Ex 26

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Description: Potent and selective S1P1 receptor antagonist
Chemical Name: 1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid
Purity: ≥98% (HPLC)
Citations (4)

Biological Activity for Ex 26

Ex 26 is a potent and selective S1P1 receptor antagonist (IC50 = 0.93 nM). Exhibits > 3,000-fold selectivity for S1P1 over S1P2, S1P3, S1P4 and S1P5. Induces lymphocyte sequestration in peripheral lymph nodes and upregulates S1P1 receptor expression. Reduces disease severity in mice with EAE. Increases IFN-α production in stimulated dendritic cells in vivo.

Compound Libraries for Ex 26

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Technical Data for Ex 26

M. Wt 494.98
Formula C28H28ClFN2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1233332-37-0
PubChem ID 59393740
Smiles CC(C1=CC(C)=C(C=C1)Cl)NC2=CC=C(C(C3=CC(C)=C(C(C)=C3)C(NC4(C(O)=O)CC4)=O)=C2)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ex 26

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.5 100
ethanol 49.5 100

Preparing Stock Solutions for Ex 26

The following data is based on the product molecular weight 494.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.1 mL 20.2 mL
5 mM 0.4 mL 2.02 mL 4.04 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References for Ex 26

References are publications that support the biological activity of the product.

Teijaro et al (2016) S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell IF.-a autoamplification. Proc.Natl.Acad.Sci.U.S.A. 113 1351 PMID: 26787880

Cahalan et al (2013) Sphingosine 1-phosphate receptor 1 (S1P1) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P1 antagonist. Mol.Pharmacol. 83 316 PMID: 23204443

Kleinwort et al (2018) S1P signalling differentially affects migration of peritoneal B cell populations in vitro and influences the production of intestinal IgA in vivo. Int.J.Mol.Sci. 19 E391 PMID: 29382132

If you know of a relevant reference for Ex 26, please let us know.

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Keywords: Ex 26, Ex 26 supplier, Ex26, sphingosine-1-phosphate, S1P1, S1P1R, antagonists, antagonism, selective, Sphingosine-1-phosphate, Receptors, 5833, Tocris Bioscience

4 Citations for Ex 26

Citations are publications that use Tocris products. Selected citations for Ex 26 include:

Shikhar et al (2022) Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis. Cell Rep 41 111742 PMID: 36476873

Richard et al (2020) Collaborative Cross Mice Yield Genetic Modifiers for Pseudomonas aeruginosa Infection in Human Lung Disease. MBio 11 PMID: 32127447

Paolo et al (2021) Fingolimod and Diabetic Retinopathy: A Drug Repurposing Study. Front Pharmacol 12 718902 PMID: 34603029

Il-Young et al (2019) Biased S1PR1 Signaling in B Cells Subverts Responses to Homeostatic Chemokines, Severely Disorganizing Lymphoid Organ Architecture. J Immunol 203 2401-2414 PMID: 31548329

Do you know of a great paper that uses Ex 26 from Tocris? Please let us know.

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