Inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 521.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||9.59 mL||47.93 mL||95.86 mL|
|1 mM||1.92 mL||9.59 mL||19.17 mL|
|2 mM||0.96 mL||4.79 mL||9.59 mL|
|10 mM||0.19 mL||0.96 mL||1.92 mL|
References are publications that support the biological activity of the product.
James et al (2012) WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling. PLoS One 7 e50457 PMID: 23227175
If you know of a relevant reference for WIKI4, please let us know.
View Related Products by Product Action
Keywords: WIKI4, WIKI4 supplier, Wnt, signaling, signalling, inhibitors, inhibits, b-catenin, beta-catenin, β-catenin, tankyrase, TNKS2, Poly(ADP-ribose), Polymerase, Stem, Cell, Signaling, Tankyrase, 4855, Tocris Bioscience
Citations for WIKI4
Citations are publications that use Tocris products.
Currently there are no citations for WIKI4. Do you know of a great paper that uses WIKI4 from Tocris? Please let us know.
Reviews for WIKI4
There are currently no reviews for this product. Be the first to review WIKI4 and earn rewards!
Have you used WIKI4?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.