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CYM 5520 is a selective S1P2 allosteric agonist (EC50 = 0.48 μM). Selective for S1P2 receptors over a panel of 29 other receptors and transporters.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 345.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.9 mL||14.48 mL||28.95 mL|
|5 mM||0.58 mL||2.9 mL||5.79 mL|
|10 mM||0.29 mL||1.45 mL||2.9 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
References are publications that support the biological activity of the product.
Satsu et al (2013) A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorg.Med.Chem. 21 5373 PMID: 23849205
If you know of a relevant reference for CYM 5520, please let us know.
Keywords: CYM 5520, CYM 5520 supplier, selective, allosteric, agonists, sphingosine-1-phosphate, receptor, 2, S1P2, S1PR2, agonism, CYM5520, Sphingosine-1-phosphate, Receptors, 5418, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for CYM 5520 include:
Matsushima-Nishiwaki et al (2018) Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2. PLoS One 13 e0209050 PMID: 30543684
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