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Description: Potent tankyrase inhibitor
Chemical Name: 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for WIKI4

WIKI4 is an inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin. WIKI4 inhibits expression of β-catenin target genes in cancer cell lines as well as in human embryonic stem cells (ESC).

WIKI4 synthesized to Ancillary Material Grade also available.

Technical Data for WIKI4

M. Wt 521.59
Formula C29H23N5O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 838818-26-1
PubChem ID 2984337
Smiles O=C(C5=C4C(C6=O)=CC=CC4=CC=C5)N6CCCSC1=NN=C(C3=CC=NC=C3)N1C2=CC=C(OC)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WIKI4

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.22 10

Preparing Stock Solutions for WIKI4

The following data is based on the product molecular weight 521.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.17 mL 95.86 mL 191.72 mL
0.5 mM 3.83 mL 19.17 mL 38.34 mL
1 mM 1.92 mL 9.59 mL 19.17 mL
5 mM 0.38 mL 1.92 mL 3.83 mL

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Product Datasheets for WIKI4

Certificate of Analysis / Product Datasheet
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References for WIKI4

References are publications that support the biological activity of the product.

James et al (2012) WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling. PLoS One 7 e50457 PMID: 23227175

If you know of a relevant reference for WIKI4, please let us know.

View Related Products by Product Action

View all Tankyrase Inhibitors

Keywords: WIKI4, WIKI4 supplier, Wnt, signaling, signalling, inhibitors, inhibits, b-catenin, beta-catenin, β-catenin, tankyrase, TNKS2, Poly(ADP-ribose), Polymerase, Stem, Cell, Signaling, Tankyrase, Organoids, 4855, Tocris Bioscience

1 Citation for WIKI4

Citations are publications that use Tocris products. Selected citations for WIKI4 include:

Yung et al (2019) Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat.Commun. 10 4647 PMID: 31604927

Do you know of a great paper that uses WIKI4 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products