NS 383

Pricing Availability   Qty
Description: ASIC blocker; active in vivo
Chemical Name: 8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime

Biological Activity for NS 383

NS 383 is an ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.

Technical Data for NS 383

M. Wt 321.37
Formula C19H19N3O2
Storage Store at -20°C
CAS Number 309711-59-9
PubChem ID 135418391
Smiles CCN1CCC2=C(C3=C(/C(C(N3)=O)=N\O)C=C2C4=CC=CC=C4)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NS 383

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 1.61 5

Preparing Stock Solutions for NS 383

The following data is based on the product molecular weight 321.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 62.23 mL 311.17 mL 622.34 mL
0.25 mM 12.45 mL 62.23 mL 124.47 mL
0.5 mM 6.22 mL 31.12 mL 62.23 mL
2.5 mM 1.24 mL 6.22 mL 12.45 mL

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References for NS 383

References are publications that support the biological activity of the product.

Munro et al (2016) NS383 Selectively inhibits acid-sensing ion channels containing 1a and 3 subunits to reverse inflammatory and neuropathic hyperalgesia in rats. CNS Neurosci.Ther. 22 135 PMID: 26663905

If you know of a relevant reference for NS 383, please let us know.

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Keywords: NS 383, NS 383 supplier, NS383, ASIC, blockers, acid-sensing, ion, channels, inflammatory, pain, Voltage-gated, Sodium, Channels, 5927, Tocris Bioscience

Citations for NS 383

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