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Description: Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
Alternative Names: Kempferol
Chemical Name: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Citations (2)
Reviews (1)
Literature (1)
Pathways (1)

Biological Activity for Kaempferol

Activates the mitochondrial Ca2+ uniporter (EC50 = 7 μM). Induces caspase-9-mediated apoptosis in cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells. Activates transcriptional coactivator with PDZ-binding motif (TAZ) and increases osteoblast differentiation of mesenchymal stem cells while inhibiting adipocyte differentiation. Naturally occurring flavonoid found in Gingko biloba and red wine. Kaempferol has antiviral activity against Japanese encephalitis virus (JEV) in infected BHK21 (EC50 = 21.5 μM). Kaempferol directly inhibits viral replication and protein expression by binding JEV frameshift site RNA (fsRNA). Kaempferol influences frameshift efficiency in virus-infected cells through interfering with a downstream RNA pseudoknot structure. Kaempferol has also been reported to exhibit activity against herpes simplex virus, influenza viruses (H1N1 and H9N2) and hepatitis B virus under in vitro conditions.

Technical Data for Kaempferol

M. Wt 286.24
Formula C15H10O6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 520-18-3
PubChem ID 5280863
Smiles O=C2C1=C(O)C=C(O)C=C1OC(C3=CC=C(O)C=C3)=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Kaempferol

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.62 100
ethanol 28.62 100

Preparing Stock Solutions for Kaempferol

The following data is based on the product molecular weight 286.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.49 mL 17.47 mL 34.94 mL
5 mM 0.7 mL 3.49 mL 6.99 mL
10 mM 0.35 mL 1.75 mL 3.49 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets for Kaempferol

Certificate of Analysis / Product Datasheet
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References for Kaempferol

References are publications that support the biological activity of the product.

Montero et al (2004) Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids. Biochem.J. 384 19 PMID: 15324303

Suh et al (2009) Kaempferol attenuates 2-deoxy-D-ribose-induced oxidative cell damage in MC3T3-E1 osteoblastic cells. Biol.Pharm.Bull. 32 746 PMID: 19336918

Kang et al (2009) Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. Eur.J.Pharmacol. 611 17 PMID: 19356725

Vay et al (2009) Modulation of Ca2+ release and Ca2+ oscillations in HeLa cells and fibroblasts by mitochondrial Ca2+ uniporter stimulation. J.Physiol. 580 39

Cho et al (2007) Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation. Cancer Res. 67 8104 PMID: 17804722

Byun et al (2012) TAZ is required for the osteogenic and anti-adipogenic activities of kaempferol. Bone 50 364 PMID: 22108137

Li et al (2008) In vitro and in vivo anti-hepatitis B virus activities of a plant extract from Geranium carolinianum L. Antiviral Res. 79 114 PMID: 18423640

If you know of a relevant reference for Kaempferol, please let us know.

Keywords: Kaempferol, Kaempferol supplier, Mitochondrial, Ca2+, uniporter, MCU, activators, proapoptotic, downregulates, PLK1, expression, Ion, Pumps, Transporters, Apoptosis, Inducer, TAZ, activates, transcriptional, coactivator, with, PDZ-binding, motif, osteogenesis, MSC, mesenchymal, stem, cells, antiviral, Kempferol, Inducers, IRE1, Calcium, Uniporter, RSK, Hippo/Yap, signaling, Stem, Cell, Signaling, Non-selective, Antivirals, 3603, Tocris Bioscience

2 Citations for Kaempferol

Citations are publications that use Tocris products. Selected citations for Kaempferol include:

Tran et al (2014) Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol 9 2796 PMID: 25279668

Lorena et al (2022) Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells. Elife 11 PMID: 35617485

Do you know of a great paper that uses Kaempferol from Tocris? Please let us know.

Reviews for Kaempferol

Average Rating: 5 (Based on 1 Review.)

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treat kaemferol in vitro system.
By Anonymous on 11/03/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: mouse insulinoma cell lines

Islets were maintained in CMRL medium supplemented with 10% FBS and kaempferol

PMID: 25279668
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Kaempferol

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.