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Potent sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 = 45 nM). Displays no activity at other S1P receptor subtypes (S1P1-3 and S1P5) at concentrations up to 25 μM.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 350.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.85 mL||14.26 mL||28.52 mL|
|5 mM||0.57 mL||2.85 mL||5.7 mL|
|10 mM||0.29 mL||1.43 mL||2.85 mL|
|50 mM||0.06 mL||0.29 mL||0.57 mL|
References are publications that support the biological activity of the product.
Guerrero et al (2011) Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists. Bioorg.Med.Chem.Lett. 22 537 PMID: 22119461
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Keywords: CYM 50260, CYM 50260 supplier, CYM50260, sphingosine-1-phosphate, receptors, S1P4, agonists, potent, selective, Sphingosine-1-phosphate, Receptors, 4677, Tocris Bioscience
1 Citation for CYM 50260
Citations are publications that use Tocris products. Selected citations for CYM 50260 include:
Matsushima-Nishiwaki R et al (2018) Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2 PLoS One 13 e0209050 PMID: 30543684
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Literature in this Area
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