TASP 0277308

Pricing Availability   Qty
Cat.No. 6498 - TASP 0277308 | C23H28Cl2N6O3S | CAS No. 945725-50-8
Description: Potent and selective S1P1 receptor antagonist; inhibits angiogenesis
Chemical Name: 3,4-Dichloro-N-[(1R)-1-[4-ethyl-5-[3-(4-methyl-1-piperazinyl)phenoxy]-4H-1,2,4-triazol-3-yl]ethyl]benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for TASP 0277308

TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesis in vivo. TASP 0277308 also blocks VEGF-induced tube-formation of HUVECs in vitro and reverses or impairs the development of arthritis or mechano-allodynia.

Technical Data for TASP 0277308

M. Wt 539.48
Formula C23H28Cl2N6O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 945725-50-8
PubChem ID 56935569
InChI Key MVOULGOLHZCXLD-MRXNPFEDSA-N
Smiles CCN1C(OC2=CC(N3CCN(CC3)C)=CC=C2)=NN=C1[C@H](NS(=O)(C4=CC(Cl)=C(C=C4)Cl)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TASP 0277308

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.7 5

Preparing Stock Solutions for TASP 0277308

The following data is based on the product molecular weight 539.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 37.07 mL 185.36 mL 370.73 mL
0.25 mM 7.41 mL 37.07 mL 74.15 mL
0.5 mM 3.71 mL 18.54 mL 37.07 mL
2.5 mM 0.74 mL 3.71 mL 7.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for TASP 0277308

References are publications that support the biological activity of the product.

Fujii et al (2012) Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities. J.Immunol. 188 PMID: 22131329

Fujii et al (2012) Blocking S1P interaction with S1P1 receptor by a novel competitive S1P1-selective antagonist inhibits angiogenesis. Biochem.Biophys.Res.Commun. 419 754 PMID: 22387544


If you know of a relevant reference for TASP 0277308, please let us know.

View Related Products by Product Action

View all Sphingosine-1-Phosphate Receptor Antagonists

Keywords: TASP 0277308, TASP 0277308 supplier, TASP0277308, potent, selective, sphingosine, 1-phosphate, antagonists, S1P1-receptors, Sphingosine-1-phosphate, Receptors, Antiangiogenics, 6498, Tocris Bioscience

Citations for TASP 0277308

Citations are publications that use Tocris products.

Currently there are no citations for TASP 0277308. Do you know of a great paper that uses TASP 0277308 from Tocris? Please let us know.

Reviews for TASP 0277308

There are currently no reviews for this product. Be the first to review TASP 0277308 and earn rewards!

Have you used TASP 0277308?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling