17-AAG

Pricing Availability   Qty
Cat.No. 1515 - 17-AAG | C31H43N3O8 | CAS No. 75747-14-7
Description: Selective Hsp90 inhibitor
Alternative Names: NSC 330507, 17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin
Chemical Name: 17-Demethoxy-17-(2-propenylamino)geldanamycin
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (3)

Biological Activity

Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro.

Technical Data

M. Wt 585.7
Formula C31H43N3O8
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 75747-14-7
PubChem ID 6440175
InChI Key AYUNIORJHRXIBJ-HTLBVUBBSA-N
Smiles O=C1C(NCC=C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 58.57 100

Preparing Stock Solutions

The following data is based on the product molecular weight 585.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.71 mL 8.54 mL 17.07 mL
5 mM 0.34 mL 1.71 mL 3.41 mL
10 mM 0.17 mL 0.85 mL 1.71 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Hostein et al (2001) Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Res. 61 4003 PMID: 11358818

Schnur et al (1995) Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives. J.Med.Chem. 38 3806 PMID: 7562911

Yang et al (2001) Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin. Cancer Res. 61 4010 PMID: 11358819

Wang et al (2011) Protection of murine neural progenitor cells by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin in the low nanomolar concentration range. J.Neurochem. 117 703 PMID: 21395580


If you know of a relevant reference for 17-AAG, please let us know.

View Related Products by Product Action

View all Hsp90 Inhibitors

Keywords: 17-AAG, 17-AAG supplier, Selective, Hsp90, inhibitors, inhibits, Heat, Shock, Protein, 90, NSC330507, antibiotics, stem, cells, protects, neural, progenitors, neuorprogenitors, stress-induced, apoptosis, Geldanamycin, NSC, 330507, 17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin, Antibiotics, Stem, Cell, Signaling, 1515, Tocris Bioscience

6 Citations for 17-AAG

Citations are publications that use Tocris products. Selected citations for 17-AAG include:

Truman et al (2015) Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase. J Proteomics 112 285 PMID: 25452130

Siebert et al (2019) Heat Shock Protein 90 as a Prognostic Marker and Therapeutic Target for Adrenocortical Carcinoma. Front Endocrinol (Lausanne) 10 487 PMID: 31379752

Sontake et al (2017) Hsp90 regulation of fibroblast activation in pulmonary fibrosis. JCI Insight 2 e91454 PMID: 28239659

Fang et al (2014) HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β. Nat Commun 5 5513 PMID: 25423885

Donnelly et al (2014) HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells. EMBO J 33 2374 PMID: 25205676

Hughes et al (2012) Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with trastu. Pharmaceuticals (Basel) 5 674 PMID: 24281706


Do you know of a great paper that uses 17-AAG from Tocris? Please let us know.

Reviews for 17-AAG

There are currently no reviews for this product. Be the first to review 17-AAG and earn rewards!

Have you used 17-AAG?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.