WIKI4

Pricing Availability   Qty
Cat.No. 4855 - WIKI4 | C29H23N5O3S | CAS No. 838818-26-1
Description: Potent tankyrase inhibitor
Chemical Name: 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin.

Compound Libraries

WIKI4 is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 521.59
Formula C29H23N5O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 838818-26-1
PubChem ID 2984337
InChI Key RNUXIZKXJOGYQP-UHFFFAOYSA-N
Smiles O=C(C5=C4C(C6=O)=CC=CC4=CC=C5)N6CCCSC1=NN=C(C3=CC=NC=C3)N1C2=CC=C(OC)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.43 20

Preparing Stock Solutions

The following data is based on the product molecular weight 521.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.59 mL 47.93 mL 95.86 mL
1 mM 1.92 mL 9.59 mL 19.17 mL
2 mM 0.96 mL 4.79 mL 9.59 mL
10 mM 0.19 mL 0.96 mL 1.92 mL

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References

References are publications that support the biological activity of the product.

James et al (2012) WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling. PLoS One 7 e50457 PMID: 23227175


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View all Tankyrase Inhibitors

Keywords: WIKI4, WIKI4 supplier, Wnt, signaling, signalling, inhibitors, inhibits, b-catenin, beta-catenin, β-catenin, tankyrase, TNKS2, Poly(ADP-ribose), Polymerase, Stem, Cell, Signaling, Tankyrase, 4855, Tocris Bioscience

Citations for WIKI4

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Literature in this Area

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