Licarbazepine

Pricing Availability Delivery Time Qty
Cat.No. 3865 - Licarbazepine | C15H14N2O2 | CAS No. 29331-92-8
Description: Active metabolite of oxcarbazepine (Cat. No. 3864)
Alternative Names: GP 47779
Chemical Name: 10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Active metabolite of oxcarbazepine (Cat. No. 3864). Produces dose-dependent inhibition of glutamatergic excitatory postsynaptic potentials (EPSPs). Displays anticonvulsant activity; exhibits minor potentiation of GABAA receptor currents.

Compound Libraries

Licarbazepine is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 254.28
Formula C15H14N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 29331-92-8
PubChem ID 114709
InChI Key BMPDWHIDQYTSHX-UHFFFAOYSA-N
Smiles NC(N2C1=CC=CC=C1C(O)CC3=C2C=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.43 100
ethanol 12.71 50

Preparing Stock Solutions

The following data is based on the product molecular weight 254.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.66 mL 39.33 mL
5 mM 0.79 mL 3.93 mL 7.87 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Calabresi et al (1995) Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. I. Modulation of corticostriatal synaptic transmission. Epilepsia 36 990 PMID: 7555963

Benes et al (1999) Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. J.Med.Chem. 42 2582 PMID: 10411478

Zheng et al (2009) Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures. Epilepsia 50 83 PMID: 18717705


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Keywords: antiepileptics anticonvulsants anticonvulsives sodium channels voltage-gated Na+ voltage-dependent inhibitors inhibits NaV GP47779 GP 47779 GP 47779 Voltage-gated Sodium Channels

Citations for Licarbazepine

Citations are publications that use Tocris products.

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Pathways for Licarbazepine

Protocols

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