Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
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Calcium-Activated Potassium (KCa) Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
|---|---|---|
| 6481 | AP 14145 hydrochloride | Nov 2019 |
| KCa2 channel negative allosteric modulator | ||
Inward Rectifier Potassium (Kir) Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6889 | ML 418 | Sep 2019 |
| Kir 7.1 inhibitor; also inhibits Kir 6.2 | ||
| 6877 | VU 0134992 | Jul 2019 |
| Kir4.1 blocker | ||
Melanocortin (MC) Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6926 | Fenoprofen calcium | May 2019 |
| Positive allosteric modulator of MC3 receptors; exhibits biased signaling | ||
Glutamate (Metabotropic) Group I Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6859 | FITM | Aug 2019 |
| Potent and selective negative allosteric modulator of mGlu1 receptors | ||
| 6895 | VU 0424465 | Oct 2019 |
| Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity | ||
Glutamate (Metabotropic) Group III Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6893 | VU 6005649 | Sep 2019 |
| Positive allosteric modulators of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant | ||
Purinergic (P2X) Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6493 | A 317491 sodium salt | May 2019 |
| Selective, high affinity P2X3 and P2X2/3 receptor antagonist; antinociceptive | ||
Akt (Protein Kinase B) | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6978 | AZD 5363 | Aug 2019 |
| Potent pan-AKT inhibitor | ||
Somatostatin (sst) Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6201 | J 2156 | Aug 2019 |
| Selective high affinity human sst4 agonist | ||
Nicotinic (α7) Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6764 | B 973B | Sep 2019 |
| Positive allosteric modulator of α7 nAChRs; analgesic | ||
Sphingosine-1-Phosphate Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6690 | Ceralifimod | May 2019 |
| Highly potent and selective S1P1 and S1P5 agonist | ||
M1 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6872 | BQCA | May 2019 |
| Positive allosteric modulator of M1 receptors | ||
Bcl-2 Family | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6835 | ABT 737 | May 2019 |
| Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines | ||
EZH2 | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6790 | GSK 126 | Jul 2019 |
| Very high affinity and selective EZH2 inhibitor | ||
Bcl-2 Family | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6960 | ABT 199 | Jul 2019 |
| Selective, high affinity Bcl-2 inhibitor; orally bioavailable | ||
EZH2 | ||
| Cat. No. | Product Name / Activity | Date Added |
| 5847 | ZLD 1039 | Sep 2019 |
| Potent and selective EZH2 inhibitor; orally bioavailable | ||
Functionalized E3 Ligase Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6969 | cis VH 032, amine dihydrochloride | Jul 2019 |
| Negative control for VH 032, amine (Cat. No. 6462) | ||
PI 3-kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6792 | Omipalisib | May 2019 |
| Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK | ||
Ubiquitin E3 Ligases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6782 | Indisulam | May 2019 |
| Molecular glue; pre-mRNA splicing modulator | ||
Histamine H3 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6778 | S 38093 | May 2019 |
| Selective H3 antagonist and inverse agonist; also σ1 receptor antagonist; antinociceptive | ||
Ubiquitin E3 Ligases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6904 | Idasanutlin | Jul 2019 |
| Potent MDM2 inhibitor; inhibits MDM2-p53 interaction | ||
M4 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6932 | VU 0467485 | Oct 2019 |
| Potent and selective positive allosteric modulator of M4 receptors; orally bioavailable and brain penetrant | ||
| 7027 | LY 2033298 | Sep 2019 |
| Selective positive allosteric modulator of M4 receptors; active in vivo; antipsychotic | ||
Active Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6938 | BSJ-03-204 | Aug 2019 |
| Selective Cdk4/6 degrader | ||
| 6948 | CRBN-6-5-5-VHL | Jun 2019 |
| Potent and selective cereblon degrader; cell-permeable | ||
| 6937 | BSJ-04-132 | Sep 2019 |
| Selective Cdk4 degrader | ||
| 6936 | VZ 185 | Oct 2019 |
| Potent and selective BRD7/9 Degrader | ||
| 6713 | ZXH 3-26 | Jun 2019 |
| Potent and selective BRD4 degrader | ||
| 6921 | BSJ-03-123 | Aug 2019 |
| Selective Cdk6 degrader | ||
| 6922 | BSJ-Bump | Aug 2019 |
| Negative control for BSJ-03-123 (Cat. No. 6921) | ||
BMP and Other Activin Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6881 | SB 4 | May 2019 |
| Potent BMP4 agonist | ||
Focal Adhesion Kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6891 | PND 1186 | May 2019 |
| Potent FAK inhibitor; orally bioavailable | ||
Poly(ADP-ribose) Polymerase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6703 | BGP 15 | Jul 2019 |
| PARP inhibitor; cytoprotectant | ||
| 6228 | H10 | Jul 2019 |
| PARP14 inhibitor; cell-permeable | ||
Aldehyde Dehydrogenases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6934 | 673 A | Jun 2019 |
| ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC) | ||
| 6933 | CM 10 | Jul 2019 |
| ALDH1A inhibitor; depletes CD133+ cancer stem cells | ||
ALK | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6905 | Ceritinib | Jun 2019 |
| Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3 | ||
AMPA Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6847 | TAT-GluA2 3Y | Oct 2019 |
| Inhibitor of AMPA receptor endocytosis | ||
Antivirals | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6994 | HODHBt | Aug 2019 |
| STAT5-SUMO protein-protein interaction inhibitor | ||
Biochemicals and Molecular Biology | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7044 | (±)-α-Lipoic acid | Nov 2019 |
| Liquid-liquid phase separated condensate modifier; reduces stress granule formation | ||
| 7046 | 1,6-Hexanediol | Sep 2019 |
| Tool for probing liquid-liquid phase separation | ||
| 7045 | (±)-α-Lipoamide | Oct 2019 |
| Phase-separated condensate modifier; orally bioavailable | ||
| 6930 | Amphotericin B | Aug 2019 |
| Forms monovalent ion channels in lipid bilyers; antifungal | ||
| 6574 | Fluorescein-NAD+ | Oct 2019 |
| Fluorescent NAD+; substrate for ADP-ribosylation for use in PARP assays | ||
| 6573 | Biotin-NAD+ | Oct 2019 |
| Biotinylated-NAD+; substrate for ADP-ribosylation | ||
| 7005 | 4-Thiouridine | Sep 2019 |
| Photoreactive uridine analog for RNA sequencing | ||
Bromodomains | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6521 | I-BET 762 | Jun 2019 |
| Potent and high affinity BRD inhibitor; anti-inflammatory; orally bioavailable. | ||
Stem Cell Proliferation | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6797 | KLD 12 | Sep 2019 |
| Self-assembling peptide; forms hydrogel to support cell growth | ||
Cereblon Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6967 | Thalidomide - linker 14 | Jun 2019 |
| Thalidomide-PEG2-ethylamine | ||
| 6950 | Thalidomide - linker 11 | Sep 2019 |
| Thalidomide-PEG3-ethylamine | ||
| 6968 | Thalidomide - linker 15 | Jun 2019 |
| Thalidomide-alkylC6-amine | ||
| 6966 | Thalidomide - linker 13 | Jun 2019 |
| Thalidomide-PEG1-ethylamine | ||
| 6951 | Thalidomide - linker 12 | May 2019 |
| Thalidomide-PEG5-ethylamine | ||
| 6949 | Thalidomide - linker 10 | May 2019 |
| Thalidomide-alkylC2-amine | ||
| 6917 | Thalidomide - linker 9 | Jun 2019 |
| Thalidomide-alkylC4-amine | ||
| 6963 | Pomalidomide - linker 8 | Jun 2019 |
| Pomalidomide-PEG4-ethylamine | ||
| 6716 | Pomalidomide - linker 4 | Jun 2019 |
| Pomalidomide-alkylC5-amine | ||
Two-P Potassium Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6888 | ML 402 | Sep 2019 |
| Selective TREK channel activator | ||
| 6972 | A 1899 | Sep 2019 |
| Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker | ||
| 6887 | ML 335 | Jun 2019 |
| Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator | ||
| 6886 | ML 67-33 | Jul 2019 |
| K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator | ||
Chemiluminescent Substrates | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6823 | CycLuc 1 | Jul 2019 |
| Synthetic luciferase substrate; brain penetrant; displays NIR emission | ||
Chemokine CXC Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6957 | Reparixin L-lysine salt | Jun 2019 |
| Potent CXCR1 and CXCR2 allosteric antagonist | ||
Tocriscreen Compound Libraries | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6801 | Tocriscreen Epigenetics Library | Jul 2019 |
| A library of 101 epigenetic compounds (250 μL, 10 mM DMSO solutions) | ||
Cytokines | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7066 | RCGD 423 | Nov 2019 |
| gp130 modulator; activates JAK/STAT signaling | ||
TAG Degradation Platform | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6970 | aTAG 2139 | Sep 2019 |
| Degrader of MTH1 fusion proteins for use within the aTAG system | ||
Other Dehydrogenases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6054 | R162 | Aug 2019 |
| Glutamate dehydrogenase (GDH1) inhibitor | ||
Histone Demethylases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6935 | GSK J5 HCl | May 2019 |
| Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable | ||
Deubiquitinating Enzymes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6776 | G5 | Jul 2019 |
| Ubiquitin isopeptidase inhibitor; induces apoptosis | ||
RNA/DNA Polymerase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6974 | BMS 986094 | Oct 2019 |
| Prodrug of HCV RNA polymerase inhibitor 2'-C-methyl guanosine triphosphate; potent HCV replication inhibitor | ||
DNA, RNA and Protein Synthesis | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6884 | TC SL C5 | Jul 2019 |
| Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor | ||
TFAX Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6619 | TFAX 488, SE | Aug 2019 |
| Green fluorescent dye; amine reactive | ||
Other Fluorescent Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6489 | Ocean Blue, SE | Jun 2019 |
| Blue fluorescent dye; supplied as NHS ester | ||
TFAX Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6623 | TFAX 546, SE | Aug 2019 |
| Yellow fluorescent dye; amine reactive | ||
Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6500 | Janelia Fluor® 549, Maleimide | Jul 2019 |
| Cell permeable yellow fluorescent dye; supplied with a maleimide reactive group | ||
Dynamin | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6897 | P110 | Oct 2019 |
| Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable | ||
Viral Transduction Enhancers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6982 | Cyclosporin H | Oct 2019 |
| Viral transduction enhancer | ||
Other Transcription Factors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 4265 | AS 1842856 | Nov 2019 |
| Potent and selective Foxo1 inhibitor; orally bioavailable | ||
Fluorescent Substrates | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6882 | DiFMUP | May 2019 |
| Fluorescent phosphatase substrate | ||
| 6717 | FFN 270 | May 2019 |
| Fluorescent substrate for NET and VMAT2 | ||
Glucagon Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6927 | Glucagon (Human, Porcine) | Aug 2019 |
| Endogenous glucagon receptor agonist | ||
Ras GTPases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6906 | BAY 293 Negative Control | Sep 2019 |
| Negative control for BAY 293 (Cat. No. 6857) | ||
| 6857 | BAY 293 | Sep 2019 |
| Potent KRas/SOS1 interaction inhibitor | ||
| 6920 | SAH-SOS1A | Jul 2019 |
| KRas/SOS1 interaction inhibitor | ||
Rho GTPases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6701 | 1A-116 | Jul 2019 |
| Rac1 inhibitor; blocks Rac1-P-Rex1 interaction | ||
Other Hydrolases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6903 | DPTIP | Jul 2019 |
| Potent and selective N-SMase2 inhibitor; brain penetrant | ||
| 7006 | PDD 00017272 | Sep 2019 |
| Potent PARG inhibitor | ||
| 6757 | t-TUCB | Jul 2019 |
| Potent soluble epoxide hydrolase (sEH) Inhibitor; anti-inflammatory and antinociceptive | ||
| 6691 | LP 922056 | Oct 2019 |
| Notum inhibitor; activates Wnt signaling | ||
| 5861 | ARN 726 | Aug 2019 |
| Potent N-acylethanolamine acid amidase (NAAA) inhibitor; NAAA activity-based protein profiling (ABPP) probe | ||
Inflammasomes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6902 | OLT 1177 | Jul 2019 |
| NLRP3 inflammasome inhibitor; disrupts inflammasome formation | ||
| 6924 | Oridonin | Jul 2019 |
| High affinity NLRP3 inflammasome inhibitor | ||
Integrins | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7020 | LDV | Sep 2019 |
| α4β1 (VLA-4) ligand | ||
| 6908 | TR 14035 | Jul 2019 |
| Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable | ||
Other Ion Pumps/Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 5026 | KYT 0353 | May 2019 |
| Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo | ||
Kainate Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7065 | Kainic acid (synthetic) | Oct 2019 |
| Kainate agonist; excitant and neurotoxin | ||
Ketamine and Metabolites | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6751 | (R)-(-)-Ketamine hydrochloride | Jul 2019 |
| NMDA antagonist; antidepressant; may not display psychotomimetic or addictive side effects of (S)-ketamine | ||
Raf Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6854 | LY 3009120 | Jun 2019 |
| Potent pan-Raf kinase inhibitor | ||
Kinesin | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6837 | GSK 923295A | May 2019 |
| Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor | ||
VHL Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6909 | VH 032 phenol - linker 1 | Jul 2019 |
| VH 032 phenol-alkylC4-amine | ||
| 6910 | VH 032 phenol - linker 2 | Jul 2019 |
| VH 032 phenol-alkylC6-amine | ||
LIMK | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6899 | TH 257 | Sep 2019 |
| Potent and selective allosteric LIMK 1/2 inhibitor | ||
Other Lysine Methyltransferases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6803 | MRK 740 | Sep 2019 |
| Potent PRDM9 inhibitor | ||
| 6665 | BI 9321 | May 2019 |
| Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain | ||
| 6561 | BAY 6035 | Jun 2019 |
| Potent and selective SMYD3 inhibitor | ||
MEK | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6815 | Selumetinib | May 2019 |
| Potent and selective MEK inhibitor; orally bioavailable | ||
Monocarboxylate Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6817 | BAY 8002 | May 2019 |
| Potent dual MCT1/2 inhibitor; orally bioavailable | ||
Multidrug Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6885 | PU 23 | May 2019 |
| Multidrug resistance protein (MRP) 4 inhibitor | ||
μ Opioid Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6109 | Methylnaltrexone bromide | Aug 2019 |
| μ antagonist; peripherally restricted | ||
Other RTKs | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6821 | ZAP 180013 | Sep 2019 |
| Zap70 inhibitor; inhibits interaction with ITAMs | ||
Other Transferases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6765 | JTP 103237 | Aug 2019 |
| Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor | ||
Other Synthases/Synthetases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6954 | L-Buthionine sulfoximine | Jul 2019 |
| Irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; induces ferroptosis | ||
Oxidative Phosphorylation | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6898 | Mitochondrial fusion promoter M1 | May 2019 |
| Mitochondrial fusion promoter | ||
| 6980 | BAY 87-2243 | Sep 2019 |
| Mitochondrial complex I inhibitor | ||
Phosphodiesterases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6313 | A 33 | May 2019 |
| Potent and selective PDE4B inhibitor | ||
Prion Protein | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6861 | Anle138b | May 2019 |
| Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation | ||
Prostanoid Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6427 | Tafluprost | Sep 2019 |
| Very high affinity FP receptor agonist | ||
TGF-β Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6956 | Galunisertib | Jun 2019 |
| ALK4 and ALK5 (TGFβRI) inhibitor | ||
TRPC | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6940 | BTD | Oct 2019 |
| Selective TRPC5 activator | ||
| 6495 | AM 12 | May 2019 |
| TRPC5 inhibitor | ||
TRPM | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6874 | AMG 333 | Jul 2019 |
| Potent and selective TRPM8 antagonist; active in vivo | ||
TRPV | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6433 | GSK 1016790A | May 2019 |
| Potent TRPV4 agonist; active in vivo | ||
VEGFR | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6986 | EG 00229 trifluoroacetate | Jul 2019 |
| Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1 | ||