17-AAG

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Cat.No. 1515 - 17-AAG | C31H43N3O8 | CAS No. 75747-14-7
Description: Selective Hsp90 inhibitor
Alternative Names: NSC 330507, 17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin
Chemical Name: 17-Demethoxy-17-(2-propenylamino)geldanamycin
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews (1)
Literature (4)

Biological Activity for 17-AAG

17-AAG is an inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro.

Technical Data for 17-AAG

M. Wt 585.7
Formula C31H43N3O8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 75747-14-7
PubChem ID 6440175
InChI Key AYUNIORJHRXIBJ-HTLBVUBBSA-N
Smiles O=C1C(NCC=C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 17-AAG

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.86 10

Preparing Stock Solutions for 17-AAG

The following data is based on the product molecular weight 585.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.07 mL 85.37 mL 170.74 mL
0.5 mM 3.41 mL 17.07 mL 34.15 mL
1 mM 1.71 mL 8.54 mL 17.07 mL
5 mM 0.34 mL 1.71 mL 3.41 mL

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Product Datasheets for 17-AAG

Certificate of Analysis / Product Datasheet
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References for 17-AAG

References are publications that support the biological activity of the product.

Hostein et al (2001) Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Res. 61 4003 PMID: 11358818

Schnur et al (1995) Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives. J.Med.Chem. 38 3806 PMID: 7562911

Yang et al (2001) Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin. Cancer Res. 61 4010 PMID: 11358819

Wang et al (2011) Protection of murine neural progenitor cells by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin in the low nanomolar concentration range. J.Neurochem. 117 703 PMID: 21395580


If you know of a relevant reference for 17-AAG, please let us know.

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Keywords: 17-AAG, 17-AAG supplier, Selective, Hsp90, inhibitors, inhibits, Heat, Shock, Protein, 90, NSC330507, antibiotics, stem, cells, protects, neural, progenitors, neuorprogenitors, stress-induced, apoptosis, Geldanamycin, NSC, 330507, 17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin, Antibiotics, Stem, Cell, Signaling, 1515, Tocris Bioscience

6 Citations for 17-AAG

Citations are publications that use Tocris products. Selected citations for 17-AAG include:

Truman et al (2015) Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase. J Proteomics 112 285 PMID: 25452130

Siebert et al (2019) Heat Shock Protein 90 as a Prognostic Marker and Therapeutic Target for Adrenocortical Carcinoma. Front Endocrinol (Lausanne) 10 487 PMID: 31379752

Sontake et al (2017) Hsp90 regulation of fibroblast activation in pulmonary fibrosis. JCI Insight 2 e91454 PMID: 28239659

Fang et al (2014) HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β. Nat Commun 5 5513 PMID: 25423885


Do you know of a great paper that uses 17-AAG from Tocris? Please let us know.

Reviews for 17-AAG

Average Rating: 5 (Based on 1 Review.)

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HSP70 promoter/HSP90 inhibitor, strong data!.
By Anonymous on 01/02/2021
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Microglia

I used it to down regulate the expression of HSP90. I checked using an antibody for HSP70 and showed upregulation of HSP70 with 10nM of 17-AAG. Easy to use product with informative data sheet. Stable in solution for months.

This is highly cytotoxic to human microglia at a high concentration (>100nM) from our cell viability data. We also confirmed this using imaging.

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Literature in this Area

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