Ceramidases

Ceramidases (EC 3.5.1.23) are a group of enzymes which catalyze the hydrolysis of ceramides to produce sphingosine, which subsequently undergoes phosphorylation to generate sphingosine-1-phosphate (S1P).

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
4448 Ceranib 1
Ceramidase inhibitor; antiproliferative
1484 Oleylethanolamide
GPR55 agonist; ceramidase inhibitor

Ceramidases (EC 3.5.1.23) are a group of enzymes which catalyze the hydrolysis of ceramides to produce sphingosine, which subsequently undergoes phosphorylation to generate sphingosine-1-phosphate (S1P). Ceramide and its downstream products, sphingosine and S1P, are bioactive lipids that mediate various cellular processes including cell growth arrest, differentiation and apoptosis.

The expression of ceramides increases in response to stressful stimuli, such as proapoptotic cytokines, cancer chemotherapeutic agents, UV and ionizing radiation, vitamins such as retinoic acid, and serum deprivation.

Members of the ceramidase enzyme family can be classified according to their substrate as well as their optimum pH for biological activity. Due to differences in substrate specificity between the ceramidases, cellular localization, tissue distribution and expression, several distinct physiological roles have been suggested for these enzymes. For example, upregulation of acid and neutral ceramidases is linked to cell proliferation and survival, whilst upregulation of alkaline ceramidases has divergent effects dependent on the enzyme subtype (Alkaline ceramidases 1, 2 or 3).

Literature for Ceramidases

Cancer

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Ceramidase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Alkaline ceramidase 1 Human ACER1 NM_133492 Q8TDN7
Mouse Acer1 NM_175731 Q8R4X1
Rat Acer1 NM_001106875 -
Alkaline ceramidase 2 Human ACER2 XM_294540 Q5QJU3
Mouse Acer2 NM_139306 Q8VD53
Rat Acer2 NM_001107943 -
Alkaline ceramidase 3 Human ACER3 NM_018367 Q9NUN7
Mouse Acer3 NM_025408 Q9D099
Rat Acer3 XM_574497 -
N-acylsphingosine amidohydrolase (acid ceramidase) 1 Human ASAH1 NM_004315 Q13510
Mouse Asah1 NM_019734 Q9WV54
Rat Asah1 NM_053407 Q6P7S1
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 Human ASAH2 NM_019893 Q9NR71
Mouse Asah2 NM_018830 Q9JHE3
Rat Asah2 NM_053646 Q91XT9
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B Human ASAH2B NM_001079516 P0C7U1
Mouse - - -
Rat - - -
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2C Human ASAH2C NG_012763 P0C7U2
Mouse - - -
Rat - - -
N-acylethanolamine acid amidase Human NAAA NM_001042402 Q02083
Mouse Naaa NM_025972 Q9D7V9
Rat Naaa NM_001010967 Q5KTC7
Galactosylceramidase Human GALC NM_000153 P54803
Mouse Galc NM_008079 P54818
Rat Galc NM_001005888 Q5YKG1
Glucosidase, beta, acid Human GBA NM_000157 P04062
Mouse Gba NM_008094 P17439
Rat - - -
Glucosidase, beta (bile acid) 2 Human GBA2 NM_020944 Q9HCG7
Mouse Gba2 NM_172692 Q69ZF3
Rat Gba2 NM_001013091 Q5M868