A 971432

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Cat.No. 5766 - A 971432 | C18H17Cl2NO3 | CAS No. 1240308-45-5
Description: Potent and selective S1P5 agonist
Chemical Name: 1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid
Purity: ≥99% (HPLC)
Datasheet
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Biological Activity

Potent and selective S1P5 agonist (EC50 values are 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively). Exhibits 60-fold selectivity over S1P1, and >1,600-fold selectivity over S1P2-4, and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo. Orally available.

Technical Data

M. Wt 366.24
Formula C18H17Cl2NO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1240308-45-5
PubChem ID 46872626
InChI Key WAAWETUDFSIYSD-UHFFFAOYSA-N
Smiles ClC1=C(Cl)C=C(COC2=CC=C(CN3CC(C(O)=O)C3)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 36.62 100
1eq. NaOH 36.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 366.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.65 mL 27.3 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.37 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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References

References are publications that support the products' biological activity.

Hobson et al (2015) Discovery of A-971432, an orally bioavailable selective sphingosine-1-phosphate receptor 5 (S1P5) agonist for the potential treatment of neurodegenerative disorders. J.Med.Chem. 58 9154 PMID: 26509640


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Keywords: A 971432, supplier, A971432, potent, selective, S1P5, sphingosine, phosphate, receptors, neurodegeneration, orally, bioavailable, blood-brain, barrier, Sphingosine-1-phosphate, Receptors, Tocris Bioscience

Citations for A 971432

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Literature in this Area

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