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MS 41

Cat. No. 8919 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective degrader of Eleven-Nineteen Leukemia (ENL)
Chemical Name: 5-[4-(Dimethylcarbamoyl)-3-hydroxyphenyl]-N-[(1R)-6-[[10-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-10-oxodecyl]carbamoyl]-2,3-dihydro-1H-inden-1-yl]-1,2-oxazole-3-carboxamide
Purity: ≥97%
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for MS 41

MS 41 is a potent and selective degrader of Eleven-Nineteen Leukemia (ENL), a histone acylation reader crucial in sustaining oncogenic gene expression, especially in MLL-r (Mixed Lineage Leukemia-rearranged) leukemia. DC50 = 2.84 nM, 3.03 nM, 3.50 nM and 26.58 nM in SEMK2, Jurkat, MV4;11 and KASUMI1 cells, respectively.

Comprises an ENL-binding moiety (PFI-6) joined by a linker to VHL1-Me as the ligand for von Hippel-Lindau E3 ubiquitin ligase.

MS41 effectively inhibits leukemia cell proliferation and clonogenic ability in vitro and suppresses leukemia progression in a xenograft mouse model of MLL-r leukemia in vivo.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license

Technical Data for MS 41

M. Wt 1031.28
Formula C56H70N8O9S
Storage Store at -20°C
Purity ≥97%
CAS Number 2768610-97-3
PubChem ID 172407974
InChI Key XPICNVKPGAOVBF-VCNVHFLLSA-N
Smiles O=C(N[C@H]1C2=CC(C(NCCCCCCCCCC(N[C@H](C(N3[C@H](C(N[C@@H](C)C4=CC=C(C=C4)C5=C(C)N=CS5)=O)C[C@@H](O)C3)=O)C(C)(C)C)=O)=O)=CC=C2CC1)C6=NOC(C7=CC(O)=C(C(N(C)C)=O)C=C7)=C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MS 41

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 103.13 100

Preparing Stock Solutions for MS 41

The following data is based on the product molecular weight 1031.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.97 mL 4.85 mL 9.7 mL
5 mM 0.19 mL 0.97 mL 1.94 mL
10 mM 0.1 mL 0.48 mL 0.97 mL
50 mM 0.02 mL 0.1 mL 0.19 mL

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References for MS 41

References are publications that support the biological activity of the product.

Xue et al (2024) A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression. Sci.Adv. 10

If you know of a relevant reference for MS 41, please let us know.

View Related Products by Target

Keywords: MS 41, MS 41 supplier, MS41, potent, selective, degrader, ENL, eleven, nineteen, leukemia, oncogenesis, VHL, PROTAC, PROTACS, in, vivo, Other, Degraders, 8919, Tocris Bioscience

Citations for MS 41

Citations are publications that use Tocris products.

Currently there are no citations for MS 41. Do you know of a great paper that uses MS 41 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia