STATs

STATs (signal transducers and activators of transcription) are a family of seven transcription factors that form part of the JAK-STAT signaling cascade, the basis of the signal transduction mechanism for many cytokine receptors. STATs are activated by phosphorylation by JAKs.

Products
Background
Literature
Pathways
Gene Data

Inhibitors

Cat No Product Name / Activity
3713 Cryptotanshinone
STAT3 inhibitor. Also displays multiple other activities
1571 Cucurbitacin I
Selective inhibitor of STAT3/JAK2 signaling
6218 Galiellalactone
STAT3 inhibitor; active in vivo
5522 Napabucasin
STAT3 inhibitor; also blocks cancer stem cell self-renewal
4079 Niclosamide
STAT3 inhibitor; also inhibits mTORC1 signaling
4655 NSC 74859
Selective STAT3 inhibitor
3918 Pyrimethamine
STAT3 inhibitor; also potent inhibitor of multidrug and toxin extrusion (MATE) transporters and DHFR inhibitor
5138 RSVA 405
STAT3 inhibitor; also AMPK activator
3035 SD 1008
JAK2/STAT3 signaling pathway inhibitor
2798 Stattic
Selective STAT3 inhibitor

Activators

Cat No Product Name / Activity
3945 Colivelin
STAT3 activator. Also protects against β-amyloid neurotoxicity

Other

Cat No Product Name / Activity
3495 Fludarabine
Purine analog; inhibits cytokine-induced STAT1 activation

STATs (signal transducers and activators of transcription) are a family of seven transcription factors that form part of the JAK-STAT signaling cascade. This cascade is the basis of the signal transduction mechanism for many cytokine receptors. Once activated by phosphorylation by JAKs, STATs translocate to the nucleus.

Accumulation of STATs in the nucleus is both rapid and tightly controlled. A number of factors regulate the JAK-STAT pathway including STAT dephosphorylation by phosphatases, altered nuclear import-export dynamics of STAT, and STAT gene activation antagonists such as SOCS (suppressors of cytokine signaling) and PIAS (Protein Inhibitors of Activated STATs).

Literature for STATs

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for STATs

JAK-STAT

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.

STAT Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
STAT1 Human STAT1 NM_007315 P42224
Mouse Stat1 NM_009283 P42225
Rat Stat1 NM_032612 Q9QXK0
STAT2 Human STAT2 NM_005419 P52630
Mouse Stat2 NM_019963 Q9WVL2
Rat Stat2 NM_001011905 Q5XI26
STAT3 Human STAT3 NM_139276 P40763
Mouse Stat3 NM_213659 P42227
Rat Stat3 NM_012747 P52631
STAT4 Human STAT4 NM_003151 Q14765
Mouse Stat4 NM_011487 P42228
Rat Stat4 NM_001012226 O70428
STAT5A Human STAT5A NM_003152 P42229
Mouse Stat5a NM_011488 P42230
Rat Stat5a NM_017064 Q62771
STAT5B Human STAT5B NM_012448 P51692
Mouse Stat5b NM_011489 P42232
Rat Stat5b NM_022380 P52632
STAT6 Human STAT6 NM_003153 P42226
Mouse Stat6 NM_009284 P52633
Rat Stat6 NM_001044250 O70429