Kaempferol

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Cat.No. 3603 - Kaempferol | C15H10O6 | CAS No. 520-18-3
Description: Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
Alternative Names: Kempferol
Chemical Name: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature
Pathways

Biological Activity

Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca2+ uniporter (EC50 = 7 μM). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.

Compound Libraries

Kaempferol is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 286.24
Formula C15H10O6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 520-18-3
PubChem ID 5280863
InChI Key IYRMWMYZSQPJKC-UHFFFAOYSA-N
Smiles O=C2C1=C(O)C=C(O)C=C1OC(C3=CC=C(O)C=C3)=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.62 100
ethanol 28.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 286.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.49 mL 17.47 mL 34.94 mL
5 mM 0.7 mL 3.49 mL 6.99 mL
10 mM 0.35 mL 1.75 mL 3.49 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Montero et al (2004) Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids. Biochem.J. 384 19 PMID: 15324303

Suh et al (2009) Kaempferol attenuates 2-deoxy-D-ribose-induced oxidative cell damage in MC3T3-E1 osteoblastic cells. Biol.Pharm.Bull. 32 746 PMID: 19336918

Kang et al (2009) Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. Eur.J.Pharmacol. 611 17 PMID: 19356725

Vay et al (2009) Modulation of Ca2+ release and Ca2+ oscillations in HeLa cells and fibroblasts by mitochondrial Ca2+ uniporter stimulation. J.Physiol. 580 39 PMID:

Cho et al (2007) Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation. Cancer Res. 67 8104 PMID: 17804722


If you know of a relevant reference for Kaempferol, please let us know.

Keywords: Kaempferol, supplier, Mitochondrial, Ca2+, uniporter, MCU, activators, proapoptotic, downregulates, PLK1, expression, Ion, Pumps, Transporters, Apoptosis, Inducer, Kempferol, Apoptosis, Inducers, Tocris Bioscience

1 Citation for Kaempferol

Citations are publications that use Tocris products. Selected citations for Kaempferol include:

Tran et al (2014) Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol 9 2796 PMID: 25279668


Do you know of a great paper that uses Kaempferol from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Kaempferol

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

Protocols

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