New ProductsView all New Products by pharmacological action
Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
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Cyclin Dependent Kinase (CDK) Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
|---|---|---|
| 7940 | HEMTAC 26 | Jan 2025 |
| CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader | ||
Voltage-gated Potassium (KV) Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8137 | Ebio1 | Feb 2025 |
| KCNQ2 activator | ||
Near Infrared (NIR) Fluorescent Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8881 | IRDye® 800CW, NHS ester | Feb 2025 |
| Near-infared dye (reactive group NHS ester) | ||
| 8879 | IRDye® 800CW, DBCO | Feb 2025 |
| Near-infared dye (reactive group DBCO) | ||
| 8880 | IRDye® 800CW, Maleimide | Feb 2025 |
| Near-infrared dye (Reactive group: maleimide) | ||
| 8877 | IRDye® 680RD, Maleimide | Feb 2025 |
| Near-infared dye (reactive group maleimide) | ||
| 8878 | IRDye® 680RD, NHS ester | Feb 2025 |
| Near-infared dye (reactive group NHS ester) | ||
CB2 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8835 | RNB 61 | Feb 2025 |
| Highly potent and selective CB2R agonist | ||
Adrenergic α2 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8006 | BAY 6096 | May 2025 |
| Potent and selective adrenergic α2B antagonist | ||
Ubiquitin E3 Ligases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7960 | PFI 7 | Jan 2025 |
| Selective GID4 antagonist | ||
| 8047 | JP-2-196 alkyne | Feb 2025 |
| RNF126 chemical handle; alkyne functionalized version of JP-2-196 (Cat. No. 8046). | ||
Functionalized E3 Ligase Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8075 | VHF 543, amine | Feb 2025 |
| DCAF1 WD40 ligand with terminal amine for onward chemistry | ||
Ubiquitin E3 Ligases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8046 | JP-2-196 | Feb 2025 |
| RNF126 chemical handle | ||
| 8091 | KH-4-43 | Feb 2025 |
| Selective CUL4 inhibitor | ||
Orphan 7-TM Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8131 | OX 04528 | Feb 2025 |
| Highly potent and selective GPR84 agonist | ||
Free Acid Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8915 | Janelia Fluor® 646, free acid | Apr 2025 |
| Red dye (Reactive group: free acid). Application: flow cytometry, confocal microscopy, super resolution microscopy (SRM) including dSTORM & STED. Suitable for live cell imaging | ||
ADAMs | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8826 | BAY 9835 | Jul 2025 |
| Potent ADAMTS7 and ADAMTS12 inhibitor | ||
ALK | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8832 | MU 1700 trihydrochloride | Feb 2025 |
| Potent and selective ALK1/2 inhibitor. Brain-penetrant | ||
Calcium Binding Proteins | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7877 | SGC CAMKK2-1 | Jan 2025 |
| Potent and selective CAMKK1/2 inhibitor | ||
Biochemicals and Molecular Biology | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8911 | ImmunoFect STAR™ Antibody Transfection Reagent | May 2025 |
| Reagent capable of efficiently delivering functional antibodies into the cytosol of cells | ||
| 8869 | ArMan | Apr 2025 |
| DC-SIGN ligand used to target dendritic cells | ||
| 8888 | LaKe | Apr 2025 |
| Orally bioavailable prodrug metabolite, undergoes hydrolytic conversion to yield (S)-lactate and (R)-1,3-butanediol in cells | ||
Cereblon Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8848 | Lenalidomide 5'-piperazine-7'-methoxy | Apr 2025 |
| Cereblon ligand with terminal piperazine for onward chemistry | ||
Class I HDACs | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8811 | ESI 1 | Apr 2025 |
| Selective HDAC3 inhibitor; also myelination inducer | ||
Other Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8854 | KL 465 | Mar 2025 |
| MAGE-A3 Degrader (PROTAC®) | ||
| 7964 | hCAII Degrader 11 | Mar 2025 |
| Potent human carbonic anhydrase II Degrader (PROTAC®) | ||
| 8890 | VHL-SNAP2-5C | Mar 2025 |
| Degrader (PROTAC®) of SNAP-tag™ labeled fusion proteins | ||
Kinase Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8116 | PPM-3 | Mar 2025 |
| Potent and selective ERK5 Degrader (PROTAC®) | ||
| 8030 | JNJ 1013NC | Feb 2025 |
| Negative control for the IRAK1 degrader JNJ 1013 (Cat. No. 8029) | ||
Other Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8891 | CRBN5-SNAP2-1C-PIP | Mar 2025 |
| Degrader (PROTAC®) of SNAP-tag™ labeled fusion proteins | ||
Histone Demethylases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8167 | 193 D7 | Feb 2025 |
| JMJD1C inhibitor | ||
DNA-Dependent Protein Kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 5834 | LTURM 34 | Mar 2025 |
| Potent DNA-PK inhibitor; also increases CRISPR-Cas9 deletion efficiency | ||
Deubiquitinating Enzymes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7984 | BAY 805 | Feb 2025 |
| Potent and selective inhibitor of USP21; also NF-κB activator | ||
DNA, RNA and Protein Synthesis | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7942 | Lac-Phe | Feb 2025 |
| Metabolite generated by cytosol nonspecific dipeptidase (CNDP2) during intense exercise | ||
ROS and Other Gaseous Donors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7949 | MitoBoronic acid | Jul 2025 |
| Ratiometric mass spectrometry mitochondrial hydrogen peroxide (H2O2) probe | ||
Photoactivatable Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8132 | PA Janelia Fluor® 549, Maleimide | Jun 2025 |
| Yellow photoactivatable dye (Reactive group: maleimide). Application: flow cytometry, confocal microscopy, super-resolution microscopy including dSTORM & STED. Suitable for live cell imaging | ||
Sulfhydryl-Reactive Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8025 | Janelia Fluor® 525, Maleimide | Feb 2025 |
| Yellow dye (Reactive group: maleimide). Application: flow cytometry, confocal microscopy, super resolution microscopy including dSTORM & STED. Suitable for live cell imaging | ||
Photoactivatable Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8133 | PA Janelia Fluor® 646, Maleimide | Feb 2025 |
| Red photoactivatable dye (Reactive group: maleimide). Application: flow cytometry, confocal microscopy, super resolution microscopy including dSTORM & STED. Suitable for live cell imaging | ||
Endocytosis | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8829 | TransMoDE 3 Biotin | May 2025 |
| Biotinylated angiopep-2, induces internalization and degradation of streptavidin in brain cell lines | ||
Viral Transduction Enhancers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8822 | Protamine sulfate | Mar 2025 |
| Transduction efficiency enhancer, also apelin receptor antagonist | ||
Other Fluorescent Probes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8110 | BI 2852 FL | Apr 2025 |
| Pan RAS Tracer | ||
| 8086 | Acridonylalanine | Apr 2025 |
| Fluorescent unnatural amino acid. | ||
Molecular Glues | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8129 | IBG3 | Jan 2025 |
| Potent molecular glue Degrader of BET proteins BRD4 and BRD2 | ||
| 8141 | SJ 3149 | Mar 2025 |
| Potent and selective CK1α molecular glue Degrader | ||
Gonadotropin-Releasing Hormone Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8821 | Cetrorelix acetate | Feb 2025 |
| Potent GnRH receptor antagonist | ||
Hippo and YAP/TAZ Signaling | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8176 | VT 104 | Jun 2025 |
| Potent pan-TEAD inhibitor | ||
Other Ion Pumps/Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8057 | V 9302 hydrochloride | Mar 2025 |
| ASCT2 (SLC1A5) inhibitor | ||
Rho-Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7881 | CHDI 00580985 | Mar 2025 |
| Potent and selective ROCK inhibitor; orally bioavailable and brain penetrant | ||
Kinesin | ||
| Cat. No. | Product Name / Activity | Date Added |
| 5109 | SB 743921 hydrochloride | May 2025 |
| Potent kinesin spindle protein (KSP) inhibitor | ||
Self-labeling Tags | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8814 | PA Janelia Fluor® 549, Haloalkane | Jul 2025 |
| Photoactivatable Janelia Fluor® 549 with haloalkane for labeling HaloTag fusion proteins | ||
LDL Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8828 | Angiopep-2 | May 2025 |
| Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB | ||
Lipid Nanoparticles | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8903 | RVG29-Cys | May 2025 |
| Nicotinic acetylcholine receptor targeting peptide for neuronal delivery | ||
| 8889 | MC3 LNP Luciferase | Mar 2025 |
| Dlin-MC3 containing LNP for in vitro and in vivo delivery of luciferase mRNA | ||
| 8909 | SM 102 | Apr 2025 |
| Cationic ionizable lipid | ||
| 8902 | Angiopep-2-Cys | May 2025 |
| Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB | ||
| 8904 | Cys-T7 Peptide | May 2025 |
| Targeting peptide for the transferrin receptor (N-term Cys) | ||
| 8837 | DSPE-PEG 2000 Azide | Feb 2025 |
| PEGylated DSPE with azide reactive group | ||
| 8838 | DSPE-PEG 2000 Biotin | Feb 2025 |
| Biotinylated DSPE PEG lipid | ||
| 8895 | DLin-KC2-DMA | Apr 2025 |
| Ionizable cationic lipid | ||
Matrix Metalloproteases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8842 | BI 4394 | Jan 2025 |
| Highly potent and selective MMP-13 inhibitor | ||
Myosin | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8804 | para-Nitroblebbistatin | Feb 2025 |
| Selective inhibitor of myosin II ATPase activity. Non-cytotoxic version of (±)-Blebbistatin (Cat. No. 1760) | ||
Organoids | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8853 | RS 246204 | May 2025 |
| R-Spondin-1 substitute used to initiate small intestinal organoids | ||
Pregnane X Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8839 | SJPYT 310 | May 2025 |
| Potent and selective PXR antagonist | ||
Telomerase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8825 | TAC | Mar 2025 |
| TERT activator | ||