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Submit ReviewOvalbumin peptide (257-264) is an immunogenic glycoprotein used as model antigen for immunization and vaccination research and to investigate antigen presentation and T cell activation. This peptide plays a critical role in cancer studies, serving as a key agent to evaluate macrophage antigen presentation and to drive robust CD8+ T cell proliferation. Used in multiple cancer models, including oral squamous cell carcinoma, breast cancer, glioblastoma, triple-negative breast cancer, esophageal squamous cell carcinoma, and B-cell malignancies. Used for investigation into immune response dynamics, cytotoxic T cell activity, tumor microenvironment interactions, and immune evasion mechanisms.
| M. Wt | 963.13 |
| Formula | C45H74N10O13 |
| Sequence | SIINFEKL |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 138831-86-4 |
| PubChem ID | 447764 |
| InChI Key | JVJGCCBAOOWGEO-RUTPOYCXSA-N |
| Smiles | O=C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
| Solubility | Soluble to 1 mg/ml in water |
References are publications that support the biological activity of the product.
Booty et al (2022) Microfluidic squeezing enables MHC class I antigen presentation by diverse immune cells to elicit CD8+ T cell responses with antitumor activity. J.Immunol. 208 929 PMID: 35091434
Jaeger et al (2022) Deciphering the immunopeptidome in vivo reveals new tumour antigens. Nature 607 149 PMID: 35705813
Li et al (2023) Histone demethylase KDM5D upregulation drives sex differences in colon cancer. Nature 619 632 PMID: 37344599
Dong et al (2021) Poria cocos polysaccharide induced Th1-type immune responses to ovalbumin in mice. PLOS One 16 PMID: 33411807
Ritter et al (2022) ESCRT-mediated membrane repair protects tumor-derived cells against T cell attack. Science 376 377 PMID: 35446649
If you know of a relevant reference for Ovalbumin peptide (257-264), please let us know.
Keywords: Ovalbumin peptide (257-264), Ovalbumin peptide (257-264) supplier, Ovalbumin, peptide, antigen, presentation, activation, T, cell, macrophage, cancer, oncology, immunology, OVA, Biochemicals, and, Molecular, Biology, 7790, Tocris Bioscience
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