Sphingosine-1-phosphate receptor antagonist; inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|Acidified DMSO (5% 1N HCl in DMSO)||3.72||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 372.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.69 mL||13.43 mL||26.85 mL|
|5 mM||0.54 mL||2.69 mL||5.37 mL|
|10 mM||0.27 mL||1.34 mL||2.69 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Davis et al (2005) Sphingosine-1-phosphate analogs as receptor antagonists. J.Biol.Chem. 280 9833 PMID: 15590668
Aoki et al (2007) The suppressive effect of sphingosine-1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins α5β1 and αVβ3. J.Thromb.Haemost. 5 1292 PMID: 17403093
Mihovilovic et al (2007) High-fat/cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. J.Lipid Res. 48 806 PMID: 17264352
If you know of a relevant reference for VPC 23019, please let us know.
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Keywords: VPC23019 sphingosine-1-phosphate s1p1 s1p3 antagonists s1p sphingolipids Sphingosine-1-phosphate Receptors
3 Citations for VPC 23019
Citations are publications that use Tocris products. Selected citations for VPC 23019 include:
Miller et al (2008) Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. Mol Cell Biol 28 4142 PMID: 18426913
Wirrig et al (2016) Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells Biochemical Pharmacology 115 43 PMID: 27402345
Willems et al (2016) Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy. Evid Based Complement Alternat Med 4 28 PMID: 27036416
Do you know of a great paper that uses VPC 23019 from Tocris? If so please let us know.