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Inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin. WIKI4 inhibits expression of β-catenin target genes in cancer cell lines as well as in human embryonic stem cells (ESC).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 521.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||19.17 mL||95.86 mL||191.72 mL|
|0.5 mM||3.83 mL||19.17 mL||38.34 mL|
|1 mM||1.92 mL||9.59 mL||19.17 mL|
|5 mM||0.38 mL||1.92 mL||3.83 mL|
References are publications that support the biological activity of the product.
James et al (2012) WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling. PLoS One 7 e50457 PMID: 23227175
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Keywords: WIKI4, WIKI4 supplier, Wnt, signaling, signalling, inhibitors, inhibits, b-catenin, beta-catenin, β-catenin, tankyrase, TNKS2, Poly(ADP-ribose), Polymerase, Stem, Cell, Signaling, Tankyrase, 4855, Tocris Bioscience
1 Citation for WIKI4
Citations are publications that use Tocris products. Selected citations for WIKI4 include:
Yung et al (2019) Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat.Commun. 10 4647 PMID: 31604927
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