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GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 567.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.76 mL||8.81 mL||17.62 mL|
|5 mM||0.35 mL||1.76 mL||3.52 mL|
|10 mM||0.18 mL||0.88 mL||1.76 mL|
|50 mM||0.04 mL||0.18 mL||0.35 mL|
References are publications that support the biological activity of the product.
Zhang et al (2007) Small-molecule synergist of the Wnt/β-catenin signaling pathway. Proc.Natl.Acad.Sci.USA 104 7444 PMID: 17460038
Emre et al (2007) A chemical approach to stem cell biology Curr.Opin.Chem.Biol. 11 252 PMID: 17493865
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Keywords: QS 11, QS 11 supplier, QS11, ARFGAP1, inhibitor, inhibits, modulator, Wnt, signaling, signalling, ADP-ribosylation, factor, 1, inhibitors, Other, Signaling, Stem, Cell, Arf, 3324, Tocris Bioscience
2 Citations for QS 11
Citations are publications that use Tocris products. Selected citations for QS 11 include:
Wu, J et al (2016) Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles Scientific Reports 6 29418 PMID: 27435629
Gowda et al (2018) Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-β-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression. Mol Cell Biol 38 PMID: 29463646
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