Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.
5-HT2A Receptors | ||
| Cat No | Product Name / Activity | Date Added |
|---|---|---|
| 6336 | Trazodone hydrochloride | Sep 2017 |
| 5-HT2A and α1 adrenoceptor antagonist; also enhances neural differentiation; antidepressant and neuroprotectant | ||
Ack1 | ||
| Cat No | Product Name / Activity | Date Added |
| 6061 | XMD 8-87 | May 2017 |
| Potent Ack1/TNK2 inhibitor | ||
Actin | ||
| Cat No | Product Name / Activity | Date Added |
| 3974 | Latrunculin B | May 2017 |
| Inhibitor of actin polymerization | ||
ADAMs | ||
| Cat No | Product Name / Activity | Date Added |
| 5523 | TAPI 0 | Sep 2017 |
| ADAM-17 (TACE) and MMP inhibitor | ||
| 6013 | TAPI 2 | Sep 2017 |
| ADAM-17 (TACE) and MMP inhibitor | ||
| 6162 | TAPI 1 | Sep 2017 |
| ADAM-17 (TACE) and MMP inhibitor | ||
Adenylyl Cyclases | ||
| Cat No | Product Name / Activity | Date Added |
| 6271 | ST 034307 | May 2017 |
| Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo | ||
AMPA Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6278 | JNJ 55511118 | Aug 2017 |
| Selective, high affinity negative modulator of AMPA receptors containing TARP-γ8 | ||
Antivirals | ||
| Cat No | Product Name / Activity | Date Added |
| 6045 | NITD 008 | Jul 2017 |
| Antiviral; selective flavivirus inhibitor | ||
| 6183 | Nanchangmycin | May 2017 |
| Antiviral; active against Zika, West Nile and dengue viruses | ||
Apelin Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6291 | ELA-32 (human) | Jul 2017 |
| Potent, high affinity apelin receptor agonist; stimulates angiogenesis | ||
| 6294 | ELA-14 negative control | Jun 2017 |
| Negative control for ELA-14 (Cat.No.6293). | ||
| 6292 | ELARR>GG | Jul 2017 |
| Negative control for ELA-32 (Cat.No.6291). | ||
| 6293 | ELA-14 (human) | Jun 2017 |
| Potent apelin (APJ) receptor agonist | ||
Aptamers | ||
| Cat No | Product Name / Activity | Date Added |
| 6102 | Ep23, 5'-DY647 | Oct 2017 |
| High affinity fluorescently tagged aptamer for EpCam | ||
| 6104 | CD133-B19, 5'-DY647 | Oct 2017 |
| High affinity fluorescently tagged aptamer for CD133 (extracellular domain epitope) | ||
| 6103 | CD133-A15, 5'-DY647 | Oct 2017 |
| High affinity fluorescently tagged aptamer for CD133 (AC133 epitope) | ||
BMP and Other Activin Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6152 | LDN 214117 | Apr 2017 |
| Potent and selective ALK2 inhibitor | ||
Bromodomains | ||
| Cat No | Product Name / Activity | Date Added |
| 6181 | OTX 015 | May 2017 |
| BET bromodomain inhibitor; orally bioavailable | ||
Buffers, Solvents and Solutions | ||
| Cat No | Product Name / Activity | Date Added |
| 5888 | MOPSO, free acid | May 2017 |
| Buffer; working pH range in aqueous solution: 6.2-7.6 | ||
Caged Amino Acid Compounds | ||
| Cat No | Product Name / Activity | Date Added |
| 6121 | NB-caged Tyrosine hydrochloride | May 2017 |
| ortho-nitrobenzyl caged L- tyrosine | ||
Calcium-Sensing Receptor | ||
| Cat No | Product Name / Activity | Date Added |
| 6165 | AC 265347 | Jul 2017 |
| CaSR biased allosteric modulator | ||
Casein Kinase 1 | ||
| Cat No | Product Name / Activity | Date Added |
| 6346 | PF 5006739 | Sep 2017 |
| Potent CK1δ/ε inhibitor | ||
CB1 Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6193 | AM 4113 | Aug 2017 |
| Selective, high affinity CB1 antagonist | ||
CB2 Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 5826 | LEI 101 hydrochloride | May 2017 |
| Potent and selective CB2 partial agonist; orally biovailable | ||
Cyclin-Dependent Protein Kinases | ||
| Cat No | Product Name / Activity | Date Added |
| 6174 | CVT 313 | Jun 2017 |
| cdk2 inhibitor | ||
Cytokine Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 5372 | Bioymifi | May 2017 |
| DR5 (TRAIL receptor) agonist; induces apoptosis | ||
Death-Associated Protein Kinase | ||
| Cat No | Product Name / Activity | Date Added |
| 5768 | HS 38 | Jul 2017 |
| ATP-competitive inhibitor of DAPK and ZIPK | ||
Diacylglycerol O-Acyltransferase | ||
| Cat No | Product Name / Activity | Date Added |
| 5863 | PF 04620110 | Sep 2017 |
| Potent and selective DGAT-1 inhibitor; orally bioavailable | ||
Dihydrofolate Reductase | ||
| Cat No | Product Name / Activity | Date Added |
| 6185 | Pemetrexed | Jun 2017 |
| High affinity dihydrofolate reductase inhibitor; also inhibits thymidylate synthase, GARFT and AICART | ||
DREADD Ligands | ||
| Cat No | Product Name / Activity | Date Added |
| 6329 | Clozapine N-oxide dihydrochloride | Sep 2017 |
| Activator of muscarinic DREADDs | ||
EGFR | ||
| Cat No | Product Name / Activity | Date Added |
| 6231 | Dacomitinib | Jul 2017 |
| Potent irreversible pan ErbB inhibitor | ||
Estrogen (GPER) Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6116 | BHPI | Aug 2017 |
| ERα antagonist; also activates unfolded protein response; active in vivo | ||
Estrogen and Related Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6342 | Tamoxifen | Sep 2017 |
| Estrogen receptor partial agonist/antagonist | ||
| 6158 | (S)-Equol | May 2017 |
| Potent estrogen receptor β (ERβ) agonist; dihydrotestosterone antagonist | ||
Free Fatty Acid Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6163 | AR 420626 | Oct 2017 |
| FFA3 agonist | ||
GABAA Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6192 | PZ-II-029 | Sep 2017 |
| α6β3γ2-selective GABAA channel modulator | ||
Ghrelin Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6347 | PF 04628935 | Sep 2017 |
| Potent ghrelin receptor inverse agonist | ||
Glucose Transporters | ||
| Cat No | Product Name / Activity | Date Added |
| 6100 | Fasentin | May 2017 |
| GLUT1/GLUT4 inhibitor; also Fas-sensitizer | ||
| 6143 | WZB 117 | Aug 2017 |
| GLUT inhibitor | ||
GPR171 | ||
| Cat No | Product Name / Activity | Date Added |
| 6306 | BigLEN (rat) | Jul 2017 |
| Potent GPR171 agonist | ||
| 6304 | BigLEN (mouse) | Jul 2017 |
| GPR171 agonist | ||
| 6299 | MS 15203 | Aug 2017 |
| Potent and selective GPR171 partial agonist | ||
Heme Oxygenase | ||
| Cat No | Product Name / Activity | Date Added |
| 6119 | OB 24 hydrochloride | Aug 2017 |
| Potent and selective heme oxygenase 1 (HO-1) inhibitor | ||
Hexokinases | ||
| Cat No | Product Name / Activity | Date Added |
| 6049 | PF 04937319 | Aug 2017 |
| Glucokinase partial activator | ||
| 6345 | PF 04991532 | Sep 2017 |
| Potent hepatoselective glucokinase activator | ||
Histone Acetyltransferases | ||
| Cat No | Product Name / Activity | Date Added |
| 5103 | Lys-CoA | Jun 2017 |
| Selective p300 inhibitor | ||
Histone Deacetylases | ||
| Cat No | Product Name / Activity | Date Added |
| 6270 | Tubastatin A hydrochloride | Jun 2017 |
| Potent HDAC6 inhibitor | ||
| 6208 | MS 275 | Jun 2017 |
| HDAC (Class I) inhibitor | ||
| 6284 | BRD 73954 | Jun 2017 |
| Dual histone deacetylase (HDAC) 6/8 inhibitor | ||
Histone Peptides | ||
| Cat No | Product Name / Activity | Date Added |
| 6215 | H3K4(Me2) (1-20) | May 2017 |
| Histone H3 peptide | ||
Integrins | ||
| Cat No | Product Name / Activity | Date Added |
| 6048 | R-BC154 | Aug 2017 |
| High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs | ||
ITK | ||
| Cat No | Product Name / Activity | Date Added |
| 5401 | GSK 2250665A | Aug 2017 |
| Itk inhibitor | ||
JAK Kinase | ||
| Cat No | Product Name / Activity | Date Added |
| 5818 | NVP BSK 805 | Aug 2017 |
| Potent JAK2 inhibitor; orally bioavailable | ||
JNK/c-Jun | ||
| Cat No | Product Name / Activity | Date Added |
| 6258 | CC 401 dihydrochloride | May 2017 |
| High affinity JNK inhibitor; also inhibits HCMV replication | ||
LRRK2 | ||
| Cat No | Product Name / Activity | Date Added |
| 6289 | JH-II-127 | Aug 2017 |
| Potent and selective LRRK2 inhibitor | ||
Lysine Methyltransferases | ||
| Cat No | Product Name / Activity | Date Added |
| 4930 | UNC 2399 | Jun 2017 |
| Biotinylated UNC 1999 (Cat.No. 4904) | ||
| 6128 | GSK 343 | Jun 2017 |
| Potent and selective SAM-competitive EZH2 inhibitor | ||
| 6167 | A 196 | Jul 2017 |
| Potent and selective SUV420H1/H2 inhibitor | ||
| 6282 | BRD 4770 | Jun 2017 |
| G9a inhibitor and S-adenosyl methionine mimetic; cell permeable | ||
Monoacylglycerol Lipase | ||
| Cat No | Product Name / Activity | Date Added |
| 5956 | NF 1819 | Aug 2017 |
| Potent and selective irreversible MAGL inhibitor; membrane permeable and brain penetrant | ||
Monocarboxylate Transporters | ||
| Cat No | Product Name / Activity | Date Added |
| 5658 | AR-C 141990 hydrochloride | Jul 2017 |
| MCT1 inhibitor | ||
Na+/Ca2+ Exchanger | ||
| Cat No | Product Name / Activity | Date Added |
| 6164 | SEA 0400 | Apr 2017 |
| Potent Na+/Ca2+ exchanger (NCX) inhibitor. | ||
Nek2 Kinase | ||
| Cat No | Product Name / Activity | Date Added |
| 4322 | JH 295 | May 2017 |
| Irreversible Nek2 inhibitor | ||
| 5150 | NCL 00017509 | May 2017 |
| Potent and reversible NIMA related kinase 2 (Nek2) inhibitor | ||
Nicotinic (α4β2) Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 5963 | CMPI hydrochloride | May 2017 |
| Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs | ||
NPY Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6288 | Peptide YY (3-36) human | Jun 2017 |
| NPY Y2 receptor agonist | ||
NTPDase | ||
| Cat No | Product Name / Activity | Date Added |
| 6083 | PSB 12379 | Aug 2017 |
| Ecto-5'-nucleotidase (CD73) inhibitor | ||
Orphan 7-TM Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6277 | 7α,25-Dihydroxycholesterol | Jun 2017 |
| Highly potent GPR183 (EBI2) agonist | ||
| 6309 | PEN (rat) | Sep 2017 |
| GPR83 agonist | ||
| 6307 | PEN (human) | Sep 2017 |
| GPR83 agonist | ||
| 6308 | PEN (mouse) | Sep 2017 |
| GPR83 agonist | ||
Other Dehydrogenases | ||
| Cat No | Product Name / Activity | Date Added |
| 6196 | Brequinar sodium | Aug 2017 |
| Potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor | ||
| 6084 | ASP 9521 | Sep 2017 |
| Potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor;orally bioavailable | ||
Other Hydrolases | ||
| Cat No | Product Name / Activity | Date Added |
| 6099 | Lalistat 2 | Sep 2017 |
| Selective lysosomal acid lipase inhibitor | ||
| 6370 | Nor NOHA monoacetate | Sep 2017 |
| Arginase inhibitor | ||
| 6098 | Lalistat 1 | Aug 2017 |
| Potent and selective lysosomal acid lipase (LAL) inhibitor | ||
Other Kinases | ||
| Cat No | Product Name / Activity | Date Added |
| 6036 | STK16-IN-1 | May 2017 |
| Serine/threonine protein kinase 16 (STK16) inhibitor; also inhibits PI 3Kδ, PI 3Kγ and mTOR kinases. | ||
Other Nuclear Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 5821 | C-DIM 12 | May 2017 |
| Nurr1 activator; inhibits NF-κB-dependent gene expression | ||
Other Proteases | ||
| Cat No | Product Name / Activity | Date Added |
| 6194 | TM 5441 | Jun 2017 |
| Plasminogen activator inhibitor-1 (PAI-1) inhibitor | ||
Other Reductases | ||
| Cat No | Product Name / Activity | Date Added |
| 5842 | MK 386 | May 2017 |
| Potent, selective human type 1 5α-reductase inhibitor | ||
P21-activated Kinases | ||
| Cat No | Product Name / Activity | Date Added |
| 6051 | G 5555 | Sep 2017 |
| High affinity group 1 PAK inhibitor | ||
Parathyroid Hormone Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6303 | Parathyroid hormone (1-34) (bovine) | Jun 2017 |
| Parathyroid hormone (PTH) receptor agonist. | ||
| 6301 | Parathyroid hormone (1-34) (rat) | Jun 2017 |
| Parathyroid hormone (PTH) receptor agonist | ||
PFKFB3 | ||
| Cat No | Product Name / Activity | Date Added |
| 5675 | AZ PFKFB3 26 | May 2017 |
| Potent and selective PFKFB3 inhibitor | ||
Phosphodiesterases | ||
| Cat No | Product Name / Activity | Date Added |
| 6311 | Tadalafil | May 2017 |
| Potent and highly selective PDE5 inhibitor; orally bioavailable | ||
Pim Kinase | ||
| Cat No | Product Name / Activity | Date Added |
| 6310 | AZD 1208 | Oct 2017 |
| Potent pan Pim kinase inhibitor | ||
Poly(ADP-ribose) Polymerase | ||
| Cat No | Product Name / Activity | Date Added |
| 6060 | AZD 2461 | May 2017 |
| Potent PARP inhibitor; orally bioavailable | ||
| 6230 | Rucaparib camsylate | Aug 2017 |
| PARP inhibitor | ||
Progesterone Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6285 | Megestrol Acetate | May 2017 |
| Synthetic progesterone analog | ||
Prostanoid Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 5924 | ER 819762 | Sep 2017 |
| Potent EP4 receptor antagonist; orally bioavailable | ||
| 6240 | DG 041 | Aug 2017 |
| Potent and selective EP3 antagonist; antiplatelet and antithrombotic | ||
Protein Kinase A | ||
| Cat No | Product Name / Activity | Date Added |
| 6287 | st-Ht31 P | Jul 2017 |
| Negative control for st-Ht31 (Cat. No. 6286) | ||
| 6286 | st-Ht31 | Jul 2017 |
| Inhibits PKA/AKAP interactions; cell permeable | ||
Protein Kinase C | ||
| Cat No | Product Name / Activity | Date Added |
| 5343 | TPPB | May 2017 |
| High affinity PKC activator; also APP modulator | ||
Protein Prenyltransferases | ||
| Cat No | Product Name / Activity | Date Added |
| 6265 | Lonafarnib | Jul 2017 |
| Potent farnesyl transferase inhibitor | ||
Purinergic (P2Y) Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6317 | Prasugrel | Jul 2017 |
| Irreversible P2Y12 antagonist; antiplatelet and orally active | ||
| 6078 | BPTU | Jul 2017 |
| P2Y1 allosteric antagonist | ||
RAGE | ||
| Cat No | Product Name / Activity | Date Added |
| 6259 | RAGE antagonist peptide | May 2017 |
| RAGE antagonist | ||
| 6237 | FPS ZM1 | Aug 2017 |
| High affinity antagonist of RAGE | ||
Rev-Erb Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6038 | SR 10067 | Aug 2017 |
| Selective Rev-Erbα/β agonist; anxiolytic | ||
Sphingosine Kinase | ||
| Cat No | Product Name / Activity | Date Added |
| 5452 | SKI 178 | May 2017 |
| Non-lipid sphingosine kinase 1 (SphK1) inhibitor | ||
Src Kinases | ||
| Cat No | Product Name / Activity | Date Added |
| 6073 | P21d hydrochloride | Jun 2017 |
| Potent and selective Brk inhibitor | ||
Syk Kinase | ||
| Cat No | Product Name / Activity | Date Added |
| 6012 | OXSI 2 | May 2017 |
| Potent Syk kinase inhibitor; also inhibits assembly of NLRP3 inflammasomes | ||
TGF-β Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 6016 | IN 1130 | Jul 2017 |
| Potent and selective inhibitor of TGF-βRI | ||
Thioredoxin Reductases | ||
| Cat No | Product Name / Activity | Date Added |
| 5921 | D9 | May 2017 |
| Potent thioredoxin reductase (TrxR) inhibitor | ||
| 6189 | Myricetin | Jun 2017 |
| Irreversible TrxR inhibitor | ||
Toll-like Receptors | ||
| Cat No | Product Name / Activity | Date Added |
| 5705 | M62812 | Aug 2017 |
| TLR-4 inhibitor | ||
| 6191 | TH 1020 | Jul 2017 |
| Toll-like receptor (TLR) 5/Flagellin complex antagonist | ||
| 6142 | CL 075 | Sep 2017 |
| TLR8 agonist | ||
TRPA1 | ||
| Cat No | Product Name / Activity | Date Added |
| 5914 | AM 0902 | Oct 2017 |
| Potent and selective TRPA1 antagonist | ||
TRPC | ||
| Cat No | Product Name / Activity | Date Added |
| 5831 | SAR 7334 | Sep 2017 |
| Potent TRPC6 inhibitor | ||
Ubiquitin E3 Ligases | ||
| Cat No | Product Name / Activity | Date Added |
| 6305 | Lenalidomide | Jun 2017 |
| Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase | ||
| 6327 | dBET1 | Aug 2017 |
| (+)-JQ1 based PROTAC that selectively degrades BRD4 in cells | ||
| 6302 | Pomalidomide | Jun 2017 |
| Cereblon ubiquitination inhibitor; also TNF-α inhibitor and antiangiogenic | ||
| 6075 | Nutlin 3a | Sep 2017 |
| MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984) | ||