New ProductsView all New Products by pharmacological action
Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
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Cyanine Dyes (Cy Dyes) | ||
| Cat. No. | Product Name / Activity | Date Added |
|---|---|---|
| 7510 | Indocyanine green | Jun 2022 |
| Near-infrared fluorescent dye | ||
Class III HDACs (Sirtuins) | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7558 | SRT 1720 | Jul 2022 |
| Selective SIRT1 activator; induces autophagy and mitochondrial biogenesis | ||
Tyramide Signal Amplification (TSA) | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7236 | Digoxigenin Tyramide | Jul 2022 |
| Reagent used for Tyramide Signal Amplification in IHC, ICC and ISH | ||
Sphingosine-1-Phosphate Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7663 | Ozanimod | May 2022 |
| Potent and selective S1P1 and S1P5 agonist | ||
σ1 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7630 | Pridopidine | Mar 2022 |
| Highly selective σ1 agonist | ||
Bcl-2 Family | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7680 | ABT 263 | May 2022 |
| High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor | ||
5-HT2A Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7667 | Pimavanserin | Mar 2022 |
| Selective 5-HT2A inverse agonist | ||
Ubiquitin E3 Ligases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7089 | CSN5i-3 | Apr 2022 |
| Potent and selective CSN5 (COP9 signalosome) inhibitor | ||
| 7542 | SJ 1008066 | Mar 2022 |
| MAGE-A11 inhibitor disrupts MAGE-A11:PCF11 interaction | ||
| 7483 | BDY FL VH032 | Mar 2022 |
| High-affinity VHL fluorescent probe for TR-FRET and FP assays | ||
Functionalized E3 Ligase Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7716 | N-methylated pomalidomide | Jul 2022 |
| Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control | ||
| 7678 | 5-Amino-Thalidomide | Jul 2022 |
| Cereblon ligand with amine on C5 for onward chemistry | ||
| 7670 | Phenyl-glutarimide 4'-oxyacetic acid | Jun 2022 |
| Functionalized cereblon ligand for PROTAC development | ||
3C and 3CL Proteases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7695 | Mpro 61 | Jul 2022 |
| Potent non-covalent inhibitor of SARS-CoV-2 main protease | ||
Ubiquitin E3 Ligases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7532 | CSN5i-3-NEG | Apr 2022 |
| Negative control for CSN5i-3 (Cat. No. 7089) | ||
| 7498 | SPOP-i-6lc | Mar 2022 |
| SPOP E3 ubiquitin ligase inhibitor | ||
Glycogen Synthase Kinase 3 | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7650 | AZD 2858 | May 2022 |
| Highly potent GSK-3 inhibitor; inhibits tau phosphorylation | ||
PI 3-kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7631 | Idelalisib | Feb 2022 |
| Potent PI 3-Kinase δ isoform inhibitor | ||
5-HT Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 2395 | Sertraline hydrochloride | Mar 2022 |
| 5-HT reuptake inhibitor | ||
Histone Acetyltransferases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7584 | iP300v | Feb 2022 |
| Negative control for iP300w (Cat. No. 7270) | ||
Fluorescent Actin Probes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7201 | Phalloidin-Janelia Fluor® 646 | Mar 2022 |
| Red fluorescent F-actin probe | ||
Active Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7528 | BSJ-4-116 | Jul 2022 |
| Selective CDK12 PROTAC® Degrader | ||
| 7583 | SK 575 | May 2022 |
| Potent PARP1 Degrader (PROTAC®) | ||
| 7278 | α1A-AR Degrader 9c | May 2022 |
| Selective α1A adrenergic receptor Degrader (PROTAC®) | ||
| 7675 | SJ 1008030 | Jun 2022 |
| Selective JAK2 Degrader (PROTAC®) | ||
| 7682 | JQAD1 | Feb 2022 |
| Potent and selective EP300 Degrader | ||
| 7588 | SK 575-NEG | May 2022 |
| Negative control for SK 575 (Cat. No. 7583) | ||
| 7529 | BSJ-4-116-NC | Jul 2022 |
| Negative control for BSJ-4-116 (Cat. No. 7528). | ||
Protease-Activated Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7742 | TFRGAP-NH2 | Aug 2022 |
| PAR3 peptide agonist | ||
Cell Adhesion Molecules | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7723 | RGD peptide | May 2022 |
| Minimal recognition sequence for integrin binding; potent integrin inhibitor | ||
| 7692 | C26-A6 | Jul 2022 |
| Disrupts MTDH and SND1 interaction, enhances immune surveillance | ||
Poly(ADP-ribose) Polymerase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6795 | GeA-69 | Jul 2022 |
| Selective allosteric PARP14 inhibitor | ||
AMPK | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7685 | IND 1316 | Jul 2022 |
| AMPK activator | ||
Fluorescent Amyloid β Probes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7122 | Thioflavin T | Apr 2022 |
| Fluorescent amyloid stain, binds to the stacked β sheets of amyloid fibrils | ||
Amyloid β Peptides | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7712 | Semax | Jun 2022 |
| Reduces Aβ aggregation and fibrillogenesis; neuroprotective and neurotrophic peptide | ||
Ancillary Material Grade Small Molecules | ||
| Cat. No. | Product Name / Activity | Date Added |
| TB1285-RMU | Staurosporine | Mar 2022 |
| Staurosporine synthesized to Ancillary Material Grade | ||
| TB2939-RMU | A 83-01 | May 2022 |
| A 83-01 synthesized to Ancillary Material Grade | ||
| TB6666-RMU | T3 | May 2022 |
| T3 synthesized to Ancillary Material Grade | ||
| TB4439-RMU | ISX 9 | Mar 2022 |
| ISX 9 synthesized to Ancillary Material Grade | ||
Coronavirus Antivirals | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7554 | SSYA10-001 | Jul 2022 |
| Potent coronavirus helicase inhibitor; also inhibits human papillomavirus E6 | ||
Aptamer-based RNA Imaging | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7660 | TBI | Aug 2022 |
| Fluorogenic ligand for Broccoli RNA aptamer | ||
Fluorescent Probes for Imaging Bacteria | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7714 | EDA-DA | May 2022 |
| Unnatural dipeptide building block with alkyne group for functionalizing peptidoglycan | ||
Biochemicals and Molecular Biology | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7301 | NHS-LC-Biotin | Jul 2022 |
| Amine reactive biotinylation reagent, cell permeable | ||
| 7726 | DMSO, Cell Cryopreserve Grade | Apr 2022 |
| Intracellular cryoprotective agent | ||
| 7553 | Ac4ManNDAz | Apr 2022 |
| Photo-crosslinking probe for studying glycoproteins and glycolipids | ||
| 7506 | Click N-Acetylmuramic acid - azide | Jul 2022 |
| Bacterial peptidoglycan derivative; suitable for 'click'-conjugation to fluorescent dyes. | ||
| 7479 | Ac4ManNAz | Jul 2022 |
| Azide-containing monosaccharide building block; used as glycoprotein, glycolipid and glycoRNA probe | ||
LYTAC Building Blocks | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7635 | tri-GalNAc biotin | May 2022 |
| Biotinylated ASGPR ligand for LYTAC research and development | ||
β-catenin | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7580 | WIC1 | Jul 2022 |
| Inhibitor of Wnt/β-catenin signaling | ||
Fluorescent Lipid Probes and Cell Membrane Stains | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7538 | NBD-PE | Jul 2022 |
| Single tail (16:0) phospholipid derivative with a fluorophore (NBD) on the head | ||
Fluorescent Cell Indicators and Sensors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7641 | Mito-HE | May 2022 |
| Fluorescent mitochondrial superoxide indicator in live cells | ||
Cereblon Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7737 | Thalidomide 5'-amine-PEG3-amine | Jul 2022 |
| Cereblon ligand with PEG linker and terminal amine for onward chemistry | ||
| 7736 | Thalidomide 5'-amine-PEG2-amine | Jul 2022 |
| Cereblon ligand with PEG linker and terminal amine for onward chemistry | ||
| 7735 | Thalidomide 5'-amine-PEG1-amine | Jul 2022 |
| Cereblon ligand with PEG linker and terminal amine for onward chemistry | ||
| 7733 | Thalidomide 5'-amine-alkylC10-amine | Jun 2022 |
| Cereblon ligand with alkyl linker and terminal amine for onward chemistry | ||
| 7732 | Pomalidomide 4'-alkylC10-amine | Jul 2022 |
| Cereblon ligand with alkyl linker and terminal amine for onward chemistry | ||
| 7557 | Thalidomide 5'-amine-alkylC8-amine | May 2022 |
| Cereblon ligand with alkyl linker and terminal amine for onward chemistry | ||
Checkpoint Control Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7589 | Adavosertib | Feb 2022 |
| Potent and selective Wee1 inhibitor | ||
Tissue Clearing | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7565 | Tissue Clearing Pro-Organoid Reagent | Jul 2022 |
| 3D cell culture clearing reagent | ||
| 7564 | Tissue Clearing Pro Reagent 2 | Jul 2022 |
| Tissue clearing reagent | ||
| 7563 | Tissue Clearing Pro Reagent 1 | Jul 2022 |
| Tissue clearing reagent | ||
Cytokine Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7010 | EM 163 | Mar 2022 |
| TIR-TIR interaction inhibitor | ||
TAG Degradation Platform | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7531 | dTAG-47-NEG | May 2022 |
| Negative control for dTAG-47 (Cat. No. 7530) | ||
| 7687 | BromoTag® cis-AGB1 | Apr 2022 |
| Negative control for BromoTag® AGB1 (Cat.No. 7686) | ||
| 7686 | BromoTag® AGB1 | Apr 2022 |
| Potent and selective Degrader of Brd4BD2 L387A fusion proteins (BromoTag®) | ||
| 7530 | dTAG-47 | May 2022 |
| Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation | ||
| 7392 | 5-Ph-IAA | May 2022 |
| Selective and potent TAG Degrader for auxin-inducible degron 2 system | ||
Dihydrofolate Reductase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7362 | Phototrexate | Mar 2022 |
| Photoswitchable inhibitor of human dihydrofolate reductase | ||
Protein Dimerizers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7681 | Mandi | Jul 2022 |
| Highly efficient chemical inducer of proximity (CIP) | ||
Fluorescent DNA Stains | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7665 | 5-TAMRA NHS | Aug 2022 |
| Fluorescent amine-reactive DNA and RNA probe; also stains telomeres | ||
DNA Polymerase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7684 | Rilpivirine | May 2022 |
| Non-nucleoside reverse transcriptase inhibitor | ||
DNA, RNA and Protein Synthesis | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7679 | RECTAS | May 2022 |
| IKBKAP pre-mRNA splicing modulator | ||
| 7376 | 2A3 | Mar 2022 |
| Reagent for RNA SHAPE-MaP experiments in vivo; cell permeable | ||
| 7485 | Covidcil-19 | Apr 2022 |
| Binds to SARS-CoV-2 frameshifting element and reduces frameshifting efficiency | ||
| 7586 | Molnupiravir | Mar 2022 |
| Prodrug of antiviral nucleoside analog; inhibits SARS-CoV, SARS-CoV-2 and MERS-CoV infection | ||
EGFR | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7640 | Tucatinib | May 2022 |
| Potent and selective ErbB2 inhibitor | ||
| 6290 | WZ 4002 | Aug 2022 |
| Potent mutant-selective EGFR inhibitor | ||
Viral Transduction Enhancers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7711 | Polybrene | Jul 2022 |
| Viral transduction enhancer | ||
Other Fluorescent Probes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7446 | SCOTfluor 510, fluoro | May 2022 |
| Amine-reactive fluorescent probe precursor | ||
Functionalized Warhead Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7689 | (+)-JQ1 bump, acid functionalized | May 2022 |
| Functionalized BET bromodomain ligand; precursor for Tag Degraders | ||
Molecular Glues | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7720 | SJ 6986 | Jul 2022 |
| Molecular glue; induces degradation of GSPT1/2 | ||
GMP Small Molecules | ||
| Cat. No. | Product Name / Activity | Date Added |
| TB6053-GMP | LDN 193189 | Apr 2022 |
| LDN 193189 synthesized to cGMP guidelines | ||
Ras GTPases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7488 | MRTX 849 | Feb 2022 |
| Mutation-selective inhibitor of KRASG12C | ||
Non-selective HDACs | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7629 | Panobinostat | Jun 2022 |
| Pan-histone deacetylase inhibitor | ||
Hedgehog Signaling | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7710 | Vismodegib | Aug 2022 |
| Potent hedgehog pathway inhibitor | ||
HIV Protease | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7196 | Indinavir sulfate | Jun 2022 |
| Potent and selective HIV-1 and HIV-2 protease inhibitor | ||
Other Hydrolases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6923 | AMZ 30 | Jun 2022 |
| Potent, selective and irreversible protein phosphatase methylesterase-1 (PME-1) inhibitor | ||
| 7137 | Cambinol | May 2022 |
| nSMase2 inhibitor | ||
Insulin and Insulin-like Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7652 | Linsitinib | Apr 2022 |
| Potent and selective dual inhibitor of the IGF-1 receptor and insulin receptor | ||
Receptor Interacting Protein Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7339 | RIPA 56 | May 2022 |
| Potent and metabolically stable RIP1 kinase inhibitor | ||
Other Ion Pumps/Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6878 | BMS 466442 | May 2022 |
| Potent and selective inhibitor of asc-1 | ||
Other Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6604 | VER 246608 | May 2022 |
| Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 /4 inhibitor | ||
| 6529 | SGC AAK1 1N | May 2022 |
| Negative control for SGC AAK1 1 (Cat.No. 6528) | ||
| 7018 | CBR-470-1 | Feb 2022 |
| PGK1 inhibitior; activates Nrf2 | ||
VHL Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7215 | VH 032 amide-PEG4-acid | May 2022 |
| VHL ligand with PEG linker and terminal acid for onward chemistry | ||
Other Lipid Metabolism | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7492 | Lomitapide mesylate | May 2022 |
| Potent microsomal triglyceride transfer protein (MTP) inhibitor | ||
MEK | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7709 | Trametinib | Jul 2022 |
| Potent and selective MEK inhibitor; orally bioavailable | ||
Melatonin Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7493 | Tasimelteon | Aug 2022 |
| Selective dual melatonin receptor (MT1/MT2) agonist | ||
Monocarboxylate Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7512 | 3-Bromopyruvate | Apr 2022 |
| MCT1 inhibitor; also inhibits hexokinase II | ||
Other Nuclear Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7494 | CIA 1 | Apr 2022 |
| COUP-TFII inhibitor | ||
Other Proteases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7659 | Verubecestat | Apr 2022 |
| BACE1 and BACE2 inhibitor | ||
Other RTKs | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7696 | Selpercatinib | May 2022 |
| Potent and selective RET inhibitor | ||
| 7590 | Pexidartinib | Apr 2022 |
| Potent CSF-1R inhibitor | ||
Proteasome | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6781 | Capzimin dimer | Jul 2022 |
| Selective proteasome inhibitor | ||
RAGE | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7701 | RAGE 229 | Jun 2022 |
| ctRAGE-DIAPH1 interaction antagonist; reduces inflammatory signaling in diabetic mice | ||