CYM 50308

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Cat.No. 4678 - CYM 50308 | C20H21F2N3O2S | CAS No. 1345858-76-5
Description: Potent and selective S1P4 agonist
Chemical Name: (2Z,5Z)-5-[[1-(2,4-Difluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene]-2-[(2-methoxyethyl)imino]-3-methyl-4-thiazolidinone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 values are 56 nM and 2100 nM for S1P4 and S1P5 receptors, respectively). Displays no activity at S1P1, S1P2 and S1P3 receptors at concentrations up to 25 μM.

Technical Data

M. Wt 405.46
Formula C20H21F2N3O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1345858-76-5
PubChem ID 49835928
InChI Key BKQZKTRCUAWRHT-ONBPWHQPSA-N
Smiles FC1=CC(F)=C(N2C(C)=CC(/C=C3\S/C(N(C)C3=O)=N\CCOC)=C2C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.05 10

Preparing Stock Solutions

The following data is based on the product molecular weight 405.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.66 mL 123.32 mL 246.63 mL
0.5 mM 4.93 mL 24.66 mL 49.33 mL
1 mM 2.47 mL 12.33 mL 24.66 mL
5 mM 0.49 mL 2.47 mL 4.93 mL

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References

References are publications that support the biological activity of the product.

Urbano et al (2011) Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. Bioorg.Med.Chem.Lett. 21 6739 PMID: 21982495


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Citations for CYM 50308

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