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Biological Activity for TY 52156
TY 52156 is an S1P3 receptor antagonist (Ki = 110 nM); inhibits S1P-induced Ca2+ release in HUVEC cells. Suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.
Compound Libraries for TY 52156
Technical Data for TY 52156
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TY 52156
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TY 52156
The following data is based on the product molecular weight 364.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.75 mL||13.73 mL||27.45 mL|
|5 mM||0.55 mL||2.75 mL||5.49 mL|
|10 mM||0.27 mL||1.37 mL||2.75 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
References for TY 52156
References are publications that support the biological activity of the product.
Murakami et al (2010) Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol.Pharmacol. 77 704 PMID: 20097776
Hirata et al (2014) Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat.Commun. 25 4806 PMID: 25254944
If you know of a relevant reference for TY 52156, please let us know.
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Keywords: TY 52156, TY 52156 supplier, TY52156, S1P3, receptors, antagonists, antagonism, sphingosine-1-phosphate, Sphingosine-1-phosphate, Receptors, Cancer, Stem, Cells, 5328, Tocris Bioscience
5 Citations for TY 52156
Citations are publications that use Tocris products. Selected citations for TY 52156 include:
Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184 PMID: 26419927
Heo and Im (2019) Pro-Inflammatory Role of S1P3 in Macrophages. Biomol Ther (Seoul) PMID: 30917625
Schuhmann et al (2015) Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model. J Neurosci 16 29454 PMID: 26690412
Hübner et al (2018) Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nat Commun 9 4860 PMID: 30451830
Ma et al (2017) A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. Dev Cell 41 366 PMID: 28535372
Do you know of a great paper that uses TY 52156 from Tocris? Please let us know.
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Literature in this Area
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