New ProductsView all New Products by pharmacological action
Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.
Labels & Stains | ||
| Cat. No. | Product Name / Activity | Date Added |
|---|---|---|
| 7555 | SenTraGor™ | Mar 2023 |
| Reagent for staining and detection of lipofuscin in senescent cells | ||
Cyanine Dyes (Cy Dyes) | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7626 | NIR Dye s775z, NHS | Dec 2022 |
| Bright and photostable non-aggregating near-IR cyanine dye. Reactive group: NHS ester | ||
Estrogen (GPER) Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7812 | CIMBA hydrochloride | Jan 2023 |
| Potent and selective G protein-coupled estrogen receptor (GPER) antagonist | ||
| 7811 | CITFA | Jan 2023 |
| Potent G protein-coupled estrogen receptor (GPER) agonist | ||
Isocitrate Dehydrogenase 1 (IDH1) | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7761 | Ivosidenib | Jan 2023 |
| Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1) | ||
Near Infrared (NIR) Fluorescent Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7749 | ICG-d7 | Feb 2023 |
| Near-infrared fluorescent dye; partially deuterated form of Indocyanine Green (Cat. No. 7510) | ||
Purinergic (P2X) Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7573 | BAY 1797 | Jan 2023 |
| Selective P2X4 antagonist | ||
Akt (Protein Kinase B) | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7850 | MK 2206 dihydrochloride | Feb 2023 |
| Potent and selective allosteric Akt1, Akt2 and Akt3 inhibitor | ||
Unnatural Amino Acids / Non Canonical Amino Acids | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7936 | Ac-Cys-NHMe | Mar 2023 |
| Building block for the lysine acylation using conjugating enzymes (LACE) technique | ||
Functionalized E3 Ligase Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7861 | VH 032, thiol | Feb 2023 |
| Functionalized VHL ligand for PROTAC® development | ||
| 7859 | PD 4'-piperazine | Feb 2023 |
| Stable cereblon ligand, for PROTAC synthesis | ||
| 7858 | PD 4'-oxyacetic acid | Jan 2023 |
| Functionalized cereblon ligand for PROTAC development | ||
3C and 3CL Proteases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7853 | Mpro 13b-H | Dec 2022 |
| Negative control for Mpro 13b-K (Cat. No. 7228) | ||
Functionalized E3 Ligase Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7634 | Me VH 032, amine | Feb 2023 |
| Amine functionalized VHL ligand for PROTAC® research | ||
Adenosine A3 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7628 | DPTN | Jan 2023 |
| Potent and selective A3 adenosine receptor antagonist | ||
Functionalized E3 Ligase Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7884 | VH 101, thiol | Mar 2023 |
| Thiol functionalized VHL ligand | ||
| 7759 | UNC 1215, acid | Dec 2022 |
| Functionalized L3MBTL3 ligand for PROTACs | ||
Ubiquitin E3 Ligases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7715 | C25-140 | Jan 2023 |
| TRAF6-Ubc13 interaction inhibitor | ||
PI 3-kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7902 | PIK 90 | Mar 2023 |
| Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation | ||
5-HT Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7898 | ZZL 7 | Mar 2023 |
| Inhibitor of the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS) | ||
| 7841 | Imipramine hydrochloride | Jan 2023 |
| Potent inhibitor of 5-HT and noradrenalin transporters; promotes immunostimulatory tumor microenvironment | ||
Active Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7721 | SJ 11646 | May 2023 |
| Potent and selective LCK Degrader (PROTAC®) | ||
| 7842 | NAMPT PROTAC® A7 | Mar 2023 |
| Potent and selective nicotinamide phosphoribosyl transferase (NAMPT) Degrader (PROTAC®) | ||
| 7818 | GSK 215 | May 2023 |
| Potent and selective focal adhesion kinase (FAK) degrader | ||
| 7813 | LL-K9-3 | May 2023 |
| Selective HyT-based degrader of the CDK9-cyclin T1 complex | ||
| 7837 | JB 300 | Mar 2023 |
| Aurora A Degrader (PROTAC®) | ||
| 7699 | AUTAC4 | Apr 2023 |
| Mitochondrial targeting AUTAC Degrader | ||
Focal Adhesion Kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7786 | GSK 2256098 | Mar 2023 |
| Potent focal adhesion kinase (FAK) inhibitor | ||
Ancillary Material Grade Small Molecules | ||
| Cat. No. | Product Name / Activity | Date Added |
| TB1496-RMU | SP 600125 | Mar 2023 |
| SP 600125 synthesized to Ancillary Material Grade | ||
Antioxidants | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7874 | N-Acetylcysteine | Jan 2023 |
| Glutathione (GSH) precursor; maintains stem cell function in culture. | ||
NF-κB and IκB | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7136 | NIKi | Mar 2023 |
| Potent NIK inhibitor | ||
Fluorescent Probes for Imaging Bacteria | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7860 | sBADA | Dec 2022 |
| Green fluorescent D-amino acid for labeling peptidoglycans in bacteria | ||
| 7449 | Se-NADA | Jan 2023 |
| Orange fluorescent benzoselenadiazole D-amino acid (FDAA) for imaging bacteria; also photosensitizer | ||
Biochemicals and Molecular Biology | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7854 | PEI STAR™ transfection reagent | Dec 2022 |
| Polyethylenimine (PEI) transfection reagent, chemically-defined | ||
| 7863 | THPTA | May 2023 |
| Click chemistry auxiliary reagent; accelerating ligand for copper-catalyzed azide-alkyne cycloaddition reaction | ||
| 7862 | TBTA | Mar 2023 |
| Click chemistry auxiliary reagent; stabilizing ligand for copper-catalyzed azide-alkyne cycloaddition reaction | ||
| 7833 | preQ1-azide | Apr 2023 |
| preQ1 with azide handle for click chemistry | ||
| 7804 | preQ1-biotin | Dec 2022 |
| PreQ1 with biotin handle for RNA labeling and purification | ||
| 7768 | Disulfide biotin azide | Jan 2023 |
| Azide-activated biotinylation reagent; labels alkyne moieties via copper-catalyzed click chemistry | ||
| 7368 | Cell Counting Kit-8 | Mar 2023 |
| Cell viability and proliferation assay test solution | ||
| 7480 | DBCO PEG4 Biotin | Jan 2023 |
| Biotinylation reagent for labeling azide-containing biomolecules via Cu(I)-free click chemistry | ||
| 7176 | DC-Cholesterol hydrochloride | Mar 2023 |
| Liposomal transfection reagent | ||
| 7524 | Biotin-PEG3-Azide | May 2023 |
| Biotin with PEG linker and reactive click handle | ||
LYTAC Building Blocks | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7781 | tri-GalNAc-C5-amine | Jan 2023 |
| Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry | ||
| 7780 | β-GalNAc-PEG4-Azide | Feb 2023 |
| Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry | ||
Bromodomains | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7757 | AZ 13824374 | Feb 2023 |
| Potent and selective ATAD2 bromodomain inhibitor | ||
| 7645 | FHT 2344 | Mar 2023 |
| Potent SMARCA2/4 inhibitor | ||
| 7644 | FHT 1015 | Mar 2023 |
| Potent and selective SMARCA4/2 inhibitor | ||
Protein Kinase C | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7962 | TAT-SAMβA Peptide | May 2023 |
| Selective antagonist of Mfn1-βIIPKC association | ||
CaM Kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7572 | NR 162 | Feb 2023 |
| Potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor | ||
Cathepsin | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7130 | AZD 5248 | Jan 2023 |
| Potent cathepsin C inhibitor | ||
Stem Cell Proliferation | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7791 | WS 6 | Apr 2023 |
| Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons | ||
Fluorescent Cell Indicators and Sensors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7756 | DAF FM diacetate | Nov 2022 |
| Cell permeable photostable nitric oxide (NO) fluorescent indicator | ||
Cereblon Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7677 | Lenalidomide 5'-amine | Dec 2022 |
| Cereblon ligand with terminal amine for onward chemistry | ||
Tocriscreen™ Compound Libraries | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7844 | Tocriscreen Kinase Inhibitor 3.0 | Nov 2022 |
| A bioactive compound library of 210 kinase inhibitors (100 μL 10 mM DMSO solutions) for high-throughput screening, high-content screening and chemical biology applications | ||
CRISPR Reagents | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7806 | preQ1-alkyne | Dec 2022 |
| preQ1 with alkyne handle for click chemistry | ||
TAG Degradation Platform | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7892 | dTAG-Fluorescein | Apr 2023 |
| Fluorescent probe for labeling mutant FKBP12F36V proteins | ||
| 7893 | 5-Ph-IAA-AM | Mar 2023 |
| Selective and potent TAG Degrader for auxin-inducible degron 2 system; 5-Ph-IAA analog | ||
| 7883 | dTAG-Biotin | Mar 2023 |
| Affinity probe for mutant FKBP12F36V proteins | ||
Other Dehydrogenases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7561 | G6PDi 1 | Feb 2023 |
| Potent, reversible glucose-6-phosphate dehydrogenase (G6PD) inhibitor | ||
DNA-Dependent Protein Kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7825 | AZD 7648 | Jan 2023 |
| Potent and selective DNA-PK inhibitor | ||
DNA, RNA and Protein Synthesis | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7974 | P3S | May 2023 |
| Reagent for modifying RNA at 2'-OH position, for SHAPE-MAP experiments | ||
| 7760 | Selinexor | Jan 2023 |
| Selective exportin 1 (XPO1/CRM1) inhibitor | ||
DREADD Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7926 | MOMBA | May 2023 |
| Selective orthostatic agonist of hFFA2-DREADDs | ||
Estrogen and Related Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7690 | T 112 | Dec 2022 |
| Estrogen-related receptor γ agonist; promotes maturation of hiPSC-derived cardiomyocytes | ||
FGFR | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7823 | AZD 4547 | Feb 2023 |
| Potent and selective FGFR inhibitor | ||
Other Fluorescent Probes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7181 | Caffeine Orange | Jan 2023 |
| Selective, BODIPY-based fluorescent caffeine chemosensor | ||
Functionalized Warhead Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7576 | (+)-JQ1 maleimide | May 2023 |
| JQ1-maleimide functionalized probe; induces proteasomal degradation of BRD4 | ||
Receptor Interacting Protein Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6603 | RIPK2 inhibitor 1 | Jan 2023 |
| Potent RIPK2 inhibitor | ||
Other Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6617 | LYN 1604 dihydrochloride | Jan 2023 |
| Potent UNC-51-like kinase 1 (ULK1) agonist | ||
| 7809 | TEPP 46 | Apr 2023 |
| Potent and selective pyruvate kinase M2 (PKM2) allosteric activator | ||
| 7511 | ARN 3236 | May 2023 |
| Potent inhibitor of salt-inducible kinases | ||
VHL Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7867 | VH 032 amide-alkylC5-azide | Feb 2023 |
| VHL ligand with alkylC5 linker and terminal azide for onward chemistry | ||
Other Lyases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7577 | 3-Mercaptopicolinic acid hydrochloride | Jan 2023 |
| Phospoenolpyruvate carboxykinase (PEPCK) inhibitor; inhibits gluconeogenesis | ||
Other Lysine Methyltransferases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7183 | UNC 6934 | Jan 2023 |
| Antagonizes PWWP1 interaction with nucleosomal H3K36me2, alters NSD2 nucleolar localization | ||
| 7762 | EED 226 | Jan 2023 |
| Potent and selective EED inhibitor | ||
mTOR | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7840 | AZD 8055 | Feb 2023 |
| Highly potent and selective mTOR inhibitor | ||
Other MAPK | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7637 | GSK 329 | Mar 2023 |
| Potent and selective TNNI3K inhibitor, orally bioavailable | ||
| 6984 | KIN001-266 | Dec 2022 |
| Potent and selective Tpl2 (MAP3K8) inhibitor | ||
Other Reductases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7821 | ML 162 | Feb 2023 |
| Inhibits glutathione peroxidase (GPX4); induces ferroptosis | ||
Protein Tyrosine Phosphatases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7481 | BCI | May 2023 |
| DUSP6 and DUSP1 inhibitor | ||
Smoothened Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7807 | Hh-Ag1.5 | Feb 2023 |
| Potent and high affinity Smo receptor agonist | ||
| 7826 | Sonidegib | Feb 2023 |
| Potent Smoothened receptor antagonist | ||