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RP 001 hydrochloride is a potent agonist of S1P1 receptors (EC50 = 9 pM). Induces internalization and polyubiquitination of S1P1 in vitro. Selective for S1P1 over S1P2 - S1P4.
RP 001 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 468.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.13 mL||10.66 mL||21.33 mL|
|5 mM||0.43 mL||2.13 mL||4.27 mL|
|10 mM||0.21 mL||1.07 mL||2.13 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References are publications that support the biological activity of the product.
Cahalan et al (2011) Actions of a picomolar short-acting S1P1 agonist in S1P1-eGFP knock-in mice. Nat.Chem.Biol. 7 254 PMID: 21445057
If you know of a relevant reference for RP 001 hydrochloride, please let us know.
Keywords: RP 001 hydrochloride, RP 001 hydrochloride supplier, RP001, sphingosine, 1, phosphate, s1p1, receptors, agonists, selective, Sphingosine-1-phosphate, Receptors, 4289, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for RP 001 hydrochloride include:
Li et al (2019) RP001 hydrochloride improves neurological outcome after subarachnoid hemorrhage. J.Neurol.Sci. 399 6 PMID: 30738334
Do you know of a great paper that uses RP 001 hydrochloride from Tocris? Please let us know.
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