Riluzole hydrochloride

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Cat.No. 0768 - Riluzole hydrochloride | C8H5F3N2OS.HCl | CAS No. 850608-87-6
Description: GABA uptake inhibitor. Also glutamate release inhibitor
Chemical Name: 2-Amino-6-trifluoromethoxybenzothiazole hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (9)
Literature

Biological Activity

Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Inhibits glutamate release from presynaptic terminals and increases Na+-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes; neuroprotective.

Technical Data

M. Wt 270.66
Formula C8H5F3N2OS.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 50608-87-6
PubChem ID 6419992
InChI Key QEAOELIJQRYJJS-UHFFFAOYSA-N
Smiles Cl.NC1=NC2=CC=C(OC(F)(F)F)C=C2S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.07 100
water 2.71 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 270.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.69 mL 18.47 mL 36.95 mL
5 mM 0.74 mL 3.69 mL 7.39 mL
10 mM 0.37 mL 1.85 mL 3.69 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Fumagalli et al (2008) Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur.J.Pharmacol. 578 171 PMID: 18036519

Song et al (1997) Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J.Pharmacol.Exp.Ther. 282 707 PMID: 9262334

Taylor and Meldrum (1995) Na+ channels as targets for neuroprotective drugs. TiPS 16 309 PMID: 7482996

Umeniya and Berger (1995) Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones. Br.J.Pharmacol. 116 3227 PMID: 8719800


If you know of a relevant reference for Riluzole hydrochloride, please let us know.

View Related Products by Product Action

View all GABA Inhibitors

Keywords: Glutamate release inhibitors inhibits GABA uptake Na+ channel blockers glutamate mGlur Receptors Metabotropic Sodium NaV Channels voltage-gated voltage-dependent iGlu Ionotropic BGT-1 GAT Transporters Monoamine Neurotransmitter neuroprotective GABA Transporters

9 Citations for Riluzole hydrochloride

Citations are publications that use Tocris products. Selected citations for Riluzole hydrochloride include:

Du et al (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun 6 6626 PMID: 25806427

Rosenberg et al (2015) Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression. Front Neural Circuits 8 42614 PMID: 25749171

Du et al (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat.Commun. 6 6626 PMID: 25806427

Veettil et al (2014) Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation. PLoS Pathog 10 e1004389 PMID: 25299066

Viemari et al (2013) ╬▓-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro. Neurochem Int 7 179 PMID: 24273495

Carbone et al (2012) Riluzole elevates GLT-1 activity and levels in striatal astrocytes. BMC Neurosci 60 42613 PMID: 22080156

Carbone et al (2012) Riluzole neuroprotection in a Parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation. Cells 13 38 PMID: 22480308

Morgado-Valle et al (2010) Glycinergic pacemaker neurons in preB├Âtzinger complex of neonatal mouse. J Neurosci 30 3634 PMID: 20219997

Le et al (2010) The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells. J Invest Dermatol 130 2240 PMID: 20505744


Do you know of a great paper that uses Riluzole hydrochloride from Tocris? If so please let us know.

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