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Inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 521.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||9.59 mL||47.93 mL||95.86 mL|
|1 mM||1.92 mL||9.59 mL||19.17 mL|
|2 mM||0.96 mL||4.79 mL||9.59 mL|
|10 mM||0.19 mL||0.96 mL||1.92 mL|
References are publications that support the biological activity of the product.
James et al (2012) WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling. PLoS One 7 e50457 PMID: 23227175
If you know of a relevant reference for WIKI4, please let us know.
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Keywords: WIKI4, WIKI4 supplier, Wnt, signaling, signalling, inhibitors, inhibits, b-catenin, beta-catenin, β-catenin, tankyrase, TNKS2, Poly(ADP-ribose), Polymerase, Stem, Cell, Signaling, Tankyrase, 4855, Tocris Bioscience
1 Citation for WIKI4
Citations are publications that use Tocris products. Selected citations for WIKI4 include:
Yung et al (2019) Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat.Commun. 10 4647 PMID: 31604927
Do you know of a great paper that uses WIKI4 from Tocris? Please let us know.
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Literature in this Area
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