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Board spectrum anticonvulsant. Prolongs the inactivation of sodium channels and limits the frequency of action potential firing in cultured and acutely isolated neurons. Displays anticonvulsive activity in a range of animal seizure models.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 238.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.2 mL||20.99 mL||41.98 mL|
|5 mM||0.84 mL||4.2 mL||8.4 mL|
|10 mM||0.42 mL||2.1 mL||4.2 mL|
|50 mM||0.08 mL||0.42 mL||0.84 mL|
References are publications that support the biological activity of the product.
Rogawski et al (2006) Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 69 273 PMID: 16621450
Arroyo (2007) Rufinamide. Neurotherapeutics 4 155 PMID: 17199032
White et al (2008) The anticonvulsant profile of rufin. (CGP 33101) in rodent seizure models. Epilepsia 49 1213 PMID: 18325020
If you know of a relevant reference for Rufinamide, please let us know.
Keywords: Rufinamide, Rufinamide supplier, CGP33101, sodium, channels, voltage-gated, voltage-dependent, NaV, Na+, prolongs, inactivation, anticonvulsant, anticonvulsive, antiepileptic, CGP, 33101, Voltage-gated, Sodium, Channels, 3828, Tocris Bioscience
Citations for Rufinamide
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.