CYM 50358 hydrochloride

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Description: Potent and selective S1P4 antagonist
Chemical Name: N-[(4-(Aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-2-furancarboxamide hydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations (2)
Reviews

Biological Activity for CYM 50358 hydrochloride

CYM 50358 hydrochloride is a potent S1P4 antagonist (IC50 = 25 nM). Displays selectivity for S1P4 against S1P1, S1P2, S1P3 and S1P5 receptors.

Technical Data for CYM 50358 hydrochloride

M. Wt 425.74
Formula C20H18Cl2N2O2.HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1781750-72-8
PubChem ID 78243726
InChI Key OFDSTJOMVDAKCS-UHFFFAOYSA-N
Smiles O=C(NC3=C(C)C=C(CN)C=C3C)C1=CC=C(C2=C(Cl)C=CC(Cl)=C2)O1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CYM 50358 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 42.57 100
DMSO 42.57 100

Preparing Stock Solutions for CYM 50358 hydrochloride

The following data is based on the product molecular weight 425.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.74 mL 23.49 mL
5 mM 0.47 mL 2.35 mL 4.7 mL
10 mM 0.23 mL 1.17 mL 2.35 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets for CYM 50358 hydrochloride

Certificate of Analysis / Product Datasheet
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References for CYM 50358 hydrochloride

References are publications that support the biological activity of the product.

Guerrero et al (2011) Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg.Med.Chem.Lett. 21 3632 PMID: 21570287

Cencetti et al (2013) TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation. FASEB J. 27 4532 PMID: 23913862


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2 Citations for CYM 50358 hydrochloride

Citations are publications that use Tocris products. Selected citations for CYM 50358 hydrochloride include:

Richard M et al (2022) Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. Immunity 55 254-271.e7 PMID: 35139352

Chen et al (2023) Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux. Front Immunol 14 1090202 PMID: 36798132


Do you know of a great paper that uses CYM 50358 hydrochloride from Tocris? Please let us know.

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