TY 52156

Pricing Availability Delivery Time Qty
Cat.No. 5328 - TY 52156 | C18H19Cl2N3O | CAS No. 934369-14-9
Description: S1P3 receptor antagonist
Chemical Name: N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

S1P3 receptor antagonist (Ki = 110 nM); inhibits S1P-induced Ca2+ release in HUVEC cells. Suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.

Compound Libraries

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Technical Data

M. Wt 364.27
Formula C18H19Cl2N3O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 934369-14-9
PubChem ID 16046248
InChI Key XONRRGIRSGNWFP-UHFFFAOYSA-N
Smiles ClC1=CC=C(/N=C(NNC2=CC=C(Cl)C=C2)/C(C(C)(C)C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.43 100
ethanol 36.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 364.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.73 mL 27.45 mL
5 mM 0.55 mL 2.75 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.75 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Murakami et al (2010) Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol.Pharmacol. 77 704 PMID: 20097776

Hirata et al (2014) Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat.Commun. 25 4806 PMID: 25254944


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Keywords: TY52156 S1P3 receptors antagonists antagonism sphingosine-1-phosphate Sphingosine-1-phosphate Receptors

2 Citations for TY 52156

Citations are publications that use Tocris products. Selected citations for TY 52156 include:

Schuhmann et al (2015) Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model. J Neurosci 16 29454 PMID: 26690412

Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184 PMID: 26419927


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Literature in this Area

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Pathways for TY 52156

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