GSK 2018682

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Cat.No. 6709 - GSK 2018682 | C22H21ClN4O4 | CAS No. 1034688-30-6
Description: S1P1 and S1P5 agonist
Chemical Name: 4-[5-[5-Chloro-6-(1-methylethoxy)-3-pyridinyl]-1,2,4-oxadiazol-3-yl]-1H-indole-1-butanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Sphingosine-1-phosphate receptor 1 (S1P1) and 5 (S1P5) agonist.

Technical Data

M. Wt 440.88
Formula C22H21ClN4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1034688-30-6
PubChem ID 24988201
InChI Key NFIGDBFIDKDNIG-UHFFFAOYSA-N
Smiles CC(OC1=NC=C(C2=NC(C3=C4C=CN(C4=CC=C3)CCCC(O)=O)=NO2)C=C1Cl)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.09 100

Preparing Stock Solutions

The following data is based on the product molecular weight 440.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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References

References are publications that support the biological activity of the product.

Bigaud et al (2014) Second generation S1P pathway modulators: research strategies and clinical developments. Biochim.Biophys.Acta. 1841 745 PMID: 24239768

Subei and Cohen (2015) Sphingosine 1-phosphate receptor modulators in multiple sclerosis. CNS.Drugs. 29 565 PMID: 26239599


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Citations for GSK 2018682

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