GANT 61

Pricing Availability Delivery Time Qty
Cat.No. 3191 - GANT 61 | C27H35N5 | CAS No. 500579-04-4
Description: GLI antagonist; inhibits Hedgehog (Hh) signaling
Chemical Name: 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

GLI antagonist that inhibits GLI1 and GLI2-induced transcription (IC50 ~ 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo. Inhibits the pluripotency factors Oct4, Sox-2, Nanog and c-Myc in pancreatic cancer stem cells.

Compound Libraries

GANT 61 is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 429.61
Formula C27H35N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 500579-04-4
PubChem ID 421610
InChI Key KVQOGDQTWWCZFX-UHFFFAOYSA-N
Smiles CN(C1=CC=CC=C1CN2CCCN(CC4=C(N(C)C)C=CC=C4)C2C3=CC=NC=C3)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.48 50
ethanol 42.96 100

Preparing Stock Solutions

The following data is based on the product molecular weight 429.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.64 mL 23.28 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lauth et al (2007) Inhibition of GLI-mediated transcription and tumor cell growth by small molecule antagonists. Proc.Natl.Acad.Sci.USA 104 8455 PMID: 17494766

Fu et al (2012) GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 330 22 PMID: 23200667

Mazumdar et al (2011) Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. Cancer Res. 71 5904 PMID: 21747117


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View all Hedgehog Signaling Inhibitors

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1 Citation for GANT 61

Citations are publications that use Tocris products. Selected citations for GANT 61 include:

Lim et al (2015) Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis. Oncotarget 6 1519 PMID: 25544756


Do you know of a great paper that uses GANT 61 from Tocris? If so please let us know.

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