CYM 50358 hydrochloride
Potent S1P4 antagonist (IC50 = 25 nM). Displays selectivity for S1P4 against S1P1, S1P2, S1P3 and S1P5 receptors.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 425.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.35 mL||11.74 mL||23.49 mL|
|5 mM||0.47 mL||2.35 mL||4.7 mL|
|10 mM||0.23 mL||1.17 mL||2.35 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
References are publications that support the biological activity of the product.
Guerrero et al (2011) Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg.Med.Chem.Lett. 21 3632 PMID: 21570287
Cencetti et al (2013) TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation. FASEB J. 27 4532 PMID: 23913862
If you know of a relevant reference for CYM 50358 hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CYM 50358 hydrochloride, CYM 50358 hydrochloride supplier, CYM50358, hydrochloride, sphingosine-1-phosphate, receptors, S1P, S1P4, antagonists, potent, selective, Sphingosine-1-phosphate, Receptors, 4679, Tocris Bioscience
Citations for CYM 50358 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for CYM 50358 hydrochloride. Do you know of a great paper that uses CYM 50358 hydrochloride from Tocris? Please let us know.
Reviews for CYM 50358 hydrochloride
There are currently no reviews for this product. Be the first to review CYM 50358 hydrochloride and earn rewards!
Have you used CYM 50358 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.