Rufinamide

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Cat.No. 3828 - Rufinamide | C10H8F2N4O | CAS No. 106308-44-5
Description: Prolongs inactivation of sodium channels; anticonvulsant
Alternative Names: CGP 33101
Chemical Name: 1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Board spectrum anticonvulsant. Prolongs the inactivation of sodium channels and limits the frequency of action potential firing in cultured and acutely isolated neurons. Displays anticonvulsive activity in a range of animal seizure models.

Technical Data

M. Wt 238.19
Formula C10H8F2N4O
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 106308-44-5
PubChem ID 129228
InChI Key POGQSBRIGCQNEG-UHFFFAOYSA-N
Smiles O=C(N)C1=CN(CC2=C(F)C=CC=C2F)N=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.82 100
ethanol 1.19 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 238.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.2 mL 20.99 mL 41.98 mL
5 mM 0.84 mL 4.2 mL 8.4 mL
10 mM 0.42 mL 2.1 mL 4.2 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rogawski et al (2006) Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 69 273 PMID: 16621450

Arroyo (2007) Rufinamide. Neurotherapeutics 4 155 PMID: 17199032

White et al (2008) The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia 49 1213 PMID: 18325020


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View Related Products by Target

Keywords: CGP33101 sodium channels voltage-gated voltage-dependent NaV Na+ prolongs inactivation anticonvulsant anticonvulsive antiepileptic CGP 33101 Voltage-gated Sodium Channels

Citations for Rufinamide

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Pathways for Rufinamide

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