Sphingosine Kinase

Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosine-1-phosphate, a key sphingolipid signaling molecule involved in cell growth, survival, differentiation and motility. Two mammalian isoforms have been cloned - SPHK1 and SPHK2.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
4640 N,N-Dimethylsphingosine
Sphingosine kinase inhibitor
5803 MP A08
Selective ATP competitive SphK1 and 2 inhibitor; cell permeable
5754 PF 543 hydrochloride
Potent and selective SphK1 inhibitor
5452 SKI 178
Non-lipid sphingosine kinase 1 (SphK1) inhibitor
2097 SKI II
Selective non-lipid inhibitor of sphingosine kinase

Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosine-1-phosphate, a key sphingolipid signaling molecule involved in cell growth, survival, differentiation and motility. SphK constitutes an important checkpoint in the regulation of circulating levels of ceramide, sphingosine and sphingosine-1-phosphate. Two mammalian isoforms have been cloned - SPHK1 and SPHK2.

Sphingosine kinase is activated in response to pro-growth signals via GPCRs (e.g. acetylcholine muscarinic receptors), small GTPases and tyrosine kinase receptors (e.g. VEGFR and PDGFR). Once activated, sphingosine kinase translocates to the plasma membrane, a process aided by TNFα and PMA.

Due to its role in sphingosine-1-phosphate synthesis, SphK is a target of interest in cancer research.

Literature for Sphingosine Kinase

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Sphingosine Kinase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
SPHK1 Human SPHK1 NM_001142601 Q9NYA1
Rat Sphk1 NM_133386 Q91V26
SPHK2 Human SPHK2 NM_001204158 Q9NRA0
Rat Sphk2 NM_001012066 Q6AYB2