Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewW146 is a potent sphingosine-1-phosphate receptor S1P1 selective antagonist (Ki = 18 nM); displays no effect at S1P2, S1P3 or S1P5. Enhances capillary leakage and restores lymphocyte egress in vivo.
M. Wt | 342.37 |
Formula | C16H27N2O4P |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 909725-61-7 |
PubChem ID | 6857802 |
InChI Key | FWJRVGZWNDOOFH-OAHLLOKOSA-N |
Smiles | CCCCCCC1=CC=CC(NC([C@H](N)CCP(O)(O)=O)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
3eq. NaOH | 6.85 | 20 |
The following data is based on the product molecular weight 342.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.2 mM | 14.6 mL | 73.02 mL | 146.04 mL |
1 mM | 2.92 mL | 14.6 mL | 29.21 mL |
2 mM | 1.46 mL | 7.3 mL | 14.6 mL |
10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
References are publications that support the biological activity of the product.
Sanna et al (2006) Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat.Chem.Biol. 8 434 PMID: 16829954
Gonzalez-Cabrera et al (2008) Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol.Pharmacol. 74 1308 PMID: 18708635
If you know of a relevant reference for W146, please let us know.
Keywords: W146, W146 supplier, potent, selective, sphingosine-1-phosphate, s1p1, antagonists, sphingolipids, ML056, ML, 056, Sphingosine-1-phosphate, Receptors, 3602, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for W146 include:
Schuhmann et al (2015) Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model. Mol Cell Biol 16 29454 PMID: 26690412
Beckham et al (2013) Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis 2 e49 PMID: 23732709
Beckham et al (2013) Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. PLoS One 8 e76593 PMID: 24098536
Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184 PMID: 26419927
Do you know of a great paper that uses W146 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review W146 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image