Sphingosine Kinase

Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosine-1-phosphate, a key sphingolipid signaling molecule involved in cell growth, survival, differentiation and motility. Two mammalian isoforms have been cloned - SPHK1 and SPHK2.

Products
Background
Gene Data

Sphingosine Kinase Inhibitors

Cat. No. Product Name / Activity
5803 MP A08
Selective ATP competitive SphK1 and 2 inhibitor; cell permeable
5754 PF 543 hydrochloride
Potent and selective SphK1 inhibitor
2097 SKI II
Selective non-lipid inhibitor of sphingosine kinase
6281 SLM 6031434 hydrochloride
Selective sphingosine kinase 2 (Sphk2) inhibitor

Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosine-1-phosphate, a key sphingolipid signaling molecule involved in cell growth, survival, differentiation and motility. SphK constitutes an important checkpoint in the regulation of circulating levels of ceramide, sphingosine and sphingosine-1-phosphate. Two mammalian isoforms have been cloned - SPHK1 and SPHK2.

Sphingosine kinase is activated in response to pro-growth signals via GPCRs (e.g. acetylcholine muscarinic receptors), small GTPases and tyrosine kinase receptors (e.g. VEGFR and PDGFR). Once activated, sphingosine kinase translocates to the plasma membrane, a process aided by TNFα and PMA.

Due to its role in sphingosine-1-phosphate synthesis, SphK is a target of interest in cancer research.

External sources of pharmacological information for Sphingosine Kinase :

    Sphingosine Kinase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    SPHK1 Human SPHK1 NM_001142601 Q9NYA1
    Rat Sphk1 NM_133386 Q91V26
    SPHK2 Human SPHK2 NM_001204158 Q9NRA0
    Rat Sphk2 NM_001012066 Q6AYB2