New Products

View all New Products by pharmacological action

Search for new products by date added, alphabetically, or by pharmacological action.

New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

5-HT2A Receptors

Cat No Product Name / Activity Date Added
6336 Trazodone hydrochloride Sep 2017
5-HT2A and α1 adrenoceptor antagonist; also enhances neural differentiation; antidepressant and neuroprotectant

ADAMs

Cat No Product Name / Activity Date Added
5523 TAPI 0 Sep 2017
ADAM-17 (TACE) and MMP inhibitor
6013 TAPI 2 Sep 2017
ADAM-17 (TACE) and MMP inhibitor
6162 TAPI 1 Sep 2017
ADAM-17 (TACE) and MMP inhibitor

AMPA Receptors

Cat No Product Name / Activity Date Added
6278 JNJ 55511118 Aug 2017
Selective, high affinity negative modulator of AMPA receptors containing TARP-γ8

Androgen Receptors

Cat No Product Name / Activity Date Added
5274 BMS 564929 Nov 2017
Highly potent and muscle-selective androgen receptor (AR) agonist

Antibiotics

Cat No Product Name / Activity Date Added
6337 Sulopenem Nov 2017
Penem antibiotic
3637 Salinomycin sodium salt Nov 2017
Antibiotic; also selectively inhibits cancer stem cells

Antivirals

Cat No Product Name / Activity Date Added
6045 NITD 008 Jul 2017
Antiviral; selective flavivirus inhibitor
6339 Netilmicin sulfate Oct 2017
Inhibits HIV-1 replication; also semisynthetic aminoglycoside antibiotic

Apelin Receptors

Cat No Product Name / Activity Date Added
6292 ELARR>GG Jul 2017
Negative control for ELA-32 (Cat.No.6291).
6293 ELA-14 (human) Jun 2017
Potent apelin (APJ) receptor agonist
6294 ELA-14 negative control Jun 2017
Negative control for ELA-14 (Cat.No.6293).
6291 ELA-32 (human) Jul 2017
Potent, high affinity apelin receptor agonist; stimulates angiogenesis

Aptamers

Cat No Product Name / Activity Date Added
6104 CD133-B19, 5'-DY647 Oct 2017
High affinity fluorescently tagged aptamer for CD133 (extracellular domain epitope)
6102 Ep23, 5'-DY647 Oct 2017
High affinity fluorescently tagged aptamer for EpCam
6103 CD133-A15, 5'-DY647 Oct 2017
High affinity fluorescently tagged aptamer for CD133 (AC133 epitope)

Bcl-2 Family

Cat No Product Name / Activity Date Added
5733 ML 311 Nov 2017
Inhibits Mcl-1-BIM interaction

Bromodomains

Cat No Product Name / Activity Date Added
6251 L Moses dihydrochloride Nov 2017
High affinity and selective PCAF bromodomain inhibitor

Buffers, Solvents and Solutions

Cat No Product Name / Activity Date Added
5883 CHES Nov 2017
Buffering agent
5885 HEPPS Oct 2017
Used as a buffering agent
5877 MOPS, sodium salt Oct 2017
Used as a buffering agent
5891 TES, free acid Nov 2017
Buffering agent
5887 MES, free acid Oct 2017
Commonly used buffer
5884 DIPSO Nov 2017
Buffering agents
5875 MES sodium salt Nov 2017
Buffering agent
5889 PIPES, free acid Oct 2017
Commonly used buffer
5886 HEPPSO Nov 2017
Buffering agent

Calcium-Sensing Receptor

Cat No Product Name / Activity Date Added
6165 AC 265347 Jul 2017
CaSR biased allosteric modulator

Casein Kinase 1

Cat No Product Name / Activity Date Added
6346 PF 5006739 Sep 2017
Potent CK1δ/ε inhibitor

Caspases

Cat No Product Name / Activity Date Added
6172 INF 4E Oct 2017
Caspase-1 and NLRP3 inflammasome inhibitor

CB1 Receptors

Cat No Product Name / Activity Date Added
6193 AM 4113 Aug 2017
Selective, high affinity CB1 antagonist

Death-Associated Protein Kinase

Cat No Product Name / Activity Date Added
5768 HS 38 Jul 2017
ATP-competitive inhibitor of DAPK and ZIPK

Diacylglycerol O-Acyltransferase

Cat No Product Name / Activity Date Added
5863 PF 04620110 Sep 2017
Potent and selective DGAT-1 inhibitor; orally bioavailable
6348 PF 06424439 Oct 2017
Potent and selective DGAT2 inhibitor

DNA, RNA and Protein Synthesis

Cat No Product Name / Activity Date Added
6222 PFM 01 Nov 2017
MRE11 endonuclease inhibitor
6359 Nelarabine Dec 2017
Purine nuceloside analog; inhibits DNA synthesis

DREADD Ligands

Cat No Product Name / Activity Date Added
6329 Clozapine N-oxide dihydrochloride Sep 2017
Activator of muscarinic DREADDs

EGFR

Cat No Product Name / Activity Date Added
6231 Dacomitinib Jul 2017
Potent irreversible pan ErbB inhibitor

Elastases

Cat No Product Name / Activity Date Added
5706 BAY 678 Nov 2017
Potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor
6389 BAY 677 Nov 2017
Inactive control for BAY 678 (Cat.No.5706)

Estrogen (GPER) Receptors

Cat No Product Name / Activity Date Added
6116 BHPI Aug 2017
ERα antagonist; also activates unfolded protein response; active in vivo

Estrogen and Related Receptors

Cat No Product Name / Activity Date Added
6342 Tamoxifen Sep 2017
Estrogen receptor partial agonist/antagonist

Fatty Acid Amide Hydrolase

Cat No Product Name / Activity Date Added
6374 PF 04457845 Nov 2017
Potent and selective irreversible FAAH inhibitor

Free Fatty Acid Receptors

Cat No Product Name / Activity Date Added
6163 AR 420626 Oct 2017
FFA3 agonist

GABAA Receptors

Cat No Product Name / Activity Date Added
6192 PZ-II-029 Sep 2017
α6β3γ2-selective GABAA channel modulator

Ghrelin Receptors

Cat No Product Name / Activity Date Added
6347 PF 04628935 Sep 2017
Potent ghrelin receptor inverse agonist
6350 PF 05190457 Dec 2017
High affinity and selective ghrelin receptor inverse agonist

Glucocorticoid Receptors

Cat No Product Name / Activity Date Added
6357 Ciclesonide Nov 2017
Glucocorticoid antiasthmatic prodrug

Glucose Transporters

Cat No Product Name / Activity Date Added
6143 WZB 117 Aug 2017
GLUT inhibitor

GPR171

Cat No Product Name / Activity Date Added
6299 MS 15203 Aug 2017
Potent and selective GPR171 partial agonist
6298 MS 21570 Nov 2017
GPR171 antagonist
6306 BigLEN (rat) Jul 2017
Potent GPR171 agonist
6304 BigLEN (mouse) Jul 2017
GPR171 agonist

GTPases

Cat No Product Name / Activity Date Added
5969 (R)-CE3F4 Dec 2017
Epac inhibitor
6248 EHop 016 Dec 2017
Rac inhibitor
6407 Fendiline Hydrochloride Dec 2017
K-Ras inhibitor; inhibits K-Ras localization to the plasma membrane

Heme Oxygenase

Cat No Product Name / Activity Date Added
6119 OB 24 hydrochloride Aug 2017
Potent and selective heme oxygenase 1 (HO-1) inhibitor

Hexokinases

Cat No Product Name / Activity Date Added
6049 PF 04937319 Aug 2017
Glucokinase partial activator
6345 PF 04991532 Sep 2017
Potent hepatoselective glucokinase activator

Histone Deacetylases

Cat No Product Name / Activity Date Added
6270 Tubastatin A hydrochloride Jun 2017
Potent HDAC6 inhibitor
6208 MS 275 Jun 2017
HDAC (Class I) inhibitor
6284 BRD 73954 Jun 2017
Dual histone deacetylase (HDAC) 6/8 inhibitor

Histone Demethylases

Cat No Product Name / Activity Date Added
6384 Ciclopirox Nov 2017
Pan-histone demethylase inhibitor

HMG-CoA Reductase

Cat No Product Name / Activity Date Added
6343 Rosuvastatin calcium Nov 2017
Potent HMG-CoA reductase inhibitor

Inflammasomes

Cat No Product Name / Activity Date Added
6366 Muramyl Dipeptide Nov 2017
Activates NOD2 receptors

Integrins

Cat No Product Name / Activity Date Added
6048 R-BC154 Aug 2017
High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs

IRAK

Cat No Product Name / Activity Date Added
6373 PF 06650833 Nov 2017
Potent and selective IRAK4 inhibitor

ITK

Cat No Product Name / Activity Date Added
5401 GSK 2250665A Aug 2017
Itk inhibitor

JAK Kinase

Cat No Product Name / Activity Date Added
5818 NVP BSK 805 Aug 2017
Potent JAK2 inhibitor; orally bioavailable

Labels & Stains

Cat No Product Name / Activity Date Added
6182 Pimonidazole Nov 2017
Hypoxia detection reagent

LRRK2

Cat No Product Name / Activity Date Added
6289 JH-II-127 Aug 2017
Potent and selective LRRK2 inhibitor

Lysine Methyltransferases

Cat No Product Name / Activity Date Added
6128 GSK 343 Jun 2017
Potent and selective SAM-competitive EZH2 inhibitor
6096 UNC 3866 Nov 2017
High affinity CBX4 and CBX7 inhibitor
6282 BRD 4770 Jun 2017
G9a inhibitor and S-adenosyl methionine mimetic; cell permeable
6167 A 196 Jul 2017
Potent and selective SUV420H1/H2 inhibitor

Matrix Metalloproteases

Cat No Product Name / Activity Date Added
6134 T 26c disodium salt Nov 2017
Highly potent and selective MMP13 inhibitor

Monoacylglycerol Lipase

Cat No Product Name / Activity Date Added
5956 NF 1819 Aug 2017
Potent and selective irreversible MAGL inhibitor; membrane permeable and brain penetrant

Monocarboxylate Transporters

Cat No Product Name / Activity Date Added
5658 AR-C 141990 hydrochloride Jul 2017
MCT1 inhibitor

MTH1

Cat No Product Name / Activity Date Added
5334 TH 588 Nov 2017
Potent MTH1 inhibitor

Neural Stem Cells

Cat No Product Name / Activity Date Added
6385 Phenanthroline Nov 2017
Enhances hPSC differentiation into cranial placode cells

NMDA Receptors

Cat No Product Name / Activity Date Added
6226 IC 87201 Oct 2017
nNOS-PSD95 protein-protein interaction inhibitor; also antinociceptive and antidepressant

NPY Receptors

Cat No Product Name / Activity Date Added
6288 Peptide YY (3-36) human Jun 2017
NPY Y2 receptor agonist

NTPDase

Cat No Product Name / Activity Date Added
6083 PSB 12379 Aug 2017
Ecto-5'-nucleotidase (CD73) inhibitor

Orphan 7-TM Receptors

Cat No Product Name / Activity Date Added
6309 PEN (rat) Sep 2017
GPR83 agonist
6307 PEN (human) Sep 2017
GPR83 agonist
6308 PEN (mouse) Sep 2017
GPR83 agonist

Other Dehydrogenases

Cat No Product Name / Activity Date Added
6196 Brequinar sodium Aug 2017
Potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor
6084 ASP 9521 Sep 2017
Potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor;orally bioavailable

Other Hydrolases

Cat No Product Name / Activity Date Added
6098 Lalistat 1 Aug 2017
Potent and selective lysosomal acid lipase (LAL) inhibitor
6099 Lalistat 2 Sep 2017
Selective lysosomal acid lipase inhibitor
6370 Nor NOHA monoacetate Sep 2017
Arginase inhibitor

Other Ligases

Cat No Product Name / Activity Date Added
6326 Ginkgolic Acid Nov 2017
Inhibits SUMOylation by binding E1

Other Nuclear Receptors

Cat No Product Name / Activity Date Added
6376 DIM-C-pPhOCH3 Dec 2017
Nur77 agonist

Other Proteases

Cat No Product Name / Activity Date Added
6333 Phosphoramidon disodium salt Nov 2017
Neutral endopeptidase and endothelin converting enzyme inhibitor
6414 Rupintrivir Nov 2017
Potent and selective irreversible human rhinovirus 3C protease inhibitor

Other Transferases

Cat No Product Name / Activity Date Added
6055 SPT Imidazopyridine 1 Dec 2017
Potent serine palmitoyl transferase inhibitor

Oxytocin Receptors

Cat No Product Name / Activity Date Added
6332 Atosiban Nov 2017
Potent oxytocin receptor antagonist

P21-activated Kinases

Cat No Product Name / Activity Date Added
6132 NVS PAK1 1 Oct 2017
Potent and selective PAK1 inhibitor
6051 G 5555 Sep 2017
High affinity group 1 PAK inhibitor

Parathyroid Hormone Receptors

Cat No Product Name / Activity Date Added
6303 Parathyroid hormone (1-34) (bovine) Jun 2017
Parathyroid hormone (PTH) receptor agonist.
6301 Parathyroid hormone (1-34) (rat) Jun 2017
Parathyroid hormone (PTH) receptor agonist

Phosphodiesterases

Cat No Product Name / Activity Date Added
6035 (S)-C33 Oct 2017
Potent PDE9 inhibitor
6024 PF 04671536 hydrochloride Nov 2017
Potent and selective PDE8B/8A inhibitor
6405 PF 05180999 Nov 2017
Potent and selective PDE2A inhibitor

Pim Kinase

Cat No Product Name / Activity Date Added
6310 AZD 1208 Oct 2017
Potent pan Pim kinase inhibitor

Poly(ADP-ribose) Polymerase

Cat No Product Name / Activity Date Added
6230 Rucaparib camsylate Aug 2017
PARP inhibitor

Prostanoid Receptors

Cat No Product Name / Activity Date Added
5924 ER 819762 Sep 2017
Potent EP4 receptor antagonist; orally bioavailable
6240 DG 041 Aug 2017
Potent and selective EP3 antagonist; antiplatelet and antithrombotic

Protein Kinase A

Cat No Product Name / Activity Date Added
6286 st-Ht31 Jul 2017
Inhibits PKA/AKAP interactions; cell permeable
6287 st-Ht31 P Jul 2017
Negative control for st-Ht31 (Cat. No. 6286)

Protein Prenyltransferases

Cat No Product Name / Activity Date Added
6265 Lonafarnib Jul 2017
Potent farnesyl transferase inhibitor

Purinergic (P2Y) Receptors

Cat No Product Name / Activity Date Added
6078 BPTU Jul 2017
P2Y1 allosteric antagonist
6317 Prasugrel Jul 2017
Irreversible P2Y12 antagonist; antiplatelet and orally active

RAGE

Cat No Product Name / Activity Date Added
6237 FPS ZM1 Aug 2017
High affinity antagonist of RAGE

Rev-Erb Receptors

Cat No Product Name / Activity Date Added
6038 SR 10067 Aug 2017
Selective Rev-Erbα/β agonist; anxiolytic

Src Kinases

Cat No Product Name / Activity Date Added
6073 P21d hydrochloride Jun 2017
Potent and selective Brk inhibitor

TGF-β Receptors

Cat No Product Name / Activity Date Added
6016 IN 1130 Jul 2017
Potent and selective inhibitor of TGF-βRI

Thioredoxin Reductases

Cat No Product Name / Activity Date Added
6189 Myricetin Jun 2017
Irreversible TrxR inhibitor

Toll-like Receptors

Cat No Product Name / Activity Date Added
5705 M62812 Aug 2017
TLR-4 inhibitor
6142 CL 075 Sep 2017
TLR8 agonist
6191 TH 1020 Jul 2017
Toll-like receptor (TLR) 5/Flagellin complex antagonist

TRPA1

Cat No Product Name / Activity Date Added
5914 AM 0902 Oct 2017
Potent and selective TRPA1 antagonist

TRPC

Cat No Product Name / Activity Date Added
5831 SAR 7334 Sep 2017
Potent TRPC6 inhibitor

Ubiquitin E3 Ligases

Cat No Product Name / Activity Date Added
6075 Nutlin 3a Sep 2017
MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
6302 Pomalidomide Jun 2017
Cereblon ubiquitination inhibitor; also TNF-α inhibitor and antiangiogenic
6327 dBET1 Aug 2017
(+)-JQ1 based PROTAC that selectively degrades BET bromodomains in cells

Vasopressin Receptors

Cat No Product Name / Activity Date Added
6195 SSR 149415 Nov 2017
Potent and selective vasopressin V1B antagonist