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Submit ReviewLicarbazepine
Description: Active metabolite of oxcarbazepine (Cat. No. 3864)
Alternative Names: GP 47779
Chemical Name: 10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for Licarbazepine
Licarbazepine is an active metabolite of oxcarbazepine (Cat. No. 3864). Produces dose-dependent inhibition of glutamatergic excitatory postsynaptic potentials (EPSPs). Displays anticonvulsant activity; exhibits minor potentiation of GABAA receptor currents.
Compound Libraries for Licarbazepine
Licarbazepine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Licarbazepine
| M. Wt | 254.28 |
| Formula | C15H14N2O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 29331-92-8 |
| PubChem ID | 114709 |
| InChI Key | BMPDWHIDQYTSHX-UHFFFAOYSA-N |
| Smiles | NC(N2C1=CC=CC=C1C(O)CC3=C2C=CC=C3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Licarbazepine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.43 | 100 |
Preparing Stock Solutions for Licarbazepine
The following data is based on the product molecular weight 254.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.93 mL | 19.66 mL | 39.33 mL |
| 5 mM | 0.79 mL | 3.93 mL | 7.87 mL |
| 10 mM | 0.39 mL | 1.97 mL | 3.93 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.79 mL |
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Product Datasheets for Licarbazepine
References for Licarbazepine
References are publications that support the biological activity of the product.
Calabresi et al (1995) Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. I. Modulation of corticostriatal synaptic transmission. Epilepsia 36 990 PMID: 7555963
Benes et al (1999) Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. J.Med.Chem. 42 2582 PMID: 10411478
Zheng et al (2009) Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures. Epilepsia 50 83 PMID: 18717705
If you know of a relevant reference for Licarbazepine, please let us know.
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Keywords: Licarbazepine, Licarbazepine supplier, antiepileptics, anticonvulsants, anticonvulsives, sodium, channels, voltage-gated, Na+, voltage-dependent, inhibitors, inhibits, NaV, GP47779, GP, 47779, Voltage-gated, Sodium, Channels, 3865, Tocris Bioscience
Citations for Licarbazepine
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Currently there are no citations for Licarbazepine. Do you know of a great paper that uses Licarbazepine from Tocris? Please let us know.
Reviews for Licarbazepine
Average Rating: 5 (Based on 1 Review.)
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Inhibiting currents through Nav1.5 voltage gated sodium channel.
By
Theresa Leslie on 05/08/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK293-Nav1.5
Inhibiting currents through voltage gated sodium channel Nav1.5 in HEK-293-Nav1.5 cells. We used it at a concentration of 300 micromolar.
A stock solution of 100 mM in DMSO was used.
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