CYM 5541

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Cat.No. 4897 - CYM 5541 | C19H28N2O2 | CAS No. 945128-26-7
Description: Selective S1P3 receptor allosteric agonist
Chemical Name: N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
Purity: ≥97% (HPLC)
Citations (3)
Literature (3)

Biological Activity for CYM 5541

CYM 5541 is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P3 than S1P. Displays no activity at S1P1, S1P2, S1P4 and S1P5 receptors at concentrations up to 10 μM. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.

Compound Libraries for CYM 5541

CYM 5541 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CYM 5541

M. Wt 316.44
Formula C19H28N2O2
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 945128-26-7
PubChem ID 17253208

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CYM 5541

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.64 100
ethanol 15.82 50

Preparing Stock Solutions for CYM 5541

The following data is based on the product molecular weight 316.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.8 mL 31.6 mL
5 mM 0.63 mL 3.16 mL 6.32 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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References for CYM 5541

References are publications that support the biological activity of the product.

Jo et al (2012) Novel selective allosteric and bitopic ligands for the S1P3 receptor. ACS Chem.Biol. 7 1975 PMID: 22971058

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Keywords: CYM 5541, CYM 5541 supplier, CYM5541, Selective, S1P3, receptors, allosteric, agonists, SIP, Sphingosine-1-phosphate, Sphingosine, Receptors, 4897, Tocris Bioscience

3 Citations for CYM 5541

Citations are publications that use Tocris products. Selected citations for CYM 5541 include:

Matsushima-Nishiwaki et al (2018) Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2. PLoS One 13 e0209050 PMID: 30543684

Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184 PMID: 26419927

O'Sullivan et al (2016) The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. Nat Commun 13 31 PMID: 26856814

Do you know of a great paper that uses CYM 5541 from Tocris? Please let us know.

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Literature in this Area

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