A 971432

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Description: Potent and selective S1P5 agonist
Chemical Name: 1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity for A 971432

A 971432 is a potent and selective S1P5 agonist (EC50 values are 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively). Exhibits 60-fold selectivity over S1P1, and >1,600-fold selectivity over S1P2-4, and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo. Orally available.

Technical Data for A 971432

M. Wt 366.24
Formula C18H17Cl2NO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1240308-45-5
PubChem ID 46872626
Smiles ClC1=C(Cl)C=C(COC2=CC=C(CN3CC(C(O)=O)C3)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A 971432

Solvent Max Conc. mg/mL Max Conc. mM
1eq. NaOH 36.62 100
1eq. HCl 36.62 100

Preparing Stock Solutions for A 971432

The following data is based on the product molecular weight 366.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.65 mL 27.3 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.37 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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References for A 971432

References are publications that support the biological activity of the product.

Hobson et al (2015) Discovery of A-971432, an orally bioavailable selective sphingosine-1-phosphate receptor 5 (S1P5) agonist for the potential treatment of neurodegenerative disorders. J.Med.Chem. 58 9154 PMID: 26509640

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Keywords: A 971432, A 971432 supplier, A971432, potent, selective, S1P5, sphingosine, phosphate, receptors, neurodegeneration, orally, bioavailable, blood-brain, barrier, Sphingosine-1-phosphate, Receptors, 5766, Tocris Bioscience

1 Citation for A 971432

Citations are publications that use Tocris products. Selected citations for A 971432 include:

Matsushima-Nishiwaki et al (2018) Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2. PLoS One 13 e0209050 PMID: 30543684

Do you know of a great paper that uses A 971432 from Tocris? Please let us know.

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