CYM 5541

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Cat.No. 4897 - CYM 5541 | C19H28N2O2 | CAS No. 945128-26-7
Description: Selective S1P3 receptor allosteric agonist
Chemical Name: N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
Purity: ≥97% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P3 than S1P. Displays no activity at S1P1, S1P2, S1P4 and S1P5 receptors at concentrations up to 10 μM. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.

Compound Libraries

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Technical Data

M. Wt 316.44
Formula C19H28N2O2
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 945128-26-7
PubChem ID 17253208
InChI Key NDKGACIWVAOUQH-UHFFFAOYSA-N
Smiles O=C(N(C3CCCCC3)C2CCCCC2)C1=NOC(C4CC4)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.64 100
ethanol 15.82 50

Preparing Stock Solutions

The following data is based on the product molecular weight 316.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.8 mL 31.6 mL
5 mM 0.63 mL 3.16 mL 6.32 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Jo et al (2012) Novel selective allosteric and bitopic ligands for the S1P3 receptor. ACS Chem.Biol. 7 1975 PMID: 22971058


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Keywords: CYM 5541, supplier, CYM5541, Selective, S1P3, receptors, allosteric, agonists, SIP, Sphingosine-1-phosphate, Sphingosine, Sphingosine-1-phosphate, Receptors, Sphingosine-1-phosphate, Receptors, Tocris Bioscience

2 Citations for CYM 5541

Citations are publications that use Tocris products. Selected citations for CYM 5541 include:

O'Sullivan et al (2016) The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. Nat Commun 13 31 PMID: 26856814

Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184 PMID: 26419927


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Literature in this Area

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