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Description: Dibutyryl-cAMP, sodium salt synthesized to Ancillary Material Grade
Alternative Names: Bucladesine sodium
Chemical Name: N6,O2'-Dibutyryladenosine 3',5'-cyclic monophosphate sodium salt
Purity: ≥98%
Biological Activity for Dibutyryl-cAMP, sodium salt
Dibutyryl-cAMP sodium salt is a cell-permeable analog of cAMP that activates cAMP-dependent protein kinases and is a phosphodiesterase inhibitor. Combined with other reagents, dibutyryl-cAMP promotes differentiation of neural stem/progenitor cells (NSPCs) and other cell lines (see our protocol below) and increases survival rates of NSPCs and differentiation into neurons in vivo. Promotes neurite outgrowth in cell cultures. Dibutyryl-cAMP has anti-inflammatory activity and is used to promote wound healing. Choline acetyltransferase and vesicular acetylcholine transporter mRNA are increased in cells treated with dibutyryl-cAMP.
For more information about how Dibutyryl-cAMP, sodium salt may be used, see our protocol: Generating Midbrain Dopaminergic Neurons from hPSCs
This product is Bio-Techne's ancillary Material Grade version of Dibutyryl-cAMP sodium salt (Cat. No. 1141). Suitable for use in research and further manufacturing of cell therapies. Find out more about our Ancillary Material Grade product range.
Technical Data for Dibutyryl-cAMP, sodium salt
| M. Wt | 491.37 |
| Formula | C18H23N5NaO8P |
| Storage | Store at -20°C(±5°C) |
| Purity | ≥98% |
| CAS Number | 16980-89-5 |
| PubChem ID | 23663967 |
| InChI Key | KRBZRVBLIUDQNG-JBVYASIDSA-M |
| Smiles | [H][C@]([C@]1([H])[C@H]2OC(CCC)=O)(COP(O1)([O-])=O)O[C@H]2N3C=NC4=C3N=CN=C4NC(CCC)=O.[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Dibutyryl-cAMP, sodium salt
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Protocols for Dibutyryl-cAMP, sodium salt
The following protocol features additional information for the use of Dibutyryl-cAMP, sodium salt (Cat. No. TB1141-RMU).
Literature in this Area
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