CYM 5442 hydrochloride

Pricing Availability   Qty
Description: Selective S1P1 receptor agonist
Chemical Name: 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride
Purity: ≥98% (HPLC)
Citations (6)

Biological Activity for CYM 5442 hydrochloride

CYM 5442 hydrochloride is a potent and selective S1P1 agonist in vitro (EC50 = 1.35 nM). Activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.

Compound Libraries for CYM 5442 hydrochloride

CYM 5442 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CYM 5442 hydrochloride

M. Wt 445.94
Formula C23H27N3O4.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1783987-80-3
PubChem ID 90488865
Smiles OCCNC3CCC(C3=CC=C4)=C4C1=NOC(C2=CC(OCC)=C(OCC)C=C2)=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CYM 5442 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 4.46 10
DMSO 44.59 100

Preparing Stock Solutions for CYM 5442 hydrochloride

The following data is based on the product molecular weight 445.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.21 mL 22.42 mL
5 mM 0.45 mL 2.24 mL 4.48 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for CYM 5442 hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for CYM 5442 hydrochloride

References are publications that support the biological activity of the product.

Gonzalez-Cabrera et al (2008) Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions Mol.Pharmacol. 74 1308 PMID: 18708635

If you know of a relevant reference for CYM 5442 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Sphingosine-1-Phosphate Receptor Agonists

Keywords: CYM 5442 hydrochloride, CYM 5442 hydrochloride supplier, sphingosine-1-phosphate, S1P1, receptors, agonists, CYM5442, hydrochloride, Sphingosine-1-phosphate, Receptors, 3601, Tocris Bioscience

6 Citations for CYM 5442 hydrochloride

Citations are publications that use Tocris products. Selected citations for CYM 5442 hydrochloride include:

Hübner et al (2018) Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nat Commun 9 4860 PMID: 30451830

Balaji M et al (2021) Two distinct trophectoderm lineage stem cells from human pluripotent stem cells. J Biol Chem 296 100386 PMID: 33556374

Li et al (2015) Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. J Neuroinflammation 12 70 PMID: 25880547

Janes et al (2014) The development and maintenance of PacT.-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. J Biol Chem 289 21082 PMID: 24876379

Do you know of a great paper that uses CYM 5442 hydrochloride from Tocris? Please let us know.

Reviews for CYM 5442 hydrochloride

There are currently no reviews for this product. Be the first to review CYM 5442 hydrochloride and earn rewards!

Have you used CYM 5442 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review