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Submit Reviewβ-Lipotropin 61-91 New
Description: Endogenous opioid peptide; component of the LIP cocktail for preconditioning human β-cells
Alternative Names: β-Endorphin
Purity: ≥95% (HPLC)
Biological Activity for β-Lipotropin 61-91
β-Lipotropin 61-91 (or β-Endorphin) is an endogenous opioid peptide with potent antinociceptive activity, physiologically released in response to painful stimuli.
β-Lipotropin 61-91 can be used to study the expression of μ-opioid receptor in organ cultures and to investigate cardiovascular regulation.
In combination with 10 μM Prostaglandin E2 (Cat. No. 2296) and 1 μg/mL IGF-1, β-Lipotropin 61-91 (0.01 μM) constitutes the LIP cocktail, a small molecule mixture used to precondition human β-cells and primary islets, significantly enhancing function and survival when transplanted subcutaneously to female mice.
Technical Data for β-Lipotropin 61-91
| M. Wt | 3465.03 |
| Formula | C158H251N39O46S |
| Sequence | YGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 61214-51-5 |
| PubChem ID | 16132316 |
| InChI Key | JMHFFDIMOUKDCZ-NTXHZHDSSA-N |
| Smiles | O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCSC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N2[C@@H](CCC2)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC5=CC=C(C=C5)O)N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for β-Lipotropin 61-91
| Solubility | Soluble to 1 mg/ml in 20% ethanol / water |
Product Datasheets for β-Lipotropin 61-91
References for β-Lipotropin 61-91
References are publications that support the biological activity of the product.
Vandana et al (2025) ChemPerturb-seq screen identifies a small molecule cocktail enhancing human beta cell survival after subcutaneous transplantation. CellStemCell 32 1 PMID: 40562034
Bloom et al (1976) Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness. Science 194 630 PMID: 185694
Hill et al (2002) The effects of beta-endorphin (beta-END) on cardiovascular and behavioral dynamics in conscious rats. Brain Res.Bull 59 29 PMID: 12372545
If you know of a relevant reference for β-Lipotropin 61-91, please let us know.
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Citations for β-Lipotropin 61-91
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