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Endogenous second messenger involved in the control of cell proliferation and motility, and Ca2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12. Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase. Also activates VRAC-mediated transport of 2'3'-cyclic-GMP-AMP (cGAMP).
|Storage||Desiccate at +4°C|
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Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Essler et al (2002) Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase activity in human endothelial cells. Cell.Signal. 14 607 PMID: 11955953
Pyne and Pyne (2000) Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors. Pharmacol.Ther. 88 115 PMID: 11150592
Uhlenbrock et al (2002) Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. Cell.Signal. 14 941 PMID: 12220620
van Koppen et al (1996) Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate. J.Biol.Chem. 271 2082 PMID: 8567663
Morstein et al (2019) Optical control of sphingosine-1-phosphate formation and function. Nat.Chem 15 623 PMID: 31036923
Lahey et al (2020) LRRC8A:C/E heteromeric channels are ubiquitous transporters of cGAMP. Mol.Cell. 80 1 PMID: 33171122
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Keywords: Sphingosine-1-phosphate, Sphingosine-1-phosphate supplier, Endogenous, agonists, S1P1, S1P2, S1P3, S1P4, S1P5, Receptors, EDG, Sphingosine-1-Phosphate, GPR3, GPR6, GPR12, cGAMP, transports, transporters, VRAC, LRRC8, Sphingosine-1-phosphate, STING-Dependent, Signaling, 1370, Tocris Bioscience
10 Citations for Sphingosine-1-phosphate
Citations are publications that use Tocris products. Selected citations for Sphingosine-1-phosphate include:
Kho et al (2015) Application of xCELLigence RTCA Biosensor Technology for Revealing the Profile and Window of Drug Responsiveness in Real Time. Mol Pain 5 199 PMID: 25893878
Hu et al (2016) Hemovascular Progenitors in the Kidney Require Sphingosine-1-Phosphate Receptor 1 for Vascular Development. J Am Soc Nephrol 27 1984 PMID: 26534925
Pierre et al (2004) PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. EMBO J 23 3031 PMID: 15257286
Evseenko et al (2013) Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. PLoS One 8 e63718 PMID: 23696850
Hannedouche et al (2013) Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells. Biosensors (Basel) 288 27434 PMID: 23940034
Hill et al (2018) The signaling lipid sphingosine 1-phosphate regulates mechanical pain. Elife 7 PMID: 29561262
Krispin et al (2018) Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling. Arterioscler Thromb Vasc Biol 38 353 PMID: 29284606
Hübner et al (2018) Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nat Commun 9 4860 PMID: 30451830
Simula et al (2018) Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming. Cell Rep 25 3059 PMID: 30540939
Camp et al (2016) Dynamic mass redistribution reveals diverging importance of PDZ-ligands for G protein-coupled receptor pharmacodynamics. Pharmacol Res 105 13 PMID: 26773201
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