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Description: Cdc42 inhibitor
Chemical Name: 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for CASIN

CASIN is a Cdc42 GTPase inhibitor (IC50 = 2 μM). Reduces active levels of Cdc42 in aged hematopoietic stem cells (HSCs) to that in young HSCs. Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo. Increases histone H4K16 acetylation in aged HSCs.

Compound Libraries for CASIN

CASIN is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for CASIN

M. Wt 306.4
Formula C20H22N2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 425399-05-9
PubChem ID 2882155
Smiles OCCNC1C2=C(C(C=C(C4=CC=CC=C4)C=C3)=C3N2)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CASIN

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.64 100
ethanol 15.32 50

Preparing Stock Solutions for CASIN

The following data is based on the product molecular weight 306.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.26 mL 16.32 mL 32.64 mL
5 mM 0.65 mL 3.26 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.26 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets for CASIN

Certificate of Analysis / Product Datasheet
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References for CASIN

References are publications that support the biological activity of the product.

Florian et al (2012) Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 10 520 PMID: 22560076

Peterson et al (2006) Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem.Biol. 13 443 PMID: 16632257

Li et al (2013) Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell 13 270 PMID: 24012368

If you know of a relevant reference for CASIN, please let us know.

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Keywords: CASIN, CASIN supplier, Cdc42, GTPase, inhibitors, inhibits, hematopoietic, stem, cells, HSCs, aged, young, cell, signaling, Stem, Cell, Signaling, Rho, Hematopoietic, Cells, 5050, Tocris Bioscience

2 Citations for CASIN

Citations are publications that use Tocris products. Selected citations for CASIN include:

Raymond P et al (2022) Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model. J Virus Erad 8 100307 PMID: 36514715

Cheng et al (2011) Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel. FEBS Lett 585 328 PMID: 21156174

Do you know of a great paper that uses CASIN from Tocris? Please let us know.

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