Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.
Inward Rectifier Potassium (Kir) Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
|---|---|---|
| 6877 | VU 0134992 | Jul 2019 |
| Kir4.1 blocker | ||
| 6889 | ML 418 | Sep 2019 |
| Kir 7.1 inhibitor; also inhibits Kir 6.2 | ||
Melanocortin (MC) Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6926 | Fenoprofen calcium | May 2019 |
| Positive allosteric modulator of MC3 receptors; exhibits biased signaling | ||
Glutamate (Metabotropic) Group I Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6859 | FITM | Aug 2019 |
| Potent and selective negative allosteric modulator of mGlu1 receptors | ||
Glutamate (Metabotropic) Group III Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6893 | VU 6005649 | Sep 2019 |
| Positive allosteric modulators of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant | ||
Purinergic (P2X) Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6493 | A 317491 sodium salt | May 2019 |
| Selective, high affinity P2X3 and P2X2/3 receptor antagonist; antinociceptive | ||
Purinergic (P2Y) Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6864 | Ticagrelor | Apr 2019 |
| High affinity and reversible P2Y12 antagonist; displays inverse agonism in vitro; also inhibits ENT1 | ||
Akt (Protein Kinase B) | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6762 | Urolithin A | Apr 2019 |
| PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro | ||
| 6978 | AZD 5363 | Aug 2019 |
| Potent pan-AKT inhibitor | ||
Somatostatin (sst) Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6201 | J 2156 | Aug 2019 |
| Selective high affinity human sst4 agonist | ||
CaV3.x Channels (T-type) | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6770 | ABT 639 | Mar 2019 |
| CaV3.2 and CaV3.1 channel blocker; orally bioavailable | ||
Nicotinic (α7) Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6764 | B 973B | Sep 2019 |
| Positive allosteric modulator of α7 nAChRs; analgesic | ||
CB1 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6763 | AVE 1625 | Apr 2019 |
| Potent and selective CB1 receptor antagonist | ||
Sphingosine-1-Phosphate Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6690 | Ceralifimod | May 2019 |
| Highly potent and selective S1P1 and S1P5 agonist | ||
CRF1 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6451 | Pexacerfont | Apr 2019 |
| Potent and selective CRF1 antagonist; anxiolytic | ||
M1 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6872 | BQCA | May 2019 |
| Positive allosteric modulator of M1 receptors | ||
Glucagon-Like Peptide 1 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6355 | VU 0650991 | Apr 2019 |
| Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant | ||
Bcl-2 Family | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6835 | ABT 737 | May 2019 |
| Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines | ||
σ2 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6740 | Siramesine hydrochloride | Apr 2019 |
| High affinity σ agonist (σ2 > σ1) | ||
Bcl-2 Family | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6960 | ABT 199 | Jul 2019 |
| Selective, high affinity Bcl-2 inhibitor; orally bioavailable | ||
Adenosine A2B Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6787 | KI-7 | Mar 2019 |
| Positive allosteric modulator of A2B receptors | ||
CB2 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6832 | Ec2la | May 2019 |
| Positive allosteric modulator of CB2 receptors; active in vivo | ||
EZH2 | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6790 | GSK 126 | Jul 2019 |
| Very high affinity and selective EZH2 inhibitor | ||
| 6708 | SAH-EZH2 | May 2019 |
| EZH2/EDD interaction inhibitor; suppresses PCR2 complex function | ||
P21-activated Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6490 | GNE 2861 | Mar 2019 |
| Group II PAK inhibitor; potently inhibits PAK4 and PAK 6 | ||
Ubiquitin E3 Ligases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6782 | Indisulam | May 2019 |
| Molecular glue; pre-mRNA splicing modulator | ||
Functionalized E3 Ligase Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6969 | cis VH 032, amine dihydrochloride | Jul 2019 |
| Negative control for VH 032, amine (Cat. No. 6462) | ||
PI 3-kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6792 | Omipalisib | May 2019 |
| Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK | ||
Histamine H3 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6778 | S 38093 | May 2019 |
| Selective H3 antagonist and inverse agonist; also σ1 receptor antagonist; antinociceptive | ||
Ubiquitin E3 Ligases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6904 | Idasanutlin | Jul 2019 |
| Potent MDM2 inhibitor; inhibits MDM2-p53 interaction | ||
5-HT6 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6748 | PRX 07034 | Apr 2019 |
| Potent and selective 5-HT6 antagonist | ||
Orphan 7-TM Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6784 | FTBMT | Mar 2019 |
| Potent and selective GPR52 agonist; orally bioavailable and BBB permeable | ||
Active Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6948 | CRBN-6-5-5-VHL | Jun 2019 |
| Potent and selective cereblon degrader; cell-permeable | ||
| 6747 | TL 13-22 | Apr 2019 |
| Negative control for TL 13-12 | ||
| 6744 | TL 13-12 | Apr 2019 |
| Selective ALK degrader | ||
| 6746 | TL 13-110 | Apr 2019 |
| Negative control for TL 13-112 | ||
| 6713 | ZXH 3-26 | Jun 2019 |
| Potent and selective BRD4 degrader | ||
| 6745 | TL 13-112 | Apr 2019 |
| Selective ALK Degrader | ||
| 6938 | BSJ-03-204 | Aug 2019 |
| Selective Cdk4/6 degrader | ||
| 6921 | BSJ-03-123 | Aug 2019 |
| Selective Cdk6 degrader | ||
| 6922 | BSJ-Bump | Aug 2019 |
| Negative control for BSJ-03-123 | ||
| 6937 | BSJ-04-132 | Sep 2019 |
| Selective Cdk4 degrader | ||
Protease-Activated Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6806 | AZ 3451 | Apr 2019 |
| Potent negative allosteric modulator of PAR2 receptors | ||
BMP and Other Activin Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6881 | SB 4 | May 2019 |
| Potent BMP4 agonist | ||
Cell Adhesion Molecules | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6634 | Surfen | Apr 2019 |
| Heparin sulfate antagonist | ||
Focal Adhesion Kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6891 | PND 1186 | May 2019 |
| Potent FAK inhibitor; orally bioavailable | ||
Poly(ADP-ribose) Polymerase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6703 | BGP 15 | Jul 2019 |
| PARP inhibitor; cytoprotectant | ||
| 6228 | H10 | Jul 2019 |
| PARP14 inhibitor; cell-permeable | ||
Aldehyde Dehydrogenases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6934 | 673 A | Jun 2019 |
| ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC) | ||
| 6933 | CM 10 | Jul 2019 |
| ALDH1A inhibitor; depletes CD133+ cancer stem cells | ||
ALK | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6905 | Ceritinib | Jun 2019 |
| Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3 | ||
Antimalarials | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6818 | Artemether | Mar 2019 |
| Antimalarial; also inhibits neuroinflammation | ||
Antivirals | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6994 | HODHBt | Aug 2019 |
| STAT5-SUMO protein-protein interaction inhibitor | ||
Biochemicals and Molecular Biology | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6930 | Amphotericin B | Aug 2019 |
| Forms monovalent ion channels in lipid bilyers; antifungal | ||
Bromodomains | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6521 | I-BET 762 | Jun 2019 |
| Potent and high affinity BRD inhibitor; anti-inflammatory; orally bioavailable. | ||
Bruton's Tyrosine Kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6813 | Ibrutinib | Apr 2019 |
| Potent and selective BTK inhibitor | ||
Caged Nicotinic Compounds | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6706 | DPNB-ABT 594 | Mar 2019 |
| Caged ABT 594; suitable for one- or two-photon photolysis | ||
Cancer Stem Cells | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6840 | AD 01 | May 2019 |
| FKBPL (FK506-binding protein like)-based peptide; inhibits breast cancer stem cell self-renewal; also antiangiogenic | ||
| 6856 | α-Mangostin | Apr 2019 |
| Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines | ||
Stem Cell Proliferation | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6797 | KLD 12 | Sep 2019 |
| Self-assembling peptide; forms hydrogel to support cell growth | ||
Cereblon Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6716 | Pomalidomide - linker 4 | Jun 2019 |
| Pomalidomide-alkylC5-amine | ||
| 6966 | Thalidomide - linker 13 | Jun 2019 |
| Thalidomide-PEG1-ethylamine | ||
| 6951 | Thalidomide - linker 12 | May 2019 |
| Thalidomide-PEG5-ethylamine | ||
| 6950 | Thalidomide - linker 11 | Sep 2019 |
| Thalidomide-PEG3-ethylamine | ||
| 6968 | Thalidomide - linker 15 | Jun 2019 |
| Thalidomide-alkylC6-amine | ||
| 6967 | Thalidomide - linker 14 | Jun 2019 |
| Thalidomide-PEG2-ethylamine | ||
| 6963 | Pomalidomide - linker 8 | Jun 2019 |
| Pomalidomide-PEG4-ethylamine | ||
| 6949 | Thalidomide - linker 10 | May 2019 |
| Thalidomide-alkylC2-amine | ||
| 6917 | Thalidomide - linker 9 | Jun 2019 |
| Thalidomide-alkylC4-amine | ||
Two-P Potassium Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6887 | ML 335 | Jun 2019 |
| Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator | ||
| 6886 | ML 67-33 | Jul 2019 |
| K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator | ||
| 6888 | ML 402 | Sep 2019 |
| Selective TREK channel activator | ||
Gap Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6819 | Mefloquine hydrochloride | Mar 2019 |
| Cx36 and Cx50 gap channel blocker; also antimalarial and antischistosomal | ||
Two-P Potassium Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6972 | A 1899 | Sep 2019 |
| Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker | ||
Chemiluminescent Substrates | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6823 | CycLuc 1 | Jul 2019 |
| Synthetic luciferase substrate; brain penetrant; displays NIR emission | ||
Chemokine CXC Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6957 | Reparixin L-lysine salt | Jun 2019 |
| Potent CXCR1 and CXCR2 allosteric antagonist | ||
Other Chemokine Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6378 | JMS 17-2 hydrochloride | Apr 2019 |
| CX3CR1 antagonist | ||
Class I HDACs | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6728 | RGFP 966 | Mar 2019 |
| Potent and selective HDAC3 inhibitor | ||
Tocriscreen Compound Libraries | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6801 | Tocriscreen Epigenetics Library | Jul 2019 |
| A library of 101 epigenetic compounds (250 μL, 10 mM DMSO solutions) | ||
Cyclin-Dependent Protein Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6752 | LDC 000067 | Mar 2019 |
| Potent and selective CDK9 inhibitor | ||
Deaminases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6868 | 8-Azaadenosine | May 2019 |
| ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal | ||
TAG Degradation Platform | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6970 | aTAG 2139 | Sep 2019 |
| Degrader of MTH1 fusion proteins for use within the aTAG system | ||
Other Dehydrogenases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6054 | R162 | Aug 2019 |
| Glutamate dehydrogenase (GDH1) inhibitor | ||
Histone Demethylases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6935 | GSK J5 HCl | May 2019 |
| Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable | ||
Deubiquitinating Enzymes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6776 | G5 | Jul 2019 |
| Ubiquitin isopeptidase inhibitor; induces apoptosis | ||
DNA, RNA and Protein Synthesis | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6884 | TC SL C5 | Jul 2019 |
| Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor | ||
TFAX Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6619 | TFAX 488, SE | Aug 2019 |
| Green fluorescent dye; amine reactive | ||
Other Fluorescent Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6489 | Ocean Blue, SE | Jun 2019 |
| Blue fluorescent dye; supplied as NHS ester | ||
TFAX Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6623 | TFAX 546, SE | Aug 2019 |
| Yellow fluorescent dye; amine reactive | ||
Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6502 | Janelia Fluor® 549, Tetrazine | Apr 2019 |
| Cell permeable yellow fluorescent dye; supplied as a tetrazine for 'click' chemistry | ||
| 6500 | Janelia Fluor® 549, Maleimide | Jul 2019 |
| Cell permeable yellow fluorescent dye; supplied with a maleimide reactive group | ||
EGFR | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6811 | Lapatinib | Apr 2019 |
| Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor | ||
Other Transcription Factors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6845 | RCM 1 | May 2019 |
| FOXM1 inhibitor | ||
Fluorescent Substrates | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6717 | FFN 270 | May 2019 |
| Fluorescent substrate for NET and VMAT2 | ||
Other Fluorescent Probes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6434 | DFHO | Apr 2019 |
| Mimic of RFP fluorophore for imaging RNA in living cells | ||
Fluorescent Substrates | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6882 | DiFMUP | May 2019 |
| Fluorescent phosphatase substrate | ||
Glucagon Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6927 | Glucagon (Human, Porcine) | Aug 2019 |
| Endogenous glucagon receptor agonist | ||
Glycosylases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6749 | TH 5487 | Apr 2019 |
| Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor | ||
Ras GTPases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6906 | BAY 293 Negative Control | Sep 2019 |
| Negative control for BAY 293 (Cat. No. 6857) | ||
| 6857 | BAY 293 | Sep 2019 |
| Potent KRas/SOS1 interaction inhibitor | ||
Other Small Monomeric GTPases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6575 | StRIP16 | Apr 2019 |
| Rab8a GTPase-binding stapled peptide | ||
Ras GTPases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6429 | ML 210 | Mar 2019 |
| Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis | ||
| 6920 | SAH-SOS1A | Jul 2019 |
| KRas/SOS1 interaction inhibitor | ||
Rho GTPases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6701 | 1A-116 | Jul 2019 |
| Rac1 inhibitor; blocks Rac1-P-Rex1 interaction | ||
Other Hydrolases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6903 | DPTIP | Jul 2019 |
| Potent and selective N-SMase2 inhibitor; brain penetrant | ||
| 6757 | t-TUCB | Jul 2019 |
| Potent soluble epoxide hydrolase (sEH) Inhibitor; anti-inflammatory and antinociceptive. | ||
| 6510 | LNT 1 | Apr 2019 |
| Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response | ||
| 5862 | ARN 14686 | Apr 2019 |
| Potent N-acylethanolamine acid amidase inhibitor; NAAA activity-based protein profiling (ABPP) probe | ||
| 5861 | ARN 726 | Aug 2019 |
| Potent N-acylethanolamine acid amidase (NAAA) inhibitor; NAAA activity-based protein profiling (ABPP) probe | ||
Inflammasomes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6827 | Artesunate | Mar 2019 |
| Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial | ||
| 6902 | OLT 1177 | Jul 2019 |
| NLRP3 inflammasome inhibitor; disrupts inflammasome formation | ||
| 6924 | Oridonin | Jul 2019 |
| High affinity NLRP3 inflammasome inhibitor | ||
Integrins | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6785 | E 7820 | Apr 2019 |
| α2 integrin inhibitor; anti-angiogenic | ||
| 7020 | LDV | Sep 2019 |
| α4β1 (VLA-4) ligand | ||
| 6908 | TR 14035 | Jul 2019 |
| Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable | ||
Other Ion Pumps/Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 5026 | KYT 0353 | May 2019 |
| Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo | ||
Ketamine and Metabolites | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6751 | (R)-(-)-Ketamine hydrochloride | Jul 2019 |
| NMDA antagonist; antidepressant; may not display psychotomimetic or addictive side effects of (S)-ketamine | ||
Syk Kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6362 | GSK 143 | May 2019 |
| Syk inhibitor | ||
Raf Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6854 | LY 3009120 | Jun 2019 |
| Potent pan-Raf kinase inhibitor | ||
| 6814 | Sorafenib | Apr 2019 |
| Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT | ||
Other Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6246 | BF 738735 | Apr 2019 |
| Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor | ||
Kinesin | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6837 | GSK 923295A | May 2019 |
| Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor | ||
VHL Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6679 | VH 032 - linker 4 | Apr 2019 |
| VH 032-PEG3-CH2CH2COOH | ||
| 6853 | VH 032 - linker 8 | Apr 2019 |
| VH 032-alkylC6-amine | ||
| 6909 | VH 032 phenol - linker 1 | Jul 2019 |
| VH 032 phenol-alkylC4-amine | ||
| 6907 | VH 032 - linker 12 | Apr 2019 |
| VH 032-PEG2-amine | ||
| 6890 | VH 032 - linker 11 | Apr 2019 |
| VH 032-AlkylC8-Amine | ||
| 6880 | VH 032 - linker 10 | Apr 2019 |
| VH 032-alkylC10-amine | ||
| 6852 | VH 032 - linker 7 | Apr 2019 |
| VH 032-alkylC2-amine | ||
| 6910 | VH 032 phenol - linker 2 | Jul 2019 |
| VH 032 phenol-alkylC6-amine | ||
| 6879 | VH 032 - linker 9 | Apr 2019 |
| VH 032-PEG1-amine | ||
LIMK | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6899 | TH 257 | Sep 2019 |
| Potent and selective allosteric LIMK 1/2 inhibitor | ||
Other Lysine Methyltransferases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6665 | BI 9321 | May 2019 |
| Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain | ||
| 6803 | MRK 740 | Sep 2019 |
| Potent PRDM9 inhibitor | ||
| 6561 | BAY 6035 | Jun 2019 |
| Potent and selective SMYD3 inhibitor | ||
MEK | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6815 | Selumetinib | May 2019 |
| Potent and selective MEK inhibitor; orally bioavailable | ||
Monocarboxylate Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6817 | BAY 8002 | May 2019 |
| Potent dual MCT1/2 inhibitor; orally bioavailable | ||
Multidrug Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6885 | PU 23 | May 2019 |
| Multidrug resistance protein (MRP) 4 inhibitor | ||
NAMPT | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6753 | CHS 828 | Mar 2019 |
| NAMPT inhibitor; active in vivo and cytotoxic | ||
μ Opioid Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6109 | Methylnaltrexone bromide | Aug 2019 |
| μ antagonist; peripherally restricted | ||
Other Transferases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6765 | JTP 103237 | Aug 2019 |
| Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor | ||
Other Synthases/Synthetases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6954 | L-Buthionine sulfoximine | Jul 2019 |
| Irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; induces ferroptosis | ||
Other Oxygenases/Oxidases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6867 | Rhein | Apr 2019 |
| FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3 | ||
Oxidative Phosphorylation | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6898 | Mitochondrial fusion promoter M1 | May 2019 |
| Mitochondrial fusion promoter | ||
| 6980 | BAY 87-2243 | Sep 2019 |
| Mitochondrial complex I inhibitor | ||
Protein Tyrosine Phosphatases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6771 | PHPS1 sodium salt | May 2019 |
| Shp2 (PTPN11) inhibitor | ||
| 6829 | (R)-Shikonin | May 2019 |
| PTEN inhibitor; induces necroptosis; anti-inflammatory | ||
Phosphodiesterases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6313 | A 33 | May 2019 |
| Potent and selective PDE4B inhibitor | ||
Prion Protein | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6861 | Anle138b | May 2019 |
| Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation | ||
PSEMs | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6866 | uPSEM 817 tartrate | Mar 2019 |
| Highly potent and selective PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant | ||
| 6865 | uPSEM 792 hydrochloride | Apr 2019 |
| Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant | ||
Vasopressin Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6830 | Conivaptan hydrochloride | Mar 2019 |
| Very high affinity vasopressin V1A and V2 antagonist; orally bioavailable | ||
TGF-β Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6956 | Galunisertib | Jun 2019 |
| ALK4 and ALK5 (TGFβRI) inhibitor | ||
TRPC | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6766 | AC 1903 | Mar 2019 |
| Selective TRPC5 blocker | ||
| 6495 | AM 12 | May 2019 |
| TRPC5 inhibitor | ||
TRPM | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6874 | AMG 333 | Jul 2019 |
| Potent and selective TRPM8 antagonist; active in vivo | ||
TRPV | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6433 | GSK 1016790A | May 2019 |
| Potent TRPV4 agonist; active in vivo | ||
VEGFR | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6986 | EG 00229 trifluoroacetate | Jul 2019 |
| Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1 | ||