Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.
Hypoxia Inducible Factors (HIF) | ||
| Cat. No. | Product Name / Activity | Date Added |
|---|---|---|
| 6653 | FM19G11 | Feb 2019 |
| HIF α-subunit inhibitor | ||
Inward Rectifier Potassium (Kir) Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6877 | VU 0134992 | Jul 2019 |
| Kir4.1 blocker | ||
Melanocortin (MC) Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6926 | Fenoprofen calcium | May 2019 |
| Positive allosteric modulator of MC3 receptors; exhibits biased signaling | ||
Purinergic (P2X) Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6493 | A 317491 sodium salt | May 2019 |
| Selective, high affinity P2X3 and P2X2/3 receptor antagonist; antinociceptive | ||
Purinergic (P2Y) Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6864 | Ticagrelor | Apr 2019 |
| High affinity and reversible P2Y12 antagonist; displays inverse agonism in vitro; also inhibits ENT1 | ||
Akt (Protein Kinase B) | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6762 | Urolithin A | Apr 2019 |
| PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro | ||
CaV3.x Channels (T-type) | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6770 | ABT 639 | Mar 2019 |
| CaV3.2 and CaV3.1 channel blocker; orally bioavailable | ||
M1 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6872 | BQCA | May 2019 |
| Positive allosteric modulator of M1 receptors | ||
Sphingosine-1-Phosphate Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6690 | Ceralifimod | May 2019 |
| Highly potent and selective S1P1 and S1P5 agonist | ||
CB1 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6763 | AVE 1625 | Apr 2019 |
| Potent and selective CB1 receptor antagonist | ||
CRF1 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6451 | Pexacerfont | Apr 2019 |
| Potent and selective CRF1 antagonist; anxiolytic | ||
Glucagon-Like Peptide 1 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6355 | VU 0650991 | Apr 2019 |
| Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant | ||
CB2 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6832 | Ec2la | May 2019 |
| Positive allosteric modulator of CB2 receptors; active in vivo | ||
Bcl-2 Family | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6835 | ABT 737 | May 2019 |
| Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines | ||
Adenosine A2B Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6787 | KI-7 | Mar 2019 |
| Positive allosteric modulator of A2B receptors | ||
σ2 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6740 | Siramesine hydrochloride | Apr 2019 |
| High affinity σ agonist (σ2 > σ1) | ||
Cdc2-like Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6644 | KuWal151 | Jan 2019 |
| Potent and selective CLK inhibitor | ||
Bcl-2 Family | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6960 | ABT 199 | Jul 2019 |
| Selective, high affinity Bcl-2 inhibitor; orally bioavailable | ||
EZH2 | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6790 | GSK 126 | Jul 2019 |
| Very high affinity and selective EZH2 inhibitor | ||
| 6708 | SAH-EZH2 | May 2019 |
| EZH2/EDD interaction inhibitor; suppresses PCR2 complex function | ||
P21-activated Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6490 | GNE 2861 | Mar 2019 |
| Group II PAK inhibitor; potently inhibits PAK4 and PAK 6 | ||
Functionalized E3 Ligase Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6969 | cis VH 032, amine dihydrochloride | Jul 2019 |
| Negative control for VH 032, amine (Cat. No. 6462) | ||
Glycogen Synthase Kinase 3 | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6695 | CHIR 98014 | Feb 2019 |
| Highly potent and selective GSK-3 inhibitor | ||
PI 3-kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6792 | Omipalisib | May 2019 |
| Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK | ||
Histamine H3 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6778 | S 38093 | May 2019 |
| Selective H3 antagonist and inverse agonist; antinociceptive | ||
Ubiquitin E3 Ligases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6782 | Indisulam | May 2019 |
| Molecular glue; pre-mRNA splicing modulator | ||
5-HT6 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6748 | PRX 07034 | Apr 2019 |
| Potent and selective 5-HT6 antagonist | ||
GPR55 | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6668 | ML 184 | Jan 2019 |
| Selective GPR55 agonist; also promotes NSC proliferation and differentiation | ||
Orphan 7-TM Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6784 | FTBMT | Mar 2019 |
| Potent and selective GPR52 agonist; orally bioavailable and BBB permeable | ||
A-Kinase-Anchoring Proteins | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6567 | RI-STAD 2 | Feb 2019 |
| AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable | ||
| 6566 | STAD 2 | Feb 2019 |
| AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable | ||
Histone Acetyltransferases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6692 | WM 1119 | Mar 2019 |
| High affinity KAT6A (MOZ) competitive inhibitor | ||
Fatty Acid Synthase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6702 | Cerulenin | Feb 2019 |
| Irreversible fatty acid synthase inhibitor | ||
Acid-Sensing Ion Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6705 | Diminazene aceturate | Feb 2019 |
| ASIC blocker; antihyperalgesic | ||
Active Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6948 | CRBN-6-5-5-VHL | Jun 2019 |
| Potent and selective cereblon degrader; cell-permeable | ||
Protease-Activated Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6806 | AZ 3451 | Apr 2019 |
| Potent negative allosteric modulator of PAR2 | ||
Active Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6713 | ZXH 3-26 | Jun 2019 |
| Potent and selective BRD4 degrader | ||
| 6605 | dTAG-13 | Mar 2019 |
| Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation | ||
| 6746 | TL 13-110 | Apr 2019 |
| Negative control for TL 13-112 | ||
| 6745 | TL 13-112 | Apr 2019 |
| Selective ALK Degrader | ||
| 6747 | TL 13-22 | Apr 2019 |
| Negative control for TL 13-12 | ||
| 6744 | TL 13-12 | Apr 2019 |
| Selective ALK degrader | ||
BMP and Other Activin Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6881 | SB 4 | May 2019 |
| Potent BMP4 agonist | ||
Focal Adhesion Kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6891 | PND 1186 | May 2019 |
| Potent FAK inhibitor; orally bioavailable | ||
Cell Adhesion Molecules | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6634 | Surfen | Apr 2019 |
| Heparin sulfate antagonist | ||
Poly(ADP-ribose) Polymerase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6228 | H10 | Jul 2019 |
| PARP14 inhibitor; cell-permeable | ||
Aldehyde Dehydrogenases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6934 | 673 A | Jun 2019 |
| ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC) | ||
ALK | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6905 | Ceritinib | Jun 2019 |
| Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3 | ||
Antimalarials | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6818 | Artemether | Mar 2019 |
| Antimalarial; also inhibits neuroinflammation | ||
Inhibitor of Apoptosis | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6470 | A 410099.1 | Feb 2019 |
| High affinity XIAP antagonist; active in vivo | ||
Fluorescent Probes for Imaging Bacteria | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6802 | 6 TMR Tre | Feb 2019 |
| Fluorescent trehalose; selectively labels mycobacterial cell envelope | ||
| 6659 | sBADA | Feb 2019 |
| Green fluorescent D-amino acid for labeling peptidoglycans in bacteria | ||
Biochemicals and Molecular Biology | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6798 | Click N-Acetylmuramic acid - alkyne | Feb 2019 |
| Bacterial peptidoglycan derivative; suitable for 'click'-conjugation to fluorescent dyes | ||
Bromodomains | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6521 | I-BET 762 | Jun 2019 |
| Potent and high affinity BRD inhibitor; anti-inflammatory; orally bioavailable. | ||
Bruton's Tyrosine Kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6813 | Ibrutinib | Apr 2019 |
| Potent and selective BTK inhibitor | ||
Caged Nicotinic Compounds | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6706 | DPNB-ABT 594 | Mar 2019 |
| Caged ABT 594; suitable for one- or two-photon photolysis | ||
Cancer Stem Cells | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6856 | α-Mangostin | Apr 2019 |
| Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines | ||
| 6840 | AD 01 | May 2019 |
| FKBPL (FK506-binding protein like)-based peptide; inhibits breast cancer stem cell self-renewal; also antiangiogenic | ||
Organelle and Cell Structure Stains | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6266 | Taxol Janelia Fluor® 646 | Feb 2019 |
| Red fluorescent taxol derivative | ||
Stem Cell Proliferation | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6719 | YH 239-EE | Feb 2019 |
| Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity | ||
Cereblon Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6850 | Thalidomide - linker 6 | Mar 2019 |
| Thalidomide-alkylC2-Amine | ||
| 6851 | Pomalidomide - linker 7 | Mar 2019 |
| Pomalidomide-alkylC2-amine | ||
| 6968 | Thalidomide - linker 15 | Jun 2019 |
| Thalidomide-alkylC6-amine | ||
| 6966 | Thalidomide - linker 13 | Jun 2019 |
| Thalidomide-PEG1-ethylamine | ||
| 6951 | Thalidomide - linker 12 | May 2019 |
| Thalidomide-PEG5-ethylamine | ||
| 6716 | Pomalidomide - linker 4 | Jun 2019 |
| Pomalidomide-alkylC5-amine | ||
| 6967 | Thalidomide - linker 14 | Jun 2019 |
| Thalidomide-PEG2-ethylamine | ||
| 6963 | Pomalidomide - linker 8 | Jun 2019 |
| Pomalidomide-PEG4-ethylamine | ||
| 6949 | Thalidomide - linker 10 | May 2019 |
| Thalidomide-alkylC2-amine | ||
| 6917 | Thalidomide - linker 9 | Jun 2019 |
| Thalidomide-alkylC4-amine | ||
Two-P Potassium Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6887 | ML 335 | Jun 2019 |
| Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator | ||
Gap Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6819 | Mefloquine hydrochloride | Mar 2019 |
| Cx36 and Cx50 gap channel blocker; also antimalarial and antischistosomal | ||
Chemokine CXC Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6957 | Reparixin L-lysine salt | Jun 2019 |
| Potent CXCR1 and CXCR2 allosteric antagonist | ||
Other Chemokine Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6378 | JMS 17-2 hydrochloride | Apr 2019 |
| CX3CR1 antagonist | ||
Class I HDACs | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6728 | RGFP 966 | Mar 2019 |
| Potent and selective HDAC3 inhibitor | ||
Tocriscreen Compound Libraries | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6801 | Tocriscreen Epigenetics Library | Jul 2019 |
| A library of 101 epigenetic compounds (250 μL, 10 mM DMSO solutions) | ||
Photoactivatable Cross-linking Probes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6786 | BzF | Feb 2019 |
| Photoreactive unnatural amino acid; photo-crosslinker | ||
Cyclin-Dependent Protein Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6535 | NVP 2 | Feb 2019 |
| Potent and selective ATP-competitive CDK9 inhibitor | ||
| 6752 | LDC 000067 | Mar 2019 |
| Potent and selective CDK9 inhibitor | ||
Deaminases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6868 | 8-Azaadenosine | May 2019 |
| ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal | ||
Histone Demethylases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6935 | GSK J5 HCl | May 2019 |
| Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable | ||
Protein Dimerizers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6834 | Auxin | Mar 2019 |
| Chemical dimerizer used in auxin-inducible degron (AID) system; phytohormone | ||
Dipeptidyl Peptidase IV | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6816 | Sitagliptin phosphate | Feb 2019 |
| Potent and selective DPP IV inhibitor | ||
| 3719 | Talabostat mesylate | Feb 2019 |
| Potent DPP IV inhibitor; activates NLRP1b inflammasome | ||
DNA, RNA and Protein Synthesis | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6884 | TC SL C5 | Jul 2019 |
| Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor | ||
TFAX Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6621 | TFAX 488, TFP | Jan 2019 |
| Green fluorescent dye; amine reactive | ||
Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6500 | Janelia Fluor® 549, Maleimide | Jul 2019 |
| Cell permeable yellow fluorescent dye; supplied with a maleimide reactive group | ||
Other Fluorescent Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6489 | Ocean Blue, SE | Jun 2019 |
| Blue fluorescent dye; supplied as NHS ester | ||
Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6502 | Janelia Fluor® 549, Tetrazine | Apr 2019 |
| Cell permeable yellow fluorescent dye; supplied as a tetrazine for 'click' chemistry | ||
EGFR | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6812 | Afatinib dimaleate | Mar 2019 |
| Potent dual specificity EGFR/HER2 inhibitor; active in vivo | ||
| 6811 | Lapatinib | Apr 2019 |
| Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor | ||
Other ER Stress/UPR | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6759 | AA 147 | Feb 2019 |
| ER proteostasis regulator | ||
Other Transcription Factors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6845 | RCM 1 | May 2019 |
| FOXM1 inhibitor | ||
Fluorescent Substrates | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6882 | DiFMUP | May 2019 |
| Fluorescent phosphatase substrate | ||
Other Fluorescent Probes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6434 | DFHO | Apr 2019 |
| Mimic of RFP fluorophore for imaging RNA in living cells | ||
Fluorescent Substrates | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6717 | FFN 270 | May 2019 |
| Fluorescent substrate for NET and VMAT2 | ||
Glutaminase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6809 | L-DON | Feb 2019 |
| Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters | ||
Glycosylases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6749 | TH 5487 | Apr 2019 |
| Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor | ||
Other Small Monomeric GTPases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6575 | StRIP16 | Apr 2019 |
| Rab8a GTPase-binding stapled peptide | ||
Ras GTPases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6429 | ML 210 | Mar 2019 |
| Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis | ||
Other Hydrolases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6903 | DPTIP | Jul 2019 |
| Potent and selective N-SMase2 inhibitor; brain penetrant | ||
| 6510 | LNT 1 | Apr 2019 |
| Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response | ||
| 5862 | ARN 14686 | Apr 2019 |
| Potent N-acylethanolamine acid amidase inhibitor; NAAA activity-based protein profiling (ABPP) probe | ||
Inflammasomes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6827 | Artesunate | Mar 2019 |
| Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial | ||
Integrins | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6908 | TR 14035 | Jul 2019 |
| Potent integrin α4β7 and α4β1 antagonist; orally bioavailable | ||
| 6785 | E 7820 | Apr 2019 |
| α2 integrin inhibitor; anti-angiogenic | ||
Other Ion Pumps/Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6518 | BI 01383298 | Feb 2019 |
| Potent and selective SLC13A5 (Na+/citrate cotransporter) inhibitor | ||
| 5026 | KYT 0353 | May 2019 |
| Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo | ||
JAK Kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6577 | Pyridone 6 | Feb 2019 |
| Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable | ||
Raf Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6814 | Sorafenib | Apr 2019 |
| Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT | ||
Other Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6246 | BF 738735 | Apr 2019 |
| Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor | ||
Raf Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6854 | LY 3009120 | Jun 2019 |
| Potent pan-Raf kinase inhibitor | ||
Src Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6793 | Dasatinib | Feb 2019 |
| Highly potent pan-Src/Bcr-Abl inhibitor | ||
Syk Kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6362 | GSK 143 | May 2019 |
| Syk inhibitor | ||
Kinesin | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6664 | Kinesore | Mar 2019 |
| Kinesin-1 modulator; cell permeable | ||
| 6837 | GSK 923295A | May 2019 |
| Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor | ||
VHL Targeting Ligands Plus Linkers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6879 | VH 032 - linker 9 | Apr 2019 |
| VH 032-PEG1-amine | ||
| 6909 | VH 032 phenol - linker 1 | Jul 2019 |
| VH 032 phenol-alkylC4-amine | ||
| 6890 | VH 032 - linker 11 | Apr 2019 |
| VH 032-AlkylC8-Amine | ||
| 6853 | VH 032 - linker 8 | Apr 2019 |
| VH 032-alkylC6-amine | ||
| 6679 | VH 032 - linker 4 | Apr 2019 |
| VH 032-PEG3-CH2CH2COOH | ||
| 6910 | VH 032 phenol - linker 2 | Jul 2019 |
| VH 032 phenol-alkylC6-amine | ||
| 6907 | VH 032 - linker 12 | Apr 2019 |
| VH 032-PEG2-amine | ||
| 6880 | VH 032 - linker 10 | Apr 2019 |
| VH 032-alkylC10-amine | ||
| 6852 | VH 032 - linker 7 | Apr 2019 |
| VH 032-alkylC2-amine | ||
Lipoxygenases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 1304 | BW-B 70C | Mar 2019 |
| 5-Lipoxygenase inhibitor | ||
Other Lysine Methyltransferases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6561 | BAY 6035 | Jun 2019 |
| Potent and selective SMYD3 inhibitor | ||
| 6665 | BI 9321 | May 2019 |
| Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain | ||
Matrix Metalloproteases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6439 | JNJ 0966 | Mar 2019 |
| Pro-MMP9 activation inhibitor | ||
MEK | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6815 | Selumetinib | May 2019 |
| Potent and selective MEK inhibitor; orally bioavailable | ||
Monocarboxylate Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6817 | BAY 8002 | May 2019 |
| Potent dual MCT1/2 inhibitor; orally bioavailable | ||
Multidrug Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6885 | PU 23 | May 2019 |
| Multidrug resistance protein (MRP) 4 inhibitor | ||
NAMPT | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6753 | CHS 828 | Mar 2019 |
| NAMPT inhibitor; active in vivo and cytotoxic | ||
Natriuretic Peptide Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6715 | A 71915 | Jan 2019 |
| Highly potent and competitive NPRA antagonist | ||
Other Oxygenases/Oxidases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6867 | Rhein | Apr 2019 |
| FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3 | ||
Other Proteases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6272 | KYP 2047 | Mar 2019 |
| High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant | ||
Other Reductases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6597 | SPRi 3 | Feb 2019 |
| Potent sepiapterin reductase (SPR) inhibitor; attenuates proliferation of CD4+ T cells | ||
Oxidative Phosphorylation | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6898 | Mitochondrial fusion promoter M1 | May 2019 |
| Mitochondrial fusion promoter | ||
Protein Tyrosine Phosphatases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6829 | (R)-Shikonin | May 2019 |
| PTEN inhibitor; induces necroptosis; anti-inflammatory | ||
| 6771 | PHPS1 sodium salt | May 2019 |
| Shp2 (PTPN11) inhibitor | ||
Protein Ser/Thr Phosphatases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6760 | Raphin 1 | Mar 2019 |
| Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant | ||
Phosphodiesterases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6313 | A 33 | May 2019 |
| Potent and selective PDE4B inhibitor | ||
Phospholipases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6755 | Darapladib | Mar 2019 |
| Potent lp-PLA2 inhibitor | ||
Prion Protein | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6861 | Anle138b | May 2019 |
| Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation | ||
PSEMs | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6865 | uPSEM 792 hydrochloride | Apr 2019 |
| Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant | ||
| 6866 | uPSEM 817 tartrate | Mar 2019 |
| Highly potent and selective uPSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant | ||
Vasopressin Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6830 | Conivaptan hydrochloride | Mar 2019 |
| Very high affinity vasopressin V1A and V2 antagonist; orally bioavailable | ||
TGF-β Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6245 | SM 16 | Jan 2019 |
| Potent TGF-βRI inhibitor; orally bioavailable | ||
| 6956 | Galunisertib | Jun 2019 |
| ALK4 and ALK5 (TGFβRI) inhibitor | ||
RSK | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6754 | LJI308 | Mar 2019 |
| Potent pan-RSK inhibitor | ||
TRPC | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6766 | AC 1903 | Mar 2019 |
| Selective TRPC5 blocker | ||
| 6495 | AM 12 | May 2019 |
| TRPC5 inhibitor | ||
TRPM | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6874 | AMG 333 | Jul 2019 |
| Potent and selective TRPM8 antagonist; active in vivo | ||
| 6724 | CBA | Feb 2019 |
| Selective TRPM4 blocker | ||
TRPV | ||
| Cat. No. | Product Name / Activity | Date Added |
| 6433 | GSK 1016790A | May 2019 |
| Potent TRPV4 agonist; active in vivo | ||