New Products

View all New Products by pharmacological action

Search for new products by date added, alphabetically, or by pharmacological action.

New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

Cyanine Dyes (Cy Dyes)

Cat. No. Product Name / Activity Date Added
7394 Cy5B-trisulfo, NHS Dec 2023
Restricted conformation cyanine dye with high quantum yield and long fluorescence lifetime for advanced microscopy applications

Non-selective / Other Potassium Channels

Cat. No. Product Name / Activity Date Added
7956 VU 0546110 Dec 2023
Selective SLO3 potassium channel inhibitor

FLT3

Cat. No. Product Name / Activity Date Added
7891 Gilteritinib Jan 2024
Potent FLT3 inhibitor; also potently inhibits AXL

Ubiquitin E3 Ligases

Cat. No. Product Name / Activity Date Added
7852 EM12-SO2F Nov 2023
Potent covalent inhibitor of Cereblon
7903 VL 285 Mar 2024
VHL inhibitor

Functionalized E3 Ligase Ligands

Cat. No. Product Name / Activity Date Added
8066 CST 530, Phenol Mar 2024
Functionalized IAP ligand for PROTACs®

Free Fatty Acid Receptors

Cat. No. Product Name / Activity Date Added
7890 CBMR 0083 Mar 2024
Potent allosteric FFA1 (GPR40) and 4 (GPR120) agonist

Adenylyl Cyclases

Cat. No. Product Name / Activity Date Added
8036 TDI 11861 Dec 2023
Soluble adenylyl cyclase inhibitor

Fluorescent Amyloid β Probes

Cat. No. Product Name / Activity Date Added
7958 QM-FN-SO3 Jan 2024
Brain penetrant, NIR aggregation-induced emission active probe for in vivo imaging of Aβ plaques

TR-FRET and FP Assay Reagents

Cat. No. Product Name / Activity Date Added
7985 BDY FL Staurosporine Mar 2024
Fluorescent probe targeting kinases; kinase tracer for TR-FRET assays
7950 CoraFluor™ 2, amine reactive Jan 2024
Terbium cryptate FRET donor for TR-FRET assay development; amine reactive for conjugation
7857 BDY FL Lenalidomide Feb 2024
Fluorescent cereblon ligand

Aurora Kinases

Cat. No. Product Name / Activity Date Added
7865 AMG 900 Oct 2023
Potent pan-Aurora kinase inhibitor

Fluorescent Probes for Imaging Bacteria

Cat. No. Product Name / Activity Date Added
8013 RMR-Tre Jan 2024
Far-red fluorogenic trehalose probe for live mycobacteria imaging

Biochemicals and Molecular Biology

Cat. No. Product Name / Activity Date Added
3181 β-Cyclodextrin Nov 2023
Cyclic complexing agent
3180 α-Cyclodextrin Mar 2024
Cyclic complexing agent
8098 ProtiFect STAR™ Protein Transfection Reagent Jan 2024
Protein transfection reagent

CaM Kinase

Cat. No. Product Name / Activity Date Added
7982 CS 640 Dec 2023
Potent CaM kinase I inhibitor

β-catenin

Cat. No. Product Name / Activity Date Added
7847 Klotho-derived peptide 6 Jan 2024
Wnt/β-catenin signaling inhibitor
8106 WNTinib Apr 2024
Inhibitor of mutant β-catenin signaling in hepatocellular carcinoma

Fluorescent Cell Indicators and Sensors

Cat. No. Product Name / Activity Date Added
7642 Dihydroethidium Dec 2023
Fluorescent ROS indicator

Cereblon Targeting Ligands Plus Linkers

Cat. No. Product Name / Activity Date Added
7829 Thalidomide 4'-ether-alkylC6-azide Jan 2024
Cereblon ligand with alkyl linker and terminal azide for onward chemistry
7999 PAG 4'-piperazine-4-methylpiperidine Jan 2024
Cereblon ligand with terminal piperidine for onward chemistry
7998 PAG 4'-piperazine Feb 2024
Functionalized cereblon ligand for PROTAC development

Piezo Channels

Cat. No. Product Name / Activity Date Added
8051 Yoda 2 Feb 2024
Piezo1 channel activator

Immune Checkpoints

Cat. No. Product Name / Activity Date Added
7831 AUNP 12 Nov 2023
Peptide inhibitor of the PD-1 signaling pathway

Class IV HDACs

Cat. No. Product Name / Activity Date Added
7969 SIS17 Jan 2024
Selective HDAC11 inhibitor

Tocriscreen™ Compound Libraries

Cat. No. Product Name / Activity Date Added
8100 Tocriscreen GPCR Compound Library Jan 2024
A bioactive compound library of 240 GPCR compounds (100 μL 10 mM DMSO solutions) for high-throughput screening, high-content screening, target validation and assay development

Protein Degraders

Cat. No. Product Name / Activity Date Added
8004 PROTAC®(H-PGDS)-7 Nov 2023
Potent hematopoietic prostaglandin D2 synthase Degrader (PROTAC®)
7828 HHP 9 Apr 2024
BET bromodomain Degrader (PROTAC®); also potent Hedgehog pathway inhibitor

TAG Degradation Platform

Cat. No. Product Name / Activity Date Added
6207 AP 1867 Nov 2023
Selective binding ligand for FKBP12F36V

Protein Degraders

Cat. No. Product Name / Activity Date Added
8021 CST 626 Apr 2024
Potent pan IAP Degrader (PROTAC®)
8041 α-Synuclein Degrader 2bn Feb 2024
Negative control for α Synuclein Degrader 2b (Cat. No. 8040)
8040 α-Synuclein Degrader 2b Jan 2024
α-synuclein Degrader (PROTAC®)
7983 IRAK3 Degrader 23 Feb 2024
IRAK3 PROTAC® Degrader
8005 PROTAC®(H-PGDS)-8 Nov 2023
Negative control for PROTAC®(H-PGDS)-7 (Cat. No. 8004)
8029 JNJ 1013 Jan 2024
Interleukin 1 Receptor Associated Kinase 1 (IRAK1) Degrader (PROTAC®)
7886 HER2 PROTAC® CH7C4 Jan 2024
Potent and selective HER2 targeting Degrader (PROTAC®)

TAG Degradation Platform

Cat. No. Product Name / Activity Date Added
7787 Ortho AP 1867 Jan 2024
Selective binding ligand for FKBP12F36V; precursor for dTAG compounds

Other Dehydrogenases

Cat. No. Product Name / Activity Date Added
7719 TH 9619 disodium salt Jan 2024
MTHFD2 inhibitor

Protein Dimerizers

Cat. No. Product Name / Activity Date Added
8088 NICE 01 Dec 2023
Heterobifunctional compound for nuclear import of FKBPF36V tagged proteins
8121 TRAM 1 Apr 2024
Chemical inducer of proximity for dTAG protein FKBPF36V and ecDHFR tags

DNA, RNA and Protein Synthesis

Cat. No. Product Name / Activity Date Added
8108 CEP Feb 2024
Chemoproteomic reagent, clickable electrophilic purine for RNA binding profiling in live cells
8011 FAI Feb 2024
Reagent for RNA SHAPE-MaP experiments in live cells
8063 CHDI 113 Jan 2024
Potent HTT pre-RNA splicing modulator

Estrogen and Related Receptors

Cat. No. Product Name / Activity Date Added
8112 SLU-PP-332 Apr 2024
Potent pan-ERR agonist

Fluorescent RNA Probes

Cat. No. Product Name / Activity Date Added
7814 Tricyclic cytosine tC Oct 2023
Fluorescent tricyclic cytosine analog for RNA imaging

Other Fluorescent Probes

Cat. No. Product Name / Activity Date Added
8101 dTAG Janelia Fluor® 635 Mar 2024
Fluorogenic srTAG probe for live cell imaging of FBKP12 (F36V/L) labelled proteins.

Fluorescent Lysosome Probes

Cat. No. Product Name / Activity Date Added
7901 tri-GalNAc-C5-AF647 Apr 2024
Fluorescent ASGPR ligand. Application: flow cytometry, fluorescence microscopy

Molecular Glues

Cat. No. Product Name / Activity Date Added
7851 EM 12-FS Jan 2024
Molecular glue; induces degradation of NQAT1

Glycobiology Probes

Cat. No. Product Name / Activity Date Added
7973 5-InoAz Mar 2024
Metabolic probe for labeling mycobacterium cell envelope

Non-selective HDACs

Cat. No. Product Name / Activity Date Added
7981 Belinostat Oct 2023
Potent pan-HDAC inhibitor

Other Hydrolases

Cat. No. Product Name / Activity Date Added
7963 PFI 653 Jan 2024
Potent and selective vanin 1 inhibitor

Insulin and Insulin-like Receptors

Cat. No. Product Name / Activity Date Added
7937 Trofinetide Feb 2024
IGF-1 synthetic analogue

Integrins

Cat. No. Product Name / Activity Date Added
8042 Alkyne-cRGD Jan 2024
Integrin ligand for degrader development and targeted delivery, with alkyne click handle for conjugation

Receptor Interacting Protein Kinases

Cat. No. Product Name / Activity Date Added
8104 UH15-38 Apr 2024
Potent and selective RIPK3 inhibitor; also blocks activation of necroptosis

Other Kinases

Cat. No. Product Name / Activity Date Added
7876 PZ 3022 Jan 2024
PanK Activator
7980 MTK 458 Dec 2023
PINK1 activator
7927 MSC 1186 Mar 2024
Potent and selective SRPK family inhibitor

Lipid Nanoparticles

Cat. No. Product Name / Activity Date Added
7179 DOTAP Dec 2023
Cationic agent for liposome and LNP formation

TGF-β Receptors

Cat. No. Product Name / Activity Date Added
7830 Klotho-derived peptide 1 Jan 2024
TGF-β receptor 2 (TβR2) binding peptide; disrupts the TGF-β/TβR2 interaction