CYM 5442 hydrochloride

Pricing Availability   Qty
Description: Selective S1P1 receptor agonist
Chemical Name: 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews

Biological Activity for CYM 5442 hydrochloride

CYM 5442 hydrochloride is a potent and selective S1P1 agonist in vitro (EC50 = 1.35 nM). Activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.

Compound Libraries for CYM 5442 hydrochloride

CYM 5442 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CYM 5442 hydrochloride

M. Wt 445.94
Formula C23H27N3O4.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1783987-80-3
PubChem ID 90488865
InChI Key KMZLVDAVGXYZDA-UHFFFAOYSA-N
Smiles OCCNC3CCC(C3=CC=C4)=C4C1=NOC(C2=CC(OCC)=C(OCC)C=C2)=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CYM 5442 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.46 10
DMSO 44.59 100

Preparing Stock Solutions for CYM 5442 hydrochloride

The following data is based on the product molecular weight 445.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.21 mL 22.42 mL
5 mM 0.45 mL 2.24 mL 4.48 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets for CYM 5442 hydrochloride

Certificate of Analysis / Product Datasheet
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References for CYM 5442 hydrochloride

References are publications that support the biological activity of the product.

Gonzalez-Cabrera et al (2008) Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions Mol.Pharmacol. 74 1308 PMID: 18708635


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Keywords: CYM 5442 hydrochloride, CYM 5442 hydrochloride supplier, sphingosine-1-phosphate, S1P1, receptors, agonists, CYM5442, hydrochloride, Sphingosine-1-phosphate, Receptors, 3601, Tocris Bioscience

6 Citations for CYM 5442 hydrochloride

Citations are publications that use Tocris products. Selected citations for CYM 5442 hydrochloride include:

Hübner et al (2018) Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nat Commun 9 4860 PMID: 30451830

Balaji M et al (2021) Two distinct trophectoderm lineage stem cells from human pluripotent stem cells. J Biol Chem 296 100386 PMID: 33556374

Li et al (2015) Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. J Neuroinflammation 12 70 PMID: 25880547

Janes et al (2014) The development and maintenance of PacT.-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. J Biol Chem 289 21082 PMID: 24876379


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