CYM 50260

Pricing Availability Delivery Time Qty
Cat.No. 4677 - CYM 50260 | C14H11Cl3FNO2 | CAS No. 1355026-60-6
Description: Potent and selective S1P4 agonist
Chemical Name: 2-Chloro-3-[2-(2,4-dichlorophenoxy)ethoxy]-6-(fluoromethyl)pyridine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 = 45 nM). Displays no activity at other S1P receptor subtypes (S1P1-3 and S1P5) at concentrations up to 25 μM.

Compound Libraries

CYM 50260 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 350.6
Formula C14H11Cl3FNO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1355026-60-6
PubChem ID 44620894
InChI Key FHPOTBQOUBMMCI-UHFFFAOYSA-N
Smiles ClC1=CC(Cl)=C(OCCOC2=CC=C(CF)N=C2Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.06 100

Preparing Stock Solutions

The following data is based on the product molecular weight 350.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.26 mL 28.52 mL
5 mM 0.57 mL 2.85 mL 5.7 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Guerrero et al (2011) Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists. Bioorg.Med.Chem.Lett. 22 537 PMID: 22119461


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Citations for CYM 50260

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