VPC 23019

Pricing Availability Delivery Time Qty
Cat.No. 4195 - VPC 23019 | C17H29N2O5P | CAS No. 449173-19-7
Description: S1P1 and S1P3 antagonist
Chemical Name: 2-Amino-N-(3-octylphenyl)-3-(phosphonooxy)-propanamaide
Purity: ≥95% (HPLC)
Datasheet
Citations (3)

Biological Activity

Sphingosine-1-phosphate receptor antagonist; inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively).

Technical Data

M. Wt 372.4
Formula C17H29N2O5P
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 449173-19-7
PubChem ID 11588811
InChI Key MRUSUGVVWGNKFE-MRXNPFEDSA-N
Smiles O=C([C@H](N)COP(O)(O)=O)NC1=CC(CCCCCCCC)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
2eq. NaOH 18.62 50
Acidified DMSO (5% 1N HCl in DMSO) 3.72 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 372.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.43 mL 26.85 mL
5 mM 0.54 mL 2.69 mL 5.37 mL
10 mM 0.27 mL 1.34 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Davis et al (2005) Sphingosine-1-phosphate analogs as receptor antagonists. J.Biol.Chem. 280 9833 PMID: 15590668

Aoki et al (2007) The suppressive effect of sphingosine-1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins α5β1 and αVβ3. J.Thromb.Haemost. 5 1292 PMID: 17403093

Mihovilovic et al (2007) High-fat/cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. J.Lipid Res. 48 806 PMID: 17264352


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Keywords: VPC23019 sphingosine-1-phosphate s1p1 s1p3 antagonists s1p sphingolipids Sphingosine-1-phosphate Receptors

3 Citations for VPC 23019

Citations are publications that use Tocris products. Selected citations for VPC 23019 include:

Miller et al (2008) Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. Mol Cell Biol 28 4142 PMID: 18426913

Wirrig et al (2016) Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells Biochemical Pharmacology 115 43 PMID: 27402345

Willems et al (2016) Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy. Evid Based Complement Alternat Med 4 28 PMID: 27036416


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