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CT-4

Cat. No. 8024 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective HDAC8 degrader (PROTAC®)
Chemical Name: 3-((4-((8-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)carbamoyl)benzyl)oxy)-N-hydroxy-4-methoxybenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CT-4

CT-4 is a potent and selective histone deacetylase 8 (HDAC8) degrader (PROTAC®) (DC50 = 1.8 nM after 24 h, Dmax 97%). Comprises a HDAC8-binding moiety joined by a linker to pomalidomide as the ligand for cereblon (CRBN) protein. Displays 20-fold selectivity over HDAC6 (DC50 = 38 nM after 24 h, Dmax 69%) and it does not degrade other HDACs.

Displays significant effect on metastasis of MDA-MB-231 cells, and induces degradation and cell death in T-cell leukemia Jurkat cells. Outperformed HDAC8 inhibitors in oncology models. HDAC8 mediates signalling via scaffolding functions in HDAC8/p53/fusion protein complexes, also interacts with STAT3, cAMP and DEC1 via scaffolding functions.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license

Technical Data for CT-4

M. Wt 699.76
Formula C37H41N5O9
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 3057302-21-0
PubChem ID 171378332
InChI Key ARLOQCPNXYNVDU-UHFFFAOYSA-N
Smiles ONC(C1=CC(OCC2=CC=C(C=C2)C(NCCCCCCCCNC3=CC=CC(C(N4C5CCC(NC5=O)=O)=O)=C3C4=O)=O)=C(C=C1)OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CT-4

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 69.98 100

Preparing Stock Solutions for CT-4

The following data is based on the product molecular weight 699.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.43 mL 7.15 mL 14.29 mL
5 mM 0.29 mL 1.43 mL 2.86 mL
10 mM 0.14 mL 0.71 mL 1.43 mL
50 mM 0.03 mL 0.14 mL 0.29 mL

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References for CT-4

References are publications that support the biological activity of the product.

Zhao et al (2023) Discovery of highly potent HDAC8 PROTACs with anti-tumor activity. Bioorg.Chem. 136 PMID: 37098288

If you know of a relevant reference for CT-4, please let us know.

View Related Products by Target

Keywords: CT-4, CT-4 supplier, potent, selective, degrader, degrades, HDAC8, histone, deacetylase, PROTAC, PROTACs, targeted, protein, degradation, TPD, cancer, research, metastasis, leukemia, oncology, Histone, Deacetylase, (HDAC), Degraders, 8024, Tocris Bioscience

Citations for CT-4

Citations are publications that use Tocris products.

Currently there are no citations for CT-4. Do you know of a great paper that uses CT-4 from Tocris? Please let us know.

Reviews for CT-4

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics in Cancer Research Product Guide

Epigenetics in Cancer Research Product Guide

This product guide reviews some of the main areas in cancer epigenetics research and lists around 120 products that can be used for the main epigenetic targets including:

  • Histone Methylation
  • Histone Acetylation
  • DNA Methylation
  • Ubiquitination
  • Bromodomains
TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia