CYM 5520

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Description: Selective S1P2 allosteric agonist
Chemical Name: 1-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-1,6-dihydro-6-oxo-3-pyridinecarbonitrile
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews

Biological Activity for CYM 5520

CYM 5520 is a selective S1P2 allosteric agonist (EC50 = 0.48 μM). Selective for S1P2 receptors over a panel of 29 other receptors and transporters.

Technical Data for CYM 5520

M. Wt 345.39
Formula C21H19N3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1449747-00-5
PubChem ID 25110470
InChI Key FMYGNANMYYHBSU-UHFFFAOYSA-N
Smiles CC1=C(C(CN3C=C(C#N)C=CC3=O)=O)C=C(C)N1CC2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CYM 5520

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.54 100

Preparing Stock Solutions for CYM 5520

The following data is based on the product molecular weight 345.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.9 mL 14.48 mL 28.95 mL
5 mM 0.58 mL 2.9 mL 5.79 mL
10 mM 0.29 mL 1.45 mL 2.9 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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References for CYM 5520

References are publications that support the biological activity of the product.

Satsu et al (2013) A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorg.Med.Chem. 21 5373 PMID: 23849205


If you know of a relevant reference for CYM 5520, please let us know.

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Keywords: CYM 5520, CYM 5520 supplier, selective, allosteric, agonists, sphingosine-1-phosphate, receptor, 2, S1P2, S1PR2, agonism, CYM5520, Sphingosine-1-phosphate, Receptors, 5418, Tocris Bioscience

2 Citations for CYM 5520

Citations are publications that use Tocris products. Selected citations for CYM 5520 include:

Balaji M et al (2021) Two distinct trophectoderm lineage stem cells from human pluripotent stem cells. J Biol Chem 296 100386 PMID: 33556374

Matsushima-Nishiwaki et al (2018) Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2. PLoS One 13 e0209050 PMID: 30543684


Do you know of a great paper that uses CYM 5520 from Tocris? Please let us know.

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