Rufinamide

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Cat.No. 3828 - Rufinamide | C10H8F2N4O | CAS No. 106308-44-5
Description: Prolongs inactivation of sodium channels; anticonvulsant
Alternative Names: CGP 33101
Chemical Name: 1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Board spectrum anticonvulsant. Prolongs the inactivation of sodium channels and limits the frequency of action potential firing in cultured and acutely isolated neurons. Displays anticonvulsive activity in a range of animal seizure models.

Technical Data

M. Wt 238.19
Formula C10H8F2N4O
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 106308-44-5
PubChem ID 129228
InChI Key POGQSBRIGCQNEG-UHFFFAOYSA-N
Smiles O=C(N)C1=CN(CC2=C(F)C=CC=C2F)N=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.82 100

Preparing Stock Solutions

The following data is based on the product molecular weight 238.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.2 mL 20.99 mL 41.98 mL
5 mM 0.84 mL 4.2 mL 8.4 mL
10 mM 0.42 mL 2.1 mL 4.2 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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References

References are publications that support the biological activity of the product.

Rogawski et al (2006) Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 69 273 PMID: 16621450

Arroyo (2007) Rufinamide. Neurotherapeutics 4 155 PMID: 17199032

White et al (2008) The anticonvulsant profile of rufin. (CGP 33101) in rodent seizure models. Epilepsia 49 1213 PMID: 18325020


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Citations for Rufinamide

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