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Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosine-1-phosphate, a key sphingolipid signaling molecule involved in cell growth, survival, differentiation and motility. Two mammalian isoforms have been cloned - SPHK1 and SPHK2.
|Cat. No.||Product Name / Activity|
|Sphingosine kinase inhibitor|
|Selective ATP competitive SphK1 and 2 inhibitor; cell permeable|
|5754||PF 543 hydrochloride|
|Potent and selective SphK1 inhibitor|
|Selective non-lipid inhibitor of sphingosine kinase|
|6281||SLM 6031434 hydrochloride|
|Selective sphingosine kinase 2 (Sphk2) inhibitor|
Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosine-1-phosphate, a key sphingolipid signaling molecule involved in cell growth, survival, differentiation and motility. SphK constitutes an important checkpoint in the regulation of circulating levels of ceramide, sphingosine and sphingosine-1-phosphate. Two mammalian isoforms have been cloned - SPHK1 and SPHK2.
Sphingosine kinase is activated in response to pro-growth signals via GPCRs (e.g. acetylcholine muscarinic receptors), small GTPases and tyrosine kinase receptors (e.g. VEGFR and PDGFR). Once activated, sphingosine kinase translocates to the plasma membrane, a process aided by TNFα and PMA.
Due to its role in sphingosine-1-phosphate synthesis, SphK is a target of interest in cancer research.
Tocris offers the following scientific literature for Sphingosine Kinase to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.