CYM 5520

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Cat.No. 5418 - CYM 5520 | C21H19N3O2 | CAS No. 1449747-00-5
Description: Selective S1P2 allosteric agonist
Chemical Name: 1-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-1,6-dihydro-6-oxo-3-pyridinecarbonitrile
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective S1P2 allosteric agonist (EC50 = 0.48 μM). Selective for S1P2 receptors over a panel of 29 other receptors and transporters.

Technical Data

M. Wt 345.39
Formula C21H19N3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1449747-00-5
PubChem ID 25110470
InChI Key FMYGNANMYYHBSU-UHFFFAOYSA-N
Smiles CC1=C(C(CN3C=C(C#N)C=CC3=O)=O)C=C(C)N1CC2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 345.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.9 mL 14.48 mL 28.95 mL
5 mM 0.58 mL 2.9 mL 5.79 mL
10 mM 0.29 mL 1.45 mL 2.9 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Satsu et al (2013) A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorg.Med.Chem. 21 5373 PMID: 23849205


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Keywords: CYM 5520, CYM 5520 supplier, selective, allosteric, agonists, sphingosine-1-phosphate, receptor, 2, S1P2, S1PR2, agonism, CYM5520, Sphingosine-1-phosphate, Receptors, 5418, Tocris Bioscience

Citations for CYM 5520

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