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Biological Activity for VPC 23019
VPC 23019 is a sphingosine-1-phosphate receptor antagonist; inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively).
Technical Data for VPC 23019
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for VPC 23019
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|Acidified DMSO (5% 1N HCl in DMSO)||3.72||10 with gentle warming|
Preparing Stock Solutions for VPC 23019
The following data is based on the product molecular weight 372.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.37 mL||26.85 mL||53.71 mL|
|2.5 mM||1.07 mL||5.37 mL||10.74 mL|
|5 mM||0.54 mL||2.69 mL||5.37 mL|
|25 mM||0.11 mL||0.54 mL||1.07 mL|
References for VPC 23019
References are publications that support the biological activity of the product.
Davis et al (2005) Sphingosine-1-phosphate analogs as receptor antagonists. J.Biol.Chem. 280 9833 PMID: 15590668
Aoki et al (2007) The suppressive effect of sphingosine-1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins α5β1 and αVβ3. J.Thromb.Haemost. 5 1292 PMID: 17403093
Mihovilovic et al (2007) High-fat/cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. J.Lipid Res. 48 806 PMID: 17264352
If you know of a relevant reference for VPC 23019, please let us know.
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Keywords: VPC 23019, VPC 23019 supplier, VPC23019, sphingosine-1-phosphate, s1p1, s1p3, antagonists, s1p, sphingolipids, Sphingosine-1-phosphate, Receptors, 4195, Tocris Bioscience
8 Citations for VPC 23019
Citations are publications that use Tocris products. Selected citations for VPC 23019 include:
Sharma et al (2018) Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation. Sci Rep 8 6618 PMID: 29700394
Jolene J et al (2021) Increased S1P expression in osteoclasts enhances bone formation in an animal model of Paget's disease. J Cell Biochem 122 335-348 PMID: 33107091
Wirrig et al (2016) Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells Biochemical Pharmacology 115 43 PMID: 27402345
Greig et al (2019) Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse. Eur J Pharmacol 842 1 PMID: 30359564
Miller et al (2008) Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. Mol Cell Biol 28 4142 PMID: 18426913
Willems et al (2016) Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy. Evid Based Complement Alternat Med 4 28 PMID: 27036416
Christian et al (2020) Neonatal HDL Counteracts Placental Vascular Inflammation via S1P-S1PR1 Axis. Int J Mol Sci 21 PMID: 31991780
Eva et al (2020) Circulating cord blood HDL-S1P complex preserves the integrity of the feto-placental vasculature. Biochim Biophys Acta Mol Cell Biol Lipids 1865 158632 PMID: 31954174
Do you know of a great paper that uses VPC 23019 from Tocris? Please let us know.
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Literature in this Area
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