QS 11

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Description: ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling
Chemical Name: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for QS 11

QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.

Compound Libraries for QS 11

QS 11 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for QS 11

M. Wt 567.68
Formula C36H33N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 944328-88-5
PubChem ID 42623900
Smiles OC[C@H](CC6=CC=CC=C6)NC1=C2C(N(CC3=CC=C(C7=CC=CC=C7)C=C3)C=N2)=NC(OC4=CC=C(CCC5)C5=C4)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for QS 11

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 56.77 100
ethanol 56.77 100

Preparing Stock Solutions for QS 11

The following data is based on the product molecular weight 567.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.81 mL 17.62 mL
5 mM 0.35 mL 1.76 mL 3.52 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Product Datasheets for QS 11

Certificate of Analysis / Product Datasheet
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References for QS 11

References are publications that support the biological activity of the product.

Zhang et al (2007) Small-molecule synergist of the Wnt/β-catenin signaling pathway. Proc.Natl.Acad.Sci.USA 104 7444 PMID: 17460038

Emre et al (2007) A chemical approach to stem cell biology Curr.Opin.Chem.Biol. 11 252 PMID: 17493865

If you know of a relevant reference for QS 11, please let us know.

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Keywords: QS 11, QS 11 supplier, QS11, ARFGAP1, inhibitor, inhibits, modulator, Wnt, signaling, signalling, ADP-ribosylation, factor, 1, inhibitors, Other, Signaling, Stem, Cell, Arf, 3324, Tocris Bioscience

2 Citations for QS 11

Citations are publications that use Tocris products. Selected citations for QS 11 include:

Gowda et al (2018) Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-β-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression. Mol Cell Biol 38 PMID: 29463646

Wu, J et al (2016) Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles Scientific Reports 6 29418 PMID: 27435629

Do you know of a great paper that uses QS 11 from Tocris? Please let us know.

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