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Voltage-gated Sodium (NaV) Channels

Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.

Products
Background
Literature
Gene Data

Activators
Cat No Product Name / Activity
5941 OD1
Potent hNav1.4, rNav1.6 and rNav1.7 channel activator
2918 Veratridine
Voltage-gated Na+ channel opener

Blockers
Cat No Product Name / Activity
2976 A 803467
Selective NaV1.8 channel blocker
4249 A 887826
Potent voltage-dependent NaV1.8 channel blocker
2404 Ambroxol hydrochloride
Na+ channel blocker
0890 Amiloride hydrochloride
Na+ channel blocker; also I2 imidazoline ligand
4804 APETx2
NaV1.8 and NaV1.2 blocker; also blocks ASIC3 channels
4098 Carbamazepine
Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant
2642 Co 102862
State-dependent of voltage-gated sodium channels
1470 Flecainide acetate
Cardiac Na+ channel blocker. Antiarrhythmic
0522 Flunarizine dihydrochloride
Dual Na+/Ca2+ channel (T-type) blocker
4718 Huwentoxin IV
Selective NaV1.7 channel blocker
5066 ICA 121431
Potent and selective NaV1.3 and NaV1.1 channel blocker
4913 Jingzhaotoxin III
Selective NaV1.5 channel blocker
3251 KC 12291 hydrochloride
Orally active atypical Na+ channel blocker; cardioprotective
3865 Licarbazepine
Active metabolite of oxcarbazepine (Cat. No. 3864)
3057 Lidocaine
Na+ channel blocker
2596 Mexiletine hydrochloride
Na+ channel blocker; antiarrhythmic agent
4691 NAV 26
Selective Nav1.7 channel blocker
3864 Oxcarbazepine
Anticonvulsant; inhibits Na+ channel activity
4916 PF 04885614
Potent and selective NaV1.8 channel blocker; active in vivo
5931 PF 05089771
Potent and selective Nav1.7 channel blocker
4914 Phrixotoxin 3
Potent blocker of NaV1.2, NaV1.3 and NaV1.5 channels
4665 ProTx I
CaV3.1 channel blocker; also inhibits NaV1.8 and KV2.1
4023 ProTx II
Selective NaV1.7 channel blocker
5792 ProTx III
Potent Nav1.7 blocker; analgesic
1043 QX 222
Na+ channel blocker
1014 QX 314 bromide
Na+ channel blocker
2313 QX 314 chloride
Na+ channel blocker
4029 Ralfinamide mesylate
Na+ channel blocker
0768 Riluzole hydrochloride
Na+ channel blocker
4044 Sipatrigine
NaV blocker; neuroprotective
4435 TC-N 1752
NaV channel blocker
1078 Tetrodotoxin
Na+ channel blocker
6159 4,9-Anhydrotetrodotoxin
Potent and selective Nav1.6 channel blocker
1069 Tetrodotoxin citrate
Na+ channel blocker; citrate salt of tetrodotoxin (Cat. No. 1078)
2815 Valproic acid, sodium salt
Blocks voltage-gated Na+ channels
0757 Vinpocetine
Na+ channel blocker

Other
Cat No Product Name / Activity
5184 BDS I
Attenuates inactivation of sodium currents by acting on Nav1.7 and Nav1.3 channels; neuroprotective
1539 β-Pompilidotoxin
Slows neuronal Na+ channel inactivation
5470 QAQ dichloride
Photoswitchable Nav, Kv and Cav channel blocker
3828 Rufinamide
Prolongs inactivation of sodium channels; anticonvulsant

Related Targets

Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.

Structurally, NaV channels are composed of one pore-forming α-subunit, which may be associated with either one or more β-subunits. α-subunits are composed for four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane potential. S4 is also involved in channel gating.

External sources of pharmacological information for Voltage-gated Sodium (NaV) Channels :

Literature for Voltage-gated Sodium (NaV) Channels

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Voltage-gated Sodium Channel Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
NaV1.1 Human SCN1A NM_006920 P35498
Mouse Scn1a NM_018733 NP_061203
Rat Scn1a NM_030875 P04774
NaV1.2 Human SCN2A NM_021007 Q99250
Mouse Scn2a1 NM_001099298 NP_001092768
Rat Scn2a1 NM_012647 P04775
NaV1.3 Human SCN3A NM_006922 Q9NY46
Mouse Scn3a NM_018732 NP_061202
Rat Scn3a NM_013119 P08104
NaV1.4 Human SCN4A NM_000334 P35499
Mouse Scn4a NM_133199 NP_573462
Rat Scn4a NM_013178 P15390
NaV1.5 Human SCN5A NM_198056 Q14524
Mouse Scn5a NM_021544 NP_067519
Rat Scn5a NM_013125 P15389
NaV1.6 Human SCN8A NM_014191 Q9UQD0
Mouse Scn8a NM_001077499 Q9WTU3
Rat Scn8a NM_019266 O88420
NaV1.7 Human SCN9A NM_002977 Q15858
Mouse Scn9a NM_018852 Q62205
Rat Scn9a NM_133289 O08562
NaV1.8 Human SCN10A NM_006514 Q9Y5Y9
Mouse Scn10a NM_009134 Q6QIY3
Rat Scn10a NM_017247 Q62968
NaV1.9 Human SCN11A NM_014139 Q9UI33
Mouse Scn11a NM_011887 Q9R053
Rat Scn11a NM_019265 O88457
β1 Human SCN1B NM_001037 Q07699
Mouse Scn1b NM_011322 P97952
Rat Scn1b NM_017288 Q00954
β2 Human SCN2B NM_004588 O60939
Mouse Scn2b NM_001014761 Q56A07
Rat Scn2b NM_012877 P54900
β3 Human SCN3B NM_018400 Q9NY72
Mouse Scn3b NM_153522 Q8BHK2
Rat Scn3b NM_139097 Q9JK00
β4 Human SCN4B NM_174934 Q8IWT1
Mouse Scn4b NM_001013390 Q7M729
Rat Scn4b NM_001008880 Q7M730