TY 52156

Pricing Availability   Qty
Description: S1P3 receptor antagonist
Chemical Name: N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide
Purity: ≥98% (HPLC)
Citations (7)

Biological Activity for TY 52156

TY 52156 is an S1P3 receptor antagonist (Ki = 110 nM); inhibits S1P-induced Ca2+ release in HUVEC cells. Suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.

Compound Libraries for TY 52156

TY 52156 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TY 52156

M. Wt 364.27
Formula C18H19Cl2N3O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 934369-14-9
PubChem ID 16046248
Smiles ClC1=CC=C(/N=C(NNC2=CC=C(Cl)C=C2)/C(C(C)(C)C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TY 52156

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.43 100
ethanol 36.43 100

Preparing Stock Solutions for TY 52156

The following data is based on the product molecular weight 364.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.73 mL 27.45 mL
5 mM 0.55 mL 2.75 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.75 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets for TY 52156

Certificate of Analysis / Product Datasheet
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References for TY 52156

References are publications that support the biological activity of the product.

Murakami et al (2010) Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol.Pharmacol. 77 704 PMID: 20097776

Hirata et al (2014) Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat.Commun. 25 4806 PMID: 25254944

If you know of a relevant reference for TY 52156, please let us know.

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Keywords: TY 52156, TY 52156 supplier, TY52156, S1P3, receptors, antagonists, antagonism, sphingosine-1-phosphate, Sphingosine-1-phosphate, Receptors, Cancer, Stem, Cells, 5328, Tocris Bioscience

7 Citations for TY 52156

Citations are publications that use Tocris products. Selected citations for TY 52156 include:

Rosalinda et al (2022) S1P-Induced TNF-α and IL-6 Release from PBMCs Exacerbates Lung Cancer-Associated Inflammation. Cells 11 PMID: 36010601

Ma et al (2017) A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. Dev Cell 41 366 PMID: 28535372

Hübner et al (2018) Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nat Commun 9 4860 PMID: 30451830

Schuhmann et al (2015) Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model. J Neurosci 16 29454 PMID: 26690412

Heo and Im (2019) Pro-Inflammatory Role of S1P3 in Macrophages. Biomol Ther (Seoul) PMID: 30917625

Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184 PMID: 26419927

Rosalinda et al (2021) Intracellular Sphingosine-1-Phosphate Receptor 3 Contributes to Lung Tumor Cell Proliferation. Cell Physiol Biochem 55 539-552 PMID: 34473432

Do you know of a great paper that uses TY 52156 from Tocris? Please let us know.

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