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DADPS Biotin Azide

Cat. No. 7966 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Acid cleavable biotin capture reagent, with an azide group as a click handle for conjugation
Chemical Name: N-[2-[[[(6-Azidohexyl)oxy]diphenylsilyl]oxy]-2-methylpropyl]-21-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-4,7,10,13-tetraoxa-16-azaheneicosanamide
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for DADPS Biotin Azide

DADPS Biotin Azide is an acid cleavable biotin capture reagent, with an azide group as a click handle for conjugation. The biotin portion strongly binds to avidin or streptavidin and allows to isolate specific, tagged proteins or cells from a complex biological mixture. The DADPS component is a cleavable linker, which can be cleaved under very mild acidic treatment (such as 10% formic acid), unlike traditional biotin probes that require harsh conditions (which can damage samples) to break the streptavidin bond.

Technical Data for DADPS Biotin Azide

M. Wt 886.19
Formula C43H67N7O9SSi
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1260247-50-4
PubChem ID 132505710
InChI Key CSHHHVOFXKFHMG-PCXFPAGCSA-N
Smiles [Si](OC(CNC(CCOCCOCCOCCOCCNC(CCCC[C@H]1[C@@]2([C@](CS1)(NC(=O)N2)[H])[H])=O)=O)(C)C)(OCCCCCCN=[N+]=[N-])(C3=CC=CC=C3)C4=CC=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DADPS Biotin Azide

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 88.62 100

Preparing Stock Solutions for DADPS Biotin Azide

The following data is based on the product molecular weight 886.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.13 mL 5.64 mL 11.28 mL
5 mM 0.23 mL 1.13 mL 2.26 mL
10 mM 0.11 mL 0.56 mL 1.13 mL
50 mM 0.02 mL 0.11 mL 0.23 mL

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Product Datasheets for DADPS Biotin Azide

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for DADPS Biotin Azide

References are publications that support the biological activity of the product.

Li et al (2016) Characterization of the artemisinin binding site for translationally controlled tumor protein (TCTP) by bioorthogonal click chemistry. Bioconj.Chem. 27 2828 PMID: 27998071

Rabalski et al (2019) Evaluation of chemically-cleavable linkers for quantitative mapping of small molecule-cysteinome reactivity. ACS Chem.Biol. 14 1940 PMID: 31430117

McConnell et al (2020) Maleimide-based chemical proteomics for quantitative analysis of cysteine reactivity. J.Am.Soc.Mass Spectrom. 31 1697 PMID: 32573231

Ruan et al (2022) Proteome-wide deconvolution of drug targets and binding sites by lysine reactivity profiling. Anal.Chem. 94 3352 PMID: 35147412

Lai et al (2022) Quantitative site-specific chemoproteomic profiling of protein lipoylation. JACS 144 10320 PMID: 35648456

Li et al (2022) Benchmarking cleavable biotin tags for peptide-centric chemoproteomics. J.Proteome Res. 21 1349 PMID: 35467356

If you know of a relevant reference for DADPS Biotin Azide, please let us know.

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Citations for DADPS Biotin Azide

Citations are publications that use Tocris products.

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