W146

Pricing Availability   Qty
Description: Potent and selective S1P1 receptor antagonist
Alternative Names: ML 056
Chemical Name: [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Reviews
Literature (1)

Biological Activity for W146

W146 is a potent sphingosine-1-phosphate receptor S1P1 selective antagonist (Ki = 18 nM); displays no effect at S1P2, S1P3 or S1P5. Enhances capillary leakage and restores lymphocyte egress in vivo.

Technical Data for W146

M. Wt 342.37
Formula C16H27N2O4P
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 909725-61-7
PubChem ID 6857802
InChI Key FWJRVGZWNDOOFH-OAHLLOKOSA-N
Smiles CCCCCCC1=CC=CC(NC([C@H](N)CCP(O)(O)=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for W146

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
3eq. NaOH 6.85 20

Preparing Stock Solutions for W146

The following data is based on the product molecular weight 342.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 14.6 mL 73.02 mL 146.04 mL
1 mM 2.92 mL 14.6 mL 29.21 mL
2 mM 1.46 mL 7.3 mL 14.6 mL
10 mM 0.29 mL 1.46 mL 2.92 mL

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Product Datasheets for W146

Certificate of Analysis / Product Datasheet
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References for W146

References are publications that support the biological activity of the product.

Sanna et al (2006) Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat.Chem.Biol. 8 434 PMID: 16829954

Gonzalez-Cabrera et al (2008) Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol.Pharmacol. 74 1308 PMID: 18708635


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Keywords: W146, W146 supplier, potent, selective, sphingosine-1-phosphate, s1p1, antagonists, sphingolipids, ML056, ML, 056, Sphingosine-1-phosphate, Receptors, 3602, Tocris Bioscience

8 Citations for W146

Citations are publications that use Tocris products. Selected citations for W146 include:

Lucia et al (2021) Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein. Arterioscler Thromb Vasc Biol 41 e468-e479 PMID: 34407633

Huilan et al (2021) aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis. Proc Natl Acad Sci U S A 118 PMID: 34873055

Beckham et al (2013) Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis 2 e49 PMID: 23732709

Beckham et al (2013) Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. PLoS One 8 e76593 PMID: 24098536


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Literature in this Area

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