Selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P3 than S1P. Displays no activity at S1P1, S1P2, S1P4 and S1P5 receptors at concentrations up to 10 μM. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 316.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.16 mL||15.8 mL||31.6 mL|
|5 mM||0.63 mL||3.16 mL||6.32 mL|
|10 mM||0.32 mL||1.58 mL||3.16 mL|
|50 mM||0.06 mL||0.32 mL||0.63 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Jo et al (2012) Novel selective allosteric and bitopic ligands for the S1P3 receptor. ACS Chem.Biol. 7 1975 PMID: 22971058
If you know of a relevant reference for CYM 5541, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CYM 5541, supplier, CYM5541, Selective, S1P3, receptors, allosteric, agonists, SIP, Sphingosine-1-phosphate, Sphingosine, Sphingosine-1-phosphate, Receptors, Sphingosine-1-phosphate, Receptors, Tocris Bioscience
2 Citations for CYM 5541
Citations are publications that use Tocris products. Selected citations for CYM 5541 include:
O'Sullivan et al (2016) The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. Nat Commun 13 31 PMID: 26856814
Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184 PMID: 26419927
Do you know of a great paper that uses CYM 5541 from Tocris? If so please let us know.