Stem Cell Signaling

More Information »Various stem cell signaling pathways influence stem cell generation, self-renewal and differentiation. In vivo, the microenvironment responsible for maintaining stem cells in pluripotent form and enabling their self-renewal is called the stem-cell niche.

Stem Cell Signaling Products

Product Name / Activity
1515 17-AAG
Selective Hsp90 inhibitor; protects neuroprogenitor cells against stress-induced apoptosis
3979 Alexidine dihydrochloride
Selective inhibitor of PTPMT1; maintains functional HSCs ex vivo
3299 AMD 3100 octahydrochloride
Highly selective CXCR4 antagonist; mobilizes hematopoietic stem cells in vivo
3194 BIO
Potent and selective GSK-3 inhibitor; maintains self-renewal and pluripotency of ESCs
5051 BIO 5192
Integrin α4β1 inhibitor; mobilizes HSCs and progenitors
3874 BIO-acetoxime
Selective GSK-3α/β inhibitor; inhibits CD8+ T cell effector differentiation
5050 CASIN
Cdc42 GTPase inhibitor; functionally rejuvenates aged HSCs
4529 Ciliobrevin A
Hedgehog pathway antagonist; inhibits ciliogenesis
1623 Cyclopamine
Inhibitor of Hedgehog (Hh) signaling; depletes stem-like cancer cells in glioblastoma
4027 16,16-Dimethyl Prostaglandin E2
Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development
1769 Flurbiprofen
Cyclooxygenase inhibitor; regulates prostate stem cell antigen
3889 GANT 58
GLI1 antagonist; inhibits Hh signaling
3191 GANT 61
GLI antagonist; inhibits Hh signaling
1368 Geldanamycin
Selective Hsp90 inhibitor; breast cancer stem cell inhibitor
4474 20(S)-Hydroxycholesterol
Allosteric activator of Hedgehog signaling; induces Smo accumulation
3533 IWP 2
PORCN inhibitor; suppresses self-renewal in R1 ESCs
3532 endo-IWR 1
Wnt/β-catenin signaling inhibitor; axin stabilizer
3341 JK 184
Downstream Hh signaling pathway inhibitor; inhibits alcohol dehydrogenase 7
1398 Kenpaullone
GSK-3 inhibitor; can be used to generate iPSCs
3258 Mitomycin C
Used for MEF/STO feeder layer preparation in stem cell culture
5522 Napabucasin
STAT3 inhibitor; blocks cancer stem cell self-renewal
4079 Niclosamide
STAT3 and mTORC1 signaling inhibitor; antineoplastic against AML stem cells
1267 Pifithrin-α hydrobromide
p53 inhibitor; supresses self renewal of embryonic stem cells
2296 Prostaglandin E2
Major endogenous prostanoid
3324 QS 11
ARFGAP1 inhibitor; modulates Wnt signaling pathway
3667 SR 3677 dihydrochloride
Potent, selective Rho-kinase (ROCK) inhibitor
4855 WIKI4
Tankyrase inhibitor; inhibits Wnt signaling
3748 XAV 939
Tankyrase inhibitor; promotes cardiomyogenesis
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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Stem Cell Toolbox

80 Stem Cell modulators supplied pre-dissolved in DMSO

Tocriscreen Stem Cell  Toolbox

Includes many of the latest compounds available for stem cell research. Covers compounds for stem cell differentiation, signaling and reprogramming.

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Stem Cells Review

Written by K. Clarke et al

Stem Cells Scientific Review

Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming. Request copy or view PDF today.

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