CYM 50358 hydrochloride

Pricing Availability   Qty
Cat.No. 4679 - CYM 50358 hydrochloride | C20H18Cl2N2O2.HCl | CAS No. 1781750-72-8
Description: Potent and selective S1P4 antagonist
Chemical Name: N-[(4-(Aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-2-furancarboxamide hydrochloride
Purity: ≥97% (HPLC)
Literature (3)

Biological Activity for CYM 50358 hydrochloride

CYM 50358 hydrochloride is a potent S1P4 antagonist (IC50 = 25 nM). Displays selectivity for S1P4 against S1P1, S1P2, S1P3 and S1P5 receptors.

Technical Data for CYM 50358 hydrochloride

M. Wt 425.74
Formula C20H18Cl2N2O2.HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1781750-72-8
PubChem ID 78243726
Smiles O=C(NC3=C(C)C=C(CN)C=C3C)C1=CC=C(C2=C(Cl)C=CC(Cl)=C2)O1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CYM 50358 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 42.57 100
DMSO 42.57 100

Preparing Stock Solutions for CYM 50358 hydrochloride

The following data is based on the product molecular weight 425.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.74 mL 23.49 mL
5 mM 0.47 mL 2.35 mL 4.7 mL
10 mM 0.23 mL 1.17 mL 2.35 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for CYM 50358 hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for CYM 50358 hydrochloride

References are publications that support the biological activity of the product.

Guerrero et al (2011) Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg.Med.Chem.Lett. 21 3632 PMID: 21570287

Cencetti et al (2013) TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation. FASEB J. 27 4532 PMID: 23913862

If you know of a relevant reference for CYM 50358 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Sphingosine-1-Phosphate Receptor Antagonists

Keywords: CYM 50358 hydrochloride, CYM 50358 hydrochloride supplier, CYM50358, hydrochloride, sphingosine-1-phosphate, receptors, S1P, S1P4, antagonists, potent, selective, Sphingosine-1-phosphate, Receptors, 4679, Tocris Bioscience

Citations for CYM 50358 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for CYM 50358 hydrochloride. Do you know of a great paper that uses CYM 50358 hydrochloride from Tocris? Please let us know.

Reviews for CYM 50358 hydrochloride

There are currently no reviews for this product. Be the first to review CYM 50358 hydrochloride and earn rewards!

Have you used CYM 50358 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling