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Biological Activity for Ex 26
Ex 26 is a potent and selective S1P1 receptor antagonist (IC50 = 0.93 nM). Exhibits > 3,000-fold selectivity for S1P1 over S1P2, S1P3, S1P4 and S1P5. Induces lymphocyte sequestration in peripheral lymph nodes and upregulates S1P1 receptor expression. Reduces disease severity in mice with EAE. Increases IFN-α production in stimulated dendritic cells in vivo.
Compound Libraries for Ex 26
Technical Data for Ex 26
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ex 26
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Ex 26
The following data is based on the product molecular weight 494.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.02 mL||10.1 mL||20.2 mL|
|5 mM||0.4 mL||2.02 mL||4.04 mL|
|10 mM||0.2 mL||1.01 mL||2.02 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
References for Ex 26
References are publications that support the biological activity of the product.
Teijaro et al (2016) S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell IF.-a autoamplification. Proc.Natl.Acad.Sci.U.S.A. 113 1351 PMID: 26787880
Cahalan et al (2013) Sphingosine 1-phosphate receptor 1 (S1P1) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P1 antagonist. Mol.Pharmacol. 83 316 PMID: 23204443
Kleinwort et al (2018) S1P signalling differentially affects migration of peritoneal B cell populations in vitro and influences the production of intestinal IgA in vivo. Int.J.Mol.Sci. 19 E391 PMID: 29382132
If you know of a relevant reference for Ex 26, please let us know.
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Keywords: Ex 26, Ex 26 supplier, Ex26, sphingosine-1-phosphate, S1P1, S1P1R, antagonists, antagonism, selective, Sphingosine-1-phosphate, Receptors, 5833, Tocris Bioscience
4 Citations for Ex 26
Citations are publications that use Tocris products. Selected citations for Ex 26 include:
Richard et al (2020) Collaborative Cross Mice Yield Genetic Modifiers for Pseudomonas aeruginosa Infection in Human Lung Disease. MBio 11 PMID: 32127447
Paolo et al (2021) Fingolimod and Diabetic Retinopathy: A Drug Repurposing Study. Front Pharmacol 12 718902 PMID: 34603029
Shikhar et al (2022) Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis. Cell Rep 41 111742 PMID: 36476873
Il-Young et al (2019) Biased S1PR1 Signaling in B Cells Subverts Responses to Homeostatic Chemokines, Severely Disorganizing Lymphoid Organ Architecture. J Immunol 203 2401-2414 PMID: 31548329
Do you know of a great paper that uses Ex 26 from Tocris? Please let us know.
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Literature in this Area
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