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Description: Potent and selective PXR1 agonist
Chemical Name: 1-(2,4-Dimethoxy-5-methylphenyl)-N-[5-(1,1-dimethylethyl)-2-[(1S)-1-ethylbutoxy]phenyl]-5-methyl-1H-1,2,3-triazole-4-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for SJPYT 328
SJPYT 328 is a potent and selective PXR1 agonist (IC50 = 7 nM). SJPYT 328 displays selectivity for hPXR without affecting the activity of mPXR, hCAR, hFXR, hLXRα, or hVDR. SJPYT 328 and SJPYT (PXR1 antagonist) are a useful pair of compounds for referencing "full agonist" and "full antagonist" when screening for new drugs in cellular models. SJPYT 328 shows no toxicity.
Licensing Information
Sold under license from St. Jude Children's Research Hospital
Technical Data for SJPYT 328
| M. Wt | 508.66 |
| Formula | C29H40N4O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2998548-72-2 |
| PubChem ID | 169248098 |
| InChI Key | VDHSAAKREKQAEL-NRFANRHFSA-N |
| Smiles | CC1=C(C(NC2=C(C=CC(C(C)(C)C)=C2)O[C@@H](CC)CCC)=O)N=NN1C3=C(C=C(OC)C(C)=C3)OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SJPYT 328
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.09 | 10 | |
| ethanol | 5.09 | 10 |
Preparing Stock Solutions for SJPYT 328
The following data is based on the product molecular weight 508.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.66 mL | 98.3 mL | 196.59 mL |
| 0.5 mM | 3.93 mL | 19.66 mL | 39.32 mL |
| 1 mM | 1.97 mL | 9.83 mL | 19.66 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.93 mL |
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Product Datasheets for SJPYT 328
References for SJPYT 328
References are publications that support the biological activity of the product.
Garcia-Maldonado et al (2024) Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat.Comms. 15 4054 PMID: 38744881
If you know of a relevant reference for SJPYT 328, please let us know.
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Keywords: SJPYT 328, SJPYT 328 supplier, SJPYT328, SJPYT-328, potent, selective, agonist, PXRs, pregnane, X, receptor, PXR, nuclear, receptors, Pregnane, Receptor, 8840, Tocris Bioscience
Citations for SJPYT 328
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.