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Submit ReviewSemaglutide New
Description: Highly potent, long-acting GLP-1 receptor agonist
Alternative Names: NN-9535,NNC0480-0389
Purity: ≥95% (HPLC)
Biological Activity for Semaglutide
Semaglutide is a glucon-like peptide 1 analog and a potent and long-acting GLP-1R agonist. Upon activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, causing lasting and reversible weight loss in normal and obese rats.
Semaglutide enhances autophagy by increasing the expression of LC3II, Atg7, Beclin-1 and P62; inhibits oxidative stress and apoptosis. Semaglutide has neuroprotective properties in a stroke animal model, where neurogenesis and growth factor cell signaling is normalized.
Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer.
Technical Data for Semaglutide
| M. Wt | 4113.64 |
| Formula | C187H291N45O59 |
| Sequence |
HXEGTFTSDVSSYLEGQAAKEFIAWLVRGRG (Modifications: X = Aib, Lys-20 = C18 diacid-γ-Glu-AEEA-AEEA-Lys) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 910463-68-2 |
| PubChem ID | 154733530 |
| InChI Key | DLSWIYLPEUIQAV-CIIFZSTISA-N |
| Smiles | CC[C@@H]([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(NCC(N[C@H](C(NCC(O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)=O)CC(C)C)=O)CC1=CNC2=C1C=CC=C2)=O)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H]([C@H](O)C)NC(CNC([C@@H](NC(C(C)(NC([C@H](CC3=CNC=N3)N)=O)C)=O)CCC(O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)CO)=O)CC(O)=O)=O)=O)CO)=O)CO)=O)CC5=CC=C(C=C5)O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)C)=O)C)=O)CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)=O)CCC(O)=O)=O)CC6=CC=CC=C6)=O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Semaglutide
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Semaglutide
References for Semaglutide
References are publications that support the biological activity of the product.
Knudsen et al (2019) The discovery and development of liraglutide and semaglutide. Front.Endocrinol. 10 PMID: 31031702
Lau et al (2015) Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide. J.Med.Chem 58 7370 PMID: 26308095
Gabery et al (2020) Semaglutide lowers body weight in rodents via distributed neural pathways. JCl Insight 5 PMID: 32213703
Chang et al (2020) Semaglutide-mediated protection against Aβ correlated with enhancement of autophagy and inhibition of apoptosis. J.Clin.Neurosc. 81 234 PMID: 33222922
Yang et al (2019) The diabetes drug semaglutide reduces infarct size, inflammation, and apoptosis, and normalizes neurogenesis in a rat model of stroke. Neuropharmacology 158 PMID: 31465784
Mahapatra et al (2022) Therapeutic potential of semaglutide, a newer GLP-1 receptor agonist, in abating obesity, non-Alcoholic steatohepatitis and neurodegenerative diseases: a narrative review. Pharm.Res. 39 1233 PMID: 35650449
If you know of a relevant reference for Semaglutide, please let us know.
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Keywords: Semaglutide, Semaglutide supplier, Semaglutide, potent, long, acting, glucon, like, peptide, 1, analog, agonist, binds, activates, GLP1, GLP1R, enhances, autophagy, inhibits, apoptosis, loss, weight, appetite, neuroprotective, effect, diabetes, insulin, cancer, obesity, NN-9535, NNC0480-0389, Glucagon-Like, Peptide, Receptors, 8946, Tocris Bioscience
Citations for Semaglutide
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Currently there are no citations for Semaglutide. Do you know of a great paper that uses Semaglutide from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.