FTY 720

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Cat.No. 6176 - FTY 720 | C19H33NO2.HCl | CAS No. 162359-56-0
Description: Potent S1P receptor agonist; also immunosuppressant
Alternative Names: Fingolimod, Gilenya
Chemical Name: 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppresant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.

Compound Libraries

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Technical Data

M. Wt 343.93
Formula C19H33NO2.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 162359-56-0
PubChem ID 107969
InChI Key SWZTYAVBMYWFGS-UHFFFAOYSA-N
Smiles CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 34.39 100
DMSO 34.39 100

Preparing Stock Solutions

The following data is based on the product molecular weight 343.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.91 mL 14.54 mL 29.08 mL
5 mM 0.58 mL 2.91 mL 5.82 mL
10 mM 0.29 mL 1.45 mL 2.91 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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References

References are publications that support the biological activity of the product.

Hopkins et al (2011) ACS chemical neuroscience molecule spotlight on gilenya (fingolimod; FTY720). ACS Chem. Neurosci. 2 116 PMID: 22778861

Brinkmann et al (2010) Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat. Rev. Drug Discov. 9 883 PMID: 21031003

Coelho et al (2007) The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. J.Pharmacol.Exp.Ther. 323 626 PMID: 17726159

Shiow et al (2006) CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440 540 PMID: 16525420


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Keywords: FTY 720, FTY 720 supplier, FTY720, |, Fingolimod, Gilenya, S1P, receptors, agonists, sphingosine-1-phosphate, immunosuppresent, sequesters, lymphocytes, orally, bioavailable, BBB, blood-brain, barrier, permeable, Sphingosine-1-phosphate, Receptors, Immunosuppressants, 6176, Tocris Bioscience

Citations for FTY 720

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Literature in this Area

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