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Submit ReviewNS 383
Description: ASIC blocker; active in vivo
Chemical Name: 8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime
Biological Activity for NS 383
NS 383 is an ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.
Technical Data for NS 383
| M. Wt | 321.37 |
| Formula | C19H19N3O2 |
| Storage | Store at -20°C |
| CAS Number | 309711-59-9 |
| PubChem ID | 135418391 |
| InChI Key | CHVQAXYXYIDNDC-UHFFFAOYSA-N |
| Smiles | CCN1CCC2=C(C3=C(/C(C(N3)=O)=N\O)C=C2C4=CC=CC=C4)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NS 383
References for NS 383
References are publications that support the biological activity of the product.
Munro et al (2016) NS383 Selectively inhibits acid-sensing ion channels containing 1a and 3 subunits to reverse inflammatory and neuropathic hyperalgesia in rats. CNS Neurosci.Ther. 22 135 PMID: 26663905
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Keywords: NS 383, NS 383 supplier, NS383, ASIC, blockers, acid-sensing, ion, channels, inflammatory, pain, Voltage-gated, Sodium, Channels, 5927, Tocris Bioscience
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