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Biological Activity for FTY 720
FTY 720 is an S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppressant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.
Compound Libraries for FTY 720
Technical Data for FTY 720
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FTY 720
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for FTY 720
The following data is based on the product molecular weight 343.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.91 mL||14.54 mL||29.08 mL|
|5 mM||0.58 mL||2.91 mL||5.82 mL|
|10 mM||0.29 mL||1.45 mL||2.91 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
References for FTY 720
References are publications that support the biological activity of the product.
Hopkins et al (2011) ACS chemical neuroscience molecule spotlight on gil. (fingolimod; FTY720). ACS Chem. Neurosci. 2 116 PMID: 22778861
Brinkmann et al (2010) Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat. Rev. Drug Discov. 9 883 PMID: 21031003
Coelho et al (2007) The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. J.Pharmacol.Exp.Ther. 323 626 PMID: 17726159
Shiow et al (2006) CD69 acts downstream of IF.-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440 540 PMID: 16525420
If you know of a relevant reference for FTY 720, please let us know.
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Keywords: FTY 720, FTY 720 supplier, FTY720, |, Fingolimod, Gilenya, S1P, receptors, agonists, sphingosine-1-phosphate, immunosuppresent, sequesters, lymphocytes, orally, bioavailable, BBB, blood-brain, barrier, permeable, Sphingosine-1-phosphate, Receptors, Immunosuppressants, 6176, Tocris Bioscience
5 Citations for FTY 720
Citations are publications that use Tocris products. Selected citations for FTY 720 include:
Zhao et al (2019) Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area. Sci Adv 5 eaaw7243 PMID: 31355337
Robert H et al (2014) S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes. PLoS One 9 e97196 PMID: 24819611
Alberto et al (2023) β3-adrenergic receptor on tumor-infiltrating lymphocytes sustains IFN-γ-dependent PD-L1 expression and impairs anti-tumor immunity in neuroblastoma. Cancer Gene Ther 30 890-904 PMID: 36854895
Yuan et al (2017) Directional Migration in Esophageal Squamous Cell Carcinoma (ESCC) is Epigenetically Regulated by SET Nuclear Oncogene, a Member of the Inhibitor of Histone Acetyltransferase Complex. Neoplasia 19 868 PMID: 28938158
George et al (2021) Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion. Science 373 PMID: 34326208
Do you know of a great paper that uses FTY 720 from Tocris? Please let us know.
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Literature in this Area
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