QS 11

Pricing Availability Delivery Time Qty
Cat.No. 3324 - QS 11 | C36H33N5O2 | CAS No. 944328-88-5
Description: ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling
Chemical Name: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.

Technical Data

M. Wt 567.68
Formula C36H33N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 944328-88-5
PubChem ID 42623900
InChI Key DOKZLKDGUQWMSX-HKBQPEDESA-N
Smiles OC[C@H](CC6=CC=CC=C6)NC1=C2C(N(CC3=CC=C(C7=CC=CC=C7)C=C3)C=N2)=NC(OC4=CC=C(CCC5)C5=C4)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 56.77 100
ethanol 56.77 100

Preparing Stock Solutions

The following data is based on the product molecular weight 567.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.81 mL 17.62 mL
5 mM 0.35 mL 1.76 mL 3.52 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Zhang et al (2007) Small-molecule synergist of the Wnt/β-catenin signaling pathway. Proc.Natl.Acad.Sci.USA 104 7444 PMID: 17460038

Emre et al (2007) A chemical approach to stem cell biology Curr.Opin.Chem.Biol. 11 252 PMID: 7493865


If you know of a relevant reference for QS 11, please let us know.

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Keywords: QS 11, supplier, QS11, ARFGAP1, inhibitor, inhibits, modulator, Wnt, signaling, signalling, ADP-ribosylation, factor, 1, inhibitors, G, Proteins, (Small), Tocris Bioscience

1 Citation for QS 11

Citations are publications that use Tocris products. Selected citations for QS 11 include:

Wu, J et al (2016) Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles Scientific Reports 6 29418  PMID: 27435629


Do you know of a great paper that uses QS 11 from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for QS 11

Protocols

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