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Biological Activity for CYM 50308
CYM 50308 is a potent and selective sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 values are 56 nM and 2100 nM for S1P4 and S1P5 receptors, respectively). Displays no activity at S1P1, S1P2 and S1P3 receptors at concentrations up to 25 μM.
Technical Data for CYM 50308
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CYM 50308
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CYM 50308
The following data is based on the product molecular weight 405.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||24.66 mL||123.32 mL||246.63 mL|
|0.5 mM||4.93 mL||24.66 mL||49.33 mL|
|1 mM||2.47 mL||12.33 mL||24.66 mL|
|5 mM||0.49 mL||2.47 mL||4.93 mL|
References for CYM 50308
References are publications that support the biological activity of the product.
Urbano et al (2011) Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. Bioorg.Med.Chem.Lett. 21 6739 PMID: 21982495
If you know of a relevant reference for CYM 50308, please let us know.
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Keywords: CYM 50308, CYM 50308 supplier, CYM50308, sphingosine-1-phosphate, receptors, S1P4, agonists, potent, selective, Sphingosine-1-phosphate, Receptors, 4678, Tocris Bioscience
Citations for CYM 50308
Citations are publications that use Tocris products.
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Literature in this Area
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