CYM 50260

Pricing Availability   Qty
Description: Potent and selective S1P4 agonist
Chemical Name: 2-Chloro-3-[2-(2,4-dichlorophenoxy)ethoxy]-6-(fluoromethyl)pyridine
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for CYM 50260

CYM 50260 is a potent sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 = 45 nM). Displays no activity at other S1P receptor subtypes (S1P1-3 and S1P5) at concentrations up to 25 μM.

Compound Libraries for CYM 50260

CYM 50260 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CYM 50260

M. Wt 350.6
Formula C14H11Cl3FNO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1355026-60-6
PubChem ID 44620894
Smiles ClC1=CC(Cl)=C(OCCOC2=CC=C(CF)N=C2Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CYM 50260

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.06 100

Preparing Stock Solutions for CYM 50260

The following data is based on the product molecular weight 350.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.26 mL 28.52 mL
5 mM 0.57 mL 2.85 mL 5.7 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for CYM 50260

References are publications that support the biological activity of the product.

Guerrero et al (2011) Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists. Bioorg.Med.Chem.Lett. 22 537 PMID: 22119461

If you know of a relevant reference for CYM 50260, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Sphingosine-1-Phosphate Receptor Agonists

Keywords: CYM 50260, CYM 50260 supplier, CYM50260, sphingosine-1-phosphate, receptors, S1P4, agonists, potent, selective, Sphingosine-1-phosphate, Receptors, 4677, Tocris Bioscience

1 Citation for CYM 50260

Citations are publications that use Tocris products. Selected citations for CYM 50260 include:

Matsushima-Nishiwaki R et al (2018) Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2 PLoS One 13 e0209050 PMID: 30543684

Do you know of a great paper that uses CYM 50260 from Tocris? Please let us know.

Reviews for CYM 50260

There are currently no reviews for this product. Be the first to review CYM 50260 and earn rewards!

Have you used CYM 50260?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review