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Description: Potent and selective allosteric activator of SIRT3
Chemical Name: Methyl 2-amino-1-[(4-fluorophenyl)methyl]-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylate
Purity: ≥98% (HPLC)
Biological Activity for SKLB-11A
SKLB-11A is a potent and selective allosteric activator of SIRT3 (Kd = 4.7 μM), enhancing its deacetylation activity with an EC50 = 22 μM). SKLB-11A showed no binding to SIRT5 or SIRT6, and low binding affinity for SIRT1 and SIRT2 (Kd values exceeded 200 μM, 40 times lower than its affinity for SIRT3).
SKLB-11A ameliorates Dox-Induced mitochondrial damage and promotes SIRT3-mediated autophagy in cells. SKLB-11A drives autophagy/mitophagy signaling pathways, effectively preventing mitochondrial dysfunction, and improving cardiac dysfunction in both doxorubicin (Dox)-induced cardiotoxicity and myocardial ischemia/reperfusion (I/R) models.
Technical Data for SKLB-11A
| M. Wt | 350.35 |
| Formula | C19H15FN4O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 433953-86-7 |
| PubChem ID | 987502 |
| InChI Key | ZIRBXDWXWABLAI-UHFFFAOYSA-N |
| Smiles | O=C(C1=C(N)N(CC2=CC=C(C=C2)F)C3=C1N=C4C=CC=CC4=N3)OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SKLB-11A
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.01 | 20 with gentle warming |
Preparing Stock Solutions for SKLB-11A
The following data is based on the product molecular weight 350.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.27 mL | 71.36 mL | 142.71 mL |
| 1 mM | 2.85 mL | 14.27 mL | 28.54 mL |
| 2 mM | 1.43 mL | 7.14 mL | 14.27 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.85 mL |
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Product Datasheets for SKLB-11A
Certificate of Analysis is currently unavailable on-line.
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References for SKLB-11A
References are publications that support the biological activity of the product.
Zhang et al (2025) Unraveling small molecule-mediated sirtuin 3 activation at a distinct binding site for cardioprotective therapies. ACS Cent.Sci. 11 704 PMID: 40454347
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Citations for SKLB-11A
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Literature in this Area
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Rheumatoid Arthritis Poster
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