New Products

View all New Products by pharmacological action

Search for new products by date added, alphabetically, or by pharmacological action.

New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

Calcium-Activated Potassium (KCa) Channels

Cat. No. Product Name / Activity Date Added
5814 GoSlo SR 5-69 Apr 2020
BK channel activator
6398 SKA 121 Jan 2020
Positive allosteric modulator of KCa3.1 channels

Glutamate (Metabotropic) Group II Receptors

Cat. No. Product Name / Activity Date Added
6928 VU 6001966 Feb 2020
Potent and selective negative allosteric modulator of mGlu2 receptors

Akt (Protein Kinase B)

Cat. No. Product Name / Activity Date Added
7001 AT 7867 Jun 2020
Potent pan-Akt and PKA inhibitor

CB1 Receptors

Cat. No. Product Name / Activity Date Added
5746 NESS 0327 Feb 2020
Ultra-high affinity and selective CB1 antagonist

Trace Amine 1 Receptor

Cat. No. Product Name / Activity Date Added
6833 RO 5263397 hydrochloride Feb 2020
Potent TA1 receptor agonist

5-HT2C Receptors

Cat. No. Product Name / Activity Date Added
5755 PF 04479745 Apr 2020
Potent and selective 5-HT2C agonist

K+/Cl- Cotransporter 2

Cat. No. Product Name / Activity Date Added
6758 CLP 290 Mar 2020
K+/Cl- cotransporter 2 (KCC2) activator; orally bioavailable prodrug of CLP 257 (Cat. No.5242)

OX2 Receptors

Cat. No. Product Name / Activity Date Added
6739 YNT 185 Mar 2020
Potent and selective OX2 agonist

CB2 Receptors

Cat. No. Product Name / Activity Date Added
6220 PM 226 Jan 2020
Potent and selective CB2 receptor agonist; BBB permeable; neuroprotective

M2 Receptors

Cat. No. Product Name / Activity Date Added
6964 LY 2119620 Jan 2020
Positive allosteric modulator of M2 and M4 receptors

ACE2

Cat. No. Product Name / Activity Date Added
7232 SBP1-FITC Jun 2020
Fluorescent ACE2-derived peptide; binds receptor binding domain of SARS-CoV-2 spike protein
7233 SBP1 May 2020
ACE2 derived peptide; binds SARS-CoV-2 spike protein receptor binding domain

5-HT3 Receptors

Cat. No. Product Name / Activity Date Added
7038 Palonosetron hydrochloride Feb 2020
Highly potent and high affinity 5-HT3 antagonist

D3 Receptors

Cat. No. Product Name / Activity Date Added
7039 SK 609 Feb 2020
Dopamine D3 receptor biased agonist

Functionalized E3 Ligase Ligands

Cat. No. Product Name / Activity Date Added
6952 VH 101, phenol Jan 2020
Hydroxyl functionalized VHL ligand
6911 VH 032, phenol Mar 2020
Hydroxyl functionalized VHL ligand

Free Acid Janelia Fluor® Dyes

Cat. No. Product Name / Activity Date Added
6993 Janelia Fluor® 646, free acid Feb 2020
Red dye (Reactive group: free acid). Applications: super resolution microscopy e.g. dSTORM & STED, confocal, flow and live cell imaging

Free Fatty Acid Receptors

Cat. No. Product Name / Activity Date Added
6826 AZ 1729 Mar 2020
FFA2 allosteric agonist; displays bias for the Gi signaling pathway

Retinoic Acid Receptors

Cat. No. Product Name / Activity Date Added
6873 DC 271 Jul 2020
Fluorescent retinoic acid analog; solvochromatic probe

Free Fatty Acid Receptors

Cat. No. Product Name / Activity Date Added
7082 DL 175 Apr 2020
Potent and selective GPR84 agonist

Active Degraders

Cat. No. Product Name / Activity Date Added
6945 dBET6 Jun 2020
Potent and selective (+)-JQ1 based PROTAC targeting BET bromodomains, active in vivo
6943 dBRD9-A Jul 2020
Potent BRD9 Degrader
7177 NR 7h May 2020
Potent and selective p38α and p38β degrader; active in vivo
6939 cis-VZ 185 Mar 2020
Negative control for VZ 185 (Cat. No. 6936)

Amyloid β Peptides

Cat. No. Product Name / Activity Date Added
6779 Davunetide Apr 2020
Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo

Antivirals

Cat. No. Product Name / Activity Date Added
7235 Arbidol Jul 2020
Broad spectrum antiviral

Protein Arginine Methyltransferases

Cat. No. Product Name / Activity Date Added
6838 SGC 3027N May 2020
Negative control for SGC 3027 (Cat. No. 6825)
6825 SGC 3027 May 2020
Potent and selective PRMT7 inhibitor

Fluorescent Probes for Imaging Bacteria

Cat. No. Product Name / Activity Date Added
6650 YADA May 2020
Green-yellow lucifer yellow-based fluorescent D-amino acid for labeling peptidoglycans in live bacteria
6649 RADA Apr 2020
Orange-red TAMRA-based fluorescent D-amino acid for labeling peptidoglycans in live bacteria

Biochemicals and Molecular Biology

Cat. No. Product Name / Activity Date Added
6458 Cyanine 5 Tyramide Jan 2020
Red fluorescent reagent widely used for signal amplification in IHC and ISH
6457 Cyanine 3 Tyramide Jan 2020
Orange fluorescent reagent widely used for signal amplification in IHC and ISH
6456 Fluorescein Tyramide Jan 2020
Green fluorescent reagent widely used for signal amplification in IHC and ISH
7015 IA-Alkyne Jan 2020
Broad spectrum cysteine reactive probe

Bromodomains

Cat. No. Product Name / Activity Date Added
6670 TP 238 Mar 2020
CECR2 and BPTF/FALZ inhibitor

cGMP Stem Cell Compounds

Cat. No. Product Name / Activity Date Added
TB3748-GMP XAV 939 Jan 2020
XAV 939 synthesized to cGMP guidelines

Caged Dopamine Compounds

Cat. No. Product Name / Activity Date Added
6354 CNV Dopamine May 2020
Caged dopamine; photolysed by UV light

Other Cannabinoids

Cat. No. Product Name / Activity Date Added
6372 PSB CB5 Mar 2020
Selective GPR18 antagonist

Cereblon Targeting Ligands Plus Linkers

Cat. No. Product Name / Activity Date Added
7210 Pomalidomide 4'-alkylC6-acid Jul 2020
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
7205 Pomalidomide 4'-alkylC3-amine Jun 2020
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
7096 Pomalidomide 4'-alkylC3-acid Jul 2020
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
6944 Pomalidomide 4'-alkylC8-amine Apr 2020
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
7208 Pomalidomide 4'-alkylC7-amine Jul 2020
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
7204 Pomalidomide 4'-PEG3-amine Jul 2020
Cereblon ligand with PEG linker and terminal amine for onward chemistry
7203 Pomalidomide 4'-PEG1-amine Jul 2020
Cereblon ligand with PEG linker and terminal amine for onward chemistry

Other Chemokine Receptors

Cat. No. Product Name / Activity Date Added
7116 Chemerin-9, Human Apr 2020
Potent CMKLR1 agonist; c-terminal peptide of full length human chemerin
7117 Chemerin-9, Mouse Apr 2020
Potent CMKLR1 agonist; c-terminal peptide of full length mouse chemerin

Class II HDACs

Cat. No. Product Name / Activity Date Added
7051 Tasquinimod Jan 2020
High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic

Click-Reactive Janelia Fluor® Dyes

Cat. No. Product Name / Activity Date Added
7088 Janelia Fluor® 646, Azide Feb 2020
Red dye (Reactive group: azide). Applications: super resolution microscopy e.g. dSTORM & STED, confocal, and live cell imaging

Tocriscreen Compound Libraries

Cat. No. Product Name / Activity Date Added
7152 Tocriscreen 2.0 Micro Jan 2020
A library of 1280 biologically active compounds (15 μL 10 mM DMSO solutions)
7151 Tocriscreen 2.0 Mini Jan 2020
A library of 1280 biologically active compounds (50 μL 10 mM DMSO solutions)
7150 Tocriscreen 2.0 Max Jan 2020
A library of 1280 biologically active compounds (250 μL 10 mM DMSO solutions)
7200 Tocriscreen FDA-Approved Drugs Library Apr 2020
Drug repurposing library; a library of 190 compounds equivalent to active components of drug formulations approved by the FDA

STING-Dependent Signaling

Cat. No. Product Name / Activity Date Added
7040 C 176 Feb 2020
mSTING antagonist

Protein Dimerizers

Cat. No. Product Name / Activity Date Added
6130 AP 1903 Jul 2020
Protein dimerizer; active in vivo

Fluorescent DNA Stains

Cat. No. Product Name / Activity Date Added
7246 Nucleic Acid Dye Green I Jun 2020
High affinity double-stranded DNA (dsDNA) probe; used in RT-LAMP and qPCR

DNA Polymerase

Cat. No. Product Name / Activity Date Added
7090 Digoxigenin-11-dUTP Mar 2020
Hapten modified dUTP for ISH

Fluorescent DNA Stains

Cat. No. Product Name / Activity Date Added
7121 7-Aminoactinomycin D Feb 2020
Fluorescent DNA stain

DNA, RNA and Protein Synthesis

Cat. No. Product Name / Activity Date Added
7004 NAI May 2020
Reagent for RNA SHAPE-MaP experiments in vivo; cell permeable

EGFR

Cat. No. Product Name / Activity Date Added
6962 JBJ-03-142-02 May 2020
Highly potent EGFR and ErbB2 inhibitor; inhibts wild type and mutated receptors

Glucagon Receptors

Cat. No. Product Name / Activity Date Added
6807 NNC 0640 May 2020
Negative allosteric modulator of glucagon and GLP-1 receptors

Glycosylases

Cat. No. Product Name / Activity Date Added
7056 Conduritol B epoxide Jun 2020
Irreversible glucocerebrosidase (β-glucosidase) inhibitor; used to generate Gaucher disease models

Hedgehog Signaling

Cat. No. Product Name / Activity Date Added
6896 Dynapyrazole A May 2020
Hedgehog signaling inhibitor; dynein inhibitor

Other Hydrolases

Cat. No. Product Name / Activity Date Added
6391 CD38 inhibitor 78c Jun 2020
Potent CD38 inhibitor; active in vivo
7224 Oseltamivir phosphate Jul 2020
Influenza virus neuraminidase inhibitor; antiviral prodrug

IAP Targeting Ligands Plus Linkers

Cat. No. Product Name / Activity Date Added
7220 A 410099.1 amide-PEG4-amine Jun 2020
A 410099.1 amide-PEG4-amine
7221 A 410099.1 amide-PEG5-amine Jun 2020
A 410099.1 amide-PEG5-amine

Inflammasomes

Cat. No. Product Name / Activity Date Added
6925 NBC 6 Jan 2020
NLRP3 inflammasome inhibitor
6722 NBC 19 Apr 2020
Potent NLRP3 inflammasome inhibitor

Receptor Interacting Protein Kinases

Cat. No. Product Name / Activity Date Added
6892 RIPGBM Apr 2020
RIPK2 modulator; pro-drug of cRIPGM; orally bioavailable and brain penetrant

JAK Kinase

Cat. No. Product Name / Activity Date Added
7222 Baricitinib Jun 2020
Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2
7064 Ruxolitinib Feb 2020
Potent and selective JAK1/JAK2 inhibitor; orally bioavailable
7048 Ruxolitinib phosphate Feb 2020
Phosphate salt of Ruxolitinib (Cat. No. 7064); potent and selective JAK1/JAK2 inhibitor

Other Kinases

Cat. No. Product Name / Activity Date Added
6430 Takinib Jun 2020
Potent and selective TAK1/MAP3K7 kinase inhibitor

Raf Kinases

Cat. No. Product Name / Activity Date Added
7223 Dabrafenib mesylate Jun 2020
Potent and selective B-Raf, CDK16 and NEK9 inhibitor; anticancer; also targets human proteins in the SARS-CoV-2 interactome

Rho-Kinases

Cat. No. Product Name / Activity Date Added
7163 Chroman 1 Mar 2020
Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogeneisis

VHL Targeting Ligands Plus Linkers

Cat. No. Product Name / Activity Date Added
7074 VH 032 amide-alkylC7-amine Mar 2020
VHL ligand with alkyl linker and terminal amine for onward chemistry
6985 VH 032 amide-alkylC5-amine Jan 2020
VHL ligand with alkyl linker and terminal amine for onward chemistry

Toll-like Receptors

Cat. No. Product Name / Activity Date Added
6858 MMG 11 Jan 2020
TLR2 antagonist

Other Notch Signaling

Cat. No. Product Name / Activity Date Added
6599 Yhhu 3792 Jun 2020
Notch signaling pathway activator; enhances the self-renewal capability of NSCs; active in vivo

Other Oxygenases/Oxidases

Cat. No. Product Name / Activity Date Added
7234 Nitazoxanide Jul 2020
Pyruvate flavodoxin/ferredoxin oxidoreductase inhibitor; also inhibits Wnt signaling; broad spectrum anti-infective

Other Synthases/Synthetases

Cat. No. Product Name / Activity Date Added
6791 BC-LI-0186 Feb 2020
Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor

Other Reductases

Cat. No. Product Name / Activity Date Added
7162 iFSP1 Feb 2020
Ferroptosis suppressor protein 1 (FSP1) inhibitor; ferroptosis inducer

Other Transferases

Cat. No. Product Name / Activity Date Added
6998 SHIN 1 May 2020
Potent SHMT inhibitor

Other Proteases

Cat. No. Product Name / Activity Date Added
7081 LY 2886721 Hydrochloride Jun 2020
Potent and selective β-secretase (BACE) inhibitor
7052 Lopinavir Jun 2020
Highly potent and selective HIV-1 protease inhibitor

PDGFR

Cat. No. Product Name / Activity Date Added
6976 JNJ 10198409 Mar 2020
Potent PDGFRα and PDGFRβ inhbitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases

RNA Polymerase

Cat. No. Product Name / Activity Date Added
7227 GS 441524 Jun 2020
Viral RNA-dependent RNA polymerase inhibitor; broad spectrum antiviral nucelotide
7226 Remdesivir Jun 2020
Viral RNA-dependent RNA polymerase inhibitor; broad spectrum antiviral nucelotide prodrug
7225 Favipiravir Jun 2020
Viral RNA polymerase inhibitor

STATs

Cat. No. Product Name / Activity Date Added
6110 HJC 0416 hydrochloride Feb 2020
STAT3 inhibitor

TRPV

Cat. No. Product Name / Activity Date Added
6831 TRPV3 74a May 2020
Selective TRPV3 antagonist; brain penetrant