Wnt Signaling Pathway

β-catenin β-catenin β-
catenin β-catenin PAR1 Wnt GSK-3β GSK-3β CK1ε CK1α PP2A c-Jun c-Myc Proteasomal degradation

The Wnt signaling pathway regulates several developmental processes such as differentiation, cell migration and proliferation during embryogenesis and in adult tissues. Dysregulation of this signaling pathway may promote tumorigenesis and metastasis.

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Signaling Pathway Key

Stimulates

Translocates

Kinase

Transcription Factor

Phosphatase

Inhibits

Other Protein

7-TM Receptor