Potent and selective S1P5 agonist (EC50 values are 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively). Exhibits 60-fold selectivity over S1P1, and >1,600-fold selectivity over S1P2-4, and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo. Orally available.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 366.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.73 mL||13.65 mL||27.3 mL|
|5 mM||0.55 mL||2.73 mL||5.46 mL|
|10 mM||0.27 mL||1.37 mL||2.73 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
References are publications that support the biological activity of the product.
Hobson et al (2015) Discovery of A-971432, an orally bioavailable selective sphingosine-1-phosphate receptor 5 (S1P5) agonist for the potential treatment of neurodegenerative disorders. J.Med.Chem. 58 9154 PMID: 26509640
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Keywords: A 971432, A 971432 supplier, A971432, potent, selective, S1P5, sphingosine, phosphate, receptors, neurodegeneration, orally, bioavailable, blood-brain, barrier, Sphingosine-1-phosphate, Receptors, 5766, Tocris Bioscience
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