod May 2019
Highly potent and selective S1P1 and S1P5 agonist
6709 GSK 2018682 Jan 2019
S1P1 and S1P5 agonist

Casein Kinase 1

Cat No Product Name / Activity Date Added
6676 IC 261 Dec 2018
CK1 inhibitor; displays selectivity for CK1δ and CK1ε

CRF1 Receptors

Cat No Product Name / Activity Date Added
6451 Pexacerfont Apr 2019
Potent and selective CRF1 antagonist; anxiolytic

CB1 Receptors

Cat No Product Name / Activity Date Added
6763 AVE 1625 Apr 2019
Potent and selective CB1 receptor antagonist

Nrf2

Cat No Product Name / Activity Date Added
6243 ML 385 Jan 2019
Nrf2 inhibitor; phenotypically lethal

σ2 Receptors

Cat No Product Name / Activity Date Added
6740 Siramesine hydrochloride Apr 2019
High affinity σ agonist (σ2 > σ1)

Cdc2-like Kinases

Cat No Product Name / Activity Date Added
6644 KuWal151 Jan 2019
Potent and selective CLK inhibitor

Adenosine A2B Receptors

Cat No Product Name / Activity Date Added
6787 KI-7 Mar 2019
A2B receptor positive allosteric modulator

CB2 Receptors

Cat No Product Name / Activity Date Added
6832 Ec2la May 2019
CB2 receptor positive allosteric modulator; active in vivo

EZH2

Cat No Product Name / Activity Date Added
6708 SAH-EZH2 May 2019
EZH2/EDD interaction inhibitor; suppresses PCR2 complex function

P21-activated Kinases

Cat No Product Name / Activity Date Added
6177 AZ 13705339 Dec 2018
Highly potent PAK1 and PAK2 inhibitor
6490 GNE 2861 Mar 2019
Group II PAK inhibitor; potently inhibits PAK4 and PAK 6

Glycogen Synthase Kinase 3

Cat No Product Name / Activity Date Added
6695 CHIR 98014 Feb 2019
Highly potent and selective GSK-3 inhibitor

Functionalized E3 Ligase Ligands

Cat No Product Name / Activity Date Added
6685 Thalidomide, propargyl Jan 2019
Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs
6683 VH 032, propargyl Jan 2019
Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs

PI 3-kinase

Cat No Product Name / Activity Date Added
6792 Omipalisib May 2019
Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK

FLT3

Cat No Product Name / Activity Date Added
6788 Quizartinib Jan 2019
Highly potent FLT3 inhibitor

Histamine H4 Receptors

Cat No Product Name / Activity Date Added
6279 JNJ 39758979 dihydrochloride Dec 2018
High affinity and selective histamine H4 receptor antagonist; orally bioavailable

5-HT6 Receptors

Cat No Product Name / Activity Date Added
6748 PRX 07034 Apr 2019
Potent and selective 5-HT6 antagonist

GPR55

Cat No Product Name / Activity Date Added
6668 ML 184 Jan 2019
Selective GPR55 agonist; also promotes NSC proliferation and differentiation

Orphan 7-TM Receptors

Cat No Product Name / Activity Date Added
6784 FTBMT Mar 2019
Potent and selective GPR52 agonist; orally bioavailable and BBB permeable

A-Kinase-Anchoring Proteins

Cat No Product Name / Activity Date Added
6567 RI-STAD 2 Feb 2019
AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable
6566 STAD 2 Feb 2019
AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable

Histone Acetyltransferases

Cat No Product Name / Activity Date Added
6692 WM 1119 Mar 2019
High affinity KAT6A (MOZ) competitive inhibitor

Retinoic Acid Receptors

Cat No Product Name / Activity Date Added
5984 LY 2955303 Jan 2019
High affinity and selective RARγ antagonist

Acid-Sensing Ion Channels

Cat No Product Name / Activity Date Added
6705 Diminazene aceturate Feb 2019
ASIC blocker; antihyperalgesic

Fatty Acid Synthase

Cat No Product Name / Activity Date Added
6702 Cerulenin Feb 2019
Irreversible fatty acid synthase inhibitor

Active Degraders

Cat No Product Name / Activity Date Added
6746 TL 13-110 Apr 2019
Negative control for TL 13-112
6607 dTRIM 24 Jan 2019
TRIM24 degrading PROTAC
6605 dTAG-13 Mar 2019
Degrades mutant FKBPF36V fusion proteins; useful alternative to genetic methods for target validation

Protease-Activated Receptors

Cat No Product Name / Activity Date Added
6806 AZ 3451 Apr 2019
Potent negative allosteric modulator of PAR2

Active Degraders

Cat No Product Name / Activity Date Added
6606 dBRD9 Jan 2019
Potent and selective BRD9 degrading PROTAC
6745 TL 13-112 Apr 2019
Selective ALK Degrader
6747 TL 13-22 Apr 2019
Negative control for TL 13-12
6744 TL 13-12 Apr 2019
Selective ALK degrader

BMP and Other Activin Receptors

Cat No Product Name / Activity Date Added
6881 SB 4 May 2019
Potent BMP4 agonist

Cell Adhesion Molecules

Cat No Product Name / Activity Date Added
6634 Surfen Apr 2019
Heparin sulfate antagonist

Carbonic Anhydrases

Cat No Product Name / Activity Date Added
6742 Acetazolamide Dec 2018
Carbonic anhydrase inhibitor

Antimalarials

Cat No Product Name / Activity Date Added
6818 Artemether Mar 2019
Antimalarial; also inhibits neuroinflammation

Apelin Receptors

Cat No Product Name / Activity Date Added
6698 ELA-11 (human) Jan 2019
High affinity apelin agonist
6697 ELA-21 (human) Jan 2019
High affinity apelin agonist

Inhibitor of Apoptosis

Cat No Product Name / Activity Date Added
6470 A 410099.1 Feb 2019
High affinity XIAP antagonist; active in vivo

Biochemicals and Molecular Biology

Cat No Product Name / Activity Date Added
6798 Click N-Acetylmuramic acid - alkyne Feb 2019
Bacterial peptidoglycan derivative; suitable for 'click'-conjugation to fluorescent dyes
6786 BzF Feb 2019
Photoreactive unnatural amino acid

Bromodomains

Cat No Product Name / Activity Date Added
5496 LP 99 Dec 2018
Selective BRD7 and BRD9 inhibitor
5497 ent-LP 99 Dec 2018
Negative Control for LP 99

Bruton's Tyrosine Kinase

Cat No Product Name / Activity Date Added
6813 Ibrutinib Apr 2019
Potent and selective BTK inhibitor

cGMP Stem Cell Compounds

Cat No Product Name / Activity Date Added
TB4423-GMP CHIR 99021 Dec 2018
CHIR 99021 synthesized to cGMP guidelines

Caged Glutamate Compounds

Cat No Product Name / Activity Date Added
6553 JF-NP-26 Jan 2019
Caged Raseglurant (Cat. No. 4416)

Cancer Stem Cells

Cat No Product Name / Activity Date Added
6856 α-Mangostin Apr 2019
Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines
6840 AD 01 May 2019
FKBPL (FK506-binding protein like)-based peptide; inhibits breast cancer stem cell self-renewal; also antiangiogenic

Chemokine CC Receptors

Cat No Product Name / Activity Date Added
6541 AZD 2098 Jan 2019
Potent and selective CCR4 antagonist

Organelle and Cell Structure Stains

Cat No Product Name / Activity Date Added
5783 Phalloidin-TRITC Dec 2018
Red-orange fluorescent cytoskeleton stain
6266 Taxol Janelia Fluor® 646 Feb 2019
Red fluorescent taxol derivative
5782 Phalloidin-FITC Dec 2018
Green fluorescent cytoskeleton stain
6622 Phalloidin-TFAX 488 Dec 2018
Green fluorescent cytoskeletal stain; binds F-actin

Stem Cell Proliferation

Cat No Product Name / Activity Date Added
6719 YH 239-EE Feb 2019
Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity

Cereblon Targeting Ligands Plus Linkers

Cat No Product Name / Activity Date Added
6682 Pomalidomide - linker 3 Jan 2019
Pomalidomide-alkylC5-carboxylic acid
6686 Thalidomide - linker 5 Jan 2019
Thalidomide-PEG2-alkyne
6681 Pomalidomide - linker 2 Jan 2019
Pomalidomide-PEG3-carboxylic acid
6949 Thalidomide - linker 10 May 2019
Thalidomide-alkylC2-amine
6851 Pomalidomide - linker 7 Mar 2019
Pomalidomide-alkylC2-amine
6850 Thalidomide - linker 6 Mar 2019
Thalidomide-AlkylC2-Amine
6951 Thalidomide - linker 12 May 2019
Thalidomide-PEG5-ethylamine

Gap Channels

Cat No Product Name / Activity Date Added
6819 Mefloquine hydrochloride Mar 2019
Cx36 and Cx50 gap channel blocker; also antimalarial and antischistosomal

Two-P Potassium Channels

Cat No Product Name / Activity Date Added
6689 GI 530159 Jan 2019
TREK1 and TREK2 channel activator

Other Chemokine Receptors

Cat No Product Name / Activity Date Added
6378 JMS 17-2 hydrochloride Apr 2019
CX3CR1 antagonist

Class I HDACs

Cat No Product Name / Activity Date Added
6728 RGFP 966 Mar 2019
Potent and selective HDAC3 inhibitor

Mas-Related G Protein-Coupled Receptors

Cat No Product Name / Activity Date Added
6352 (S)-ZINC 3573 Jan 2019
Negative control for (R)-ZINC 3573
6351 (R)-ZINC 3573 Jan 2019
MRGPRX2 agonist

Cyclin-Dependent Protein Kinases

Cat No Product Name / Activity Date Added
6535 NVP 2 Feb 2019
Potent and selective ATP-competitive CDK9 inhibitor
6752 LDC 000067 Mar 2019
Potent and selective CDK9 inhibitor

Deaminases

Cat No Product Name / Activity Date Added
6868 8-Azaadenosine May 2019
ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal

Histone Demethylases

Cat No Product Name / Activity Date Added
6935 GSK J5 HCl May 2019
Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable

Other Differentiation Products

Cat No Product Name / Activity Date Added
6582 D-3 Dec 2018
Selective PSC eliminating agent

Protein Dimerizers

Cat No Product Name / Activity Date Added
6834 Auxin Mar 2019
Chemical dimerizer used in auxin-inducible degron (AID) system; phytohormone

Dipeptidyl Peptidase IV

Cat No Product Name / Activity Date Added
3719 Talabostat mesylate Feb 2019
Potent DPP IV inhibitor; activates NLRP1b inflammasome
6816 Sitagliptin phosphate Feb 2019
Potent and selective DPP IV inhibitor

Other Fluorescent Dyes

Cat No Product Name / Activity Date Added
6488 5(6)-SFX (Fluorescein), SE Dec 2018
Green fluorescent dye for the labeling of primary amines

TFAX Dyes

Cat No Product Name / Activity Date Added
6624 TFAX 568, SE Dec 2018
Orange fluorescent dye; amine reactive
6621 TFAX 488, TFP Jan 2019
Green fluorescent dye; amine reactive

Janelia Fluor® Dyes

Cat No Product Name / Activity Date Added
6502 Janelia Fluor® 549, Tetrazine Apr 2019
Cell permeable yellow fluorescent dye; supplied as a tetrazine for 'click' chemistry

TFAX Dyes

Cat No Product Name / Activity Date Added
6625 TFAX 594, SE Dec 2018
Red fluorescent dye; amine reactive

Janelia Fluor® Dyes

Cat No Product Name / Activity Date Added
6590 Janelia Fluor® 646, Maleimide Dec 2018
Red fluorescent dye, supplied with a maleimide reactive group

EGFR

Cat No Product Name / Activity Date Added
6812 Afatinib dimaleate Mar 2019
Potent dual specificity EGFR/HER2 inhibitor; active in vivo
6811 Lapatinib Apr 2019
Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor

Other ER Stress/UPR

Cat No Product Name / Activity Date Added
6759 AA 147 Feb 2019
ER proteostasis regulator

Hypoxia Inducible Factors

Cat No Product Name / Activity Date Added
6653 FM19G11 Feb 2019
HIF α-subunit inhibitor

Other Transcription Factors

Cat No Product Name / Activity Date Added
6845 RCM 1 May 2019
FOXM1 inhibitor

Other Fluorescent Probes

Cat No Product Name / Activity Date Added
6434 DFHO Apr 2019
Mimic of RFP fluorophore for imaging RNA in living cells

Fluorescent Substrates

Cat No Product Name / Activity Date Added
6717 FFN 270 May 2019
Fluorescent substrate for NET and VMAT2
6882 DiFMUP May 2019
Fluorescent phophatase substrate

Other Fluorescent Probes

Cat No Product Name / Activity Date Added
6802 6 TMR Tre Feb 2019
Fluorescent trehalose; selectively labels mycobacterial cell envelope
6659 sBADA Feb 2019
Green fluorescent D-amino acid for labeling peptidoglycans in bacteria

GABAA Receptors

Cat No Product Name / Activity Date Added
6334 THDOC Jan 2019
Positive modulator of GABAA receptors; endogenous neurosteroid

GIP Receptor

Cat No Product Name / Activity Date Added
6699 [D-Ala2]-GIP (human) Jan 2019
Highly potent GIP agonist

Glutaminase

Cat No Product Name / Activity Date Added
6809 L-DON Feb 2019
Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters

Glycosylases

Cat No Product Name / Activity Date Added
6749 TH 5487 Apr 2019
Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor

Ras GTPases

Cat No Product Name / Activity Date Added
6429 ML 210 Mar 2019
Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis

Other Small Monomeric GTPases

Cat No Product Name / Activity Date Added
6575 StRIP16 Apr 2019
Rab8a GTPase-binding stapled peptide

Other Hydrolases

Cat No Product Name / Activity Date Added
6510 LNT 1 Apr 2019
Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response
5862 ARN 14686 Apr 2019
Potent N-acylethanolamine acid amidase inhibitor; NAAA activity-based protein profiling (ABPP) probe

Ion Indicators

Cat No Product Name / Activity Date Added
6704 Indo 1AM Nov 2018
Fluorescent Ca2+ indicator

Inflammasomes

Cat No Product Name / Activity Date Added
6827 Artesunate Mar 2019
Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial
6774 16673-34-0 NLRP3i Jan 2019
NLRP3 inflammasome inhibitor

Integrins

Cat No Product Name / Activity Date Added
6785 E 7820 Apr 2019
α2 integrin inhibitor; anti-angiogenic

Receptor Interacting Protein Kinases

Cat No Product Name / Activity Date Added
6598 OD 36 hydrochloride Jan 2019
Potent RIP2 kinase inhibitor

Other Ion Pumps/Transporters

Cat No Product Name / Activity Date Added
5026 KYT 0353 May 2019
Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo
6518 BI 01383298 Feb 2019
Potent and selective SLC13A5 (Na+/citrate cotransporter) inhibitor

JAK Kinase

Cat No Product Name / Activity Date Added
6577 Pyridone 6 Feb 2019
Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable

Other Kinases

Cat No Product Name / Activity Date Added
6246 BF 738735 Apr 2019
Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor

Syk Kinase

Cat No Product Name / Activity Date Added
6362 GSK 143 May 2019
Syk inhibitor

Src Kinases

Cat No Product Name / Activity Date Added
6793 Dasatinib Feb 2019
Highly potent pan-Src/Bcr-Abl inhibitor

Raf Kinases

Cat No Product Name / Activity Date Added
6814 Sorafenib Apr 2019
Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT

Kinesin

Cat No Product Name / Activity Date Added
6664 Kinesore Mar 2019
Kinesin-1 modulator; cell permeable

VHL Targeting Ligands Plus Linkers

Cat No Product Name / Activity Date Added
6890 VH 032 - linker 11 Apr 2019
VH 032-AlkylC8-Amine
6880 VH 032 - linker 10 Apr 2019
VH 032-alkylC10-amine
6853 VH 032 - linker 8 Apr 2019
VH 032-AlkylC6-Amine
6684 VH 032 - linker 6 Jan 2019
VH 032-PEG2-alkyne
6680 VH 032 - linker 5 Jan 2019
VH 032-alkylC4-terminal carboxylic acid
6679 VH 032 - linker 4 Apr 2019
VH 032-PEG3-CH2CH2COOH
6907 VH 032 - linker 12 Apr 2019
VH 032-PEG2-amine
6879 VH 032 - linker 9 Apr 2019
VH 032-PEG1-amine
6852 VH 032 - linker 7 Apr 2019
VH 032-AlkylC2-Amine

Toll-like Receptors

Cat No Product Name / Activity Date Added
6587 TAK 242 Dec 2018
TLR4 signaling inhibitor

Lipoxygenases

Cat No Product Name / Activity Date Added
1304 BW-B 70C Mar 2019
5-Lipoxygenase inhibitor

Matrix Metalloproteases

Cat No Product Name / Activity Date Added
6439 JNJ 0966 Mar 2019
Pro-MMP9 activation inhibitor

MEK

Cat No Product Name / Activity Date Added
6815 Selumetinib May 2019
Potent and selective MEK inhibitor; orally bioavailable

Melatonin Receptors

Cat No Product Name / Activity Date Added
6777 TAK 375 Jan 2019
Very high affinity and selective melatonin receptor agonist

Microtubules

Cat No Product Name / Activity Date Added
6726 T-peptide Jan 2019
Cytotoxic Tau peptide; cell permeable

NADPH Oxidase

Cat No Product Name / Activity Date Added
6654 VAS 2870 Dec 2018
NADPH oxidase (Nox) inhibitor

NAMPT

Cat No Product Name / Activity Date Added
6753 CHS 828 Mar 2019
NAMPT inhibitor; active in vivo and cytotoxic

Natriuretic Peptide Receptors

Cat No Product Name / Activity Date Added
6715 A 71915 Jan 2019
Highly potent and competitive NPRA antagonist

NMDA Receptors

Cat No Product Name / Activity Date Added
6369 GNE 9278 Jan 2019
Positive allosteric modulator of NMDA receptors; acts in transmembrane domain

Other Proteases

Cat No Product Name / Activity Date Added
6272 KYP 2047 Mar 2019
High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant
6710 Darunavir Dec 2018
Highly potent HIV protease inhibitor

Other Transferases

Cat No Product Name / Activity Date Added
6618 MB 05032 Dec 2018
Potent FBPase inhibitor; promotes HSC expansion

Other Reductases

Cat No Product Name / Activity Date Added
6597 SPRi 3 Feb 2019
Potent sepiapterin reductase (SPR) inhibitor; attenuates proliferation of CD4+ T cells

Other RTKs

Cat No Product Name / Activity Date Added
6579 BAY 826 Dec 2018
Potent Tie2 inhibitor

Other Oxygenases/Oxidases

Cat No Product Name / Activity Date Added
6867 Rhein Apr 2019
FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3

Other Transferases

Cat No Product Name / Activity Date Added
6652 NGI 1 Dec 2018
Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral

Protein Ser/Thr Phosphatases

Cat No Product Name / Activity Date Added
6760 Raphin 1 Mar 2019
Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant

Protein Tyrosine Phosphatases

Cat No Product Name / Activity Date Added
6771 PHPS1 sodium salt May 2019
Shp2 (PTPN11) inhibitor
6829 (R)-Shikonin May 2019
PTEN inhibitor; induces necroptosis; anti-inflammatory

Phospholipases

Cat No Product Name / Activity Date Added
6755 Darapladib Mar 2019
Potent lp-PLA2 inhibitor

PSEMs

Cat No Product Name / Activity Date Added
6865 uPSEM 792 hydrochloride Apr 2019
Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
6866 uPSEM 817 tartrate Mar 2019
Highly potent and selective uPSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant

TGF-β Receptors

Cat No Product Name / Activity Date Added
6245 SM 16 Jan 2019
Potent TGF-βRI inhibitor; orally bioavailable

Vasopressin Receptors

Cat No Product Name / Activity Date Added
6830 Conivaptan hydrochloride Mar 2019
Very high affinity vasopressin V1A and V2 antagonist; orally bioavailable

TGF-β Receptors

Cat No Product Name / Activity Date Added
6712 A 77-01 Dec 2018
Potent inhibitor of TGF-βRI

RSK

Cat No Product Name / Activity Date Added
6754 LJI308 Mar 2019
Potent pan-RSK inhibitor

TRPC

Cat No Product Name / Activity Date Added
6766 AC 1903 Mar 2019
Selective TRPC5 blocker

TRPM

Cat No Product Name / Activity Date Added
6724 CBA Feb 2019
Selective TRPM4 blocker