New Products

View all New Products by pharmacological action

Search for new products by date added, alphabetically, or by pharmacological action.

New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

5-HT1A Receptors

Cat No Product Name / Activity Date Added
6202 Vilazodone hydrochloride Apr 2017
Potent 5-HT1A partial agonist and SSRI; antidepressant

5-HT2A Receptors

Cat No Product Name / Activity Date Added
6336 Trazodone hydrochloride Sep 2017
5-HT2A and α1 adrenoceptor antagonist; also enhances neural differentiation; antidepressant and neuroprotectant

Ack1

Cat No Product Name / Activity Date Added
6061 XMD 8-87 May 2017
Potent Ack1/TNK2 inhibitor

Actin

Cat No Product Name / Activity Date Added
3974 Latrunculin B May 2017
Inhibitor of actin polymerization

ADAMs

Cat No Product Name / Activity Date Added
5523 TAPI 0 Sep 2017
ADAM-17 (TACE) and MMP inhibitor
6013 TAPI 2 Sep 2017
ADAM-17 (TACE) and MMP inhibitor
6162 TAPI 1 Sep 2017
ADAM-17 (TACE) and MMP inhibitor

Adenylyl Cyclases

Cat No Product Name / Activity Date Added
6271 ST 034307 May 2017
Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

Adrenergic β2 Receptors

Cat No Product Name / Activity Date Added
6219 Arformoterol tartrate Apr 2017
Long-acting β2 agonist (LABA)

AMPA Receptors

Cat No Product Name / Activity Date Added
6278 JNJ 55511118 Aug 2017
Selective, high affinity negative modulator of AMPA receptors containing TARP-γ8

Androgen Receptors

Cat No Product Name / Activity Date Added
6161 Ailanthone Apr 2017
Potent inhibitor of androgen receptor (AR)

Antivirals

Cat No Product Name / Activity Date Added
5741 25-Hydroxycholesterol Apr 2017
Antiviral; also α-crystallin (cryAB) chaperone
6045 NITD 008 Jul 2017
Antiviral; selective flavivirus inhibitor
6183 Nanchangmycin May 2017
Antiviral; active against Zika, West Nile and dengue viruses

Apelin Receptors

Cat No Product Name / Activity Date Added
6293 ELA-14 (human) Jun 2017
Potent apelin (APJ) receptor agonist
6294 ELA-14 negative control Jun 2017
Negative control for ELA-14 (Cat.No.6293).
6292 ELARR>GG Jul 2017
Negative control for ELA-32 (Cat.No.6291).
6291 ELA-32 (human) Jul 2017
Potent, high affinity apelin receptor agonist; stimulates angiogenesis

Biochemicals and Molecular Biology

Cat No Product Name / Activity Date Added
6253 F 127 (20% solution in DMSO) Apr 2017
Nonionic detergent
6175 DBHDA Apr 2017
Reagent for synthetic biology; converts cysteine to dehydroalanine

BMP and Other Activin Receptors

Cat No Product Name / Activity Date Added
6152 LDN 214117 Apr 2017
Potent and selective ALK2 inhibitor
6151 LDN 212854 Apr 2017
Potent bone morphogenetic protein type I (ALK) inhibitor

Bradykinin Receptors

Cat No Product Name / Activity Date Added
6190 Retrobradykinin Apr 2017
Reverse analog of Bradykinin

Bromodomains

Cat No Product Name / Activity Date Added
6105 TC AC 28 Mar 2017
High affinity BET bromodomain ligand
6181 OTX 015 May 2017
BET bromodomain inhibitor; orally bioavailable

Buffers, Solvents and Solutions

Cat No Product Name / Activity Date Added
5888 MOPSO, free acid May 2017
Buffer; working pH range in aqueous solution: 6.2-7.6

Caged Amino Acid Compounds

Cat No Product Name / Activity Date Added
6121 NB-caged Tyrosine hydrochloride May 2017
ortho-nitrobenzyl caged L- tyrosine

Calcium-Sensing Receptor

Cat No Product Name / Activity Date Added
6165 AC 265347 Jul 2017
CaSR biased allosteric modulator

Casein Kinase 1

Cat No Product Name / Activity Date Added
6346 PF 5006739 Sep 2017
Potent CK1δ/ε inhibitor

CB1 Receptors

Cat No Product Name / Activity Date Added
6193 AM 4113 Aug 2017
Selective, high affinity CB1 antagonist

CB2 Receptors

Cat No Product Name / Activity Date Added
5826 LEI 101 hydrochloride May 2017
Potent and selective CB2 partial agonist; orally biovailable

Cdc2-like Kinases

Cat No Product Name / Activity Date Added
5700 ML 315 hydrochloride Apr 2017
Inhibitor of Clk and DYRK kinases

Cyclin-Dependent Protein Kinases

Cat No Product Name / Activity Date Added
6174 CVT 313 Jun 2017
cdk2 inhibitor

Cytokine Receptors

Cat No Product Name / Activity Date Added
5372 Bioymifi May 2017
DR5 (TRAIL receptor) agonist; induces apoptosis

Death-Associated Protein Kinase

Cat No Product Name / Activity Date Added
5768 HS 38 Jul 2017
ATP-competitive inhibitor of DAPK and ZIPK

Diacylglycerol O-Acyltransferase

Cat No Product Name / Activity Date Added
5863 PF 04620110 Sep 2017
Potent and selective DGAT-1 inhibitor; orally bioavailable

Dihydrofolate Reductase

Cat No Product Name / Activity Date Added
6185 Pemetrexed Jun 2017
High affinity dihydrofolate reductase inhibitor; also inhibits thymidylate synthase, GARFT and AICART

DNA, RNA and Protein Synthesis

Cat No Product Name / Activity Date Added
6168 RI 1 Apr 2017
RAD51 recombinase inhibitor

EGFR

Cat No Product Name / Activity Date Added
6231 Dacomitinib Jul 2017
Potent irreversible pan ErbB inhibitor

Enzyme Substrates / Activators

Cat No Product Name / Activity Date Added
6216 H3K4(Me3) (1-20) Apr 2017
Histone H3 peptide; substrate for methyltransferase/demethylase enzymes
6214 H3K4(Me) (1-20) Apr 2017
Histone H3 peptide; substrate for methyltransferase/demethylase enzymes
6212 H3K27(Me2) (15-34) Apr 2017
Histone H3 peptide; substrate for methyltransferase/demethylase enzymes
6217 Histone H3 (1-34) Apr 2017
Histone H3 peptide
6213 H3K27(Me3) (15-34) Apr 2017
Histone H3 peptide; substrate for methyltransferase/demethylase enzymes
6211 H3K27(Me) (15-34) Apr 2017
Histone H3 peptide; substrate for demethylase/methyltransferase enzymes

Estrogen (GPER) Receptors

Cat No Product Name / Activity Date Added
6116 BHPI Aug 2017
ERα antagonist; also activates unfolded protein response; active in vivo

Estrogen and Related Receptors

Cat No Product Name / Activity Date Added
6342 Tamoxifen Sep 2017
Estrogen receptor partial agonist/antagonist
6158 (S)-Equol May 2017
Potent estrogen receptor β (ERβ) agonist; dihydrotestosterone antagonist

Fluorescent Dyes

Cat No Product Name / Activity Date Added
5437 Cyanine 7, SE Mar 2017
Near-infrared fluorescent dye for labeling of amines
5435 Cyanine 3, SE Mar 2017
Orange fluorescent dye for labeling of amines
6149 PA Janelia Fluor® 549, SE Apr 2017
Photoactivatable cell permeable fluorescent dye; supplied as NHS ester
6150 PA Janelia Fluor® 646, SE Apr 2017
Photoactivatable cell permeable fluorescent dye; supplied as NHS ester

GABAA Receptors

Cat No Product Name / Activity Date Added
6192 PZ-II-029 Sep 2017
α6β3γ2-selective GABAA channel modulator

Gap Channels

Cat No Product Name / Activity Date Added
6227 TAT-Gap19 Apr 2017
Cx43 hemichannel blocker

General Calcium Signaling Agents

Cat No Product Name / Activity Date Added
5976 Ned K Apr 2017
NAADP signaling inhibitor

Ghrelin Receptors

Cat No Product Name / Activity Date Added
6347 PF 04628935 Sep 2017
Potent ghrelin receptor inverse agonist

Glucose Transporters

Cat No Product Name / Activity Date Added
6100 Fasentin May 2017
GLUT1/GLUT4 inhibitor; also Fas-sensitizer
6143 WZB 117 Aug 2017
GLUT inhibitor

GPR171

Cat No Product Name / Activity Date Added
6306 BigLEN (rat) Jul 2017
Potent GPR171 agonist
6304 BigLEN (mouse) Jul 2017
GPR171 agonist
6299 MS 15203 Aug 2017
Potent and selective GPR171 partial agonist

Heme Oxygenase

Cat No Product Name / Activity Date Added
6119 OB 24 hydrochloride Aug 2017
Potent and selective heme oxygenase 1 (HO-1) inhibitor

Hexokinases

Cat No Product Name / Activity Date Added
6049 PF 04937319 Aug 2017
Glucokinase partial activator
6345 PF 04991532 Sep 2017
Potent hepatoselective glucokinase activator

Histone Acetyltransferases

Cat No Product Name / Activity Date Added
5103 Lys-CoA Jun 2017
Selective p300 inhibitor

Histone Deacetylases

Cat No Product Name / Activity Date Added
6284 BRD 73954 Jun 2017
Dual histone deacetylase (HDAC) 6/8 inhibitor
6270 Tubastatin A hydrochloride Jun 2017
Potent HDAC6 inhibitor
6208 MS 275 Jun 2017
HDAC (Class I) inhibitor

Histone Peptides

Cat No Product Name / Activity Date Added
6215 H3K4(Me2) (1-20) May 2017
Histone H3 peptide

Integrins

Cat No Product Name / Activity Date Added
6048 R-BC154 Aug 2017
High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs

IRE1

Cat No Product Name / Activity Date Added
6009 B I09 Apr 2017
IRE1 endonuclease inhibitor; cell permeable

ITK

Cat No Product Name / Activity Date Added
5401 GSK 2250665A Aug 2017
Itk inhibitor

JAK Kinase

Cat No Product Name / Activity Date Added
5818 NVP BSK 805 Aug 2017
Potent JAK2 inhibitor; orally bioavailable

JNK/c-Jun

Cat No Product Name / Activity Date Added
6258 CC 401 dihydrochloride May 2017
High affinity JNK inhibitor; also inhibits HCMV replication

LRRK2

Cat No Product Name / Activity Date Added
6289 JH-II-127 Aug 2017
Potent and selective LRRK2 inhibitor

Lysine Methyltransferases

Cat No Product Name / Activity Date Added
4930 UNC 2399 Jun 2017
Biotinylated UNC 1999 (Cat.No. 4904)
6282 BRD 4770 Jun 2017
G9a inhibitor and S-adenosyl methionine mimetic; cell permeable
6167 A 196 Jul 2017
Potent and selective SUV420H1/H2 inhibitor
6128 GSK 343 Jun 2017
Potent and selective SAM-competitive EZH2 inhibitor

Monoacylglycerol Lipase

Cat No Product Name / Activity Date Added
5956 NF 1819 Aug 2017
Potent and selective irreversible MAGL inhibitor; membrane permeable and brain penetrant

Monocarboxylate Transporters

Cat No Product Name / Activity Date Added
5658 AR-C 141990 hydrochloride Jul 2017
MCT1 inhibitor

mTOR

Cat No Product Name / Activity Date Added
6188 Everolimus Apr 2017
mTOR inhibitor;immunosuppressant

Na+/Ca2+ Exchanger

Cat No Product Name / Activity Date Added
6164 SEA 0400 Apr 2017
Potent Na+/Ca2+ exchanger (NCX) inhibitor.

Nek2 Kinase

Cat No Product Name / Activity Date Added
5150 NCL 00017509 May 2017
Potent and reversible NIMA related kinase 2 (Nek2) inhibitor
4322 JH 295 May 2017
Irreversible Nek2 inhibitor

Nicotinic (α4β2) Receptors

Cat No Product Name / Activity Date Added
5963 CMPI hydrochloride May 2017
Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs

Non-selective CCK

Cat No Product Name / Activity Date Added
6264 Caerulein Mar 2017
CCK agonist

NPY Receptors

Cat No Product Name / Activity Date Added
6288 Peptide YY (3-36) human Jun 2017
NPY Y2 receptor agonist

NTPDase

Cat No Product Name / Activity Date Added
6083 PSB 12379 Aug 2017
Ecto-5'-nucleotidase (CD73) inhibitor

Orphan 7-TM Receptors

Cat No Product Name / Activity Date Added
6277 7α,25-Dihydroxycholesterol Jun 2017
Highly potent GPR183 (EBI2) agonist
6309 PEN (rat) Sep 2017
GPR83 agonist
6308 PEN (mouse) Sep 2017
GPR83 agonist
6307 PEN (human) Sep 2017
GPR83 agonist

Other Dehydrogenases

Cat No Product Name / Activity Date Added
6084 ASP 9521 Sep 2017
Potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor;orally bioavailable
6196 Brequinar sodium Aug 2017
Potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor

Other Hydrolases

Cat No Product Name / Activity Date Added
5865 KLH 45 Mar 2017
Potent DDHD2 inhibitor
6098 Lalistat 1 Aug 2017
Potent and selective lysosomal acid lipase (LAL) inhibitor

Other Kinases

Cat No Product Name / Activity Date Added
6036 STK16-IN-1 May 2017
Serine/threonine protein kinase 16 (STK16) inhibitor; also inhibits PI 3Kδ, PI 3Kγ and mTOR kinases.

Other Nuclear Receptors

Cat No Product Name / Activity Date Added
5821 C-DIM 12 May 2017
Nurr1 activator; inhibits NF-κB-dependent gene expression

Other Proteases

Cat No Product Name / Activity Date Added
6194 TM 5441 Jun 2017
Plasminogen activator inhibitor-1 (PAI-1) inhibitor

Other Reductases

Cat No Product Name / Activity Date Added
5842 MK 386 May 2017
Potent, selective human type 1 5α-reductase inhibitor

P21-activated Kinases

Cat No Product Name / Activity Date Added
6051 G 5555 Sep 2017
Selective high affinity group 1 PAK inhibitor

p97 ATPase

Cat No Product Name / Activity Date Added
6180 NMS 873 Apr 2017
Potent and selective p97 ATPase (VCP) allosteric inhibitor

Parathyroid Hormone Receptors

Cat No Product Name / Activity Date Added
6303 Parathyroid hormone (1-34) (bovine) Jun 2017
Parathyroid hormone (PTH) receptor agonist.
6301 Parathyroid hormone (1-34) (rat) Jun 2017
Parathyroid hormone (PTH) receptor agonist

PFKFB3

Cat No Product Name / Activity Date Added
5675 AZ PFKFB3 26 May 2017
Potent and selective PFKFB3 inhibitor

Phosphodiesterases

Cat No Product Name / Activity Date Added
6311 Tadalafil May 2017
Potent and highly selective PDE5 inhibitor; orally bioavailable

Poly(ADP-ribose) Polymerase

Cat No Product Name / Activity Date Added
6060 AZD 2461 May 2017
Potent PARP inhibitor; orally bioavailable
6230 Rucaparib camsylate Aug 2017
PARP inhibitor

Progesterone Receptors

Cat No Product Name / Activity Date Added
6285 Megestrol Acetate May 2017
Synthetic progesterone analog

Prostanoid Receptors

Cat No Product Name / Activity Date Added
5924 ER 819762 Sep 2017
Potent EP4 receptor antagonist; orally bioavailable
6240 DG 041 Aug 2017
Potent and selective EP3 antagonist; antiplatelet and antithrombotic

Protein Kinase A

Cat No Product Name / Activity Date Added
6286 st-Ht31 Jul 2017
Inhibits PKA/AKAP interactions; cell permeable
6221 PKI (5-24) Mar 2017
High affinity PKA inhibitor
6287 st-Ht31 P Jul 2017
Negative control for st-Ht31 (Cat. No. 6286)

Protein Kinase C

Cat No Product Name / Activity Date Added
5343 TPPB May 2017
High affinity PKC activator; also APP modulator

Protein Prenyltransferases

Cat No Product Name / Activity Date Added
6265 Lonafarnib Jul 2017
Potent farnesyl transferase inhibitor

Purinergic (P2Y) Receptors

Cat No Product Name / Activity Date Added
6078 BPTU Jul 2017
P2Y1 allosteric antagonist
6317 Prasugrel Jul 2017
Irreversible P2Y12 antagonist; antiplatelet and orally active

RAGE

Cat No Product Name / Activity Date Added
6237 FPS ZM1 Aug 2017
High affinity antagonist of RAGE
6259 RAGE antagonist peptide May 2017
RAGE antagonist

Retinoic Acid-related Orphan Receptors

Cat No Product Name / Activity Date Added
5987 (±)-ML 209 Apr 2017
RORγt inverse agonist; suppresses Th17 cell differentiation

Rev-Erb Receptors

Cat No Product Name / Activity Date Added
6038 SR 10067 Aug 2017
Selective Rev-Erbα/β agonist; anxiolytic

RNA/DNA Polymerase

Cat No Product Name / Activity Date Added
6234 Entecavir Apr 2017
Potent and selective hepatitis B virus inhibitor

Sphingosine Kinase

Cat No Product Name / Activity Date Added
5452 SKI 178 May 2017
Non-lipid sphingosine kinase 1 (SphK1) inhibitor

Src Kinases

Cat No Product Name / Activity Date Added
6073 P21d hydrochloride Jun 2017
Potent and selective Brk inhibitor

STATs

Cat No Product Name / Activity Date Added
6218 Galiellalactone Apr 2017
STAT3 inhibitor; active in vivo

Syk Kinase

Cat No Product Name / Activity Date Added
6012 OXSI 2 May 2017
Potent Syk kinase inhibitor; also inhibits assembly of NLRP3 inflammasomes

TGF-β Receptors

Cat No Product Name / Activity Date Added
6016 IN 1130 Jul 2017
Potent and selective inhibitor of TGF-βRI

Thioredoxin Reductases

Cat No Product Name / Activity Date Added
5921 D9 May 2017
Potent thioredoxin reductase (TrxR) inhibitor
6189 Myricetin Jun 2017
Irreversible TrxR inhibitor

Tocriscreen Toolboxes

Cat No Product Name / Activity Date Added
5933 Tocriscreen Kinase Inhibitor Toolbox I Apr 2017
A library of 80 kinase inhibitor compounds (250 μL 10 mM DMSO solutions)
6268 Tocriscreen Kinase Inhibitor Toolbox I & II Apr 2017
A library of 160 kinase inhibitor compounds (250 μL 10 mM DMSO solutions)
6225 Tocriscreen Kinase Inhibitor Toolbox II Apr 2017
A library of 80 kinase inhibitor compounds (250 μL 10 mM DMSO solutions)

Toll-like Receptors

Cat No Product Name / Activity Date Added
5705 M62812 Aug 2017
TLR-4 inhibitor
6142 CL 075 Sep 2017
TLR8 agonist
6191 TH 1020 Jul 2017
Toll-like receptor (TLR) 5/Flagellin complex antagonist

Ubiquitin E3 Ligases

Cat No Product Name / Activity Date Added
6075 Nutlin 3a Sep 2017
MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
6157 cis VH 298 Apr 2017
Negative control for VH 298
6302 Pomalidomide Jun 2017
Cereblon ubiquitination inhibitor; also TNF-α inhibitor and antiangiogenic
6156 VH 298 Apr 2017
High-affinity inhibitor of VHL
6155 cis MZ 1 Apr 2017
Negative Control for MZ1
6154 MZ 1 Apr 2017
(+)-JQ1 based PROTAC that selectively degrades BRD4 in cells
6327 dBET1 Aug 2017
(+)-JQ1 based PROTAC that selectively degrades BRD4 in cells
6305 Lenalidomide Jun 2017
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

Vasopressin Receptors

Cat No Product Name / Activity Date Added
5729 TASP 0390325 Apr 2017
Potent and selective V1B receptor antagonist; orally bioavailable