You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for FTY 720
FTY 720 is a S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppresant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.
Compound Libraries for FTY 720
Technical Data for FTY 720
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FTY 720
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for FTY 720
The following data is based on the product molecular weight 343.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.91 mL||14.54 mL||29.08 mL|
|5 mM||0.58 mL||2.91 mL||5.82 mL|
|10 mM||0.29 mL||1.45 mL||2.91 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
References for FTY 720
References are publications that support the biological activity of the product.
Hopkins et al (2011) ACS chemical neuroscience molecule spotlight on gil. (fingolimod; FTY720). ACS Chem. Neurosci. 2 116 PMID: 22778861
Brinkmann et al (2010) Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat. Rev. Drug Discov. 9 883 PMID: 21031003
Coelho et al (2007) The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. J.Pharmacol.Exp.Ther. 323 626 PMID: 17726159
Shiow et al (2006) CD69 acts downstream of IF.-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440 540 PMID: 16525420
If you know of a relevant reference for FTY 720, please let us know.
View Related Products by Product Action
Keywords: FTY 720, FTY 720 supplier, FTY720, |, Fingolimod, Gilenya, S1P, receptors, agonists, sphingosine-1-phosphate, immunosuppresent, sequesters, lymphocytes, orally, bioavailable, BBB, blood-brain, barrier, permeable, Sphingosine-1-phosphate, Receptors, Immunosuppressants, 6176, Tocris Bioscience
2 Citations for FTY 720
Citations are publications that use Tocris products. Selected citations for FTY 720 include:
Zhao et al (2019) Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area. Sci Adv 5 eaaw7243 PMID: 31355337
Yuan et al (2017) Directional Migration in Esophageal Squamous Cell Carcinoma (ESCC) is Epigenetically Regulated by SET Nuclear Oncogene, a Member of the Inhibitor of Histone Acetyltransferase Complex. Neoplasia 19 868 PMID: 28938158
Do you know of a great paper that uses FTY 720 from Tocris? Please let us know.
Reviews for FTY 720
There are currently no reviews for this product. Be the first to review FTY 720 and earn rewards!
Have you used FTY 720?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.