Home / Pharmacology / GPCRs / 7-TM Receptors / Sphingosine-1-Phosphate Receptors / Sphingosine-1-Phosphate Receptor Antagonists / W146

W146

Cat. No. 3602 4 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective S1P1 receptor antagonist
Alternative Names: ML 056
Chemical Name: [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for W146

W146 is a potent sphingosine-1-phosphate receptor S1P1 selective antagonist (Ki = 18 nM); displays no effect at S1P2, S1P3 or S1P5. Enhances capillary leakage and restores lymphocyte egress in vivo.

Technical Data for W146

M. Wt 342.37
Formula C16H27N2O4P
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 909725-61-7
PubChem ID 6857802
InChI Key FWJRVGZWNDOOFH-OAHLLOKOSA-N
Smiles CCCCCCC1=CC=CC(NC([C@H](N)CCP(O)(O)=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for W146

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
3eq. NaOH 6.85 20

Preparing Stock Solutions for W146

The following data is based on the product molecular weight 342.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 14.6 mL 73.02 mL 146.04 mL
1 mM 2.92 mL 14.6 mL 29.21 mL
2 mM 1.46 mL 7.3 mL 14.6 mL
10 mM 0.29 mL 1.46 mL 2.92 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for W146

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for W146

References are publications that support the biological activity of the product.

Sanna et al (2006) Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat.Chem.Biol. 8 434 PMID: 16829954

Gonzalez-Cabrera et al (2008) Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol.Pharmacol. 74 1308 PMID: 18708635

If you know of a relevant reference for W146, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Sphingosine-1-Phosphate Receptor Antagonists

Keywords: W146, W146 supplier, potent, selective, sphingosine-1-phosphate, s1p1, antagonists, sphingolipids, ML056, ML, 056, Sphingosine-1-phosphate, Receptors, 3602, Tocris Bioscience

4 Citations for W146

Citations are publications that use Tocris products. Selected citations for W146 include:

Beckham et al (2013) Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis 2 e49 PMID: 23732709

Beckham et al (2013) Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. PLoS One 8 e76593 PMID: 24098536

Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184 PMID: 26419927

Schuhmann et al (2015) Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model. Mol Cell Biol 16 29454 PMID: 26690412

Do you know of a great paper that uses W146 from Tocris? Please let us know.

Reviews for W146

There are currently no reviews for this product. Be the first to review W146 and earn rewards!

Have you used W146?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling