Sphingosine-1-Phosphate Receptors

Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
5766 A 971432
Potent and selective S1P5 agonist
4543 CS 2100
Selective S1P1 agonist
4677 CYM 50260
Potent and selective S1P4 agonist
4678 CYM 50308
Potent and selective S1P4 agonist
3601 CYM 5442 hydrochloride
Selective S1P1 receptor agonist
5418 CYM 5520
Selective S1P2 allosteric agonist
4897 CYM 5541
Selective S1P3 receptor allosteric agonist
6176 FTY 720
Potent S1P receptor agonist; also immunosuppressant
4289 RP 001 hydrochloride
Potent S1P1 agonist
2284 SEW 2871
Cell-permeable, selective S1P1 receptor agonist
1370 Sphingosine-1-phosphate
Endogenous agonist at S1P1-5
4747 TC-G 1006
Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist
4363 TC-SP 14
Potent S1P1 receptor agonist

Antagonists

Cat No Product Name / Activity
4679 CYM 50358 hydrochloride
Potent and selective S1P4 antagonist
5833 Ex 26
Potent and selective S1P1 receptor antagonist
2392 JTE 013
S1P2 receptor antagonist
5328 TY 52156
S1P3 receptor antagonist
4195 VPC 23019
S1P1 and S1P3 antagonist
3602 W146
Potent and selective S1P1 receptor antagonist

Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest density on leukocytes.

Both the S1P1 and S1P3 receptors are expressed ubiquitously. The S1P2 receptor is expressed postnatally in the brain, heart, lung, stomach, intestine and adrenal gland. The expression of S1P4 and S1P5 is less widespread, and confined to lymphoid tissue and white matter respectively.

S1P receptors couple to different G proteins to mediate a range of biological effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal remodeling and cell-shape changes; and Gq modulates a range of cellular effector functions.

External sources of pharmacological information for Sphingosine-1-Phosphate Receptors :

Literature for Sphingosine-1-Phosphate Receptors

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Sphingosine-1-Phosphate Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
S1P1 Human S1PR1 NM_001400 P21453
Mouse S1pr1 NM_007901 O08530
Rat S1pr1 NM_017301 P48303
S1P2 Human S1PR2 NM_004230 O95136
Mouse S1pr2 NM_010333 P52592
Rat S1pr2 NM_017192 P47752
S1P3 Human S1PR3 NM_005226 Q99500
Mouse S1pr3 NM_010101 Q9Z0U9
Rat S1pr3 XM_225216 Q9QZG4
S1P4 Human S1PR4 NM_003775 O95977
Mouse S1pr4 NM_010102 Q9Z0L1
Rat S1pr4 NM_001108075 NP_001101545
S1P5 Human S1PR5 NM_030760 Q9H228
Mouse S1pr5 NM_053190 Q91X56
Rat S1pr5 NM_021775 Q9JKM5