CYM 50358 hydrochloride

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Cat.No. 4679 - CYM 50358 hydrochloride | C20H18Cl2N2O2.HCl
Description: Potent and selective S1P4 antagonist
Chemical Name: N-[(4-(Aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-2-furancarboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent S1P4 antagonist (IC50 = 25 nM). Displays selectivity for S1P4 against S1P1, S1P2, S1P3 and S1P5 receptors.

Compound Libraries

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Technical Data

M. Wt 425.74
Formula C20H18Cl2N2O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 78243726
InChI Key OFDSTJOMVDAKCS-UHFFFAOYSA-N
Smiles O=C(NC3=C(C)C=C(CN)C=C3C)C1=CC=C(C2=C(Cl)C=CC(Cl)=C2)O1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.57 100
water 42.57 100

Preparing Stock Solutions

The following data is based on the product molecular weight 425.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.74 mL 23.49 mL
5 mM 0.47 mL 2.35 mL 4.7 mL
10 mM 0.23 mL 1.17 mL 2.35 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Guerrero et al (2011) Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg.Med.Chem.Lett. 21 3632 PMID: 21570287

Cencetti et al (2013) TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation. FASEB J. 27 4532 PMID: 23913862


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Citations for CYM 50358 hydrochloride

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Literature in this Area

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