S1P3 receptor antagonist (Ki = 110 nM); inhibits S1P-induced Ca2+ release in HUVEC cells. Suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 364.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.75 mL||13.73 mL||27.45 mL|
|5 mM||0.55 mL||2.75 mL||5.49 mL|
|10 mM||0.27 mL||1.37 mL||2.75 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Murakami et al (2010) Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol.Pharmacol. 77 704 PMID: 20097776
Hirata et al (2014) Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat.Commun. 25 4806 PMID: 25254944
If you know of a relevant reference for TY 52156, please let us know.
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Keywords: TY52156 S1P3 receptors antagonists antagonism sphingosine-1-phosphate Sphingosine-1-phosphate Receptors
2 Citations for TY 52156
Citations are publications that use Tocris products. Selected citations for TY 52156 include:
Schuhmann et al (2015) Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model. J Neurosci 16 29454 PMID: 26690412
Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184 PMID: 26419927
Do you know of a great paper that uses TY 52156 from Tocris? If so please let us know.