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CS 2100 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 4.0 nM). Exhibits 5000-fold selectivity for human S1P1 over S1P3. Displays efficacy in a rat adjuvant-induced arthritis model.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||2.31||5 with gentle warming|
The following data is based on the product molecular weight 461.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||43.33 mL||216.67 mL||433.34 mL|
|0.25 mM||8.67 mL||43.33 mL||86.67 mL|
|0.5 mM||4.33 mL||21.67 mL||43.33 mL|
|2.5 mM||0.87 mL||4.33 mL||8.67 mL|
References are publications that support the biological activity of the product.
Nakamura et al (2012) Synthesis and evaluation of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. Eur.J.Med.Chem. 51 92 PMID: 22405291
Nakamura et al (2012) Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. Bioorg.Med.Chem.Lett. 22 1788 PMID: 22264485
If you know of a relevant reference for CS 2100, please let us know.
Keywords: CS 2100, CS 2100 supplier, CS2100, sphingosine-1-phosphate, receptors, S1P1, selective, agonists, Sphingosine-1-phosphate, Receptors, 4543, Tocris Bioscience
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