New Products

View all New Products by pharmacological action

Search for new products by date added, alphabetically, or by pharmacological action.

New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

Calcium-Activated Potassium (KCa) Channels

Cat. No. Product Name / Activity Date Added
6398 SKA 121 Jan 2020
Positive allosteric modulator of KCa3.1 channels
6481 AP 14145 hydrochloride Nov 2019
KCa2 channel negative allosteric modulator

Glutamate (Metabotropic) Group II Receptors

Cat. No. Product Name / Activity Date Added
6928 VU 6001966 Feb 2020
Potent and selective negative allosteric modulator of mGlu2 receptors

Glutamate (Metabotropic) Group I Receptors

Cat. No. Product Name / Activity Date Added
6895 VU 0424465 Oct 2019
Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity

Adenosine A1 Receptors

Cat. No. Product Name / Activity Date Added
6863 N6-Cyclohexyladenosine Nov 2019
High affinity A1 receptor agonist

Trace Amine 1 Receptor

Cat. No. Product Name / Activity Date Added
6833 RO 5263397 hydrochloride Feb 2020
Potent TA1 receptor agonist

CB1 Receptors

Cat. No. Product Name / Activity Date Added
5746 NESS 0327 Feb 2020
Ultra-high affinity and selective CB1 antagonist

OX2 Receptors

Cat. No. Product Name / Activity Date Added
6739 YNT 185 Mar 2020
Potent and selective OX2 agonist

K+/Cl- Cotransporter 2

Cat. No. Product Name / Activity Date Added
6758 CLP 290 Mar 2020
K+/Cl- cotransporter 2 (KCC2) activator; orally bioavailable prodrug of CLP 257 (Cat. No.5242)

CB2 Receptors

Cat. No. Product Name / Activity Date Added
6220 PM 226 Jan 2020
Potent and selective CB2 receptor agonist; BBB permeable; neuroprotective

M2 Receptors

Cat. No. Product Name / Activity Date Added
6964 LY 2119620 Jan 2020
Positive allosteric modulator of M2 and M4 receptors

Functionalized E3 Ligase Ligands

Cat. No. Product Name / Activity Date Added
6911 VH 032, phenol Mar 2020
Hydroxyl functionalized VHL ligand

5-HT3 Receptors

Cat. No. Product Name / Activity Date Added
7038 Palonosetron hydrochloride Feb 2020
Highly potent and high affinity 5-HT3 antagonist

Functionalized E3 Ligase Ligands

Cat. No. Product Name / Activity Date Added
6952 VH 101, phenol Jan 2020
Hydroxyl functionalized VHL ligand

Adrenergic β3 Receptors

Cat. No. Product Name / Activity Date Added
7070 Mirabegron Nov 2019
Potent and selective β3 agonist

D3 Receptors

Cat. No. Product Name / Activity Date Added
7039 SK 609 Feb 2020
Dopamine D3 receptor biased agonist

Functionalized E3 Ligase Ligands

Cat. No. Product Name / Activity Date Added
6471 A 410099.1, amine Nov 2019
Functionalized IAP ligand for PROTACs

M4 Receptors

Cat. No. Product Name / Activity Date Added
6932 VU 0467485 Oct 2019
Potent and selective positive allosteric modulator of M4 receptors; orally bioavailable and brain penetrant

Orphan 7-TM Receptors

Cat. No. Product Name / Activity Date Added
6931 AF 64394 Dec 2019
Potent and selective GPR3 inverse agonist

Free Fatty Acid Receptors

Cat. No. Product Name / Activity Date Added
6826 AZ 1729 Mar 2020
FFA2 allosteric agonist; displays bias for the Gi signaling pathway

Free Acid Janelia Fluor® Dyes

Cat. No. Product Name / Activity Date Added
6993 Janelia Fluor® 646, free acid Feb 2020
Red dye (Reactive group: free acid). Applications: super resolution microscopy e.g. dSTORM & STED, confocal, flow and live cell imaging

Active Degraders

Cat. No. Product Name / Activity Date Added
6939 cis-VZ 185 Mar 2020
Negative control for VZ 185 (Cat. No. 6936)
6936 VZ 185 Oct 2019
Potent and selective BRD7/9 Degrader

Poly(ADP-ribose) Polymerase

Cat. No. Product Name / Activity Date Added
7026 Veliparib dihydrochloride Dec 2019
High affinity PARP-1 and -2 inhibitor; orally bioavailable

AMPA Receptors

Cat. No. Product Name / Activity Date Added
6847 TAT-GluA2 3Y Oct 2019
Inhibitor of AMPA receptor endocytosis

Amyloid β Peptides

Cat. No. Product Name / Activity Date Added
7031 Amyloid β-Peptide (1-37) (human) Nov 2019
Amyloid β-protein fragment

Apelin Receptors

Cat. No. Product Name / Activity Date Added
7053 MM 07 Dec 2019
Apelin receptor biased agonist; exhibits bias for the G protein pathway

Biochemicals and Molecular Biology

Cat. No. Product Name / Activity Date Added
7044 (±)-α-Lipoic acid Nov 2019
Liquid-liquid phase separated condensate modifier; reduces stress granule formation
7015 IA-Alkyne Jan 2020
Broad spectrum cysteine reactive probe
7045 (±)-α-Lipoamide Oct 2019
Phase-separated condensate modifier; orally bioavailable
6456 Fluorescein Tyramide Jan 2020
Green fluorescent reagent widely used for signal amplification in IHC and ISH
6574 Fluorescein-NAD+ Oct 2019
Fluorescent NAD+; substrate for ADP-ribosylation for use in PARP assays
6458 Cyanine 5 Tyramide Jan 2020
Red fluorescent reagent widely used for signal amplification in IHC and ISH
6457 Cyanine 3 Tyramide Jan 2020
Orange fluorescent reagent widely used for signal amplification in IHC and ISH

Bromodomains

Cat. No. Product Name / Activity Date Added
6670 TP 238 Mar 2020
CECR2 and BPTF/FALZ inhibitor

cGMP Stem Cell Compounds

Cat. No. Product Name / Activity Date Added
TB3748-GMP XAV 939 Jan 2020
XAV 939 synthesized to cGMP guidelines

Other Cannabinoids

Cat. No. Product Name / Activity Date Added
6372 PSB CB5 Mar 2020
Selective GPR18 antagonist

β-catenin

Cat. No. Product Name / Activity Date Added
7002 KYA 1797K Dec 2019
Wnt/β-catenin signaling inhibitor
6961 FzM1.8 Dec 2019
Frizzled 4 allosteric agonist; exhibits biased siginaling; preserves stemness

Chemokine CC Receptors

Cat. No. Product Name / Activity Date Added
7071 GSK 2239633A Dec 2019
Potent CCR4 antagonist

Stem Cell Proliferation

Cat. No. Product Name / Activity Date Added
6991 Poly Vinyl Alcohol Dec 2019
Carrier molecule for stem cell culture; replaces serum albumin for ex vivo stem cell expansion

Cereblon Targeting Ligands Plus Linkers

Cat. No. Product Name / Activity Date Added
6946 Thalidomide 4'-oxyacetamide-alkylC8-amine Nov 2019
Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Class II HDACs

Cat. No. Product Name / Activity Date Added
7051 Tasquinimod Jan 2020
High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic
6725 CHDI 00390576 Dec 2019
Potent and selective class IIa HDAC inhibitor; brain penetrant

Click-Reactive Janelia Fluor® Dyes

Cat. No. Product Name / Activity Date Added
7088 Janelia Fluor® 646, Azide Feb 2020
Red dye (Reactive group: azide). Applications: super resolution microscopy e.g. dSTORM & STED, confocal, and live cell imaging

Complement

Cat. No. Product Name / Activity Date Added
6860 SB 290157 trifluoroacetate Dec 2019
Potent C3a receptor antagonist

Tocriscreen Compound Libraries

Cat. No. Product Name / Activity Date Added
7152 Tocriscreen 2.0 Micro Jan 2020
A library of 1280 biologically active compounds (15 μL 10 mM DMSO solutions)
7151 Tocriscreen 2.0 Mini Jan 2020
A library of 1280 biologically active compounds (50 μL 10 mM DMSO solutions)
7150 Tocriscreen 2.0 Max Jan 2020
A library of 1280 biologically active compounds (250 μL 10 mM DMSO solutions)

Cyclin-Dependent Protein Kinases

Cat. No. Product Name / Activity Date Added
7050 Ribociclib Dec 2019
Dual cdk4/cdk6 inhibitor; orally bioavailable

Cytokines

Cat. No. Product Name / Activity Date Added
7066 RCGD 423 Nov 2019
gp130 modulator; activates JAK/STAT signaling

TAG Degradation Platform

Cat. No. Product Name / Activity Date Added
6971 aTAG 4531 Nov 2019
Degrader of MTH1 fusion proteins for use within the aTAG system
6912 dTAG-7 Dec 2019
First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

STING-Dependent Signaling

Cat. No. Product Name / Activity Date Added
7040 C 176 Feb 2020
mSTING antagonist

RNA/DNA Polymerase

Cat. No. Product Name / Activity Date Added
6974 BMS 986094 Oct 2019
Prodrug of HCV RNA polymerase inhibitor 2'-C-methyl guanosine triphosphate; potent HCV replication inhibitor
7090 Digoxigenin-11-dUTP Mar 2020
Hapten modified dUTP for ISH

DNA, RNA and Protein Synthesis

Cat. No. Product Name / Activity Date Added
6586 Targapremir 210 Dec 2019
Inhibits formation of miR-210

Fluorescent DNA Stains

Cat. No. Product Name / Activity Date Added
7121 7-Aminoactinomycin D Feb 2020
Fluorescent DNA stain

DREADD Ligands

Cat. No. Product Name / Activity Date Added
7119 Sorbic acid Nov 2019
Activator of hFFA2-DREADDs

Dynamin

Cat. No. Product Name / Activity Date Added
6799 MB 0223 Dec 2019
Dynamin-related GTPase DRP1 partial inhibitor
6897 P110 Oct 2019
Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable

Viral Transduction Enhancers

Cat. No. Product Name / Activity Date Added
6982 Cyclosporin H Oct 2019
Enhances lentiviral transduction

Other Transcription Factors

Cat. No. Product Name / Activity Date Added
4265 AS 1842856 Nov 2019
Potent and selective Foxo1 inhibitor; orally bioavailable

Other Hydrolases

Cat. No. Product Name / Activity Date Added
7007 PDD 00017238 Dec 2019
High affinity and potent PARG inhibitor
6691 LP 922056 Oct 2019
Notum inhibitor; activates Wnt signaling
7009 PDD 00031705 Dec 2019
Negative control for PDD 00017238 (Cat. No. 7007).

IAP Targeting Ligands Plus Linkers

Cat. No. Product Name / Activity Date Added
6474 A 410099.1 amide-alkylC4-amine Nov 2019
A 410099.1 amide-alkylC4-amine
6472 A 410099.1 amide-PEG3-amine Nov 2019
A 410099.1 amide-PEG3-amine
6473 A 410099.1 amide-PEG2-amine Nov 2019
A 410099.1 amide-PEG2-amine

Inflammasomes

Cat. No. Product Name / Activity Date Added
6925 NBC 6 Jan 2020
NLRP3 inflammasome inhibitor

JAK Kinase

Cat. No. Product Name / Activity Date Added
7064 Ruxolitinib Feb 2020
Potent and selective JAK1/JAK2 inhibitor; orally bioavailable
7048 Ruxolitinib phosphate Feb 2020
Phosphate salt of Ruxolitinib (Cat. No. 7064); potent and selective JAK1/JAK2 inhibitor

Kainate Receptors

Cat. No. Product Name / Activity Date Added
7065 Kainic acid (synthetic) Oct 2019
Kainate agonist; excitant and neurotoxin

Rho-Kinases

Cat. No. Product Name / Activity Date Added
7163 Chroman 1 Mar 2020
Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogeneisis

Src Kinases

Cat. No. Product Name / Activity Date Added
6981 TL 0259 Dec 2019
Selective and highly potent Fgr and Lyn kinase inhibitor; orally bioavailable

VHL Targeting Ligands Plus Linkers

Cat. No. Product Name / Activity Date Added
7074 VH 032 amide-alkylC7-amine Mar 2020
VHL ligand with alkyl linker and terminal amine for onward chemistry
6985 VH 032 amide-alkylC5-amine Jan 2020
VHL ligand with alkyl linker and terminal amine for onward chemistry

Photoswitchable Ligands

Cat. No. Product Name / Activity Date Added
7013 OptoBI-1 Nov 2019
Photoswitchable TRPC3/6/7 agonist

Toll-like Receptors

Cat. No. Product Name / Activity Date Added
6858 MMG 11 Jan 2020
TLR2 antagonist

δ Opioid Receptors

Cat. No. Product Name / Activity Date Added
6729 TAN 452 Dec 2019
Potent and selective peripherally acting δ opioid antagonist; antianalgesic.

Other Reductases

Cat. No. Product Name / Activity Date Added
7162 iFSP1 Feb 2020
Ferroptosis suppressor protein 1 (FSP1) inhibitor; ferroptosis inducer

Other Transferases

Cat. No. Product Name / Activity Date Added
6775 ST 045849 Dec 2019
O-GlcNAc transferase (OGT) inhibitor
6900 NNMTi Dec 2019
Nicotinamide N-methyltransferase (NNMT) inhibitor; promotes myoblast differentiation

Other Synthases/Synthetases

Cat. No. Product Name / Activity Date Added
6791 BC-LI-0186 Feb 2020
Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor

Other RTKs

Cat. No. Product Name / Activity Date Added
5860 7rh Dec 2019
Potent and selective DDR1 inhibitor; orally bioavailable

PDGFR

Cat. No. Product Name / Activity Date Added
6976 JNJ 10198409 Mar 2020
Potent PDGFRα and PDGFRβ inhbitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases

TGF-β Receptors

Cat. No. Product Name / Activity Date Added
6870 AZ 12799734 Nov 2019
Potent TGF-βRI inhibitor

STATs

Cat. No. Product Name / Activity Date Added
6110 HJC 0416 hydrochloride Feb 2020
STAT3 inhibitor

TRPC

Cat. No. Product Name / Activity Date Added
6940 BTD Oct 2019
Selective TRPC5 activator
6875 TRPC6-PAM-C20 Dec 2019
Selective TRPC6 positive allosteric modulator

VEGFR

Cat. No. Product Name / Activity Date Added
7049 Nintedanib Dec 2019
Potent VEGFR, PDGFR and FGFR inhibitor