Ozanimod

Pricing Availability   Qty
Description: Potent and selective S1P1 and S1P5 agonist
Chemical Name: 5-[3-[(1S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity for Ozanimod

Ozanimod is a potent and selective sphingosine-1-phosphate receptor 1 (S1P1) and 5 (S1P5) agonist (EC50 values are 0.41 and 11 nM, respectively, in a [35S]-GTPγS assay). Ozanimod exhibits 27-fold selectivity over S1P5, and >10,000-fold selectivity over S1P2-4. In vitro, Ozanimod induces sustained S1P1 receptor internalization and degradation in S1P1 receptor-HEK293T cells. In vivo, Ozanimod reduces inflammation and disease parameters in rat models of autoimmune disease. Ozanimod reduces chronic inflammation and alleviates kidney pathology in a murine model of systemic lupus erythematosus. Ozanimod is orally bioavailable.

Compound Libraries for Ozanimod

Ozanimod is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ozanimod

M. Wt 404.46
Formula C23H24N4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1306760-87-1
PubChem ID 52938427
InChI Key XRVDGNKRPOAQTN-FQEVSTJZSA-N
Smiles N(CCO)[C@@H]1C=2C(=C(C=CC2)C=3N=C(ON3)C4=CC(C#N)=C(OC(C)C)C=C4)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ozanimod

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.45 100

Preparing Stock Solutions for Ozanimod

The following data is based on the product molecular weight 404.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.36 mL 24.72 mL
5 mM 0.49 mL 2.47 mL 4.94 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Keywords: Ozanimod, Ozanimod supplier, sphingosine-1-phosphate, receptors, S1P1, S1P5, potent, selective, agonists, agonism, orally, bioavailable, SLE, systemic, lupus, erythematosus, Sphingosine-1-phosphate, Receptors, 7663, Tocris Bioscience

Citations for Ozanimod

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