NS 383

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Cat.No. 5927 - NS 383 | C19H19N3O2 | CAS No. 309711-59-9
Description: ASIC blocker; active in vivo
Chemical Name: 8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.

Technical Data

M. Wt 321.37
Formula C19H19N3O2
Storage Store at -20°C
CAS Number 309711-59-9
PubChem ID 135418391
InChI Key CHVQAXYXYIDNDC-UHFFFAOYSA-N
Smiles CCN1CCC2=C(C3=C(/C(C(N3)=O)=N\O)C=C2C4=CC=CC=C4)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.61 5

Preparing Stock Solutions

The following data is based on the product molecular weight 321.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 62.23 mL 311.17 mL 622.34 mL
0.25 mM 12.45 mL 62.23 mL 124.47 mL
0.5 mM 6.22 mL 31.12 mL 62.23 mL
2.5 mM 1.24 mL 6.22 mL 12.45 mL

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References

References are publications that support the biological activity of the product.

Munro et al (2016) NS383 Selectively inhibits acid-sensing ion channels containing 1a and 3 subunits to reverse inflammatory and neuropathic hyperalgesia in rats. CNS Neurosci.Ther. 22 135 PMID: 26663905


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Keywords: NS 383, NS 383 supplier, NS383, ASIC, blockers, acid-sensing, ion, channels, inflammatory, pain, Voltage-gated, Sodium, Channels, 5927, Tocris Bioscience

Citations for NS 383

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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